L2L Microarray Analysis Tool
Results for P01AX.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in P01AX.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| emt_dn | Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 89 | 0.22 | 6 | 27.27 | 1.11e-07 |
| hdaci_colon_cur30min_up | Upregulated by curcumin at 30 min in SW260 colon carcinoma cells | 9 | 0.02 | 3 | 134.85 | 1.25e-06 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 5 | 25.93 | 1.68e-06 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.20 | 5 | 24.67 | 2.15e-06 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.03 | 3 | 86.69 | 5.39e-06 |
| tcell_anergic_up | Genes up-regulated in anergic mouse T helper cells (A.E7), versus non-anergic stimulated controls | 132 | 0.33 | 5 | 15.32 | 2.20e-05 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 4 | 24.52 | 2.38e-05 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 4 | 24.52 | 2.38e-05 |
| uvb_nhek1_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 336 | 0.83 | 7 | 8.43 | 2.50e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
| uvb_nhek3_c3 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 8 | 5.46 | 1.41e-04 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 8 | 5.46 | 1.41e-04 |
| dex_keratinocyte_1hr_up | Up-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 8 | 0.02 | 2 | 101.14 | 1.69e-04 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 5 | 8.95 | 2.76e-04 |
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
| cmv_hcmv_timecourse_8hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 8 hours | 63 | 0.16 | 3 | 19.26 | 5.37e-04 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.16 | 3 | 18.96 | 5.62e-04 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| stress_genotoxic_specific_up | Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress | 67 | 0.17 | 3 | 18.11 | 6.43e-04 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 7 | 4.67 | 9.00e-04 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 4 | 9.14 | 1.05e-03 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
| cmv_hcmv_timecourse_10hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| tpa_sens_late_up | Upregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
| microrna_vertebrate | Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu | 214 | 0.53 | 4 | 7.56 | 2.10e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 5 | 5.38 | 2.64e-03 |
| uvb_nhek1_c1 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 1 | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
| tpa_sens_middle_up | Upregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells | 114 | 0.28 | 3 | 10.65 | 2.96e-03 |
| p53genes_all | p53 transcriptional targets | 33 | 0.08 | 2 | 24.52 | 3.07e-03 |
| bep_mcf7_dn | Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with non-carcinogenic benzo(e)pyrene (BeP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| dex_keratinocyte_4hr_up | Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 35 | 0.09 | 2 | 23.12 | 3.44e-03 |
| ros_mouse_aorta_dn | Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 127 | 0.31 | 3 | 9.56 | 4.01e-03 |
| nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| vegf_huvec_30min_up | Up-regulated 30 minutes after VEGF treatment in human umbilical vein endothelial cells | 41 | 0.10 | 2 | 19.73 | 4.70e-03 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.33 | 3 | 8.99 | 4.75e-03 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 2 | 18.39 | 5.40e-03 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| uvb_nhek3_c6 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 6 | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 9 | 2.76 | 6.41e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 5 | 3.97 | 9.34e-03 |
| hdaci_colon_cur_up | Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 174 | 0.43 | 3 | 6.97 | 9.52e-03 |