L2L Microarray Analysis Tool
Results for D10AA.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in D10AA.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.89 | 13 | 14.61 | 1.05e-11 |
| dex_keratinocyte_1hr_dn | Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 24 | 0.12 | 6 | 50.57 | 1.82e-09 |
| dex_keratinocyte_4hr_dn | Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 69 | 0.34 | 7 | 20.52 | 5.96e-08 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.22 | 6 | 27.58 | 8.77e-08 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 1.48 | 11 | 7.44 | 4.17e-07 |
| scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.82 | 7 | 8.53 | 2.21e-05 |
| stress_genotoxic_specific_up | Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress | 67 | 0.33 | 5 | 15.09 | 2.21e-05 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 12 | 4.01 | 6.63e-05 |
| o6bg_resist_medulloblastoma_up | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 46 | 0.23 | 4 | 17.59 | 8.26e-05 |
| scw_joint_24hrs_up | Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 143 | 0.71 | 6 | 8.49 | 8.75e-05 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.09 | 3 | 31.94 | 1.10e-04 |
| scw_joint_4hrs_up | Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 230 | 1.14 | 7 | 6.16 | 1.70e-04 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 1.15 | 7 | 6.08 | 1.85e-04 |
| idx_tsa_dn_cluster3 | Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 108 | 0.53 | 5 | 9.36 | 2.16e-04 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.85 | 6 | 7.10 | 2.32e-04 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.32 | 4 | 12.64 | 3.00e-04 |
| uvc_high_b4_up | Progressively up-regulated from 12-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b4) | 6 | 0.03 | 2 | 67.42 | 3.62e-04 |
| hpv_hnscc_up | Up-regulated in HPV-positive head and neck squamous cell carcinomas (HNSCC) compared to HPV-negative HNSCC. | 68 | 0.34 | 4 | 11.90 | 3.78e-04 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 1.32 | 7 | 5.32 | 4.10e-04 |
| adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| arthritis_mouse_common_up | Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. | 459 | 2.27 | 9 | 3.97 | 5.59e-04 |
| hdaci_colon_cluster9 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) | 78 | 0.39 | 4 | 10.37 | 6.37e-04 |
| stress_tpa_specific_up | Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents | 78 | 0.39 | 4 | 10.37 | 6.37e-04 |
| hdaci_three_up | Upregulated in several cell lines by all of TSA, SAHA, and MS-275 | 8 | 0.04 | 2 | 50.57 | 6.71e-04 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 9 | 3.83 | 7.11e-04 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 4 | 9.87 | 7.69e-04 |
| hdaci_colon_cluster2 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.43 | 4 | 9.41 | 9.19e-04 |
| il2_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 503 | 2.49 | 9 | 3.62 | 1.06e-03 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 2.03 | 8 | 3.95 | 1.15e-03 |
| cmv_hcmv_timecourse_6hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 6 hours | 95 | 0.47 | 4 | 8.52 | 1.33e-03 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.22 | 3 | 13.48 | 1.47e-03 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 9 | 3.43 | 1.51e-03 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 10 | 3.13 | 1.68e-03 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.24 | 3 | 12.64 | 1.77e-03 |
| adipocyte_brca_dn | Downregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 5 | 5.71 | 2.00e-03 |
| cmv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 109 | 0.54 | 4 | 7.42 | 2.20e-03 |
| cis_xpc_dn | Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 363 | 1.79 | 7 | 3.90 | 2.45e-03 |
| ad12_any_up | Up-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| shh_up | Upregulated by sonic hedgehog (shh) expression in murine neuronal precursor cells | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 1.86 | 7 | 3.77 | 2.97e-03 |
| h2o2_csbdiff_c1 | Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) | 58 | 0.29 | 3 | 10.46 | 3.04e-03 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 5 | 5.13 | 3.17e-03 |
| uvb_scc_up | Upregulated by UV-B light in squamous cell carcinoma cells | 198 | 0.98 | 5 | 5.11 | 3.24e-03 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 4.15 | 11 | 2.65 | 3.62e-03 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 3 | 9.19 | 4.38e-03 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 3 | 9.19 | 4.38e-03 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 8 | 3.17 | 4.40e-03 |
| brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 1.52 | 6 | 3.94 | 4.66e-03 |
| adip_diff_cluster3 | Strongly upregulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 3) | 68 | 0.34 | 3 | 8.92 | 4.77e-03 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 3.13 | 9 | 2.87 | 4.90e-03 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 1.57 | 6 | 3.82 | 5.42e-03 |
| il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 2.63 | 8 | 3.05 | 5.51e-03 |
| ifn_beta_up | Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon beta | 143 | 0.71 | 4 | 5.66 | 5.79e-03 |
| dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.37 | 3 | 8.20 | 6.03e-03 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 8 | 2.97 | 6.33e-03 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 3 | 7.78 | 6.98e-03 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| ifn_gamma_up | Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon gamma | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 1.69 | 6 | 3.56 | 7.53e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.43 | 3 | 6.97 | 9.41e-03 |