L2L L2L Microarray Analysis Tool

Results for N05AB.profile.u50

Results summary View all lists in L2L MDB View all genes in N05AB.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 0.79 21 26.63 3.37e-23
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 23 18.21 1.59e-21
cpr_low_liver_up Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls 32 0.08 11 139.06 2.59e-21
fsh_ovary_mcv152_up Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 120 0.30 15 50.57 2.92e-21
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 21 13.15 5.99e-17
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 18 15.33 6.96e-16
cpr_null_liver_up Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls 64 0.16 10 63.21 1.14e-15
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 13 26.03 8.42e-15
rb_ko_up Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. 155 0.38 11 28.71 3.28e-13
idx_tsa_dn_cluster4 Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 46 0.11 8 70.35 3.35e-13
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 14 10.69 1.29e-10
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 13 11.07 3.81e-10
adipogenesis_hmsc_class3_up Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.27 8 29.69 4.24e-10
insulin_adip_insens_dn Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 25 0.06 5 80.91 4.71e-09
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 17 5.21 6.67e-08
hypoxia_review Genes known to be induced by hypoxia 160 0.40 7 17.70 1.89e-07
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 5 25.60 1.79e-06
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 10 6.82 3.17e-06
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 10 6.82 3.17e-06
as3_hek293_dn Downregulated in HEK293 cells by treatment with arsenite 12 0.03 3 101.14 3.27e-06
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 10 6.68 3.84e-06
tsa_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). 1237 3.06 14 4.58 4.03e-06
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 5 21.29 4.44e-06
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.93 8 8.61 5.73e-06
hypoxia_fibro_young_up Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) 15 0.04 3 80.91 6.72e-06
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.04 3 75.85 8.26e-06
uvc_xpcs_8hr_up Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 108 0.27 5 18.73 8.33e-06
uvc_xpcs_all_up Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 112 0.28 5 18.06 9.94e-06
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 1.34 9 6.69 1.13e-05
brca1_overexp_prostate_up Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 308 0.76 7 9.19 1.44e-05
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 5 16.58 1.50e-05
il2_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.16 4 24.52 2.38e-05
il2_pbmc_30min_up Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.16 4 24.52 2.38e-05
scw_joint_react_dn Down-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 231 0.57 6 10.51 2.81e-05
uvc_high_d8_dn Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.17 4 23.12 3.01e-05
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 7 8.16 3.07e-05
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 7 8.16 3.07e-05
rb_creko_dn Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 0.62 6 9.71 4.35e-05
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 8 6.35 5.00e-05
hypoxia_reg_up Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.20 4 20.23 5.08e-05
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 3 35.69 8.53e-05
insulin_adip_insens_up Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 37 0.09 3 32.80 1.10e-04
et743_hela_up Upregulated by Et-743 in HeLa cells 99 0.24 4 16.35 1.17e-04
tpa_resist_middle_dn Downregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells 209 0.52 5 9.68 1.92e-04
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.57 8 5.10 2.21e-04
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 3 25.82 2.26e-04
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 3 24.77 2.56e-04
bcnu_glioma_nomgmt_48hrs_dn Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU 50 0.12 3 24.27 2.71e-04
ros_mouse_aorta_dn Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.31 4 12.74 3.03e-04
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 5 8.68 3.17e-04
stemcell_neural_up Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells 2805 6.93 18 2.60 3.17e-04
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 3 22.47 3.41e-04
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.14 3 21.67 3.80e-04
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.03 2 67.42 3.97e-04
hippocampus_development_prenatal Highly expressed in prenatal mouse hippocampus (cluster 1) 58 0.14 3 20.92 4.21e-04
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.15 3 19.90 4.88e-04
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 2 53.94 6.28e-04
