L2L L2L Microarray Analysis Tool

Results for R03AC.profile.u50

Results summary View all lists in L2L MDB View all genes in R03AC.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01 13 12.83 6.35e-11
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 14 9.35 7.23e-10
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 11 8.73 9.31e-08
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 1.34 11 8.18 1.77e-07
scw_joint_4hrs_up Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 230 0.57 7 12.31 2.15e-06
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 9 6.87 9.24e-06
cmv-uv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 226 0.56 6 10.74 2.48e-05
insulin_adip_insens_dn Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 25 0.06 3 48.54 3.34e-05
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 9 5.64 4.30e-05
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 8 6.33 5.07e-05
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 3 35.69 8.53e-05
cmvuv-cmv_common_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 37 0.09 3 32.80 1.10e-04
uv-cmv_unique_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 194 0.48 5 10.43 1.36e-04
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 5 10.01 1.64e-04
cmv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 46 0.11 3 26.38 2.12e-04
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 7 5.96 2.14e-04
il2_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 531 1.31 7 5.33 4.16e-04
h2o2_csbdiff_c1 Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) 58 0.14 3 20.92 4.21e-04
igfr_vs_ir_up Up-regulated following stimulation of chimeric TrkC/IGFR in NIH3T3 cells, compared to stimulation of TrkC/IR 13 0.03 2 62.24 4.68e-04
adipocyte_brca_up Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 14 0.03 2 57.79 5.45e-04
bay_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 268 0.66 5 7.55 5.98e-04
space_up Upregulated in space-flown fibroblasts 16 0.04 2 50.57 7.17e-04
hypoxia_review Genes known to be induced by hypoxia 160 0.40 4 10.11 7.22e-04
caries_pulp_high_up Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 168 0.42 4 9.63 8.66e-04
hdaci_colon_cluster8 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 8) 18 0.04 2 44.95 9.11e-04
bay_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 318 0.79 5 6.36 1.28e-03
tnfalpha_adip_up Upregulated in mature, differentiated adipocytes following treatment with TNFalpha 22 0.05 2 36.78 1.37e-03
il2_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 503 1.24 6 4.83 1.76e-03
tnfalpha_tgz_adip_up Upregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha 28 0.07 2 28.90 2.21e-03
dixoin_chloracne_pbmnc_up Up-regulated in peripheral blood mononuclear cells of subjects who developed chloracne as a result of dioxin exposure, compared to subjects who did not. 34 0.08 2 23.80 3.25e-03
dex_keratinocyte_4hr_up Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 35 0.09 2 23.12 3.44e-03
aged_mouse_retina_any_up Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 36 0.09 2 22.47 3.64e-03
rb_creko_dn Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 0.62 4 6.47 3.66e-03
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 2 21.29 4.05e-03
xpb_ttd-cs_dn Down-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) 41 0.10 2 19.73 4.70e-03
cmv_hcmv_timecourse_48hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours 135 0.33 3 8.99 4.75e-03
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.34 3 8.92 4.85e-03
ageing_brain_up Age-upregulated in the human frontal cortex 446 1.10 5 4.54 5.41e-03
idx_tsa_dn_cluster4 Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 46 0.11 2 17.59 5.88e-03
ifna_uv-cmv_common_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following either infection with UV-inactivated CMV or interferon-alpha 47 0.12 2 17.21 6.14e-03
hg_progeria_dn Downregulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals 48 0.12 2 16.86 6.39e-03
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 2 16.51 6.65e-03
bay_pbmc_6hr_dn Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 483 1.19 5 4.19 7.50e-03
brca1_overexp_prostate_up Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 308 0.76 4 5.25 7.58e-03
reovirus_hek293_up Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 1.21 5 4.12 8.02e-03
jnk_dn Downregulated by expression of constitutively active JNK in 3T3 cells 57 0.14 2 14.19 8.91e-03
dac_bladder_up Upregulated by DAC treatment in T24 bladder carcinoma cells 60 0.15 2 13.48 9.83e-03

Raw data (tab-delimited .txt)