L2L L2L Microarray Analysis Tool

Results for D01AC.profile.d50

Results summary View all lists in L2L MDB View all genes in D01AC.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 0.84 17 20.17 4.82e-17
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.34 10 29.75 2.73e-12
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.49 11 22.59 4.52e-12
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.42 10 23.66 2.67e-11
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 11 14.88 3.90e-10
rb_creko_up Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 344 0.85 11 12.94 1.69e-09
adip_diff_cluster4 Strongly upregulated at 16 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 4) 56 0.14 6 43.34 6.66e-09
dox_resist_gastric_up Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.18 6 32.80 3.66e-08
inos_all_up Upregulated following iNOS induction in hepatocytes (Tables 3-17) 87 0.22 5 23.25 2.88e-06
stemcell_neural_up Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells 2805 6.93 21 3.03 1.22e-05
wnt3a_mammary_up Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). 133 0.33 5 15.21 2.28e-05
erm_ko_testes_dn Down-regulated in testes from 4 week old ERM knockout mice, compared to wild-type controls 24 0.06 3 50.57 2.94e-05
p21_p53_any_dn Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 77 0.19 4 21.02 4.37e-05
p21_p53_middle_dn Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 37 0.09 3 32.80 1.10e-04
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 6 7.93 1.32e-04
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 7 5.96 2.14e-04
inos_10_up Ten most-upregulated genes following iNOS induction in hepatocytes 10 0.02 2 80.91 2.71e-04
stemcell_embryonic_up Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 4.92 14 2.85 5.84e-04
csb_reliable_up Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 1.27 6 4.73 1.94e-03
heatshock_hela_4hr_dn Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 4.52 12 2.65 2.46e-03
scchn_hpvpos_up Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 31 0.08 2 26.10 2.71e-03
bay_pbmc_4hr_dn Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 400 0.99 5 5.06 3.44e-03
cmv_hcmv_timecourse_48hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours 135 0.33 3 8.99 4.75e-03
serum_fibroblast_core_up Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) 292 0.72 4 5.54 6.31e-03
vhl_rcc_up Upregulated in VHL-null renal carcinoma cells vs. VHL-rescued (Fig. 1a+b) 153 0.38 3 7.93 6.71e-03

Raw data (tab-delimited .txt)