L2L Microarray Analysis Tool
Results for G03CA.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in G03CA.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 21 | 3.22 | 4.86e-06 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 10 | 5.83 | 1.18e-05 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 10 | 5.83 | 1.18e-05 |
| 5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 9.05 | 23 | 2.54 | 6.85e-05 |
| cmv_hcmv_timecourse_16hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 16 hours | 93 | 0.46 | 5 | 10.87 | 1.07e-04 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 4 | 9.87 | 7.69e-04 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 10 | 3.41 | 8.95e-04 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 10 | 3.41 | 8.95e-04 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 11.58 | 23 | 1.99 | 1.94e-03 |
| 17aag_ovca_up | Up-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) | 53 | 0.26 | 3 | 11.45 | 2.35e-03 |
| cancer_neoplastic_meta_up | Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database | 115 | 0.57 | 4 | 7.04 | 2.67e-03 |
| brca_prognosis_pos | Genes whose expression is consistently positively correlated with breast cancer outcomes - higher expression is associated with good prognosis | 57 | 0.28 | 3 | 10.65 | 2.90e-03 |
| alk5_hmvec_2hr_dn | Down-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 202 | 1.00 | 5 | 5.01 | 3.53e-03 |
| alk5_hmvec_4hr_dn | Down-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 202 | 1.00 | 5 | 5.01 | 3.53e-03 |
| brca_er_pos | Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-positive tumors | 842 | 4.16 | 11 | 2.64 | 3.72e-03 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 3 | 9.19 | 4.38e-03 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 3 | 9.19 | 4.38e-03 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 1.08 | 5 | 4.62 | 4.95e-03 |
| uvc_ttd_all_up | Up-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 140 | 0.69 | 4 | 5.78 | 5.38e-03 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 1.12 | 5 | 4.47 | 5.64e-03 |
| scw_joint_24hrs_dn | Down-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
| cantharidin_up | Upregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
| tsa_hepg2_up | Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). | 936 | 4.63 | 11 | 2.38 | 7.94e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| hypoxia_rcc_novhl_up | Upregulated by hypoxia in VHL-null renal carcinoma cells (Fig. 4h+i) | 88 | 0.44 | 3 | 6.90 | 9.70e-03 |