L2L Microarray Analysis Tool
Results for R06AX.profile.u50
| Results summary | View all lists in GO:BiolProc | View all genes in R06AX.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| negative regulation of I-kappaB kinase/NF-kappaB cascade | Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. | 5 | 0.01 | 2 | 161.82 | 6.08e-05 |
| apoptosis | A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface. | 1078 | 2.66 | 11 | 4.13 | 1.04e-04 |
| programmed cell death | Cell death resulting from activation of endogenous cellular processes. | 1086 | 2.68 | 11 | 4.10 | 1.11e-04 |
| steroid biosynthetic process | The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. | 99 | 0.24 | 4 | 16.35 | 1.17e-04 |
| cell death | The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. | 1152 | 2.85 | 11 | 3.86 | 1.84e-04 |
| death | A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. | 1152 | 2.85 | 11 | 3.86 | 1.84e-04 |
| sterol metabolic process | The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. | 117 | 0.29 | 4 | 13.83 | 2.22e-04 |
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. | 49 | 0.12 | 3 | 24.77 | 2.56e-04 |
| steroid metabolic process | The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. | 234 | 0.58 | 5 | 8.64 | 3.23e-04 |
| cell differentiation | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate. | 2359 | 5.83 | 16 | 2.74 | 3.69e-04 |
| cellular developmental process | A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. | 2359 | 5.83 | 16 | 2.74 | 3.69e-04 |
| alcohol metabolic process | The chemical reactions and pathways involving alcohols, any of a class of alkyl compounds containing a hydroxyl group. | 408 | 1.01 | 6 | 5.95 | 6.05e-04 |
| anti-apoptosis | A process which directly inhibits any of the steps required for cell death by apoptosis. | 278 | 0.69 | 5 | 7.28 | 7.05e-04 |
| transcription from RNA polymerase II promoter | The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). | 997 | 2.46 | 9 | 3.65 | 1.01e-03 |
| cell development | The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. | 1692 | 4.18 | 12 | 2.87 | 1.31e-03 |
| I-kappaB kinase/NF-kappaB cascade | A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase. | 190 | 0.47 | 4 | 8.52 | 1.36e-03 |
| negative regulation of apoptosis | Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis. | 345 | 0.85 | 5 | 5.86 | 1.82e-03 |
| negative regulation of programmed cell death | Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
| isoprenoid metabolic process | The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
| cholesterol metabolic process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. | 106 | 0.26 | 3 | 11.45 | 2.41e-03 |
| protein kinase cascade | A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. | 565 | 1.40 | 6 | 4.30 | 3.12e-03 |
| cholesterol biosynthetic process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
| regulation of I-kappaB kinase/NF-kappaB cascade | Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade. | 142 | 0.35 | 3 | 8.55 | 5.46e-03 |
| negative regulation of signal transduction | Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction. | 150 | 0.37 | 3 | 8.09 | 6.36e-03 |
| lipid biosynthetic process | The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. | 299 | 0.74 | 4 | 5.41 | 6.85e-03 |
| cellular lipid metabolic process | The chemical reactions and pathways involving lipids, as carried out by individual cells. | 723 | 1.79 | 6 | 3.36 | 9.95e-03 |