L2L L2L Microarray Analysis Tool

Results for D01A.profile.d50

Results summary View all lists in L2L MDB View all genes in D01A.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 0.84 12 14.24 1.04e-10
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 11 14.88 3.90e-10
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.34 8 23.80 2.48e-09
rb_creko_up Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 344 0.85 10 11.76 2.26e-08
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.42 7 16.56 2.96e-07
erm_ko_testes_dn Down-regulated in testes from 4 week old ERM knockout mice, compared to wild-type controls 24 0.06 4 67.42 3.81e-07
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.49 7 14.37 7.68e-07
dox_resist_gastric_up Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.18 5 27.33 1.29e-06
dac_fibro_dn Downregulated by DAC treatment in LD419 fibroblast cells 17 0.04 3 71.39 1.00e-05
inos_10_up Ten most-upregulated genes following iNOS induction in hepatocytes 10 0.02 2 80.91 2.71e-04
hsc_sthsc_adult Up-regulated in mouse short-term functional hematopoietic stem cells from adult bone marrow (ST-HSC Shared + Adult) 51 0.13 3 23.80 2.88e-04
stemcell_neural_up Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells 2805 6.93 18 2.60 3.17e-04
wnt3a_mammary_up Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). 133 0.33 4 12.17 3.61e-04
adip_diff_cluster4 Strongly upregulated at 16 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 4) 56 0.14 3 21.67 3.80e-04
dac_cgi_fibro_dn Downregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island 12 0.03 2 67.42 3.97e-04
hdaci_colon_cluster9 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.19 3 15.56 1.00e-03
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 5 6.61 1.08e-03
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 6 5.11 1.32e-03
middleage_dn Downregulated in fibroblasts from middle-age individuals, compared to young 23 0.06 2 35.18 1.49e-03
p21_p53_early_dn Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 23 0.06 2 35.18 1.49e-03
pod1_ko_up Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 508 1.26 6 4.78 1.85e-03
oldwerner_fibro_up Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young 30 0.07 2 26.97 2.54e-03
scchn_hpvpos_up Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 31 0.08 2 26.10 2.71e-03
bay_pbmc_2hr_dn Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 398 0.98 5 5.08 3.36e-03
bay_pbmc_4hr_dn Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 400 0.99 5 5.06 3.44e-03
17aag_ovca_dn Down-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) 129 0.32 3 9.41 4.19e-03
cmv_hcmv_timecourse_48hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours 135 0.33 3 8.99 4.75e-03
hsc_sthsc_fetal Up-regulated in mouse short-term functional hematopoietic stem cells from fetal liver (ST-HSC Shared) 44 0.11 2 18.39 5.40e-03
hsc_sthsc_shared Up-regulated in mouse short-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (ST-HSC Shared) 44 0.11 2 18.39 5.40e-03
serum_fibroblast_core_up Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) 292 0.72 4 5.54 6.31e-03
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 2 16.86 6.39e-03
vhl_rcc_up Upregulated in VHL-null renal carcinoma cells vs. VHL-rescued (Fig. 1a+b) 153 0.38 3 7.93 6.71e-03
cmv_hcmv_timecourse_all_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 895 2.21 7 3.16 7.60e-03
hdaci_colon_but24hrs_dn Downregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 168 0.42 3 7.22 8.66e-03
hippocampus_development_prenatal Highly expressed in prenatal mouse hippocampus (cluster 1) 58 0.14 2 13.95 9.21e-03
brca1_overexp_up Upregulated by induction of exogenous BRCA1 in EcR-293 cells 328 0.81 4 4.93 9.39e-03
csb_reliable_up Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 1.27 5 3.94 9.56e-03

Raw data (tab-delimited .txt)