L2L Microarray Analysis Tool
Results for D07AC.profile.u50
| Results summary | View all lists in GO:BiolProc | View all genes in D07AC.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| negative regulation of cell differentiation | Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation. | 90 | 0.22 | 4 | 17.98 | 8.05e-05 |
| negative regulation of developmental process | Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | 110 | 0.27 | 4 | 14.71 | 1.75e-04 |
| regulation of Rho GTPase activity | Any process that modulates the activity of a GTPase of the Rho family. | 9 | 0.02 | 2 | 89.90 | 2.17e-04 |
| negative regulation of small GTPase mediated signal transduction | Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction. | 9 | 0.02 | 2 | 89.90 | 2.17e-04 |
| transcription from RNA polymerase II promoter | The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). | 997 | 2.46 | 10 | 4.06 | 2.42e-04 |
| positive regulation of B cell proliferation | Any process that activates or increases the rate or extent of B cell proliferation. | 10 | 0.02 | 2 | 80.91 | 2.71e-04 |
| regulation of cell differentiation | Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features. | 233 | 0.58 | 5 | 8.68 | 3.17e-04 |
| negative regulation of cell-cell adhesion | Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. | 11 | 0.03 | 2 | 73.55 | 3.31e-04 |
| negative regulation of B cell activation | Any process that stops, prevents or reduces the frequency, rate or extent of B cell activation. | 11 | 0.03 | 2 | 73.55 | 3.31e-04 |
| erythrocyte differentiation | The process by which a myeloid precursor cell acquires specializes features of an erythrocyte. | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
| regulation of cell-matrix adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
| B cell differentiation | The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a B cell. | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| myeloid cell differentiation | The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. | 142 | 0.35 | 4 | 11.40 | 4.62e-04 |
| regulation of cell-cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. | 13 | 0.03 | 2 | 62.24 | 4.68e-04 |
| regulation of T-helper cell differentiation | Any process that modulates the frequency, rate or extent of T-helper cell differentiation. | 13 | 0.03 | 2 | 62.24 | 4.68e-04 |
| regulation of Ras GTPase activity | Any process that modulates the activity of a GTPase of the Ras superfamily. | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
| cytokine production during immune response | The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| regulation of production of molecular mediator of immune response | Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| regulation of cytokine production during immune response | Any process that modulates the frequency, rate, or extent of cytokine production during immune response. | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| regulation of B cell proliferation | Any process that modulates the frequency, rate or extent of B cell proliferation. | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| response to external stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. | 759 | 1.88 | 8 | 4.26 | 7.17e-04 |
| cell activation during immune response | A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| lymphocyte activation during immune response | A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| T cell activation during immune response | The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| T cell differentiation during immune response | The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| alpha-beta T cell differentiation during immune response | The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| CD4-positive, alpha-beta T cell differentiation during immune response | The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| leukocyte activation during immune response | A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| T-helper cell differentiation | The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| negative regulation of transcription | Any process that stops, prevents or reduces the frequency, rate or extent of transcription. | 439 | 1.09 | 6 | 5.53 | 8.83e-04 |
| regulation of isotype switching | Any process that modulates the frequency, rate or extent of isotype switching. | 18 | 0.04 | 2 | 44.95 | 9.11e-04 |
| CD4-positive, alpha beta T cell differentiation | The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. | 19 | 0.05 | 2 | 42.58 | 1.02e-03 |
| hemopoiesis | The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. | 303 | 0.75 | 5 | 6.68 | 1.03e-03 |
| negative regulation of immune system process | Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. | 20 | 0.05 | 2 | 40.45 | 1.13e-03 |
| regulation of immune effector process | Any process that modulates the frequency, rate, or extent of an immune effector process. | 20 | 0.05 | 2 | 40.45 | 1.13e-03 |
| T-helper 2 type immune response | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. | 20 | 0.05 | 2 | 40.45 | 1.13e-03 |
| negative regulation of immune response | Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. | 20 | 0.05 | 2 | 40.45 | 1.13e-03 |
| response to metal ion | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
| negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. | 478 | 1.18 | 6 | 5.08 | 1.36e-03 |
| hemopoietic or lymphoid organ development | The process whose specific outcome is the progression of any organ involved in hemopoiesis or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. | 323 | 0.80 | 5 | 6.26 | 1.37e-03 |
| regulation of adaptive immune response | Any process that modulates the frequency, rate, or extent of an adaptive immune response. | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. | Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| regulation of T cell differentiation | Any process that modulates the frequency, rate or extent of T cell differentiation. | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| organ development | Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. | 1733 | 4.28 | 12 | 2.80 | 1.59e-03 |
| positive regulation of cell proliferation | Any process that activates or increases the rate or extent of cell proliferation. | 338 | 0.84 | 5 | 5.98 | 1.67e-03 |
| regulation of defense response | Any process that modulates the frequency, rate or extent of a defense response. | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| positive regulation of locomotion | Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| positive regulation of B cell activation | Any process that activates or increases the frequency, rate or extent of B cell activation. | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| positive regulation of cell motility | Any process that activates or increases the frequency, rate or extent of the movement of a cell. | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| immune system development | The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. | 346 | 0.86 | 5 | 5.85 | 1.85e-03 |
