L2L L2L Microarray Analysis Tool

Results for N05AA.profile.d50

Results summary View all lists in L2L MDB View all genes in N05AA.profile.d50
List Name Description Total
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 0.84 8 9.49 2.81e-06
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.49 6 12.32 1.15e-05
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.42 5 11.83 7.54e-05
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 6 8.12 1.16e-04
oldage_dn Downregulated in fibroblasts from old individuals, compared to young 76 0.19 3 15.97 9.28e-04
hpv_high-risk_up Up-regulated in both HPV16- and HPV18-positive cervical tumors compared to normal cervial tissue. 21 0.05 2 38.53 1.24e-03
p21_middle_dn Down-regulated at intermediate timepoints (12-16 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 26 0.06 2 31.12 1.91e-03
cancer_undifferentiated_meta_up Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database 98 0.24 3 12.38 1.93e-03
scchn_hpvpos_up Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 31 0.08 2 26.10 2.71e-03
cis_xpc_up Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 242 0.60 4 6.69 3.26e-03
p21_p53_middle_dn Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 37 0.09 2 21.87 3.84e-03
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.34 3 8.92 4.85e-03
scchn_hpvneg_dn Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 47 0.12 2 17.21 6.14e-03
p21_any_dn Down-regulated at any timepoint (4-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 50 0.12 2 16.18 6.92e-03

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