L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in L01AD.profile.ud50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
response to unfolded protein	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.	83	0.41	8	19.50	1.01e-08
response to protein stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.	83	0.41	8	19.50	1.01e-08
response to chemical stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.	603	2.98	15	5.03	5.54e-07
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.	319	1.58	10	6.34	5.70e-06
response to oxidative stress	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.	92	0.45	6	13.19	7.24e-06
glutathione biosynthetic process	The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.	10	0.05	3	60.68	1.41e-05
response to stress	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).	1358	6.71	20	2.98	2.36e-05
oxygen and reactive oxygen species metabolic process	The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH).	121	0.60	6	10.03	3.45e-05
response to heat	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.	15	0.07	3	40.45	5.26e-05
glutathione metabolic process	The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.	16	0.08	3	37.93	6.45e-05
glutamate metabolic process	The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.	17	0.08	3	35.69	7.80e-05
response to biotic stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.	282	1.39	8	5.74	9.67e-05
sulfur amino acid metabolic process	The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.	28	0.14	3	21.67	3.61e-04
serine family amino acid metabolic process	The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.	34	0.17	3	17.85	6.45e-04
regulation of cell redox homeostasis	Any process that modulates the redox environment of a cell or compartment within a cell.	9	0.04	2	44.95	8.60e-04
response to temperature stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.	39	0.19	3	15.56	9.67e-04
keratinocyte differentiation	The process whereby a relatively unspecialized cell acquires specialized features of a keratinocyte.	40	0.20	3	15.17	1.04e-03
regulation of blood vessel size	Any process that modulates the size of blood vessels.	43	0.21	3	14.11	1.29e-03
chaperone cofactor-dependent protein folding	The process of assisting in the correct noncovalent assembly of posttranslational proteins and is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.	12	0.06	2	33.71	1.56e-03
sulfur compound biosynthetic process	The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.	49	0.24	3	12.38	1.88e-03
endosome transport	The directed movement of substances into, out of or mediated by an endosome, a membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.	50	0.25	3	12.14	1.99e-03
posttranslational protein folding	The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis.	15	0.07	2	26.97	2.46e-03
coenzyme biosynthetic process	The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.	113	0.56	4	7.16	2.51e-03
regulation of cellular process	Any process that modulates the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	5188	25.65	41	1.60	3.07e-03
glutamine family amino acid metabolic process	The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.	60	0.30	3	10.11	3.35e-03
cell redox homeostasis	The processes that maintain the redox environment of a cell or compartment within a cell.	60	0.30	3	10.11	3.35e-03
programmed cell death	Cell death resulting from activation of endogenous cellular processes.	1086	5.37	13	2.42	3.57e-03
negative regulation of cellular process	Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	1642	8.12	17	2.09	4.18e-03
cofactor biosynthetic process	The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein.	134	0.66	4	6.04	4.61e-03
negative regulation of biological process	Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.	1697	8.39	17	2.03	5.73e-03
cell death	The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.	1152	5.70	13	2.28	5.76e-03
death	A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.	1152	5.70	13	2.28	5.76e-03
biological regulation	Any process that modulates the frequency, rate or extent of any biological process, quality or function.	6089	30.10	45	1.49	6.51e-03
negative regulation of transcription	Any process that stops, prevents or reduces the frequency, rate or extent of transcription.	439	2.17	7	3.23	6.80e-03
cofactor metabolic process	The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.	247	1.22	5	4.09	8.12e-03
negative regulation of programmed cell death	Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.	347	1.72	6	3.50	8.16e-03
cell differentiation	The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.	2359	11.66	21	1.80	8.52e-03
cellular developmental process	A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.	2359	11.66	21	1.80	8.52e-03
apoptosis	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.	1078	5.33	12	2.25	8.59e-03

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

83

0.41

8

19.50

1.01e-08

response to protein stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.

83

0.41

8

19.50

1.01e-08

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

603

2.98

15

5.03

5.54e-07

protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

319

1.58

10

6.34

5.70e-06

response to oxidative stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

92

0.45

6

13.19

7.24e-06

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

10

0.05

3

60.68

1.41e-05

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

1358

6.71

20

2.98

2.36e-05

oxygen and reactive oxygen species metabolic process

The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH).

121

0.60

6

10.03

3.45e-05

response to heat

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

15

0.07

3

40.45

5.26e-05

glutathione metabolic process

The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.

16

0.08

3

37.93

6.45e-05

glutamate metabolic process

The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.

17

0.08

3

35.69

7.80e-05

response to biotic stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.

282

1.39

8

5.74

9.67e-05

sulfur amino acid metabolic process

The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.

28

0.14

3

21.67

3.61e-04

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

34

0.17

3

17.85

6.45e-04

regulation of cell redox homeostasis

Any process that modulates the redox environment of a cell or compartment within a cell.

9

0.04

2

44.95

8.60e-04

response to temperature stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.

39

0.19

3

15.56

9.67e-04

keratinocyte differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a keratinocyte.

40

0.20

3

15.17

1.04e-03

regulation of blood vessel size

Any process that modulates the size of blood vessels.

43

0.21

3

14.11

1.29e-03

chaperone cofactor-dependent protein folding

The process of assisting in the correct noncovalent assembly of posttranslational proteins and is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.

12

0.06

2

33.71

1.56e-03

sulfur compound biosynthetic process

The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.

49

0.24

3

12.38

1.88e-03

endosome transport

The directed movement of substances into, out of or mediated by an endosome, a membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.

50

0.25

3

12.14

1.99e-03

posttranslational protein folding

The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis.

15

0.07

2

26.97

2.46e-03

coenzyme biosynthetic process

The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

113

0.56

4

7.16

2.51e-03

regulation of cellular process

Any process that modulates the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

5188

25.65

41

1.60

3.07e-03

glutamine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.

60

0.30

3

10.11

3.35e-03

cell redox homeostasis

The processes that maintain the redox environment of a cell or compartment within a cell.

60

0.30

3

10.11

3.35e-03

programmed cell death

Cell death resulting from activation of endogenous cellular processes.

1086

5.37

13

2.42

3.57e-03

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

1642

8.12

17

2.09

4.18e-03

cofactor biosynthetic process

The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein.

134

0.66

4

6.04

4.61e-03

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

1697

8.39

17

2.03

5.73e-03

cell death

The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

1152

5.70

13

2.28

5.76e-03

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

1152

5.70

13

2.28

5.76e-03

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

6089

30.10

45

1.49

6.51e-03

negative regulation of transcription

Any process that stops, prevents or reduces the frequency, rate or extent of transcription.

439

2.17

7

3.23

6.80e-03

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

247

1.22

5

4.09

8.12e-03

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

347

1.72

6

3.50

8.16e-03

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.

2359

11.66

21

1.80

8.52e-03

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

2359

11.66

21

1.80

8.52e-03

apoptosis

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.

1078

5.33

12

2.25

8.59e-03

Results for L01AD.profile.ud50