| regulation of transcription from RNA polymerase II promoter | Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. | 701 | 1.73 | 7 | 4.04 | 2.05e-03 |
| response to inorganic substance | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
| B cell proliferation | The rapid expansion of a B cell population by cell division. Follows B cell activation. | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
| negative regulation of myeloid cell differentiation | Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation. | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
| alpha-beta T cell differentiation | The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an alpha-beta T cell. | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| regulation of developmental process | Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | 363 | 0.90 | 5 | 5.57 | 2.27e-03 |
| embryo implantation | Attachment of the blastocyst to the uterine lining. | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| negative regulation of cellular metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. | 536 | 1.32 | 6 | 4.53 | 2.41e-03 |
| somatic recombination of immunoglobulin genes during immune response | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| somatic diversification of immunoglobulins during immune response | The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| immunoglobulin production during immune response | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| isotype switching | The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| regulation of lymphocyte differentiation | Any process that modulates the frequency, rate or extent of lymphocyte differentiation. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| somatic diversification of immune receptors via germline recombination within a single locus | The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| somatic cell DNA recombination | Recombination occurring within or between DNA molecules in somatic cells. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| somatic recombination of immunoglobulin gene segments | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| regulation of response to stimulus | Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. | 114 | 0.28 | 3 | 10.65 | 2.96e-03 |
| B cell activation | The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. | 115 | 0.28 | 3 | 10.55 | 3.03e-03 |
| somatic diversification of immune receptors | The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| circadian rhythm | The biological processes in an organism that recur with a regularity of approximately 24 hours. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| somatic diversification of immunoglobulins | The somatic process by means of which sequence diversity of immunoglobulins is generated. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| negative regulation of lymphocyte activation | Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte activation. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| alpha-beta T cell activation | The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| cell communication | Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. | 4669 | 11.54 | 22 | 1.91 | 3.88e-03 |
| negative regulation of cell adhesion | Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion. | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| regulation of B cell activation | Any process that modulates the frequency, rate or extent of B cell activation. | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| lymphocyte differentiation | The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells. | 128 | 0.32 | 3 | 9.48 | 4.10e-03 |
| regulation of cytokine production | Any process that modulates the frequency, rate, or extent of production of a cytokine. | 39 | 0.10 | 2 | 20.75 | 4.26e-03 |
| immunoglobulin production | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 39 | 0.10 | 2 | 20.75 | 4.26e-03 |
| multicellular organismal development | The biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | 3036 | 7.50 | 16 | 2.13 | 4.58e-03 |
| negative regulation of metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. | 615 | 1.52 | 6 | 3.95 | 4.69e-03 |
| regulation of transcription, DNA-dependent | Any process that modulates the frequency, rate or extent of DNA-dependent transcription. | 2510 | 6.20 | 14 | 2.26 | 4.77e-03 |
| positive regulation of mononuclear cell proliferation | Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
| positive regulation of lymphocyte proliferation | Any process that activates or increases the rate or extent of lymphocyte proliferation. | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
| signal transduction | The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell. | 4207 | 10.40 | 20 | 1.92 | 5.18e-03 |
| negative regulation of multicellular organismal process | Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. | 46 | 0.11 | 2 | 17.59 | 5.88e-03 |
| transcription, DNA-dependent | The synthesis of RNA on a template of DNA. | 2588 | 6.40 | 14 | 2.19 | 6.16e-03 |
| response to stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. | 2860 | 7.07 | 15 | 2.12 | 6.16e-03 |
| RNA biosynthetic process | The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. | 2591 | 6.40 | 14 | 2.19 | 6.22e-03 |
| cytokine production | The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 153 | 0.38 | 3 | 7.93 | 6.71e-03 |
| cytokine and chemokine mediated signaling pathway | Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor. | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| production of molecular mediator of immune response | The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels. | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| insulin receptor signaling pathway | The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| actin cytoskeleton organization and biogenesis | A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. | 313 | 0.77 | 4 | 5.17 | 8.01e-03 |
| immune system process | Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. | 1134 | 2.80 | 8 | 2.85 | 8.10e-03 |
| regulation of transcription | Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. | 2702 | 6.68 | 14 | 2.10 | 8.77e-03 |
| regulation of cell proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. | 704 | 1.74 | 6 | 3.45 | 8.81e-03 |
| cell proliferation | The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population. | 1154 | 2.85 | 8 | 2.80 | 8.93e-03 |