L2L Microarray Analysis Tool
Results for D01AC.profile.d50
| Results summary | View all lists in GO:BiolProc | View all genes in D01AC.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| DNA replication | The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. | 277 | 0.68 | 14 | 20.45 | 2.23e-14 |
| DNA-dependent DNA replication | The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. | 140 | 0.35 | 10 | 28.90 | 3.65e-12 |
| DNA metabolic process | The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. | 922 | 2.28 | 17 | 7.46 | 3.56e-10 |
| cell cycle process | A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. | 1144 | 2.83 | 15 | 5.30 | 3.05e-07 |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. | 1307 | 3.23 | 15 | 4.64 | 1.57e-06 |
| regulation of DNA metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. | 80 | 0.20 | 5 | 25.28 | 1.90e-06 |
| regulation of progression through cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. | 875 | 2.16 | 12 | 5.55 | 2.86e-06 |
| regulation of cell cycle | A cell cycle process that modulates the rate, extent or mode of the cell cycle. | 880 | 2.18 | 12 | 5.52 | 3.03e-06 |
| cell cycle phase | A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events. | 474 | 1.17 | 9 | 7.68 | 3.79e-06 |
| DNA replication initiation | The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. | 44 | 0.11 | 4 | 36.78 | 4.68e-06 |
| M phase | Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis. | 375 | 0.93 | 8 | 8.63 | 5.62e-06 |
| M phase of mitotic cell cycle | Progression through M phase, the part of the mitotic cell cycle during which mitosis and cytokinesis take place. | 290 | 0.72 | 7 | 9.76 | 9.75e-06 |
| cell division | The processes resulting in the physical partitioning and separation of a cell into daughter cells. | 297 | 0.73 | 7 | 9.53 | 1.14e-05 |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M. | 421 | 1.04 | 8 | 7.69 | 1.29e-05 |
| negative regulation of DNA metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. | 28 | 0.07 | 3 | 43.34 | 4.72e-05 |
| DNA recombination | The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. | 158 | 0.39 | 5 | 12.80 | 5.19e-05 |
| mismatch repair | A system for the correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| mitosis | Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. | 284 | 0.70 | 6 | 8.55 | 8.78e-05 |
| response to DNA damage stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. | 412 | 1.02 | 7 | 6.87 | 8.97e-05 |
| maintenance of fidelity during DNA-dependent DNA replication | The correction of errors made during DNA replication by either intrinsic DNA polymerase proofreading activity or via mismatch repair. | 35 | 0.09 | 3 | 34.67 | 9.32e-05 |
| regulation of DNA replication | Any process that modulates the frequency, rate or extent of DNA replication. | 38 | 0.09 | 3 | 31.94 | 1.19e-04 |
| response to endogenous stimulus | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endogenous stimulus. | 453 | 1.12 | 7 | 6.25 | 1.60e-04 |
| interphase of mitotic cell cycle | Progression through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. | 134 | 0.33 | 4 | 12.08 | 3.71e-04 |
| regulation of progression through mitotic cell cycle | Any process that modulates the rate or extent of progress through the mitotic cell cycle. | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| interphase | Progression through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. | 138 | 0.34 | 4 | 11.73 | 4.15e-04 |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. | 4320 | 10.68 | 23 | 2.15 | 6.99e-04 |
| regulation of DNA recombination | Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. | 18 | 0.04 | 2 | 44.95 | 9.11e-04 |
| traversing start control point of mitotic cell cycle | Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle. | 19 | 0.05 | 2 | 42.58 | 1.02e-03 |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | 325 | 0.80 | 5 | 6.22 | 1.41e-03 |
| DNA unwinding during replication | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| DNA geometric change | The process by which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| DNA duplex unwinding | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| G2/M transition of mitotic cell cycle | Progression from G2 phase to M phase of the mitotic cell cycle. | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| somatic recombination of immunoglobulin genes during immune response | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| somatic diversification of immunoglobulins during immune response | The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| immunoglobulin production during immune response | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| isotype switching | The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| somatic diversification of immune receptors via germline recombination within a single locus | The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| somatic cell DNA recombination | Recombination occurring within or between DNA molecules in somatic cells. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| somatic recombination of immunoglobulin gene segments | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| cell cycle checkpoint | A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
| response to UV | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| response to radiation | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. | 117 | 0.29 | 3 | 10.37 | 3.18e-03 |
| somatic diversification of immune receptors | The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| somatic diversification of immunoglobulins | The somatic process by means of which sequence diversity of immunoglobulins is generated. | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| aging | The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility. | 35 | 0.09 | 2 | 23.12 | 3.44e-03 |
| G1 phase of mitotic cell cycle | Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis. | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| DNA damage response, signal transduction resulting in induction of apoptosis | A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death). | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| immunoglobulin production | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 39 | 0.10 | 2 | 20.75 | 4.26e-03 |
| G1 phase | Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis. | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
| base-excision repair | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. | 41 | 0.10 | 2 | 19.73 | 4.70e-03 |
| production of molecular mediator of immune response | The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels. | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| induction of apoptosis by intracellular signals | Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis. | 59 | 0.15 | 2 | 13.71 | 9.52e-03 |