L2L Microarray Analysis Tool
Results for L04AX.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in L04AX.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 3.13 | 16 | 5.10 | 1.95e-07 |
| uvc_high_d5_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d5) | 74 | 0.37 | 6 | 16.40 | 2.03e-06 |
| cmv_hcmv_timecourse_20hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 20 hours | 174 | 0.86 | 8 | 9.30 | 3.05e-06 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 1.10 | 8 | 7.26 | 1.86e-05 |
| uvc_ttd_4hr_dn | Down-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 641 | 3.17 | 12 | 3.79 | 1.12e-04 |
| uvc_ttd_all_dn | Down-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 780 | 3.86 | 13 | 3.37 | 1.84e-04 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.85 | 6 | 7.10 | 2.32e-04 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 1.69 | 8 | 4.75 | 3.49e-04 |
| oldwerner_fibro_up | Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young | 30 | 0.15 | 3 | 20.23 | 4.44e-04 |
| oldage_dn | Downregulated in fibroblasts from old individuals, compared to young | 76 | 0.38 | 4 | 10.65 | 5.77e-04 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 4 | 10.37 | 6.37e-04 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 4.42 | 13 | 2.94 | 6.66e-04 |
| uvc_xpcs_8hr_dn | Down-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 911 | 4.50 | 13 | 2.89 | 7.82e-04 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 1.48 | 7 | 4.74 | 8.15e-04 |
| cmv_hcmv_timecourse_14hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours | 84 | 0.42 | 4 | 9.63 | 8.41e-04 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 1.08 | 6 | 5.54 | 8.53e-04 |
| heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 9.04 | 20 | 2.21 | 1.08e-03 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 1.32 | 6 | 4.56 | 2.28e-03 |
| 5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 9.05 | 19 | 2.10 | 2.50e-03 |
| uvc_xpcs_all_dn | Down-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 1048 | 5.18 | 13 | 2.51 | 2.65e-03 |
| gamma-uv_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO | 57 | 0.28 | 3 | 10.65 | 2.90e-03 |
| bleo_mouse_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| dac_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 5 | 5.13 | 3.17e-03 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 9 | 3.07 | 3.19e-03 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 9 | 3.07 | 3.19e-03 |
| uvc_high_d6_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d6) | 65 | 0.32 | 3 | 9.34 | 4.20e-03 |
| adip_diff_cluster5 | Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) | 67 | 0.33 | 3 | 9.06 | 4.57e-03 |
| middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 542 | 2.68 | 8 | 2.99 | 6.20e-03 |
| cis_xpc_up | Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 242 | 1.20 | 5 | 4.18 | 7.47e-03 |
| werner_fibro_up | Upregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals | 81 | 0.40 | 3 | 7.49 | 7.74e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| et743_sarcoma_24hrs_dn | Down-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 163 | 0.81 | 4 | 4.96 | 9.10e-03 |
| cmv_hcmv_timecourse_10hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |