L2L L2L Microarray Analysis Tool

Results for P02CA.profile.d50

Results summary View all lists in L2L MDB View all genes in P02CA.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 10 8.52 4.40e-07
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 4 33.71 6.66e-06
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 10 6.26 6.69e-06
hippocampus_development_neonatal Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) 51 0.13 4 31.73 8.50e-06
nf90_up Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells 56 0.14 4 28.90 1.24e-05
adip_vs_fibro_dn Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes 64 0.16 4 25.28 2.11e-05
vhl_normal_up Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) 754 1.86 10 5.37 2.49e-05
adip_vs_preadip_dn Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 84 0.21 4 19.26 6.15e-05
bcnu_glioma_mgmt_48hrs_up Up-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU 33 0.08 3 36.78 7.80e-05
creb_brain_2wks_up Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic CREB 39 0.10 3 31.12 1.29e-04
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 6 7.93 1.32e-04
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.49 5 10.27 1.46e-04
o6bg_resist_medulloblastoma_dn Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 109 0.27 4 14.85 1.69e-04
camptothecin_probcell_dn Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin 52 0.13 3 23.34 3.05e-04
rcc_nl_up Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) 899 2.22 9 4.05 4.93e-04
cox1_ko_cortex_up Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. 80 0.20 3 15.17 1.08e-03
hdaci_colon_sul24hrs_dn Downregulated by sulindac at 24 hrs in SW260 colon carcinoma cells 191 0.47 4 8.47 1.39e-03
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 4 8.01 1.70e-03
hdaci_colon_sul_dn Downregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 340 0.84 5 5.95 1.71e-03
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 6 4.75 1.90e-03
aged_mouse_cortex_dn Down-regulated in the cerebral cortex of aged (22 months) BALB/c mice, compared to young (2 months) controls 98 0.24 3 12.38 1.93e-03
cancer_undifferentiated_meta_up Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database 98 0.24 3 12.38 1.93e-03
emt_up Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 105 0.26 3 11.56 2.35e-03
aged_mouse_neocortex_up Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.27 3 10.93 2.75e-03
cancer_neoplastic_meta_up Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database 115 0.28 3 10.55 3.03e-03
heartfailure_ventricles_dn Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls 120 0.30 3 10.11 3.42e-03
breastca_two_classes Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers 247 0.61 4 6.55 3.51e-03
stemcell_embryonic_up Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 4.92 12 2.44 4.74e-03
shortattacklatency_up Up-regulated in hippocampi from a mouse line selected for long attack latency (LAL) against an intruder, versus a line selected for short attack latency (SAL). 156 0.39 3 7.78 7.08e-03
pod1_ko_up Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 508 1.26 5 3.98 9.19e-03

Raw data (tab-delimited .txt)