L2L Microarray Analysis Tool
Results for N05AF.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in N05AF.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 16 | 20.29 | 3.60e-16 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.27 | 8 | 29.69 | 4.24e-10 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 11 | 12.82 | 1.85e-09 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 11 | 12.82 | 1.85e-09 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 12 | 8.92 | 1.93e-08 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 8 | 18.28 | 1.96e-08 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 12 | 8.19 | 4.90e-08 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 12 | 8.19 | 4.90e-08 |
| ad12_any_up | Up-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection | 15 | 0.04 | 4 | 107.88 | 4.99e-08 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 10 | 10.76 | 5.17e-08 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 12 | 8.01 | 6.19e-08 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 12 | 7.19 | 1.95e-07 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 10 | 8.52 | 4.40e-07 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 5 | 30.65 | 7.28e-07 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 5 | 30.65 | 7.28e-07 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 10 | 7.93 | 8.35e-07 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 4 | 47.59 | 1.63e-06 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.20 | 5 | 24.67 | 2.15e-06 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 0.65 | 7 | 10.81 | 5.05e-06 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 10 | 6.26 | 6.69e-06 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 9 | 7.12 | 6.92e-06 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 14 | 4.29 | 8.39e-06 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 9 | 6.87 | 9.24e-06 |
| adip_vs_preadip_up | Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 57 | 0.14 | 4 | 28.39 | 1.33e-05 |
| adip_diff_cluster3 | Strongly upregulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 3) | 68 | 0.17 | 4 | 23.80 | 2.68e-05 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 1.21 | 8 | 6.59 | 3.84e-05 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.07 | 3 | 41.85 | 5.26e-05 |
| tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.07 | 3 | 41.85 | 5.26e-05 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.39 | 5 | 12.72 | 5.35e-05 |
| bap_mcf7_up | Up-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 87 | 0.22 | 4 | 18.60 | 7.06e-05 |
| cpr_low_liver_up | Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 32 | 0.08 | 3 | 37.93 | 7.10e-05 |
| uvc_high_b4_up | Progressively up-regulated from 12-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b4) | 6 | 0.01 | 2 | 134.85 | 9.11e-05 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 5 | 11.24 | 9.60e-05 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 4 | 16.35 | 1.17e-04 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
| fsh_ovary_mcv152_up | Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated | 120 | 0.30 | 4 | 13.48 | 2.44e-04 |
| scw_joint_react_dn | Down-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 231 | 0.57 | 5 | 8.76 | 3.05e-04 |
| bap_hepg2_dn | Down-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 56 | 0.14 | 3 | 21.67 | 3.80e-04 |
| as3_hek293_dn | Downregulated in HEK293 cells by treatment with arsenite | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| bcnu_glioma_mgmt_48hrs_dn | Down-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU | 253 | 0.63 | 5 | 7.99 | 4.61e-04 |
| heartfailure_ventricles_up | Upregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| cpr_null_liver_up | Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls | 64 | 0.16 | 3 | 18.96 | 5.62e-04 |
| hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| uvc_high_b2_up | Up-regulated at 18-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b2) | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| tsa_hepatoma_up | Up-regulated in more than one of several human hepatoma cell lines by 24-hour treatment with trichostatin A | 67 | 0.17 | 3 | 18.11 | 6.43e-04 |
| shh_up | Upregulated by sonic hedgehog (shh) expression in murine neuronal precursor cells | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| hdaci_colon_but48hrs_dn | Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 165 | 0.41 | 4 | 9.81 | 8.10e-04 |
| stemcell_hematopoietic_up | Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells | 2092 | 5.17 | 14 | 2.71 | 9.41e-04 |
| cis_resist_lung_up | Transient up-regulation is associated with transient cisplatin resistance in a human squamous cell lung cancer line (NCI-H2170) | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 0.79 | 5 | 6.36 | 1.28e-03 |
| dex_keratinocyte_1hr_dn | Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 4 | 8.01 | 1.70e-03 |
| uvb_nhek1_c3 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| tpa_resist_middle_dn | Downregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells | 209 | 0.52 | 4 | 7.74 | 1.93e-03 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 2.21 | 8 | 3.62 | 2.01e-03 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 0.87 | 5 | 5.73 | 2.01e-03 |
| hdaci_colon_sul24hrs_up | Upregulated by sulindac at 24 hrs in SW260 colon carcinoma cells | 102 | 0.25 | 3 | 11.90 | 2.16e-03 |
| 5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 4 | 7.16 | 2.56e-03 |
| uvc_high_d1_dn | Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| mms_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS) | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| gamma_unique_fibro_dn | Down-regulated at any timepoint by treatment of human fibroblasts with gamma radiation, but not by UV lght or 4-NQO | 120 | 0.30 | 3 | 10.11 | 3.42e-03 |
| gh_hypophysectomy_rat_up | Up-regulated in liver, heart or kidney tissue following treatment of hypophysectomized rats with growth hormone | 39 | 0.10 | 2 | 20.75 | 4.26e-03 |
| hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 2.07 | 7 | 3.38 | 5.42e-03 |
| cmv_hcmv_timecourse_12hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 12 hours | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| ifna_uv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following either infection with UV-inactivated CMV or interferon-alpha | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| rb_ko_dn | Down-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. | 149 | 0.37 | 3 | 8.15 | 6.24e-03 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 6 | 3.71 | 6.26e-03 |
| bcnu_glioma_nomgmt_48hrs_dn | Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| rb_ko_up | Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. | 155 | 0.38 | 3 | 7.83 | 6.95e-03 |
| brg1_sw13_up | Up-regulated by transient expression of BRG1 at 24 hours in human, BRG1-lacking SW-13 cells | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| calres_mouse_up | Upregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| vegf_huvec_2hrs_up | Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| uvb_nhek3_c0 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 | 167 | 0.41 | 3 | 7.27 | 8.52e-03 |