L2L L2L Microarray Analysis Tool

Results for P01AX.profile.u50

Results summary View all lists in L2L MDB View all genes in P01AX.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22 6 27.27 1.11e-07
hdaci_colon_cur30min_up Upregulated by curcumin at 30 min in SW260 colon carcinoma cells 9 0.02 3 134.85 1.25e-06
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.19 5 25.93 1.68e-06
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.20 5 24.67 2.15e-06
tnfa_nfkb_ind_up Up-regulated at any timepoint following TNFa treatment, independent of NFkB function 14 0.03 3 86.69 5.39e-06
tcell_anergic_up Genes up-regulated in anergic mouse T helper cells (A.E7), versus non-anergic stimulated controls 132 0.33 5 15.32 2.20e-05
il2_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.16 4 24.52 2.38e-05
il2_pbmc_30min_up Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.16 4 24.52 2.38e-05
uvb_nhek1_up Upregulated by UV-B light in normal human epidermal keratinocytes 336 0.83 7 8.43 2.50e-05
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 3 35.69 8.53e-05
cmvuv-cmv_common_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 37 0.09 3 32.80 1.10e-04
uvb_nhek3_c3 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 3 37 0.09 3 32.80 1.10e-04
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 8 5.46 1.41e-04
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 8 5.46 1.41e-04
dex_keratinocyte_1hr_up Up-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 8 0.02 2 101.14 1.69e-04
cmv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 46 0.11 3 26.38 2.12e-04
cmv-uv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 226 0.56 5 8.95 2.76e-04
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.03 2 67.42 3.97e-04
cmv_hcmv_timecourse_8hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 8 hours 63 0.16 3 19.26 5.37e-04
adip_diff_cluster2 Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) 64 0.16 3 18.96 5.62e-04
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 2 53.94 6.28e-04
stress_genotoxic_specific_up Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress 67 0.17 3 18.11 6.43e-04
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.04 2 50.57 7.17e-04
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 7 4.67 9.00e-04
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.44 4 9.14 1.05e-03
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.05 2 38.53 1.24e-03
cmv_hcmv_timecourse_10hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours 23 0.06 2 35.18 1.49e-03
tpa_sens_late_up Upregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells 95 0.23 3 12.77 1.76e-03
microrna_vertebrate Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu 214 0.53 4 7.56 2.10e-03
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.93 5 5.38 2.64e-03
uvb_nhek1_c1 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 1 112 0.28 3 10.84 2.82e-03
tpa_sens_middle_up Upregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells 114 0.28 3 10.65 2.96e-03
p53genes_all p53 transcriptional targets 33 0.08 2 24.52 3.07e-03
bep_mcf7_dn Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with non-carcinogenic benzo(e)pyrene (BeP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 34 0.08 2 23.80 3.25e-03
dex_keratinocyte_4hr_up Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 35 0.09 2 23.12 3.44e-03
ros_mouse_aorta_dn Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.31 3 9.56 4.01e-03
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 2 21.29 4.05e-03
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.09 2 21.29 4.05e-03
vegf_huvec_30min_up Up-regulated 30 minutes after VEGF treatment in human umbilical vein endothelial cells 41 0.10 2 19.73 4.70e-03
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 3 8.99 4.75e-03
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 2 18.39 5.40e-03
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 2 17.21 6.14e-03
uvb_nhek3_c6 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 6 47 0.12 2 17.21 6.14e-03
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 9 2.76 6.41e-03
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 2 16.51 6.65e-03
hypoxia_review Genes known to be induced by hypoxia 160 0.40 3 7.59 7.58e-03
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 2 14.98 8.03e-03
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.13 2 14.98 8.03e-03
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.14 2 14.45 8.61e-03
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 5 3.97 9.34e-03
hdaci_colon_cur_up Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 174 0.43 3 6.97 9.52e-03

Raw data (tab-delimited .txt)