L2L L2L Microarray Analysis Tool

Results for G01AF.profile.ud50

Results summary View all lists in L2L MDB View all genes in G01AF.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 27 9.21 1.39e-17
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 27 9.21 1.39e-17
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 6.53 35 5.36 4.25e-15
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 18 10.49 3.54e-13
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 18 10.49 3.54e-13
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 1.69 15 8.90 3.12e-10
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.67 10 14.87 2.10e-09
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.85 10 11.83 1.91e-08
csb_reliable_up Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 2.54 15 5.91 7.19e-08
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.97 10 10.27 7.25e-08
adip_diff_cluster4 Strongly upregulated at 16 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 4) 56 0.28 6 21.67 3.84e-07
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 1.48 11 7.44 4.17e-07
bleo_human_lymph_high_4hrs_up Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 32 0.16 5 31.60 5.32e-07
p21_p53_middle_dn Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 37 0.18 5 27.33 1.13e-06
irs1_ko_adip_up Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.79 8 10.18 1.56e-06
dox_resist_gastric_up Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.37 6 16.40 2.03e-06
p21_p53_any_dn Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 77 0.38 6 15.76 2.56e-06
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 3.00 14 4.67 3.05e-06
et743_hela_up Upregulated by Et-743 in HeLa cells 99 0.49 6 12.26 1.10e-05
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 2.52 12 4.76 1.26e-05
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.35 11 4.68 3.30e-05
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.88 7 8.00 3.32e-05
hdaci_colon_sul12hrs_up Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells 40 0.20 4 20.23 4.74e-05
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.07 3 40.45 5.26e-05
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 2.53 11 4.35 6.33e-05
rb_creko_up Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 344 1.70 9 5.29 6.71e-05
5azac-tsa_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 2343 11.58 27 2.33 7.24e-05
tgfb_hmvec_2hr_dn Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 1.75 9 5.16 8.16e-05
genotoxins_all_24hrs_reg Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 49 0.24 4 16.51 1.06e-04
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 2.69 11 4.09 1.10e-04
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 3.19 12 3.76 1.20e-04
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 12 3.60 1.79e-04
hdaci_colon_sul16hrs_up Upregulated by sulindac at 16 hrs in SW260 colon carcinoma cells 67 0.33 4 12.08 3.57e-04
preadip_vs_fibro_up Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 29 0.14 3 20.92 4.01e-04
ifn_beta_glioma_up Up-regulated in human glioma cells (T98) at 48 hours following treatment with interferon-beta 124 0.61 5 8.16 4.08e-04
hdaci_colon_sul_up Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 192 0.95 6 6.32 4.29e-04
fsh_human_granulosa_up Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.15 3 19.57 4.90e-04
scchn_hpvpos_up Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 31 0.15 3 19.57 4.90e-04
hdaci_colon_cur24hrs_up Upregulated by curcumin at 24 hrs in SW260 colon carcinoma cells 73 0.36 4 11.08 4.95e-04
p53genes_all p53 transcriptional targets 33 0.16 3 18.39 5.90e-04
bay-il2_pbmc_late_dn Down-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 205 1.01 6 5.92 6.05e-04
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.39 4 10.37 6.37e-04
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.17 3 17.85 6.45e-04
hdaci_colon_sul48hrs_up Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells 140 0.69 5 7.22 7.09e-04
irs_ko_adip_up Progressively up-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) 36 0.18 3 16.86 7.64e-04
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.41 4 9.87 7.69e-04
cmvuv-cmv_common_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 37 0.18 3 16.40 8.28e-04
cis_xpc_up Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 242 1.20 6 5.01 1.42e-03
genotoxins_all_4hrs_reg Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 45 0.22 3 13.48 1.47e-03
brca_prognosis_neg Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis 166 0.82 5 6.09 1.51e-03
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 2.62 9 3.43 1.51e-03
cmv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 46 0.23 3 13.19 1.56e-03
dac_panc_up Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 654 3.23 10 3.09 1.84e-03
et743pt650_colonca_up Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) 13 0.06 2 31.12 1.84e-03
o6bg_resist_medulloblastoma_dn Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 109 0.54 4 7.42 2.20e-03
brca_brca1_pos Genes whose expression is consistently positively correlated with brca1 germline status in breast cancer - higher expression is associated with sporadic tumors 182 0.90 5 5.56 2.26e-03
aged_mouse_neocortex_up Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.55 4 7.29 2.35e-03
mms_mouse_lymph_low_4hrs_up Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of methyl methanesulfonate (MMS) 17 0.08 2 23.80 3.16e-03
diab_neph_dn Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 829 4.10 11 2.68 3.31e-03
reovirus_hek293_up Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 2.43 8 3.30 3.47e-03
tafi_kd_up Up-regulated by stable siRNA knock-down of histone chaperone TAF-I in HeLa cells. 20 0.10 2 20.23 4.38e-03
wnt3a_mammary_up Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). 133 0.66 4 6.08 4.49e-03
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 1.51 6 3.97 4.52e-03
brca_er_neg Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors 1519 7.51 16 2.13 4.56e-03
il1_cornea_up Upregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 2) 136 0.67 4 5.95 4.86e-03
pubertal_mammary Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. 1260 6.23 14 2.25 4.88e-03
bleo_mouse_lymph_high_24hrs_dn Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin 71 0.35 3 8.55 5.38e-03
5azac_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1830 9.05 18 1.99 5.48e-03
cmv-uv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 226 1.12 5 4.47 5.64e-03
cmv_hcmv_timecourse_10hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours 23 0.11 2 17.59 5.77e-03
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.39 3 7.68 7.22e-03
camptothecin_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin 28 0.14 2 14.45 8.48e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.14 2 14.45 8.48e-03
insulin_adip_sens_dn Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.14 2 13.95 9.08e-03
inos_all_up Upregulated following iNOS induction in hepatocytes (Tables 3-17) 87 0.43 3 6.97 9.41e-03
hdaci_colon_but48hrs_dn Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 165 0.82 4 4.90 9.48e-03
5fu_resist_gastric_dn Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.15 2 13.48 9.70e-03
uv_unique_fibro_up Up-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO 30 0.15 2 13.48 9.70e-03
hdaci_colon_but16hrs_dn Downregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 167 0.83 4 4.84 9.88e-03

Raw data (tab-delimited .txt)