L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in D10AA.profile.d50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
regulation of progression through cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.	875	2.16	11	5.09	1.63e-05
regulation of cell cycle	A cell cycle process that modulates the rate, extent or mode of the cell cycle.	880	2.18	11	5.06	1.72e-05
cell cycle process	A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.	1144	2.83	12	4.24	3.97e-05
positive regulation of interleukin-6 biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	7	0.02	2	115.58	1.27e-04
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.	1307	3.23	12	3.71	1.37e-04
regulation of chemokine biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.	8	0.02	2	101.14	1.69e-04
regulation of interleukin-6 biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	8	0.02	2	101.14	1.69e-04
chemokine production	The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	9	0.02	2	89.90	2.17e-04
chemokine biosynthetic process	The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.02	2	89.90	2.17e-04
chemokine metabolic process	The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.02	2	89.90	2.17e-04
interleukin-6 production	The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	10	0.02	2	80.91	2.71e-04
interleukin-6 biosynthetic process	The chemical reactions and pathways resulting in the formation of interleukin-6.	10	0.02	2	80.91	2.71e-04
thermoregulation	A homeostatic process by which an organism modulates its internal body temperature.	12	0.03	2	67.42	3.97e-04
serine family amino acid biosynthetic process	The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.	12	0.03	2	67.42	3.97e-04
positive regulation of cytokine biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.	58	0.14	3	20.92	4.21e-04
positive regulation of protein biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.	69	0.17	3	17.59	7.01e-04
positive regulation of cellular biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.	75	0.19	3	16.18	8.93e-04
adrenal gland development	The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.	18	0.04	2	44.95	9.11e-04
regulation of transforming growth factor beta receptor signaling pathway	Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.	21	0.05	2	38.53	1.24e-03
regulation of cytokine biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.	85	0.21	3	14.28	1.28e-03
positive regulation of biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.	92	0.23	3	13.19	1.61e-03
determination of left/right symmetry	The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.	24	0.06	2	33.71	1.63e-03
neutrophil chemotaxis	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.	24	0.06	2	33.71	1.63e-03
determination of symmetry	The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.	26	0.06	2	31.12	1.91e-03
determination of bilateral symmetry	The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.	26	0.06	2	31.12	1.91e-03
cytokine biosynthetic process	The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.	99	0.24	3	12.26	1.98e-03
cytokine metabolic process	The chemical reactions and pathways involving cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.	100	0.25	3	12.14	2.04e-03
positive regulation of protein metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.	106	0.26	3	11.45	2.41e-03
one-carbon compound metabolic process	The chemical reactions and pathways involving compounds containing a single carbon atom.	108	0.27	3	11.24	2.54e-03
leukocyte chemotaxis	The movement of a leukocyte in response to an external stimulus.	32	0.08	2	25.28	2.88e-03
positive regulation of progression through cell cycle	Any process that activates or increases the frequency, rate or extent of progression through the cell cycle.	33	0.08	2	24.52	3.07e-03
serine family amino acid metabolic process	The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.	34	0.08	2	23.80	3.25e-03
mitotic checkpoint	A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis.	37	0.09	2	21.87	3.84e-03
leukocyte migration	The movement of leukocytes within or between different tissues and organs of the body.	39	0.10	2	20.75	4.26e-03
acute-phase response	Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.	44	0.11	2	18.39	5.40e-03
endocrine system development	Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.	47	0.12	2	17.21	6.14e-03
biopolymer methylation	The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer.	47	0.12	2	17.21	6.14e-03
cytokine production	The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	153	0.38	3	7.93	6.71e-03
amino acid biosynthetic process	The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.	56	0.14	2	14.45	8.61e-03
regulation of transcription from RNA polymerase II promoter	Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.	701	1.73	6	3.46	8.64e-03
methylation	The process by which a methyl group is covalently attached to a molecule.	57	0.14	2	14.19	8.91e-03

regulation of progression through cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

875

2.16

11

5.09

1.63e-05

regulation of cell cycle

A cell cycle process that modulates the rate, extent or mode of the cell cycle.

880

2.18

11

5.06

1.72e-05

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

1144

2.83

12

4.24

3.97e-05

positive regulation of interleukin-6 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

7

0.02

2

115.58

1.27e-04

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

1307

3.23

12

3.71

1.37e-04

regulation of chemokine biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.

8

0.02

2

101.14

1.69e-04

regulation of interleukin-6 biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

8

0.02

2

101.14

1.69e-04

chemokine production

The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

9

0.02

2

89.90

2.17e-04

chemokine biosynthetic process

The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.02

2

89.90

2.17e-04

chemokine metabolic process

The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.02

2

89.90

2.17e-04

interleukin-6 production

The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

10

0.02

2

80.91

2.71e-04

interleukin-6 biosynthetic process

The chemical reactions and pathways resulting in the formation of interleukin-6.

10

0.02

2

80.91

2.71e-04

thermoregulation

A homeostatic process by which an organism modulates its internal body temperature.

12

0.03

2

67.42

3.97e-04

serine family amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

12

0.03

2

67.42

3.97e-04

positive regulation of cytokine biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.

58

0.14

3

20.92

4.21e-04

positive regulation of protein biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

69

0.17

3

17.59

7.01e-04

positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

75

0.19

3

16.18

8.93e-04

adrenal gland development

The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.

18

0.04

2

44.95

9.11e-04

regulation of transforming growth factor beta receptor signaling pathway

Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.

21

0.05

2

38.53

1.24e-03

regulation of cytokine biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.

85

0.21

3

14.28

1.28e-03

positive regulation of biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

92

0.23

3

13.19

1.61e-03

determination of left/right symmetry

The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

24

0.06

2

33.71

1.63e-03

neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

24

0.06

2

33.71

1.63e-03

determination of symmetry

The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.

26

0.06

2

31.12

1.91e-03

determination of bilateral symmetry

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

26

0.06

2

31.12

1.91e-03

cytokine biosynthetic process

The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

99

0.24

3

12.26

1.98e-03

cytokine metabolic process

The chemical reactions and pathways involving cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

100

0.25

3

12.14

2.04e-03

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

106

0.26

3

11.45

2.41e-03

one-carbon compound metabolic process

The chemical reactions and pathways involving compounds containing a single carbon atom.

108

0.27

3

11.24

2.54e-03

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

32

0.08

2

25.28

2.88e-03

positive regulation of progression through cell cycle

Any process that activates or increases the frequency, rate or extent of progression through the cell cycle.

33

0.08

2

24.52

3.07e-03

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

34

0.08

2

23.80

3.25e-03

mitotic checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis.

37

0.09

2

21.87

3.84e-03

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

39

0.10

2

20.75

4.26e-03

acute-phase response

Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

44

0.11

2

18.39

5.40e-03

endocrine system development

Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.

47

0.12

2

17.21

6.14e-03

biopolymer methylation

The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer.

47

0.12

2

17.21

6.14e-03

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

153

0.38

3

7.93

6.71e-03

amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.

56

0.14

2

14.45

8.61e-03