#list name reference description total probes expected actual enrichment bin prob analysis_name 17aag_ovca_dn 17409432 Down-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) 129 0.637761408018985 1 1.56798449612403 0.472361101473307 C07AB.profile.ud50 17aag_ovca_up 17409432 Up-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) 53 0.262026004845009 0 0 1 C07AB.profile.ud50 3ab_gamma_dn 12379459 Downregulated synergystically by gamma-irradiation and 3-aminobenzamine (PARP inhibitor) 20 0.098877737677362 1 10.1135 0.0943686610871122 C07AB.profile.ud50 3ab_gamma_up 12379459 Upregulated synergystically by gamma-irradiation and 3-aminobenzamine (PARP inhibitor) 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 4nqo_esr_old_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of fibroblasts from elderly donors with 4-nitroquinoline-1-oxide (4NQO) 21 0.10382162456123 0 0 1 C07AB.profile.ud50 4nqo_esr_ws_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of Werner syndrome fibroblasts with 4-nitroquinoline-1-oxide (4NQO) 59 0.291689326148218 0 0 1 C07AB.profile.ud50 4nqo-gamma_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with gamma radiation or 4-NQO, but not by UV light 18 0.0889899639096258 1 11.2372222222222 0.0853471364577099 C07AB.profile.ud50 4nqo-gamma_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with gamma radiation or 4-NQO, but not by UV light 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 4nqo_unique_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with 4-nitroquinoline-1-oxide (4NQO), but not UV or gamma radiation 25 0.123597172096702 0 0 1 C07AB.profile.ud50 4nqo_unique_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with 4-nitroquinoline-1-oxide (4NQO), but not by UV or gamma radiation 38 0.187867701586988 0 0 1 C07AB.profile.ud50 5azac_hepg2_dn 16854234 Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1830 9.04731299747862 11 1.2158306010929 0.29935459260272 C07AB.profile.ud50 5azac_hepg2_up 16854234 Up-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1630 8.058535620705 9 1.1168282208589 0.415642846693562 C07AB.profile.ud50 5azac-tsa_hepg2_dn 16854234 Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 2343 11.583526968903 16 1.38127187366624 0.12648964635112 C07AB.profile.ud50 5azac-tsa_hepg2_up 16854234 Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 1966 9.71968161368468 8 0.823072227873855 0.754119823575569 C07AB.profile.ud50 5fu_resist_gastric_dn 14734480 Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.148316606516043 0 0 1 C07AB.profile.ud50 5fu_resist_gastric_up 14734480 Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 42 0.20764324912246 0 0 1 C07AB.profile.ud50 5fu_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to 5-fluorouracil (5FU) 7 0.0346072081870767 0 0 1 C07AB.profile.ud50 5fu_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to 5-fluorouracil (5FU) 7 0.0346072081870767 0 0 1 C07AB.profile.ud50 acnu_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to ACNU 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 ad12_12hrs_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 12 hours post-infection 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 ad12_12hrs_up 15681441 Up-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 12 hours post-infection 7 0.0346072081870767 0 0 1 C07AB.profile.ud50 ad12_24hrs_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 24 hours post-infection 24 0.118653285212834 0 0 1 C07AB.profile.ud50 ad12_32hrs_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection 27 0.133484945864439 0 0 1 C07AB.profile.ud50 ad12_48hrs_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 48 hours post-infection 21 0.10382162456123 0 0 1 C07AB.profile.ud50 ad12_any_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection 42 0.20764324912246 0 0 1 C07AB.profile.ud50 ad12_any_up 15681441 Up-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 adip_diff_cluster1 12137940 Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) 96 0.474613140851337 0 0 1 C07AB.profile.ud50 adip_diff_cluster2 12137940 Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) 64 0.316408760567558 0 0 1 C07AB.profile.ud50 adip_diff_cluster3 12137940 Strongly upregulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 3) 68 0.336184308103031 0 0 1 C07AB.profile.ud50 adip_diff_cluster4 12137940 Strongly upregulated at 16 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 4) 56 0.276857665496613 0 0 1 C07AB.profile.ud50 adip_diff_cluster5 12137940 Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) 67 0.331240421219163 0 0 1 C07AB.profile.ud50 adip_diff_up 12732648 Upregulated in mature adipocytes following diffferentiation from 3T3-L1 fibroblasts 123 0.608098086715776 0 0 1 C07AB.profile.ud50 adip_human_dn 15051823 Down-regulated in primary human adipocytes, versus preadipocytes 52 0.257082117961141 0 0 1 C07AB.profile.ud50 adip_human_up 15051823 Up-regulated in primary human adipocytes, versus preadipocytes 94 0.464725367083601 0 0 1 C07AB.profile.ud50 adipocyte_brca_dn 14508521 Downregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 13 0.0642705294902853 0 0 1 C07AB.profile.ud50 adipocyte_brca_up 