Results summary | View all lists in L2L MDB | View all genes in G01AF.profile.ud50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 27 | 9.21 | 1.39e-17 |
alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 27 | 9.21 | 1.39e-17 |
tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 35 | 5.36 | 4.25e-15 |
alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 18 | 10.49 | 3.54e-13 |
alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 18 | 10.49 | 3.54e-13 |
senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 1.69 | 15 | 8.90 | 3.12e-10 |
idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.67 | 10 | 14.87 | 2.10e-09 |
senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.85 | 10 | 11.83 | 1.91e-08 |
csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 2.54 | 15 | 5.91 | 7.19e-08 |
serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 10 | 10.27 | 7.25e-08 |
adip_diff_cluster4 | Strongly upregulated at 16 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 4) | 56 | 0.28 | 6 | 21.67 | 3.84e-07 |
senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 1.48 | 11 | 7.44 | 4.17e-07 |
bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.16 | 5 | 31.60 | 5.32e-07 |
p21_p53_middle_dn | Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 37 | 0.18 | 5 | 27.33 | 1.13e-06 |
irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.79 | 8 | 10.18 | 1.56e-06 |
dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.37 | 6 | 16.40 | 2.03e-06 |
p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.38 | 6 | 15.76 | 2.56e-06 |
bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 14 | 4.67 | 3.05e-06 |
et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.49 | 6 | 12.26 | 1.10e-05 |
il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 12 | 4.76 | 1.26e-05 |
bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 11 | 4.68 | 3.30e-05 |
heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 7 | 8.00 | 3.32e-05 |
hdaci_colon_sul12hrs_up | Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells | 40 | 0.20 | 4 | 20.23 | 4.74e-05 |
fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 11 | 4.35 | 6.33e-05 |
rb_creko_up | Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 344 | 1.70 | 9 | 5.29 | 6.71e-05 |
5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 11.58 | 27 | 2.33 | 7.24e-05 |
tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 1.75 | 9 | 5.16 | 8.16e-05 |
genotoxins_all_24hrs_reg | Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 49 | 0.24 | 4 | 16.51 | 1.06e-04 |
bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 11 | 4.09 | 1.10e-04 |
il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 12 | 3.76 | 1.20e-04 |
heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 12 | 3.60 | 1.79e-04 |
hdaci_colon_sul16hrs_up | Upregulated by sulindac at 16 hrs in SW260 colon carcinoma cells | 67 | 0.33 | 4 | 12.08 | 3.57e-04 |
preadip_vs_fibro_up | Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine | 29 | 0.14 | 3 | 20.92 | 4.01e-04 |
ifn_beta_glioma_up | Up-regulated in human glioma cells (T98) at 48 hours following treatment with interferon-beta | 124 | 0.61 | 5 | 8.16 | 4.08e-04 |
hdaci_colon_sul_up | Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 192 | 0.95 | 6 | 6.32 | 4.29e-04 |
fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
scchn_hpvpos_up | Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
hdaci_colon_cur24hrs_up | Upregulated by curcumin at 24 hrs in SW260 colon carcinoma cells | 73 | 0.36 | 4 | 11.08 | 4.95e-04 |
p53genes_all | p53 transcriptional targets | 33 | 0.16 | 3 | 18.39 | 5.90e-04 |
bay-il2_pbmc_late_dn | Down-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. | 205 | 1.01 | 6 | 5.92 | 6.05e-04 |
heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 4 | 10.37 | 6.37e-04 |
uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.17 | 3 | 17.85 | 6.45e-04 |
hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.69 | 5 | 7.22 | 7.09e-04 |
irs_ko_adip_up | Progressively up-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) | 36 | 0.18 | 3 | 16.86 | 7.64e-04 |
bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 4 | 9.87 | 7.69e-04 |
cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.18 | 3 | 16.40 | 8.28e-04 |
cis_xpc_up | Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 242 | 1.20 | 6 | 5.01 | 1.42e-03 |
genotoxins_all_4hrs_reg | Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 45 | 0.22 | 3 | 13.48 | 1.47e-03 |
brca_prognosis_neg | Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis | 166 | 0.82 | 5 | 6.09 | 1.51e-03 |
il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 9 | 3.43 | 1.51e-03 |
cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.23 | 3 | 13.19 | 1.56e-03 |
dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 3.23 | 10 | 3.09 | 1.84e-03 |
et743pt650_colonca_up | Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
o6bg_resist_medulloblastoma_dn | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 109 | 0.54 | 4 | 7.42 | 2.20e-03 |
brca_brca1_pos | Genes whose expression is consistently positively correlated with brca1 germline status in breast cancer - higher expression is associated with sporadic tumors | 182 | 0.90 | 5 | 5.56 | 2.26e-03 |
aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.55 | 4 | 7.29 | 2.35e-03 |
mms_mouse_lymph_low_4hrs_up | Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of methyl methanesulfonate (MMS) | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
diab_neph_dn | Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 829 | 4.10 | 11 | 2.68 | 3.31e-03 |
reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 2.43 | 8 | 3.30 | 3.47e-03 |
tafi_kd_up | Up-regulated by stable siRNA knock-down of histone chaperone TAF-I in HeLa cells. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
wnt3a_mammary_up | Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). | 133 | 0.66 | 4 | 6.08 | 4.49e-03 |
prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 1.51 | 6 | 3.97 | 4.52e-03 |
brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 1519 | 7.51 | 16 | 2.13 | 4.56e-03 |
il1_cornea_up | Upregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 2) | 136 | 0.67 | 4 | 5.95 | 4.86e-03 |
pubertal_mammary | Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. | 1260 | 6.23 | 14 | 2.25 | 4.88e-03 |
bleo_mouse_lymph_high_24hrs_dn | Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin | 71 | 0.35 | 3 | 8.55 | 5.38e-03 |
5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 9.05 | 18 | 1.99 | 5.48e-03 |
cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 1.12 | 5 | 4.47 | 5.64e-03 |
cmv_hcmv_timecourse_10hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
inos_all_up | Upregulated following iNOS induction in hepatocytes (Tables 3-17) | 87 | 0.43 | 3 | 6.97 | 9.41e-03 |
hdaci_colon_but48hrs_dn | Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 165 | 0.82 | 4 | 4.90 | 9.48e-03 |
5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
uv_unique_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
hdaci_colon_but16hrs_dn | Downregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 167 | 0.83 | 4 | 4.84 | 9.88e-03 |