Results summary | View all lists in L2L MDB | View all genes in N05AB.profile.u50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 21 | 26.63 | 3.37e-23 |
il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 23 | 18.21 | 1.59e-21 |
cpr_low_liver_up | Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 32 | 0.08 | 11 | 139.06 | 2.59e-21 |
fsh_ovary_mcv152_up | Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated | 120 | 0.30 | 15 | 50.57 | 2.92e-21 |
il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 21 | 13.15 | 5.99e-17 |
bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 18 | 15.33 | 6.96e-16 |
cpr_null_liver_up | Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls | 64 | 0.16 | 10 | 63.21 | 1.14e-15 |
bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 13 | 26.03 | 8.42e-15 |
rb_ko_up | Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. | 155 | 0.38 | 11 | 28.71 | 3.28e-13 |
idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.11 | 8 | 70.35 | 3.35e-13 |
il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 14 | 10.69 | 1.29e-10 |
bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 13 | 11.07 | 3.81e-10 |
adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.27 | 8 | 29.69 | 4.24e-10 |
insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.06 | 5 | 80.91 | 4.71e-09 |
tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 17 | 5.21 | 6.67e-08 |
hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 7 | 17.70 | 1.89e-07 |
hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 5 | 25.60 | 1.79e-06 |
alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 10 | 6.82 | 3.17e-06 |
alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 10 | 6.82 | 3.17e-06 |
as3_hek293_dn | Downregulated in HEK293 cells by treatment with arsenite | 12 | 0.03 | 3 | 101.14 | 3.27e-06 |
bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 10 | 6.68 | 3.84e-06 |
tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). | 1237 | 3.06 | 14 | 4.58 | 4.03e-06 |
hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.23 | 5 | 21.29 | 4.44e-06 |
hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 8 | 8.61 | 5.73e-06 |
hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.04 | 3 | 75.85 | 8.26e-06 |
uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.27 | 5 | 18.73 | 8.33e-06 |
uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.28 | 5 | 18.06 | 9.94e-06 |
bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 9 | 6.69 | 1.13e-05 |
brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 0.76 | 7 | 9.19 | 1.44e-05 |
hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 5 | 16.58 | 1.50e-05 |
il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 4 | 24.52 | 2.38e-05 |
il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 4 | 24.52 | 2.38e-05 |
scw_joint_react_dn | Down-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 231 | 0.57 | 6 | 10.51 | 2.81e-05 |
uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.17 | 4 | 23.12 | 3.01e-05 |
alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 7 | 8.16 | 3.07e-05 |
alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 7 | 8.16 | 3.07e-05 |
rb_creko_dn | Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 250 | 0.62 | 6 | 9.71 | 4.35e-05 |
il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 8 | 6.35 | 5.00e-05 |
hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.20 | 4 | 20.23 | 5.08e-05 |
uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
insulin_adip_insens_up | Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 4 | 16.35 | 1.17e-04 |
tpa_resist_middle_dn | Downregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells | 209 | 0.52 | 5 | 9.68 | 1.92e-04 |
uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 8 | 5.10 | 2.21e-04 |
hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.12 | 3 | 25.82 | 2.26e-04 |
p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 3 | 24.77 | 2.56e-04 |
bcnu_glioma_nomgmt_48hrs_dn | Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU | 50 | 0.12 | 3 | 24.27 | 2.71e-04 |
ros_mouse_aorta_dn | Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 127 | 0.31 | 4 | 12.74 | 3.03e-04 |
hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 0.58 | 5 | 8.68 | 3.17e-04 |
stemcell_neural_up | Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells | 2805 | 6.93 | 18 | 2.60 | 3.17e-04 |
hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.14 | 3 | 21.67 | 3.80e-04 |
hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
hippocampus_development_prenatal | Highly expressed in prenatal mouse hippocampus (cluster 1) | 58 | 0.14 | 3 | 20.92 | 4.21e-04 |
hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 0.17 | 3 | 17.85 | 6.71e-04 |
irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.39 | 4 | 10.18 | 7.06e-04 |
bleo_mouse_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 1.10 | 6 | 5.44 | 9.57e-04 |
hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
aom-dss_colon_10wks_up | Up-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. | 22 | 0.05 | 2 | 36.78 | 1.37e-03 |
hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.22 | 3 | 13.95 | 1.37e-03 |
emt_dn | Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 89 | 0.22 | 3 | 13.64 | 1.46e-03 |
reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 1.21 | 6 | 4.97 | 1.51e-03 |
adip_diff_cluster1 | Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) | 96 | 0.24 | 3 | 12.64 | 1.82e-03 |
cmv_hcmv_timecourse_4hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
gn_camp_granulosa_up | Up-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin | 99 | 0.24 | 3 | 12.26 | 1.98e-03 |
heatshock_old_up | Upregulated after heat shock in lymphocytes from old individuals, compared to young | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
cis_xpc_dn | Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 363 | 0.90 | 5 | 5.57 | 2.27e-03 |
egf_hdmec_up | Up-regulated in human dermal (foreskin) microvascular endothelial cells that were stimulated to proliferate with prolonged EGF treatment, versus non-stimulated quiescent controls. | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
et743_sarcoma_72hrs_up | Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines | 106 | 0.26 | 3 | 11.45 | 2.41e-03 |
tgfb-wnt3a_mammary_dn | Down-regulated in common by both TGF-beta and Wnt3A in normal mouse mammary gland cells (top 124 genes). | 106 | 0.26 | 3 | 11.45 | 2.41e-03 |
heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 4.52 | 12 | 2.65 | 2.46e-03 |
5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
ageing_lymph_dn | Downregulated in human lymphocytes from old individuals, compared to young | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 5.79 | 14 | 2.42 | 2.63e-03 |
hsc_mature_fetal | Up-regulated in mouse mature bood cells from fetal liver, compared to hematopoietic progenitors (Mature Blood Cells Shared + Fetal) | 376 | 0.93 | 5 | 5.38 | 2.64e-03 |
et743_sarcoma_up | Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 111 | 0.27 | 3 | 10.93 | 2.75e-03 |
csb_reliable_dn | Down-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 558 | 1.38 | 6 | 4.35 | 2.93e-03 |
dnmt1_ko_up | Upregulated following conditional knock-out of DNMT1 in MEFs | 117 | 0.29 | 3 | 10.37 | 3.18e-03 |
tgfb_mammary_up | Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). | 118 | 0.29 | 3 | 10.28 | 3.26e-03 |
cis_xpc_up | Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 242 | 0.60 | 4 | 6.69 | 3.26e-03 |
gamma_unique_fibro_dn | Down-regulated at any timepoint by treatment of human fibroblasts with gamma radiation, but not by UV lght or 4-NQO | 120 | 0.30 | 3 | 10.11 | 3.42e-03 |
idx_tsa_up_cluster6 | Strongly up-regulated at 96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 249 | 0.62 | 4 | 6.50 | 3.61e-03 |
4nqo_unique_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with 4-nitroquinoline-1-oxide (4NQO), but not by UV or gamma radiation | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
dnmt1_ko_dn | Downregulated following conditional knock-out of DNMT1 in MEFs | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
5azac-tsa_hepg2_up | Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 1966 | 4.86 | 12 | 2.47 | 4.34e-03 |
elongina_ko_dn | Downregulated in MES cells from elongin-A knockout mice | 267 | 0.66 | 4 | 6.06 | 4.62e-03 |
zmpste24_ko_dn | Fifty genes most strongly down-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 42 | 0.10 | 2 | 19.26 | 4.93e-03 |
hdaci_colon_tsa48hrs_up | Upregulated by TSA at 48 hrs in SW260 colon carcinoma cells | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 4.52 | 11 | 2.43 | 6.85e-03 |
hippocampus_development_neonatal | Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
uvc_high_d9_dn | Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |
fsh_granulosa_up | Up-regulated in human granulosa cells stimulated with follicle stimulation hormone (FSH) | 163 | 0.40 | 3 | 7.45 | 7.98e-03 |
oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
vegf_huvec_2hrs_up | Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
lh_granulosa_up | Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) | 167 | 0.41 | 3 | 7.27 | 8.52e-03 |
brca1_overexp_up | Upregulated by induction of exogenous BRCA1 in EcR-293 cells | 328 | 0.81 | 4 | 4.93 | 9.39e-03 |
aged_mouse_muscle_dn | Downregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) | 59 | 0.15 | 2 | 13.71 | 9.52e-03 |