L2L Microarray Analysis Tool
Results for L01AD.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in L01AD.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| bay_pbmc_4hr_dn | Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 400 | 0.99 | 10 | 10.11 | 9.17e-08 |
| pdgf_es_dn | Down-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis | 6 | 0.01 | 3 | 202.27 | 3.00e-07 |
| aged_mouse_hippocampus_any_up | Up-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 78 | 0.19 | 5 | 25.93 | 1.68e-06 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 1.10 | 9 | 8.16 | 2.32e-06 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
| il2_pbmc_4hr_dn | Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 555 | 1.37 | 9 | 6.56 | 1.33e-05 |
| cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.06 | 3 | 52.77 | 2.58e-05 |
| cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
| methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.06 | 3 | 48.54 | 3.34e-05 |
| il2_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 503 | 1.24 | 8 | 6.43 | 4.55e-05 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.07 | 3 | 43.34 | 4.72e-05 |
| cmv_hcmv_timecourse_24hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 82 | 0.20 | 4 | 19.73 | 5.60e-05 |
| cmv_hcmv_timecourse_10hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 30 | 0.07 | 3 | 40.45 | 5.83e-05 |
| bay_pbmc_2hr_dn | Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 398 | 0.98 | 7 | 7.12 | 7.24e-05 |
| avoidance_dn | Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. | 40 | 0.10 | 3 | 30.34 | 1.39e-04 |
| scchn_hpvneg_dn | Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 47 | 0.12 | 3 | 25.82 | 2.26e-04 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 2.07 | 9 | 4.34 | 3.01e-04 |
| pod1_ko_up | Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 508 | 1.26 | 7 | 5.57 | 3.20e-04 |
| bay-il2_pbmc_late_up | Up-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. | 130 | 0.32 | 4 | 12.45 | 3.31e-04 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| adipocyte_brca_up | Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| uvb_nhek1_c6 | Downregulated by UV-B light in normal human epidermal keratinocytes, cluster 6 | 268 | 0.66 | 5 | 7.55 | 5.98e-04 |
| hsc_lthsc_fetal | Up-regulated in mouse long-term functional hematopoietic stem cells from fetal liver (LT-HSC Shared) | 272 | 0.67 | 5 | 7.44 | 6.39e-04 |
| hsc_lthsc_shared | Up-regulated in mouse long-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster i, LT-HSC Shared) | 272 | 0.67 | 5 | 7.44 | 6.39e-04 |
| uvb_nhek2_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 160 | 0.40 | 4 | 10.11 | 7.22e-04 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.41 | 4 | 9.87 | 7.92e-04 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 4 | 9.14 | 1.05e-03 |
| cox1_ko_cortex_up | Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 0.76 | 5 | 6.61 | 1.08e-03 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 4 | 8.99 | 1.12e-03 |
| bay_pbmc_6hr_dn | Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 483 | 1.19 | 6 | 5.03 | 1.43e-03 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 0.51 | 4 | 7.82 | 1.86e-03 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 3 | 12.26 | 1.98e-03 |
| cis_xpc_dn | Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 363 | 0.90 | 5 | 5.57 | 2.27e-03 |
| il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 1.31 | 6 | 4.57 | 2.30e-03 |
| baf57_bt549_up | Up-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 364 | 0.90 | 5 | 5.56 | 2.30e-03 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.27 | 3 | 11.13 | 2.61e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 5 | 5.38 | 2.64e-03 |
| alzheimers_disease_up | Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus | 3137 | 7.75 | 17 | 2.19 | 2.70e-03 |
| hsc_lthsc_adult | Up-regulated in mouse long-term functional hematopoietic stem cells from adult bone marrow (LT-HSC Shared + Adult) | 385 | 0.95 | 5 | 5.25 | 2.92e-03 |
| cmv_hcmv_timecourse_48hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours | 235 | 0.58 | 4 | 6.89 | 2.94e-03 |
| aged_mouse_hippocampus_multi_up | Up-regulated in the hippocampus of 16-month aged mice from at least two of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| wnt3a_mammary_up | Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). | 133 | 0.33 | 3 | 9.12 | 4.56e-03 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 6 | 3.71 | 6.26e-03 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.12 | 2 | 16.86 | 6.39e-03 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1331 | 3.29 | 9 | 2.74 | 6.71e-03 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 6 | 3.60 | 7.26e-03 |
| reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 1.21 | 5 | 4.14 | 7.82e-03 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 4 | 5.07 | 8.55e-03 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 5 | 3.97 | 9.34e-03 |
| brca1_overexp_up | Upregulated by induction of exogenous BRCA1 in EcR-293 cells | 328 | 0.81 | 4 | 4.93 | 9.39e-03 |