Results summary | View all lists in L2L MDB | View all genes in R03AC.profile.u50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 1.01 | 13 | 12.83 | 6.35e-11 |
bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 14 | 9.35 | 7.23e-10 |
il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 11 | 8.73 | 9.31e-08 |
bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 11 | 8.18 | 1.77e-07 |
scw_joint_4hrs_up | Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 230 | 0.57 | 7 | 12.31 | 2.15e-06 |
il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 9 | 6.87 | 9.24e-06 |
cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 6 | 10.74 | 2.48e-05 |
insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.06 | 3 | 48.54 | 3.34e-05 |
il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 9 | 5.64 | 4.30e-05 |
il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 8 | 6.33 | 5.07e-05 |
uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
uv-cmv_unique_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 194 | 0.48 | 5 | 10.43 | 1.36e-04 |
bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 5 | 10.01 | 1.64e-04 |
cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 7 | 5.96 | 2.14e-04 |
il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 1.31 | 7 | 5.33 | 4.16e-04 |
h2o2_csbdiff_c1 | Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) | 58 | 0.14 | 3 | 20.92 | 4.21e-04 |
igfr_vs_ir_up | Up-regulated following stimulation of chimeric TrkC/IGFR in NIH3T3 cells, compared to stimulation of TrkC/IR | 13 | 0.03 | 2 | 62.24 | 4.68e-04 |
adipocyte_brca_up | Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
bay_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 268 | 0.66 | 5 | 7.55 | 5.98e-04 |
space_up | Upregulated in space-flown fibroblasts | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 4 | 10.11 | 7.22e-04 |
caries_pulp_high_up | Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 168 | 0.42 | 4 | 9.63 | 8.66e-04 |
hdaci_colon_cluster8 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 8) | 18 | 0.04 | 2 | 44.95 | 9.11e-04 |
bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 0.79 | 5 | 6.36 | 1.28e-03 |
tnfalpha_adip_up | Upregulated in mature, differentiated adipocytes following treatment with TNFalpha | 22 | 0.05 | 2 | 36.78 | 1.37e-03 |
il2_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 503 | 1.24 | 6 | 4.83 | 1.76e-03 |
tnfalpha_tgz_adip_up | Upregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
dixoin_chloracne_pbmnc_up | Up-regulated in peripheral blood mononuclear cells of subjects who developed chloracne as a result of dioxin exposure, compared to subjects who did not. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
dex_keratinocyte_4hr_up | Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 35 | 0.09 | 2 | 23.12 | 3.44e-03 |
aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
rb_creko_dn | Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 250 | 0.62 | 4 | 6.47 | 3.66e-03 |
nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
xpb_ttd-cs_dn | Down-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) | 41 | 0.10 | 2 | 19.73 | 4.70e-03 |
cmv_hcmv_timecourse_48hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours | 135 | 0.33 | 3 | 8.99 | 4.75e-03 |
idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.34 | 3 | 8.92 | 4.85e-03 |
ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 1.10 | 5 | 4.54 | 5.41e-03 |
idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.11 | 2 | 17.59 | 5.88e-03 |
ifna_uv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following either infection with UV-inactivated CMV or interferon-alpha | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
hg_progeria_dn | Downregulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals | 48 | 0.12 | 2 | 16.86 | 6.39e-03 |
p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
bay_pbmc_6hr_dn | Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 483 | 1.19 | 5 | 4.19 | 7.50e-03 |
brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 0.76 | 4 | 5.25 | 7.58e-03 |
reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 1.21 | 5 | 4.12 | 8.02e-03 |
jnk_dn | Downregulated by expression of constitutively active JNK in 3T3 cells | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
dac_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells | 60 | 0.15 | 2 | 13.48 | 9.83e-03 |