Results summary | View all lists in L2L MDB | View all genes in P02CA.profile.d50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 10 | 8.52 | 4.40e-07 |
idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.12 | 4 | 33.71 | 6.66e-06 |
il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 10 | 6.26 | 6.69e-06 |
hippocampus_development_neonatal | Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) | 51 | 0.13 | 4 | 31.73 | 8.50e-06 |
nf90_up | Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells | 56 | 0.14 | 4 | 28.90 | 1.24e-05 |
adip_vs_fibro_dn | Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes | 64 | 0.16 | 4 | 25.28 | 2.11e-05 |
vhl_normal_up | Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) | 754 | 1.86 | 10 | 5.37 | 2.49e-05 |
adip_vs_preadip_dn | Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 84 | 0.21 | 4 | 19.26 | 6.15e-05 |
bcnu_glioma_mgmt_48hrs_up | Up-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU | 33 | 0.08 | 3 | 36.78 | 7.80e-05 |
creb_brain_2wks_up | Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic CREB | 39 | 0.10 | 3 | 31.12 | 1.29e-04 |
prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 0.76 | 6 | 7.93 | 1.32e-04 |
serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 5 | 10.27 | 1.46e-04 |
o6bg_resist_medulloblastoma_dn | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 109 | 0.27 | 4 | 14.85 | 1.69e-04 |
camptothecin_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 52 | 0.13 | 3 | 23.34 | 3.05e-04 |
rcc_nl_up | Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) | 899 | 2.22 | 9 | 4.05 | 4.93e-04 |
cox1_ko_cortex_up | Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
hdaci_colon_sul24hrs_dn | Downregulated by sulindac at 24 hrs in SW260 colon carcinoma cells | 191 | 0.47 | 4 | 8.47 | 1.39e-03 |
bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 4 | 8.01 | 1.70e-03 |
hdaci_colon_sul_dn | Downregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 340 | 0.84 | 5 | 5.95 | 1.71e-03 |
il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 6 | 4.75 | 1.90e-03 |
aged_mouse_cortex_dn | Down-regulated in the cerebral cortex of aged (22 months) BALB/c mice, compared to young (2 months) controls | 98 | 0.24 | 3 | 12.38 | 1.93e-03 |
cancer_undifferentiated_meta_up | Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database | 98 | 0.24 | 3 | 12.38 | 1.93e-03 |
emt_up | Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.27 | 3 | 10.93 | 2.75e-03 |
cancer_neoplastic_meta_up | Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database | 115 | 0.28 | 3 | 10.55 | 3.03e-03 |
heartfailure_ventricles_dn | Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls | 120 | 0.30 | 3 | 10.11 | 3.42e-03 |
breastca_two_classes | Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers | 247 | 0.61 | 4 | 6.55 | 3.51e-03 |
stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 4.92 | 12 | 2.44 | 4.74e-03 |
shortattacklatency_up | Up-regulated in hippocampi from a mouse line selected for long attack latency (LAL) against an intruder, versus a line selected for short attack latency (SAL). | 156 | 0.39 | 3 | 7.78 | 7.08e-03 |
pod1_ko_up | Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 508 | 1.26 | 5 | 3.98 | 9.19e-03 |