L2L Microarray Analysis Tool
Results for D07AB.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in D07AB.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.89 | 19 | 21.35 | 1.57e-19 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.22 | 9 | 41.37 | 1.07e-12 |
| dex_keratinocyte_1hr_dn | Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 24 | 0.12 | 6 | 50.57 | 1.82e-09 |
| dex_keratinocyte_4hr_dn | Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 69 | 0.34 | 7 | 20.52 | 5.96e-08 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 4.15 | 17 | 4.10 | 1.67e-06 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.09 | 4 | 42.58 | 2.18e-06 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 2.03 | 11 | 5.43 | 8.59e-06 |
| adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.15 | 4 | 26.10 | 1.69e-05 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.32 | 5 | 15.80 | 1.77e-05 |
| idx_tsa_dn_cluster3 | Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 108 | 0.53 | 6 | 11.24 | 1.82e-05 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 2.20 | 11 | 4.99 | 1.87e-05 |
| ni2_mouse_up | Upregulated by nickel(II) in sensitive A/J mouse lung tissue | 65 | 0.32 | 5 | 15.56 | 1.91e-05 |
| cmv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 109 | 0.54 | 6 | 11.13 | 1.91e-05 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 13 | 4.07 | 2.85e-05 |
| insulin_adip_insens_up | Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 37 | 0.18 | 4 | 21.87 | 3.46e-05 |
| hdaci_colon_cluster9 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) | 78 | 0.39 | 5 | 12.97 | 4.62e-05 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 12 | 4.01 | 6.63e-05 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.22 | 4 | 17.98 | 7.57e-05 |
| o6bg_resist_medulloblastoma_up | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 46 | 0.23 | 4 | 17.59 | 8.26e-05 |
| cmv_all_dn | Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV | 213 | 1.05 | 7 | 6.65 | 1.06e-04 |
| hsc_intermediateprogenitors_shared | Up-regulated in mouse hematopoietic intermediate progenitors from both adult bone marrow and fetal liver (Cluster v, Intermediate Progenitors Shared) | 151 | 0.75 | 6 | 8.04 | 1.18e-04 |
| cmv_hcmv_timecourse_6hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 6 hours | 95 | 0.47 | 5 | 10.65 | 1.18e-04 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 10 | 4.26 | 1.61e-04 |
| hsc_intermediateprogenitors_adult | Up-regulated in mouse hematopoietic intermediate progenitors from adult bone marrow (Intermediate Progenitors Shared + Adult) | 161 | 0.80 | 6 | 7.54 | 1.67e-04 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 12 | 3.60 | 1.79e-04 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 1.15 | 7 | 6.08 | 1.85e-04 |
| hsc_intermediateprogenitors_fetal | Up-regulated in mouse hematopoietic intermediate progenitors from fetal liver (Intermediate Progenitors Shared + Fetal) | 167 | 0.83 | 6 | 7.27 | 2.04e-04 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 3.13 | 11 | 3.51 | 4.01e-04 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 17 | 2.60 | 4.36e-04 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 1.75 | 8 | 4.58 | 4.38e-04 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
| aom-dss_colon_5wks_up | Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. | 133 | 0.66 | 5 | 7.60 | 5.62e-04 |
| stress_tpa_specific_up | Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents | 78 | 0.39 | 4 | 10.37 | 6.37e-04 |
| calres_mouse_dn | Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls | 79 | 0.39 | 4 | 10.24 | 6.68e-04 |
| hdaci_three_up | Upregulated in several cell lines by all of TSA, SAHA, and MS-275 | 8 | 0.04 | 2 | 50.57 | 6.71e-04 |
| dex_keratinocyte_4hr_up | Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 35 | 0.17 | 3 | 17.34 | 7.03e-04 |
| aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.18 | 3 | 16.86 | 7.64e-04 |
| scw_joint_24hrs_up | Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 143 | 0.71 | 5 | 7.07 | 7.79e-04 |
| hdaci_colon_cluster2 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.43 | 4 | 9.41 | 9.19e-04 |
| diab_neph_dn | Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 829 | 4.10 | 12 | 2.93 | 1.08e-03 |
| scw_joint_4hrs_up | Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 230 | 1.14 | 6 | 5.28 | 1.10e-03 |
| bay_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 318 | 1.57 | 7 | 4.45 | 1.16e-03 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 9 | 3.57 | 1.16e-03 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 9 | 3.56 | 1.18e-03 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1331 | 6.58 | 16 | 2.43 | 1.27e-03 |
| htert_up | Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls | 97 | 0.48 | 4 | 8.34 | 1.44e-03 |
| il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 2.63 | 9 | 3.43 | 1.53e-03 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 3.71 | 11 | 2.96 | 1.56e-03 |
| caries_pulp_high_up | Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 168 | 0.83 | 5 | 6.02 | 1.59e-03 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.24 | 3 | 12.64 | 1.77e-03 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 9 | 3.35 | 1.80e-03 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 3.23 | 10 | 3.09 | 1.84e-03 |
| adipocyte_brca_up | Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| tnfa_nfkb_ind_up | Up-regulated at any timepoint following TNFa treatment, independent of NFkB function | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| uvc_high_d9_dn | Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) | 53 | 0.26 | 3 | 11.45 | 2.35e-03 |
| cis_xpc_dn | Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin | 363 | 1.79 | 7 | 3.90 | 2.45e-03 |
| adipogenesis_hmsc_class2_up | Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
| cmv_uv-cmv_common_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 8 | 3.41 | 2.85e-03 |
| h2o2_csbdiff_c1 | Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) | 58 | 0.29 | 3 | 10.46 | 3.04e-03 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.97 | 5 | 5.13 | 3.17e-03 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 1.02 | 5 | 4.89 | 3.91e-03 |
| il2_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 503 | 2.49 | 8 | 3.22 | 4.01e-03 |
| bap_mcf7_dn | Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 135 | 0.67 | 4 | 5.99 | 4.73e-03 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.67 | 4 | 5.99 | 4.73e-03 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 1.08 | 5 | 4.62 | 4.95e-03 |
| pod1_ko_dn | Down-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 1135 | 5.61 | 13 | 2.32 | 5.11e-03 |
| uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.35 | 3 | 8.67 | 5.17e-03 |
| cmv_24hrs_dn | Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV | 140 | 0.69 | 4 | 5.78 | 5.38e-03 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 8 | 3.05 | 5.45e-03 |
| microrna_human | Predicted human MicroRNA targets | 2276 | 11.25 | 21 | 1.87 | 5.84e-03 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 3 | 7.78 | 6.98e-03 |
| baf57_bt549_dn | Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 554 | 2.74 | 8 | 2.92 | 7.03e-03 |
| uvb_nhek1_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 336 | 1.66 | 6 | 3.61 | 7.03e-03 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 3 | 7.68 | 7.22e-03 |
| cmv-chx_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus in the presence of cyclohexamide (CHX) | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| ifn_gamma_up | Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon gamma | 80 | 0.40 | 3 | 7.59 | 7.48e-03 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 3 | 7.40 | 8.00e-03 |
| cmv_hcmv_timecourse_24hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 82 | 0.41 | 3 | 7.40 | 8.00e-03 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 6 | 3.50 | 8.16e-03 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 6 | 3.50 | 8.16e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| arthritis_mouse_common_up | Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. | 459 | 2.27 | 7 | 3.08 | 8.56e-03 |
| tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.43 | 3 | 6.97 | 9.41e-03 |
| scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.82 | 4 | 4.87 | 9.68e-03 |
| 5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| brcax_a_up | Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| scchn_hpvneg_up | Up-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |