L2L L2L Microarray Analysis Tool

Results for G02CB.profile.ud50

Results summary View all lists in L2L MDB View all genes in G02CB.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 16 5.46 7.98e-08
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 16 5.46 7.98e-08
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 11 6.41 1.77e-06
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 11 6.41 1.77e-06
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 1.58 10 6.34 5.70e-06
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 3.19 14 4.38 6.28e-06
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 6.53 20 3.06 1.61e-05
as3_hek293_dn Downregulated in HEK293 cells by treatment with arsenite 12 0.06 3 50.57 2.57e-05
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.39 5 12.80 4.91e-05
hypoxia_fibro_young_up Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) 15 0.07 3 40.45 5.26e-05
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 2.53 11 4.35 6.33e-05
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 1.32 8 6.08 6.46e-05
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.09 3 31.94 1.10e-04
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.47 5 10.65 1.18e-04
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.27 4 14.98 1.55e-04
irs1_ko_adip_up Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.79 6 7.63 1.56e-04
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 1.15 7 6.08 1.85e-04
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.30 4 13.26 2.49e-04
il2_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 4 12.26 3.37e-04
il2_pbmc_30min_up Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 4 12.26 3.37e-04
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.60 5 8.29 3.79e-04
insulin_adip_sens_dn Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.14 3 20.92 4.01e-04
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 1.00 6 6.01 5.60e-04
hdaci_colon_cluster2 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) 9 0.04 2 44.95 8.60e-04
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 2.52 9 3.57 1.16e-03
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.23 3 12.91 1.67e-03
genotoxins_all_24hrs_reg Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 49 0.24 3 12.38 1.88e-03
5azac-tsa_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 2343 11.58 23 1.99 1.94e-03
ageing_brain_up Age-upregulated in the human frontal cortex 446 2.20 8 3.63 1.94e-03
bcnu_glioma_nomgmt_48hrs_dn Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU 50 0.25 3 12.14 1.99e-03
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.88 5 5.71 2.00e-03
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.89 5 5.62 2.15e-03
adipogenesis_hmsc_class3_up Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.54 4 7.42 2.20e-03
stemcell_embryonic_up Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 9.83 20 2.03 2.81e-03
reovirus_hek293_up Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 2.43 8 3.30 3.47e-03
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 3.00 9 3.00 3.67e-03
tpa_resist_middle_dn Downregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells 209 1.03 5 4.84 4.07e-03
hdaci_colon_sul16hrs_up Upregulated by sulindac at 16 hrs in SW260 colon carcinoma cells 67 0.33 3 9.06 4.57e-03
adip_diff_cluster3 Strongly upregulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 3) 68 0.34 3 8.92 4.77e-03
cmv_hcmv_timecourse_4hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours 69 0.34 3 8.79 4.96e-03
aom-dss_colon_10wks_up Up-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 22 0.11 2 18.39 5.29e-03
hdaci_colon_cur12hrs_up Upregulated by curcumin at 12 hrs in SW260 colon carcinoma cells 22 0.11 2 18.39 5.29e-03
heatshock_hela_4hr_dn Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 9.04 18 1.99 5.45e-03
cmv_hcmv_timecourse_all_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 895 4.42 11 2.49 5.79e-03
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.12 2 16.86 6.28e-03
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 2.69 8 2.97 6.33e-03
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 9 2.70 7.25e-03
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.41 3 7.40 8.00e-03
cantharidin_dn Downregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin 83 0.41 3 7.31 8.27e-03
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.43 3 7.06 9.11e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.43 3 6.97 9.41e-03
5fu_resist_gastric_dn Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.15 2 13.48 9.70e-03

Raw data (tab-delimited .txt)