L2L Microarray Analysis Tool
Results for L01DB.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in L01DB.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 542 | 1.34 | 11 | 8.21 | 1.70e-07 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 0.54 | 7 | 12.93 | 1.55e-06 |
| bleo_human_lymph_high_4hrs_dn | Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
| cmv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 109 | 0.27 | 5 | 18.56 | 8.71e-06 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 0.51 | 6 | 11.73 | 1.52e-05 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 8 | 5.46 | 1.41e-04 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 8 | 5.46 | 1.41e-04 |
| uvc_high_d4_dn | Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d4) | 110 | 0.27 | 4 | 14.71 | 1.75e-04 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 8 | 5.10 | 2.21e-04 |
| heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 4.52 | 14 | 3.10 | 2.58e-04 |
| cmv_uv-cmv_common_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
| uvc_xpcs_4hr_dn | Down-regulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 519 | 1.28 | 7 | 5.46 | 3.63e-04 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 4 | 8.99 | 1.12e-03 |
| uvc_xpcs_all_dn | Down-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 1048 | 2.59 | 9 | 3.47 | 1.43e-03 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 5 | 5.93 | 1.73e-03 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 10 | 3.06 | 2.00e-03 |
| brcax_a_up | Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| uvc_ttd_all_dn | Down-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 780 | 1.93 | 7 | 3.63 | 3.68e-03 |
| 5fu_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 42 | 0.10 | 2 | 19.26 | 4.93e-03 |
| uvc_ttd_4hr_dn | Down-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 641 | 1.58 | 6 | 3.79 | 5.70e-03 |
| et743_sarcoma_dn | Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 459 | 1.13 | 5 | 4.41 | 6.09e-03 |
| et743_sarcoma_24hrs_dn | Down-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 163 | 0.40 | 3 | 7.45 | 7.98e-03 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.41 | 3 | 7.40 | 8.11e-03 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 3 | 7.10 | 9.09e-03 |