L2L L2L Microarray Analysis Tool

Results for R03BA.profile.u50

Results summary View all lists in L2L MDB View all genes in R03BA.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 20 44.95 8.72e-27
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.06 8 134.85 9.90e-16
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.05 6 127.75 6.02e-12
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.08 6 78.30 1.59e-10
dex_keratinocyte_4hr_dn Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 69 0.17 7 41.04 5.32e-10
bay_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 318 0.79 10 12.72 1.08e-08
il2_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 503 1.24 10 8.04 7.38e-07
ageing_brain_up Age-upregulated in the human frontal cortex 446 1.10 9 8.16 2.32e-06
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 7 12.15 2.34e-06
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.21 5 23.52 2.72e-06
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 4 36.78 4.68e-06
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 3 80.91 6.72e-06
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.57 9 5.74 3.73e-05
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 4 20.48 4.84e-05
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 2.07 10 4.82 6.05e-05
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 0.66 6 9.12 6.13e-05
bay_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 268 0.66 6 9.06 6.39e-05
fsh_human_granulosa_up Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.08 3 39.15 6.45e-05
il2_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 531 1.31 8 6.09 6.62e-05
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01 7 6.91 8.70e-05
uvb_nhek3_all Regulated by UV-B light in normal human epidermal keratinocytes 751 1.86 9 4.85 1.34e-04
hdaci_three_up Upregulated in several cell lines by all of TSA, SAHA, and MS-275 8 0.02 2 101.14 1.69e-04
cocaine_brain_4wks_up Up-regulated in the nucleus accumbens of mice after 4 weeks of cocaine treatment 112 0.28 4 14.45 1.87e-04
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.11 3 26.97 1.98e-04
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.11 3 26.38 2.12e-04
hdaci_colon_cluster2 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) 9 0.02 2 89.90 2.17e-04
heartfailure_ventricles_dn Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls 120 0.30 4 13.48 2.44e-04
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 4 13.26 2.60e-04
tgfb_hmvec_2hr_dn Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 0.87 6 6.88 2.83e-04
scw_joint_4hrs_up Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 230 0.57 5 8.79 2.99e-04
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 7 5.55 3.28e-04
cmv_hcmv_timecourse_48hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours 235 0.58 5 8.61 3.30e-04
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 1.67 8 4.79 3.34e-04
zmpste24_ko_up Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 57 0.14 3 21.29 4.00e-04
alzheimers_disease_up Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus 3137 7.75 19 2.45 4.43e-04
scw_joint_24hrs_up Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 143 0.35 4 11.32 4.74e-04
adip_diff_cluster2 Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) 64 0.16 3 18.96 5.62e-04
ni2_mouse_up Upregulated by nickel(II) in sensitive A/J mouse lung tissue 65 0.16 3 18.67 5.88e-04
adipogenesis_hmsc_class2_up Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) 15 0.04 2 53.94 6.28e-04
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.04 2 53.94 6.28e-04
tnfalpha_30min_up Upregulated 30min after TNF-alpha treatment of HeLa cells 68 0.17 3 17.85 6.71e-04
uvc_high_d8_dn Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.17 3 17.34 7.31e-04
scw_joint_react_up Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.41 4 9.75 8.28e-04
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.44 4 9.14 1.05e-03
et743pt650_breastca_dn Downregulated by both Et-743 and Pt-650 in MDA-MB-435 cells (Fig. 6G) 20 0.05 2 40.45 1.13e-03
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.20 3 14.80 1.16e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22 3 13.64 1.46e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 3 12.77 1.76e-03
pdgf_es_up Up-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis 28 0.07 2 28.90 2.21e-03
il2_pbmc_6hr_dn Down-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 6 4.58 2.28e-03
idx_tsa_up_cluster2 Strongly up-regulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 2) 105 0.26 3 11.56 2.35e-03
pod1_ko_dn Down-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 1135 2.81 9 3.21 2.43e-03
cmv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 109 0.27 3 11.13 2.61e-03
uvc_high_d1_dn Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) 31 0.08 2 26.10 2.71e-03
fsh_ovary_mcv152_dn Down-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 111 0.27 3 10.93 2.75e-03
tnfalpha_all_up Upregulated at any timepoint after TNF-alpha treatment of HeLa cells 122 0.30 3 9.95 3.58e-03
senescence_hela_up Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 262 0.65 4 6.18 4.32e-03
ni2_lung_dn Downregulated by nickel(II) in human peripheral lung epithelial cells 40 0.10 2 20.23 4.48e-03
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 3 8.99 4.75e-03
diab_neph_dn Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 829 2.05 7 3.42 5.09e-03
hdaci_colon_tsa48hrs_up Upregulated by TSA at 48 hrs in SW260 colon carcinoma cells 43 0.11 2 18.82 5.16e-03
tpa_sens_late_dn Downregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells 451 1.11 5 4.48 5.67e-03
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 2 17.21 6.14e-03
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 9 2.76 6.41e-03
bay_pbmc_6hr_dn Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 483 1.19 5 4.19 7.50e-03
uvc_high_d9_dn Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.13 2 15.27 7.74e-03
cmv_uv-cmv_common_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 54 0.13 2 14.98 8.03e-03
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 2 14.98 8.03e-03
lh_granulosa_up Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) 167 0.41 3 7.27 8.52e-03
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 0.79 4 5.07 8.55e-03

Raw data (tab-delimited .txt)