L2L L2L Microarray Analysis Tool

Results for L04AA.profile.u50

Results summary View all lists in L2L MDB View all genes in L04AA.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
insulin_adip_insens_dn Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 25 0.06 6 97.09 3.88e-11
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 5 134.85 2.72e-10
scchn_hpvneg_dn Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 47 0.12 5 43.04 1.30e-07
pdgf_es_dn Down-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis 6 0.01 3 202.27 3.00e-07
hypoxia_review Genes known to be induced by hypoxia 160 0.40 6 15.17 3.49e-06
et743_hela_up Upregulated by Et-743 in HeLa cells 99 0.24 5 20.43 5.44e-06
il2_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 531 1.31 9 6.86 9.38e-06
zmpste24_ko_up Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 57 0.14 4 28.39 1.33e-05
cisplatin_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin 23 0.06 3 52.77 2.58e-05
cancerdrugs_probcell_up Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 24 0.06 3 50.57 2.94e-05
methotrexate_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate 24 0.06 3 50.57 2.94e-05
aged_mouse_hippocampus_any_up Up-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 78 0.19 4 20.75 4.60e-05
camptothecin_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin 28 0.07 3 43.34 4.72e-05
cmv_hcmv_timecourse_10hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours 30 0.07 3 40.45 5.83e-05
senescence_hff_up Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 0.70 6 8.55 8.78e-05
adip_diff_cluster1 Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) 96 0.24 4 16.86 1.03e-04
avoidance_dn Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. 40 0.10 3 30.34 1.39e-04
cisplatin_probcell_dn Down-regulated in pro-B cells (FL5.12) following treatment with cisplatin 9 0.02 2 89.90 2.17e-04
fsh_ovary_mcv152_up Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 120 0.30 4 13.48 2.44e-04
il2_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 503 1.24 7 5.63 3.02e-04
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.03 2 67.42 3.97e-04
5azac-tsa_hepg2_up Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 1966 4.86 14 2.88 5.22e-04
bay_pbmc_2hr_dn Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 398 0.98 6 6.10 5.32e-04
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.04 2 50.57 7.17e-04
cox1_ko_cortex_up Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. 80 0.20 3 15.17 1.08e-03
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 4 8.99 1.12e-03
old_fibro_up Upregulated in fibroblasts from old individuals, compared to young 84 0.21 3 14.45 1.24e-03
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.05 2 38.53 1.24e-03
bay_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 318 0.79 5 6.36 1.28e-03
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 0.79 5 6.34 1.30e-03
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 2.07 8 3.86 1.35e-03
methotrexate_probcell_dn Down-regulated in pro-B cells (FL5.12) following treatment with methotrexate 22 0.05 2 36.78 1.37e-03
bay_pbmc_6hr_dn Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 483 1.19 6 5.03 1.43e-03
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 1.67 7 4.20 1.66e-03
cancerdrugs_probcell_dn Down-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 26 0.06 2 31.12 1.91e-03
il2_pbmc_6hr_dn Down-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 6 4.58 2.28e-03
baf57_bt549_up Up-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 364 0.90 5 5.56 2.30e-03
adipogenesis_hmsc_class3_up Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.27 3 11.13 2.61e-03
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.93 5 5.38 2.64e-03
hypoxia_fibro_up Upregulated by hypoxia in normal fibroblasts from both young and old donors (Table 3) 34 0.08 2 23.80 3.25e-03
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 2 23.80 3.25e-03
uv_esr_old_unreg Genes involved in the environmental stress response that were not regulated following treatment of fibroblasts from elderly donors with UV light 36 0.09 2 22.47 3.64e-03
rb_creko_dn Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 0.62 4 6.47 3.66e-03
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 2 21.29 4.05e-03
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.09 2 21.29 4.05e-03
bay-il2_pbmc_late_up Up-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 130 0.32 3 9.34 4.28e-03
bay_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 268 0.66 4 6.04 4.68e-03
hsc_lthsc_fetal Up-regulated in mouse long-term functional hematopoietic stem cells from fetal liver (LT-HSC Shared) 272 0.67 4 5.95 4.93e-03
hsc_lthsc_shared Up-regulated in mouse long-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster i, LT-HSC Shared) 272 0.67 4 5.95 4.93e-03
brca_er_pos Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-positive tumors 842 2.08 7 3.36 5.53e-03
idx_tsa_dn_cluster4 Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 46 0.11 2 17.59 5.88e-03
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 2 17.21 6.14e-03
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 2 16.51 6.65e-03
brg1_h1299_up Up-regulated by transient expression of BRG1 in H1299 lung cancer cells with mutant, inactive BRG1 50 0.12 2 16.18 6.92e-03
ifnalpha_hcc_up Upregulated by interferon alpha treatment in Hep3B hepatocellular carcinoma cells 50 0.12 2 16.18 6.92e-03
camptothecin_probcell_dn Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin 52 0.13 2 15.56 7.46e-03
gamma_esr_ws_unreg Genes involved in the environmental stress response that were not regulated following treatment of Werner syndrome fibroblasts with gamma radiation 52 0.13 2 15.56 7.46e-03
uvb_nhek2_dn Downregulated by UV-B light in normal human epidermal keratinocytes 160 0.40 3 7.59 7.58e-03
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 2 14.98 8.03e-03
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.13 2 14.98 8.03e-03
uv-cmv_unique_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 164 0.41 3 7.40 8.11e-03
5azac_hepg2_up Up-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1630 4.03 10 2.48 8.44e-03
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.14 2 14.45 8.61e-03
brca_prognosis_pos Genes whose expression is consistently positively correlated with breast cancer outcomes - higher expression is associated with good prognosis 57 0.14 2 14.19 8.91e-03
hippocampus_development_prenatal Highly expressed in prenatal mouse hippocampus (cluster 1) 58 0.14 2 13.95 9.21e-03
hsc_hscandprogenitors_fetal Up-regulated in mouse hematopoietic stem cells and progenitors from fetal liver (HSC and Progenitors Shared) 717 1.77 6 3.39 9.58e-03
hsc_hscandprogenitors_shared Up-regulated in mouse hematopoietic stem cells and progenitors from both adult bone marrow and fetal liver (Cluster iii, HSC and Progenitors Shared) 717 1.77 6 3.39 9.58e-03
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.44 3 6.86 9.97e-03

Raw data (tab-delimited .txt)