L2L Microarray Analysis Tool
Results for P02CA.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in P02CA.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| uvb_nhek3_c3 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 37 | 0.09 | 4 | 43.73 | 2.31e-06 |
| tpa_sens_early_up | Upregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells | 97 | 0.24 | 5 | 20.85 | 4.92e-06 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 10 | 5.99 | 9.75e-06 |
| tpa_sens_middle_up | Upregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells | 114 | 0.28 | 5 | 17.74 | 1.08e-05 |
| dac_cgi_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island | 26 | 0.06 | 3 | 46.68 | 3.76e-05 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 1519 | 3.75 | 14 | 3.73 | 3.82e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 8 | 5.46 | 1.41e-04 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 8 | 5.46 | 1.41e-04 |
| dex_keratinocyte_1hr_up | Up-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 8 | 0.02 | 2 | 101.14 | 1.69e-04 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 8 | 4.95 | 2.71e-04 |
| aged_rhesus_dn | Downregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys | 232 | 0.57 | 5 | 8.72 | 3.11e-04 |
| dac_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells | 60 | 0.15 | 3 | 20.23 | 4.65e-04 |
| igfr_vs_ir_up | Up-regulated following stimulation of chimeric TrkC/IGFR in NIH3T3 cells, compared to stimulation of TrkC/IR | 13 | 0.03 | 2 | 62.24 | 4.68e-04 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| bay_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 268 | 0.66 | 5 | 7.55 | 5.98e-04 |
| dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 0.17 | 3 | 17.85 | 6.71e-04 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 4 | 10.11 | 7.22e-04 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 5 | 6.76 | 9.75e-04 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| uv-cmv_unique_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 194 | 0.48 | 4 | 8.34 | 1.47e-03 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 1.21 | 6 | 4.94 | 1.56e-03 |
| et743_resist_dn | Down-regulated in two Et-743-resistant cell lines (chondrosarcoma and ovarian carcinoma) compared to sensitive parental lines | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
| tpa_sens_late_up | Upregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
| ifnalpha_resist_dn | Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| middleage_up | Upregulated in fibroblasts from middle-age individuals, compared to young | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| tnfa_nfkb_dep_up | Up-regulated at any timepoint following TNFa treatment, only with functional NFkB | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| hbx_nl_dn | Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
| egf_hdmec_up | Up-regulated in human dermal (foreskin) microvascular endothelial cells that were stimulated to proliferate with prolonged EGF treatment, versus non-stimulated quiescent controls. | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 4 | 7.16 | 2.56e-03 |
| mkk6ee_up | Upregulated by expression of constitutively active MKK6 | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| cpr_null-low_liver_up | Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus mice with low expression of CPR | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| gamma_unique_fibro_dn | Down-regulated at any timepoint by treatment of human fibroblasts with gamma radiation, but not by UV lght or 4-NQO | 120 | 0.30 | 3 | 10.11 | 3.42e-03 |
| as3_fibro_c4 | Downregulated early by sodium arsenite in fibroblasts (Cluster 4) | 35 | 0.09 | 2 | 23.12 | 3.44e-03 |
| dex_keratinocyte_4hr_up | Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 35 | 0.09 | 2 | 23.12 | 3.44e-03 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 1.01 | 5 | 4.93 | 3.81e-03 |
| ros_mouse_aorta_dn | Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 127 | 0.31 | 3 | 9.56 | 4.01e-03 |
| hdaci_colon_sul12hrs_up | Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
| csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
| hbx_hcc_dn | Downregulated by expression of Hepatitis B virus HBx protein in SK-Hep-1 hepatocellular carcinoma cells (Fig. 3B+D) | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| hg_progeria_dn | Downregulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals | 48 | 0.12 | 2 | 16.86 | 6.39e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
| brg1_h1299_up | Up-regulated by transient expression of BRG1 in H1299 lung cancer cells with mutant, inactive BRG1 | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| tsa_hepatoma_cancer_dn | Cancer-related genes down-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.39 | 3 | 7.63 | 7.45e-03 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| hypoxia_rcc_up | Upregulated by hypoxia in VHL-rescued renal carcinoma cells (Fig. 3f+g) | 170 | 0.42 | 3 | 7.14 | 8.94e-03 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 5 | 3.97 | 9.34e-03 |
| as3_fibro_dn | Downregulated by sodium arsenite in fibroblasts (Clusters 4, 5, and 6) | 59 | 0.15 | 2 | 13.71 | 9.52e-03 |
| csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 1.27 | 5 | 3.94 | 9.56e-03 |