L2L L2L Microarray Analysis Tool

Results for D07XB.profile.d50

Results summary View all lists in L2L MDB View all genes in D07XB.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 10 7.63 1.18e-06
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 10 6.26 6.69e-06
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 9 7.12 6.92e-06
idx_tsa_dn_cluster3 Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 108 0.27 5 18.73 8.33e-06
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 2.07 11 5.30 1.11e-05
cmv_all_dn Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 213 0.53 6 11.40 1.78e-05
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 9 6.01 2.63e-05
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 8 6.81 3.04e-05
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 8 6.81 3.04e-05
calres_mouse_dn Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.20 4 20.48 4.84e-05
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 8 6.35 5.00e-05
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 1.34 8 5.95 7.82e-05
cmv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 109 0.27 4 14.85 1.69e-04
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 3 27.58 1.85e-04
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 3 25.28 2.40e-04
cmv_24hrs_dn Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 140 0.35 4 11.56 4.38e-04
il2_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.16 3 18.39 6.15e-04
il2_pbmc_30min_up Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.16 3 18.39 6.15e-04
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01 6 5.92 6.21e-04
heatshock_hela_4hr_dn Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 4.52 13 2.88 8.24e-04
caries_pulp_high_up Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 168 0.42 4 9.63 8.66e-04
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 5 6.76 9.75e-04
hdaci_colon_cluster9 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.19 3 15.56 1.00e-03
hdaci_colon_sul30min_dn Downregulated by sulindac at 30 min in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.20 3 14.80 1.16e-03
cmv_hcmv_timecourse_24hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.20 3 14.80 1.16e-03
uvb_nhek1_up Upregulated by UV-B light in normal human epidermal keratinocytes 336 0.83 5 6.02 1.63e-03
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 4 8.01 1.70e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 3 12.77 1.76e-03
bay-il2_pbmc_late_dn Down-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 205 0.51 4 7.89 1.80e-03
htert_up Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 97 0.24 3 12.51 1.87e-03
brca2_brca1_up Genes up-regulated in BRCA2-linked breast tumors, relative to BRCA1-linked tumors 99 0.24 3 12.26 1.98e-03
ribavirin_rsv_dn Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin 101 0.25 3 12.02 2.10e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.07 2 28.90 2.21e-03
cis_xpc_dn Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 363 0.90 5 5.57 2.27e-03
emt_up Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 105 0.26 3 11.56 2.35e-03
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.93 5 5.38 2.64e-03
baf57_bt549_dn Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 554 1.37 6 4.38 2.83e-03
insulin_adip_insens_up Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 37 0.09 2 21.87 3.84e-03
elongina_ko_up Upregulated in MES cells from elongin-A knockout mice 263 0.65 4 6.15 4.38e-03
aom-dss_colon_5wks_up Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 133 0.33 3 9.12 4.56e-03
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 3 8.99 4.75e-03
zmpste24_ko_dn Fifty genes most strongly down-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 42 0.10 2 19.26 4.93e-03
diab_neph_dn Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 829 2.05 7 3.42 5.09e-03
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.57 6 3.83 5.41e-03
ifn_beta_up Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon beta 143 0.35 3 8.49 5.57e-03
arthritis_mouse_common_up Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 1.13 5 4.41 6.09e-03
hdaci_colon_cur2hrs_up Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells 49 0.12 2 16.51 6.65e-03
microrna_mammal Predicted MicroRNA targets conserved across human, mouse and rat 1331 3.29 9 2.74 6.71e-03
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 4 5.29 7.41e-03
brca1_overexp_prostate_up Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 308 0.76 4 5.25 7.58e-03
uvc_high_d9_dn Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.13 2 15.27 7.74e-03
uvb_nhek3_c0 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 167 0.41 3 7.27 8.52e-03
pod1_ko_up Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 508 1.26 5 3.98 9.19e-03
h2o2_csbdiff_c1 Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) 58 0.14 2 13.95 9.21e-03
ifn_any_up Upregulated 2-fold in HT1080 cells 6 hours following treatment with any of interferons alpha, beta and gamma 172 0.43 3 7.06 9.23e-03
hdaci_colon_cur_up Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 174 0.43 3 6.97 9.52e-03
csb_reliable_up Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 1.27 5 3.94 9.56e-03

Raw data (tab-delimited .txt)