dsrna_up Upregulated by dsRNA (polyI:C) in IFN-null GRE cells 68 0.17 3 17.85 6.71e-04
irs1_ko_adip_up Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.39 4 10.18 7.06e-04
bleo_mouse_lymph_high_4hrs_up Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin 17 0.04 2 47.59 8.11e-04
ageing_brain_up Age-upregulated in the human frontal cortex 446 1.10 6 5.44 9.57e-04
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.05 2 38.53 1.24e-03
aom-dss_colon_10wks_up Up-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 22 0.05 2 36.78 1.37e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22 3 13.64 1.46e-03
reovirus_hek293_dn Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 488 1.21 6 4.97 1.51e-03
adip_diff_cluster1 Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) 96 0.24 3 12.64 1.82e-03
cmv_hcmv_timecourse_4hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours 26 0.06 2 31.12 1.91e-03
gn_camp_granulosa_up Up-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin 99 0.24 3 12.26 1.98e-03
heatshock_old_up Upregulated after heat shock in lymphocytes from old individuals, compared to young 27 0.07 2 29.97 2.06e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.07 2 28.90 2.21e-03
cis_xpc_dn Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 363 0.90 5 5.57 2.27e-03
egf_hdmec_up Up-regulated in human dermal (foreskin) microvascular endothelial cells that were stimulated to proliferate with prolonged EGF treatment, versus non-stimulated quiescent controls. 105 0.26 3 11.56 2.35e-03
et743_sarcoma_72hrs_up Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines 106 0.26 3 11.45 2.41e-03
tgfb-wnt3a_mammary_dn Down-regulated in common by both TGF-beta and Wnt3A in normal mouse mammary gland cells (top 124 genes). 106 0.26 3 11.45 2.41e-03
heatshock_hela_4hr_dn Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 4.52 12 2.65 2.46e-03
5fu_resist_gastric_dn Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.07 2 26.97 2.54e-03
ageing_lymph_dn Downregulated in human lymphocytes from old individuals, compared to young 30 0.07 2 26.97 2.54e-03
5azac-tsa_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 2343 5.79 14 2.42 2.63e-03
hsc_mature_fetal Up-regulated in mouse mature bood cells from fetal liver, compared to hematopoietic progenitors (Mature Blood Cells Shared + Fetal) 376 0.93 5 5.38 2.64e-03
et743_sarcoma_up Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 111 0.27 3 10.93 2.75e-03
csb_reliable_dn Down-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 558 1.38 6 4.35 2.93e-03
dnmt1_ko_up Upregulated following conditional knock-out of DNMT1 in MEFs 117 0.29 3 10.37 3.18e-03
tgfb_mammary_up Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). 118 0.29 3 10.28 3.26e-03
cis_xpc_up Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 242 0.60 4 6.69 3.26e-03
gamma_unique_fibro_dn Down-regulated at any timepoint by treatment of human fibroblasts with gamma radiation, but not by UV lght or 4-NQO 120 0.30 3 10.11 3.42e-03
idx_tsa_up_cluster6 Strongly up-regulated at 96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 249 0.62 4 6.50 3.61e-03
4nqo_unique_fibro_up Up-regulated at any timepoint by treatment of human fibroblasts with 4-nitroquinoline-1-oxide (4NQO), but not by UV or gamma radiation 38 0.09 2 21.29 4.05e-03
dnmt1_ko_dn Downregulated following conditional knock-out of DNMT1 in MEFs 38 0.09 2 21.29 4.05e-03
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 2 21.29 4.05e-03
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.09 2 21.29 4.05e-03
5azac-tsa_hepg2_up Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 1966 4.86 12 2.47 4.34e-03
elongina_ko_dn Downregulated in MES cells from elongin-A knockout mice 267 0.66 4 6.06 4.62e-03
zmpste24_ko_dn Fifty genes most strongly down-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 42 0.10 2 19.26 4.93e-03
hdaci_colon_tsa48hrs_up Upregulated by TSA at 48 hrs in SW260 colon carcinoma cells 43 0.11 2 18.82 5.16e-03
5azac_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1830 4.52 11 2.43 6.85e-03
hippocampus_development_neonatal Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) 51 0.13 2 15.86 7.19e-03
uvc_high_d9_dn Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.13 2 15.27 7.74e-03
fsh_granulosa_up Up-regulated in human granulosa cells stimulated with follicle stimulation hormone (FSH) 163 0.40 3 7.45 7.98e-03
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.13 2 14.98 8.03e-03
vegf_huvec_2hrs_up Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells 54 0.13 2 14.98 8.03e-03
lh_granulosa_up Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) 167 0.41 3 7.27 8.52e-03
brca1_overexp_up Upregulated by induction of exogenous BRCA1 in EcR-293 cells 328 0.81 4 4.93 9.39e-03
aged_mouse_muscle_dn Downregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) 59 0.15 2 13.71 9.52e-03

Raw data (tab-delimited .txt)