L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in D07AB.profile.ud50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
regulation of interleukin-6 biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	8	0.04	2	50.57	6.71e-04
regulation of transcription from RNA polymerase II promoter	Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.	701	3.47	11	3.17	9.09e-04
interleukin-6 production	The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	10	0.05	2	40.45	1.07e-03
interleukin-6 biosynthetic process	The chemical reactions and pathways resulting in the formation of interleukin-6.	10	0.05	2	40.45	1.07e-03
negative regulation of biological process	Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.	1697	8.39	19	2.26	1.09e-03
negative regulation of cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation.	90	0.44	4	8.99	1.09e-03
negative regulation of NF-kappaB import into nucleus	Any process that stops, prevents or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.	11	0.05	2	36.78	1.31e-03
transcription from RNA polymerase II promoter	The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	997	4.93	13	2.64	1.73e-03
cytoplasmic sequestering of transcription factor	The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.	13	0.06	2	31.12	1.84e-03
cytoplasmic sequestering of protein	The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.	13	0.06	2	31.12	1.84e-03
insulin receptor signaling pathway	The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	51	0.25	3	11.90	2.11e-03
negative regulation of developmental process	Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).	110	0.54	4	7.36	2.27e-03
negative regulation of protein import into nucleus	Any process that stops, prevents or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.	16	0.08	2	25.28	2.80e-03
negative regulation of transcription factor import into nucleus	Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.	16	0.08	2	25.28	2.80e-03
negative regulation of nucleocytoplasmic transport	Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.	17	0.08	2	23.80	3.16e-03
negative regulation of protein transport	Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells.	17	0.08	2	23.80	3.16e-03
organ development	Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.	1733	8.57	18	2.10	3.18e-03
adrenal gland development	The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.	18	0.09	2	22.47	3.55e-03
regulation of isotype switching	Any process that modulates the frequency, rate or extent of isotype switching.	18	0.09	2	22.47	3.55e-03
negative regulation of cellular process	Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	1642	8.12	17	2.09	4.18e-03
negative regulation of immune system process	Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.	20	0.10	2	20.23	4.38e-03
T-helper 2 type immune response	An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects.	20	0.10	2	20.23	4.38e-03
negative regulation of immune response	Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.	20	0.10	2	20.23	4.38e-03
response to metal ion	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.	21	0.10	2	19.26	4.82e-03
regulation of transforming growth factor beta receptor signaling pathway	Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.	21	0.10	2	19.26	4.82e-03
pattern specification process	The developmental processes that result in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.	218	1.08	5	4.64	4.86e-03
regulation of NF-kappaB import into nucleus	Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.	22	0.11	2	18.39	5.29e-03
NF-kappaB import into nucleus	The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.	22	0.11	2	18.39	5.29e-03
myeloid cell differentiation	The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.	142	0.70	4	5.70	5.65e-03
regulation of adaptive immune response	Any process that modulates the frequency, rate, or extent of an adaptive immune response.	23	0.11	2	17.59	5.77e-03
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.	Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.	23	0.11	2	17.59	5.77e-03
regulation of actin filament length	Any process that controls the length of actin filaments in a cell.	73	0.36	3	8.31	5.81e-03
regulation of myeloid cell differentiation	Any process that modulates the frequency, rate or extent of myeloid cell differentiation.	74	0.37	3	8.20	6.03e-03
multicellular organismal development	The biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).	3036	15.01	26	1.73	6.11e-03
determination of left/right symmetry	The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.	24	0.12	2	16.86	6.28e-03
central nervous system development	The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.	332	1.64	6	3.66	6.64e-03
multicellular organismal process	The biological processes, occurring at the level of the organism, pertinent to the function of the organism.	4325	21.38	34	1.59	6.98e-03
cytokine production	The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	153	0.76	4	5.29	7.32e-03
determination of symmetry	The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.	26	0.13	2	15.56	7.34e-03
determination of bilateral symmetry	The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.	26	0.13	2	15.56	7.34e-03
response to inorganic substance	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.	27	0.13	2	14.98	7.90e-03
negative regulation of myeloid cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation.	27	0.13	2	14.98	7.90e-03
immune system development	The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.	346	1.71	6	3.51	8.05e-03
system development	The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.	2362	11.68	21	1.80	8.64e-03
somatic recombination of immunoglobulin genes during immune response	The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.	30	0.15	2	13.48	9.70e-03
somatic diversification of immunoglobulins during immune response	The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.	30	0.15	2	13.48	9.70e-03
immunoglobulin production during immune response	The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.	30	0.15	2	13.48	9.70e-03
isotype switching	The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.	30	0.15	2	13.48	9.70e-03

regulation of interleukin-6 biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

8

0.04

2

50.57

6.71e-04

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

701

3.47

11

3.17

9.09e-04

interleukin-6 production

The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

10

0.05

2

40.45

1.07e-03

interleukin-6 biosynthetic process

The chemical reactions and pathways resulting in the formation of interleukin-6.

