L2L L2L Microarray Analysis Tool

Results for D07AB.profile.d50

Results summary View all lists in L2L MDB View all genes in D07AB.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 9 7.66 3.86e-06
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 10 6.26 6.69e-06
calres_mouse_dn Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.20 4 20.48 4.84e-05
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 8 6.33 5.07e-05
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 2.07 10 4.82 6.05e-05
dex_keratinocyte_4hr_up Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 35 0.09 3 34.67 9.32e-05
insulin_adip_insens_up Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 37 0.09 3 32.80 1.10e-04
microrna_mammal Predicted MicroRNA targets conserved across human, mouse and rat 1331 3.29 12 3.65 1.62e-04
idx_tsa_dn_cluster3 Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 108 0.27 4 14.98 1.63e-04
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 3 27.58 1.85e-04
cmv_all_dn Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 213 0.53 5 9.50 2.10e-04
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 7 5.96 2.14e-04
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 3 25.28 2.40e-04
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 7 5.34 4.12e-04
cmv_24hrs_dn Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 140 0.35 4 11.56 4.38e-04
baf57_bt549_dn Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 554 1.37 7 5.11 5.34e-04
adipocyte_brca_up Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 14 0.03 2 57.79 5.45e-04
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01 6 5.92 6.21e-04
caries_pulp_high_up Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 168 0.42 4 9.63 8.66e-04
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 7 4.67 9.00e-04
hdaci_colon_cluster9 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.19 3 15.56 1.00e-03
cmv_hcmv_timecourse_24hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.20 3 14.80 1.16e-03
uvb_nhek1_up Upregulated by UV-B light in normal human epidermal keratinocytes 336 0.83 5 6.02 1.63e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 3 12.77 1.76e-03
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 6 4.76 1.88e-03
ribavirin_rsv_dn Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin 101 0.25 3 12.02 2.10e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.07 2 28.90 2.21e-03
cis_xpc_dn Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 363 0.90 5 5.57 2.27e-03
emt_up Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 105 0.26 3 11.56 2.35e-03
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 1.34 6 4.46 2.59e-03
cmv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 109 0.27 3 11.13 2.61e-03
aom-dss_colon_5wks_up Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 133 0.33 3 9.12 4.56e-03
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 3 8.99 4.75e-03
zmpste24_ko_dn Fifty genes most strongly down-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 42 0.10 2 19.26 4.93e-03
microrna_human Predicted human MicroRNA targets 2276 5.63 13 2.31 5.28e-03
arthritis_mouse_common_up Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 1.13 5 4.41 6.09e-03
dac_panc_up Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 654 1.62 6 3.71 6.26e-03
hsc_intermediateprogenitors_shared Up-regulated in mouse hematopoietic intermediate progenitors from both adult bone marrow and fetal liver (Cluster v, Intermediate Progenitors Shared) 151 0.37 3 8.04 6.47e-03
hdaci_colon_cur2hrs_up Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells 49 0.12 2 16.51 6.65e-03
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 4 5.41 6.85e-03
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 4 5.29 7.41e-03
hsc_intermediateprogenitors_adult Up-regulated in mouse hematopoietic intermediate progenitors from adult bone marrow (Intermediate Progenitors Shared + Adult) 161 0.40 3 7.54 7.71e-03
uvc_high_d9_dn Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.13 2 15.27 7.74e-03
hsc_intermediateprogenitors_fetal Up-regulated in mouse hematopoietic intermediate progenitors from fetal liver (Intermediate Progenitors Shared + Fetal) 167 0.41 3 7.27 8.52e-03
xpb_ttd-cs_up Up-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) 57 0.14 2 14.19 8.91e-03
h2o2_csbdiff_c1 Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) 58 0.14 2 13.95 9.21e-03

Raw data (tab-delimited .txt)