L2L Microarray Analysis Tool
Results for D01AE.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in D01AE.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 9 | 12.18 | 8.44e-08 |
| stress_tpa_specific_dn | Genes down-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents | 5 | 0.01 | 2 | 161.82 | 6.08e-05 |
| tnfalpha_tgz_adip_dn | Downregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha | 39 | 0.10 | 3 | 31.12 | 1.29e-04 |
| adipocyte_brca_dn | Downregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 13 | 0.03 | 2 | 62.24 | 4.68e-04 |
| p21_p53_early_dn | Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 4 | 8.21 | 1.56e-03 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 5 | 5.93 | 1.73e-03 |
| cancer_undifferentiated_meta_up | Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database | 98 | 0.24 | 3 | 12.38 | 1.93e-03 |
| csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 1.27 | 6 | 4.73 | 1.94e-03 |
| tnfalpha_adip_dn | Downregulated in mature, differentiated adipocytes following treatment with TNFalpha | 101 | 0.25 | 3 | 12.02 | 2.10e-03 |
| breastca_two_classes | Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers | 247 | 0.61 | 4 | 6.55 | 3.51e-03 |
| adip_diff_up | Upregulated in mature adipocytes following diffferentiation from 3T3-L1 fibroblasts | 123 | 0.30 | 3 | 9.87 | 3.66e-03 |
| csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
| uv-4nqo_fibro_dn | Down-regulated at any timepoint by treatment of human fibroblasts with UV light or 4-NQO, but not by gamma radiation | 48 | 0.12 | 2 | 16.86 | 6.39e-03 |
| gamma-uv_fibro_up | Up-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 3 | 7.10 | 9.09e-03 |