10

0.05

2

40.45

1.07e-03

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

1697

8.39

19

2.26

1.09e-03

negative regulation of cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation.

90

0.44

4

8.99

1.09e-03

negative regulation of NF-kappaB import into nucleus

Any process that stops, prevents or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

11

0.05

2

36.78

1.31e-03

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

997

4.93

13

2.64

1.73e-03

cytoplasmic sequestering of transcription factor

The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.

13

0.06

2

31.12

1.84e-03

cytoplasmic sequestering of protein

The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.

13

0.06

2

31.12

1.84e-03

insulin receptor signaling pathway

The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.

51

0.25

3

11.90

2.11e-03

negative regulation of developmental process

Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

110

0.54

4

7.36

2.27e-03

negative regulation of protein import into nucleus

Any process that stops, prevents or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.

16

0.08

2

25.28

2.80e-03

negative regulation of transcription factor import into nucleus

Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.

16

0.08

2

25.28

2.80e-03

negative regulation of nucleocytoplasmic transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.

17

0.08

2

23.80

3.16e-03

negative regulation of protein transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells.

17

0.08

2

23.80

3.16e-03

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

1733

8.57

18

2.10

3.18e-03

adrenal gland development

The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.

18

0.09

2

22.47

3.55e-03

regulation of isotype switching

Any process that modulates the frequency, rate or extent of isotype switching.

18

0.09

2

22.47

3.55e-03

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

1642

8.12

17

2.09

4.18e-03

negative regulation of immune system process

Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.

20

0.10

2

20.23

4.38e-03

T-helper 2 type immune response

An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects.

20

0.10

2

20.23

4.38e-03

negative regulation of immune response

Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

20

0.10

2

20.23

4.38e-03

response to metal ion

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

21

0.10

2

19.26

4.82e-03

regulation of transforming growth factor beta receptor signaling pathway

Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.

21

0.10

2

19.26

4.82e-03

pattern specification process

The developmental processes that result in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

218

1.08

5

4.64

4.86e-03

regulation of NF-kappaB import into nucleus

Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

22

0.11

2

18.39

5.29e-03

NF-kappaB import into nucleus

The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

22

0.11

2

18.39

5.29e-03

myeloid cell differentiation

The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.

142

0.70

4

5.70

5.65e-03

regulation of adaptive immune response

Any process that modulates the frequency, rate, or extent of an adaptive immune response.

23

0.11

2

17.59

5.77e-03

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.

Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.

23

0.11

2

17.59

5.77e-03

regulation of actin filament length

Any process that controls the length of actin filaments in a cell.

73

0.36

3

8.31

5.81e-03

regulation of myeloid cell differentiation

Any process that modulates the frequency, rate or extent of myeloid cell differentiation.

74

0.37

3

8.20

6.03e-03

multicellular organismal development

The biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

3036

15.01

26

1.73

6.11e-03

determination of left/right symmetry

The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

24

0.12

2

16.86

6.28e-03

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

332

1.64

6

3.66

6.64e-03

multicellular organismal process

The biological processes, occurring at the level of the organism, pertinent to the function of the organism.

4325

21.38

34

1.59

6.98e-03

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

153

0.76

4

5.29

7.32e-03

determination of symmetry

The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.

26

0.13

2

15.56

7.34e-03

determination of bilateral symmetry

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

26

0.13

2

15.56

7.34e-03

response to inorganic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.

27

0.13

2

14.98

7.90e-03

negative regulation of myeloid cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation.

27

0.13

2

14.98

7.90e-03

immune system development

The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

346

1.71

6

3.51

8.05e-03

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

2362

11.68

21

1.80

8.64e-03

somatic recombination of immunoglobulin genes during immune response

The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.

30

0.15

2

13.48

9.70e-03

somatic diversification of immunoglobulins during immune response

The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.

30

0.15

2

13.48

9.70e-03

immunoglobulin production during immune response

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.

30

0.15

2

13.48

9.70e-03

isotype switching

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.

30

0.15

2

13.48

9.70e-03

Results for D07AB.profile.ud50