L2L Microarray Analysis Tool
Results for S01AD.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in S01AD.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 12 | 12.32 | 4.65e-10 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 1.48 | 13 | 8.79 | 5.34e-09 |
| dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.37 | 7 | 19.13 | 9.72e-08 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.85 | 8 | 9.46 | 2.68e-06 |
| middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.11 | 4 | 35.18 | 4.91e-06 |
| idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.67 | 7 | 10.41 | 6.04e-06 |
| adip_diff_cluster5 | Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) | 67 | 0.33 | 5 | 15.09 | 2.21e-05 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 1.69 | 9 | 5.34 | 6.27e-05 |
| p21_p53_early_dn | Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 23 | 0.11 | 3 | 26.38 | 1.99e-04 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 10 | 3.97 | 2.82e-04 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 4 | 12.26 | 3.37e-04 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 4 | 12.26 | 3.37e-04 |
| uvc_low_a1_up | Up-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a1) | 6 | 0.03 | 2 | 67.42 | 3.62e-04 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 10 | 3.82 | 3.81e-04 |
| scchn_hpvpos_up | Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| bleo_mouse_lymph_low_4hrs_up | Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of bleomycin | 7 | 0.03 | 2 | 57.79 | 5.05e-04 |
| oldage_dn | Downregulated in fibroblasts from old individuals, compared to young | 76 | 0.38 | 4 | 10.65 | 5.77e-04 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 4 | 9.87 | 7.69e-04 |
| cmv_ie86_up | Upregulated by expression of cytomegalovirus IE86 protein in primary human fibroblasts | 82 | 0.41 | 4 | 9.87 | 7.69e-04 |
| human_tissue_lung | Genes expressed specifically in human lung tissue | 11 | 0.05 | 2 | 36.78 | 1.31e-03 |
| adipocyte_brca_up | Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| bleo_human_lymph_high_4hrs_dn | Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| p21_early_dn | Down-regulated at early timepoints (4-8 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| cmv_hcmv_timecourse_8hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 8 hours | 63 | 0.31 | 3 | 9.63 | 3.85e-03 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 8 | 3.17 | 4.40e-03 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 1.12 | 5 | 4.47 | 5.64e-03 |
| cmv_hcmv_timecourse_10hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| parp_ko_dn | Downregulated in MEF cells from PARP knockout mice | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 8 | 2.97 | 6.33e-03 |
| p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.38 | 3 | 7.88 | 6.73e-03 |
| cox2_ko_hippocampus_up | Up-regulated in the hippocampus of COX2-/- mice compared to wild-type controls. | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| dac_cgi_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
| rb_creko_up | Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 344 | 1.70 | 6 | 3.53 | 7.84e-03 |