L2L L2L Microarray Analysis Tool

Results for D07XB.profile.ud50

Results summary View all lists in GO:BiolProc View all genes in D07XB.profile.ud50
List Name Description Total
probes		 Expected
matches		 Actual
matches		 Fold
Enrichment		 Binomial
p-value
regulation of interleukin-6 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. 8 0.04 3 75.85 6.64e-06
interleukin-6 production The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 10 0.05 3 60.68 1.41e-05
interleukin-6 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-6. 10 0.05 3 60.68 1.41e-05
B cell activation The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 115 0.57 5 8.79 2.89e-04
somatic recombination of immunoglobulin genes during immune response The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. 30 0.15 3 20.23 4.44e-04
somatic diversification of immunoglobulins during immune response The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. 30 0.15 3 20.23 4.44e-04
immunoglobulin production during immune response The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. 30 0.15 3 20.23 4.44e-04
isotype switching The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. 30 0.15 3 20.23 4.44e-04
somatic diversification of immune receptors via germline recombination within a single locus The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. 31 0.15 3 19.57 4.90e-04
somatic cell DNA recombination Recombination occurring within or between DNA molecules in somatic cells. 31 0.15 3 19.57 4.90e-04
somatic recombination of immunoglobulin gene segments The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. 31 0.15 3 19.57 4.90e-04
positive regulation of interleukin-6 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. 7 0.03 2 57.79 5.05e-04
somatic diversification of immune receptors The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. 34 0.17 3 17.85 6.45e-04
somatic diversification of immunoglobulins The somatic process by means of which sequence diversity of immunoglobulins is generated. 34 0.17 3 17.85 6.45e-04
regulation of chemokine biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. 8 0.04 2 50.57 6.71e-04
chemokine production The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 9 0.04 2 44.95 8.60e-04
chemokine biosynthetic process The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions. 9 0.04 2 44.95 8.60e-04
chemokine metabolic process The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions. 9 0.04 2 44.95 8.60e-04
immunoglobulin production The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 39 0.19 3 15.56 9.67e-04
cytokine production The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 153 0.76 5 6.61 1.05e-03
positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation. 10 0.05 2 40.45 1.07e-03
negative regulation of NF-kappaB import into nucleus Any process that stops, prevents or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 11 0.05 2 36.78 1.31e-03
acute-phase response Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. 44 0.22 3 13.79 1.38e-03
thermoregulation A homeostatic process by which an organism modulates its internal body temperature. 12 0.06 2 33.71 1.56e-03
cytoplasmic sequestering of transcription factor The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. 13 0.06 2 31.12 1.84e-03
cytoplasmic sequestering of protein The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. 13 0.06 2 31.12 1.84e-03
immune system development The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. 346 1.71 7 4.09 1.87e-03
production of molecular mediator of immune response The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels. 51 0.25 3 11.90 2.11e-03
insulin receptor signaling pathway The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. 51 0.25 3 11.90 2.11e-03
regulation of B cell proliferation Any process that modulates the frequency, rate or extent of B cell proliferation. 16 0.08 2 25.28 2.80e-03
negative regulation of protein import into nucleus Any process that stops, prevents or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. 16 0.08 2 25.28 2.80e-03
negative regulation of transcription factor import into nucleus Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 16 0.08 2 25.28 2.80e-03
B cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a B cell. 57 0.28 3 10.65 2.90e-03
negative regulation of nucleocytoplasmic transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. 17 0.08 2 23.80 3.16e-03
negative regulation of protein transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells. 17 0.08 2 23.80 3.16e-03
adrenal gland development The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. 18 0.09 2 22.47 3.55e-03
regulation of isotype switching Any process that modulates the frequency, rate or extent of isotype switching. 18 0.09 2 22.47 3.55e-03
regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of DNA-dependent transcription. 2510 12.41 23 1.85 4.41e-03
response to metal ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. 21 0.10 2 19.26 4.82e-03
regulation of transforming growth factor beta receptor signaling pathway Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway. 21 0.10 2 19.26 4.82e-03
response to external stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 759 3.75 10 2.66 5.21e-03
regulation of NF-kappaB import into nucleus Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 22 0.11 2 18.39 5.29e-03
NF-kappaB import into nucleus The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 22 0.11 2 18.39 5.29e-03
regulation of actin filament length Any process that controls the length of actin filaments in a cell. 73 0.36 3 8.31 5.81e-03
regulation of cellular metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. 3041 15.03 26 1.73 6.23e-03
transcription, DNA-dependent The synthesis of RNA on a template of DNA. 2588 12.79 23 1.80 6.26e-03
determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. 24 0.12 2 16.86 6.28e-03
neutrophil chemotaxis The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. 24 0.12 2 16.86 6.28e-03
RNA biosynthetic process The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. 2591 12.81 23 1.80 6.34e-03
central nervous system development The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. 332 1.64 6 3.66 6.64e-03
positive regulation of B cell activation Any process that activates or increases the frequency, rate or extent of B cell activation. 25 0.12 2 16.18 6.80e-03
immunoglobulin mediated immune response An immune response mediated by immunoglobulins, whether cell-bound or in solution. 79 0.39 3 7.68 7.22e-03
B cell mediated immunity Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. 79 0.39 3 7.68 7.22e-03
determination of symmetry The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. 26 0.13 2 15.56 7.34e-03
determination of bilateral symmetry The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. 26 0.13 2 15.56 7.34e-03
regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. 682 3.37 9 2.67 7.72e-03
response to inorganic substance A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 27 0.13 2 14.98 7.90e-03
B cell proliferation The rapid expansion of a B cell population by cell division. Follows B cell activation. 27 0.13 2 14.98 7.90e-03
negative regulation of myeloid cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation. 27 0.13 2 14.98 7.90e-03
signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell. 4207 20.80 33 1.59 8.00e-03
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. 2802 13.85 24 1.73 8.14e-03
DNA recombination The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. 158 0.78 4 5.12 8.18e-03
regulation of cytokine biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 85 0.42 3 7.14 8.83e-03
regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. 701 3.47 9 2.60 9.13e-03

Raw data (tab-delimited .txt)