L2L Microarray Analysis Tool
Results for L04AA.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in L04AA.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.06 | 6 | 97.09 | 3.88e-11 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 5 | 134.85 | 2.72e-10 |
| scchn_hpvneg_dn | Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 47 | 0.12 | 5 | 43.04 | 1.30e-07 |
| pdgf_es_dn | Down-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis | 6 | 0.01 | 3 | 202.27 | 3.00e-07 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 6 | 15.17 | 3.49e-06 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 5 | 20.43 | 5.44e-06 |
| il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 1.31 | 9 | 6.86 | 9.38e-06 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 4 | 28.39 | 1.33e-05 |
| cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.06 | 3 | 52.77 | 2.58e-05 |
| cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
| methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
| aged_mouse_hippocampus_any_up | Up-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 78 | 0.19 | 4 | 20.75 | 4.60e-05 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.07 | 3 | 43.34 | 4.72e-05 |
| cmv_hcmv_timecourse_10hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 30 | 0.07 | 3 | 40.45 | 5.83e-05 |
| senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 0.70 | 6 | 8.55 | 8.78e-05 |
| adip_diff_cluster1 | Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) | 96 | 0.24 | 4 | 16.86 | 1.03e-04 |
| avoidance_dn | Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. | 40 | 0.10 | 3 | 30.34 | 1.39e-04 |
| cisplatin_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 9 | 0.02 | 2 | 89.90 | 2.17e-04 |
| fsh_ovary_mcv152_up | Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated | 120 | 0.30 | 4 | 13.48 | 2.44e-04 |
| il2_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 503 | 1.24 | 7 | 5.63 | 3.02e-04 |
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
| 5azac-tsa_hepg2_up | Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 1966 | 4.86 | 14 | 2.88 | 5.22e-04 |
| bay_pbmc_2hr_dn | Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 398 | 0.98 | 6 | 6.10 | 5.32e-04 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| cox1_ko_cortex_up | Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 4 | 8.99 | 1.12e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 0.79 | 5 | 6.36 | 1.28e-03 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 5 | 6.34 | 1.30e-03 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 2.07 | 8 | 3.86 | 1.35e-03 |
| methotrexate_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 22 | 0.05 | 2 | 36.78 | 1.37e-03 |
| bay_pbmc_6hr_dn | Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 483 | 1.19 | 6 | 5.03 | 1.43e-03 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 7 | 4.20 | 1.66e-03 |
| cancerdrugs_probcell_dn | Down-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| il2_pbmc_6hr_dn | Down-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 6 | 4.58 | 2.28e-03 |
| baf57_bt549_up | Up-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 364 | 0.90 | 5 | 5.56 | 2.30e-03 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.27 | 3 | 11.13 | 2.61e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 5 | 5.38 | 2.64e-03 |
| hypoxia_fibro_up | Upregulated by hypoxia in normal fibroblasts from both young and old donors (Table 3) | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| uv_esr_old_unreg | Genes involved in the environmental stress response that were not regulated following treatment of fibroblasts from elderly donors with UV light | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| rb_creko_dn | Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 250 | 0.62 | 4 | 6.47 | 3.66e-03 |
| nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| bay-il2_pbmc_late_up | Up-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. | 130 | 0.32 | 3 | 9.34 | 4.28e-03 |
| bay_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 268 | 0.66 | 4 | 6.04 | 4.68e-03 |
| hsc_lthsc_fetal | Up-regulated in mouse long-term functional hematopoietic stem cells from fetal liver (LT-HSC Shared) | 272 | 0.67 | 4 | 5.95 | 4.93e-03 |
| hsc_lthsc_shared | Up-regulated in mouse long-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster i, LT-HSC Shared) | 272 | 0.67 | 4 | 5.95 | 4.93e-03 |
| brca_er_pos | Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-positive tumors | 842 | 2.08 | 7 | 3.36 | 5.53e-03 |
| idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.11 | 2 | 17.59 | 5.88e-03 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
| brg1_h1299_up | Up-regulated by transient expression of BRG1 in H1299 lung cancer cells with mutant, inactive BRG1 | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| ifnalpha_hcc_up | Upregulated by interferon alpha treatment in Hep3B hepatocellular carcinoma cells | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| camptothecin_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 52 | 0.13 | 2 | 15.56 | 7.46e-03 |
| gamma_esr_ws_unreg | Genes involved in the environmental stress response that were not regulated following treatment of Werner syndrome fibroblasts with gamma radiation | 52 | 0.13 | 2 | 15.56 | 7.46e-03 |
| uvb_nhek2_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.41 | 3 | 7.40 | 8.11e-03 |
| 5azac_hepg2_up | Up-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1630 | 4.03 | 10 | 2.48 | 8.44e-03 |
| et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
| brca_prognosis_pos | Genes whose expression is consistently positively correlated with breast cancer outcomes - higher expression is associated with good prognosis | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| hippocampus_development_prenatal | Highly expressed in prenatal mouse hippocampus (cluster 1) | 58 | 0.14 | 2 | 13.95 | 9.21e-03 |
| hsc_hscandprogenitors_fetal | Up-regulated in mouse hematopoietic stem cells and progenitors from fetal liver (HSC and Progenitors Shared) | 717 | 1.77 | 6 | 3.39 | 9.58e-03 |
| hsc_hscandprogenitors_shared | Up-regulated in mouse hematopoietic stem cells and progenitors from both adult bone marrow and fetal liver (Cluster iii, HSC and Progenitors Shared) | 717 | 1.77 | 6 | 3.39 | 9.58e-03 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 3 | 6.86 | 9.97e-03 |