14508521 Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 adipocyte_pparg_up 11981038 Adipocyte genes induced by both PPARgamma and rosiglitazone 23 0.113709398328966 0 0 1 C07AB.profile.ud50 adipogenesis_hmsc_class1_up 12646203 Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.153260493399911 0 0 1 C07AB.profile.ud50 adipogenesis_hmsc_class2_up 12646203 Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 adipogenesis_hmsc_class3_up 12646203 Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.538883670341623 0 0 1 C07AB.profile.ud50 adipogenesis_hmsc_class4_up 12646203 Up-regulated 14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class IV) 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 adipogenesis_hmsc_class5_up 12646203 Up-regulated 9 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class V) 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 adipogenesis_hmsc_class7_dn 12646203 Down-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class VII) 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 adipogenesis_hmsc_class8_dn 12646203 Down-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class VIII) 59 0.291689326148218 0 0 1 C07AB.profile.ud50 adip_vs_fibro_dn 12021175 Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes 64 0.316408760567558 1 3.16046875 0.2718101578629 C07AB.profile.ud50 adip_vs_fibro_up 12021175 Upregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes 59 0.291689326148218 0 0 1 C07AB.profile.ud50 adip_vs_preadip_dn 12021175 Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 84 0.41528649824492 0 0 1 C07AB.profile.ud50 adip_vs_preadip_up 12021175 Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 57 0.281801552380482 0 0 1 C07AB.profile.ud50 adr_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to adriamycin 10 0.049438868838681 0 0 1 C07AB.profile.ud50 aged_mouse_cerebellum_dn 10888876 Downregulated in the cerebellum of aged adult mice (30-month) vs. young adult (5-month) 87 0.430118158896524 0 0 1 C07AB.profile.ud50 aged_mouse_cerebellum_up 10888876 Upregulated in the cerebellum of aged adult mice (30-month) vs. young adult (5-month) 92 0.454837593315865 0 0 1 C07AB.profile.ud50 aged_mouse_cortex_dn 11172053 Down-regulated in the cerebral cortex of aged (22 months) BALB/c mice, compared to young (2 months) controls 98 0.484500914619074 1 2.06397959183673 0.384735200509055 C07AB.profile.ud50 aged_mouse_cortex_up 11172053 Up-regulated in the cerebral cortex of aged (22 months) BALB/c mice, compared to young (2 months) controls 71 0.351015968754635 0 0 1 C07AB.profile.ud50 aged_mouse_hippocampus_any_dn 15960800 Down-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 60 0.296633213032086 0 0 1 C07AB.profile.ud50 aged_mouse_hippocampus_any_up 15960800 Up-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 78 0.385623176941712 0 0 1 C07AB.profile.ud50 aged_mouse_hippocampus_multi_dn 15960800 Down-regulated in the hippocampus of 16-month aged mice from at least two of four strains (S8, S10, SR1, B6J), versus 3-month young controls 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 aged_mouse_hippocampus_multi_up 15960800 Up-regulated in the hippocampus of 16-month aged mice from at least two of four strains (S8, S10, SR1, B6J), versus 3-month young controls 38 0.187867701586988 0 0 1 C07AB.profile.ud50 aged_mouse_hypoth_dn 11172053 Down-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls 62 0.306520986799822 1 3.26241935483871 0.264556231995443 C07AB.profile.ud50 aged_mouse_hypoth_up 11172053 Up-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls 79 0.39056706382558 0 0 1 C07AB.profile.ud50 aged_mouse_muscle_dn 10464095 Downregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) 59 0.291689326148218 3 10.2849152542373 0.00319514100843706 C07AB.profile.ud50 aged_mouse_muscle_up 10464095 Upregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) 51 0.252138231077273 0 0 1 C07AB.profile.ud50 aged_mouse_neocortex_dn 10888876 Downregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 102 0.504276462154546 0 0 1 C07AB.profile.ud50 aged_mouse_neocortex_up 10888876 Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.548771444109359 0 0 1 C07AB.profile.ud50 aged_mouse_retina_any_dn 15960800 Down-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 24 0.118653285212834 0 0 1 C07AB.profile.ud50 aged_mouse_retina_any_up 15960800 Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 36 0.177979927819252 0 0 1 C07AB.profile.ud50 aged_mouse_retina_multi_up 15960800 Up-regulated in the retina of 16-month aged mice from at least two of four strains (S8, S10, SR1, B6J), versus 3-month young controls 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 aged_rhesus_dn 11309484 Downregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys 232 1.1469817570574 2 1.74370689655172 0.31826387582967 C07AB.profile.ud50 aged_rhesus_up 11309484 Upregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys 390 1.92811588470856 1 0.518641025641026 0.855271809733927 C07AB.profile.ud50 ageing_brain_dn 15190254 Age-downregulated in the human frontal cortex 244 1.20630839966382 1 0.828975409836066 0.701593966272893 C07AB.profile.ud50 ageing_brain_up 15190254 Age-upregulated in the human frontal cortex 446 2.20497355020517 4 1.81408071748879 0.181237400295523 C07AB.profile.ud50 ageing_kidney_dn 15562319 Down-regulation is associated with increasing age in normal human kidney tissue from 74 patients 238 1.17664507836061 1 0.849873949579832 0.692587043672038 C07AB.profile.ud50 ageing_kidney_specific_dn 15562319 Down-regulation is associated with increasing age in normal human kidney tissue from 74 patients, and expression is higher in kidney than in whole blood 248 1.22608394719929 1 0.815604838709677 0.70745149116227 C07AB.profile.ud50 ageing_kidney_specific_up 15562319 Up-regulation is associated with increasing age in normal human kidney tissue from 74 patients, and expression is higher in kidney than in whole blood 277 1.36945666683146 3 2.19064981949458 0.158796648359445 C07AB.profile.ud50 ageing_kidney_up 15562319 Up-regulation is associated with increasing age in normal human kidney tissue from 74 patients 611 3.02071488604341 4 1.32418985270049 0.357420060210299 C07AB.profile.ud50 ageing_lymph_dn 12618007 Downregulated in human lymphocytes from old individuals, compared to young 30 0.148316606516043 0 0 1 C07AB.profile.ud50 ageing_lymph_up 12618007 Upregulated in human lymphocytes from old individuals, compared to young 7 0.0346072081870767 1 28.8957142857143 0.0340981343215848 C07AB.profile.ud50 alk1_hmvec_2hr_dn 16405919 Down-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 189 0.93439462105107 0 0 1 C07AB.profile.ud50 alk1_hmvec_2hr_up 16405919 Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93172492213378 0 0 1 C07AB.profile.ud50 alk1_hmvec_4hr_dn 16405919 Down-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 189 0.93439462105107 0 0 1 C07AB.profile.ud50 alk1_hmvec_4hr_up 16405919 Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93172492213378 0 0 1 C07AB.profile.ud50 alk5_hmvec_2hr_dn 16405919 Down-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 202 0.998665150541356 0 0 1 C07AB.profile.ud50 alk5_hmvec_2hr_up 16405919 Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.71552874870223 0 0 1 C07AB.profile.ud50 alk5_hmvec_4hr_dn 16405919 Down-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 202 0.998665150541356 0 0 1 C07AB.profile.ud50 alk5_hmvec_4hr_up 16405919 Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.71552874870223 0 0 1 C07AB.profile.ud50 alzheimers_disease_dn 14769913 Downregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus 2117 10.4662085331488 7 0.66881908360888 0.897197718520036 C07AB.profile.ud50 alzheimers_disease_up 14769913 Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus 3137 15.5089731546942 14 0.902703219636595 0.684267406057737 C07AB.profile.ud50 alzheimers_incipient_dn 14769913 Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus 312 1.54249270776685 1 0.648301282051282 0.78696914753201 C07AB.profile.ud50 alzheimers_incipient_up 14769913 Upregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus 754 3.72769071043655 5 1.34131299734748 0.318001432059611 C07AB.profile.ud50 aom-dss_colon_10wks_dn 17506908 Down-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 aom-dss_colon_10wks_up 17506908 Up-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 22 0.108765511445098 0 0 1 C07AB.profile.ud50 aom-dss_colon_5wks_dn 17506908 Down-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 57 0.281801552380482 0 0 1 C07AB.profile.ud50 aom-dss_colon_5wks_up 17506908 Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 133 0.657536955554457 0 0 1 C07AB.profile.ud50 arthritis_mouse_common_dn 16805906 Dn-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 1 0.0049438868838681 0 0 1 C07AB.profile.ud50 arthritis_mouse_common_up 16805906 Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 2.26924407969546 0 0 1 C07AB.profile.ud50 arthritis_mouse_htlv1_dn 16805906 Down-regulated in joint tissue from severely arthritic 6-9 week-old HTLV-I transgenic mice, versus wild-type littermate controls. 159 0.786078014535027 2 2.54427672955975 0.186021334771238 C07AB.profile.ud50 arthritis_mouse_htlv1_up 16805906 Up-regulated in joint tissue from severely arthritic 6-9 week-old HTLV-I transgenic mice, versus wild-type littermate controls. 251 1.24091560785089 1 0.805856573705179 0.711769055293292 C07AB.profile.ud50 arthritis_mouse_il1ko_dn 16805906 Down-regulated in joint tissue from severely arthritic 13 week-old IL-1Ra knock-out mice, versus wild-type littermate controls. 105 0.51910812280615 1 1.92638095238095 0.40571458228544 C07AB.profile.ud50 arthritis_mouse_il1ko_up 16805906 Up-regulated in joint tissue from severely arthritic 13 week-old IL-1Ra knock-out mice, versus wild-type littermate controls. 271 1.33979334552825 0 0 1 C07AB.profile.ud50 as3_fibro_c1 12016162 Upregulated strongly by sodium arsenite in fibroblasts (Cluster 1) 67 0.331240421219163 0 0 1 C07AB.profile.ud50 as3_fibro_c2 12016162 Upregulated moderately by sodium arsenite in fibroblasts (Cluster 2) 67 0.331240421219163 0 0 1 C07AB.profile.ud50 as3_fibro_c3 12016162 Upregulated late by sodium arsenite in fibroblasts (Cluster 3) 95 0.469669253967469 0 0 1 C07AB.profile.ud50 as3_fibro_c4 12016162 Downregulated early by sodium arsenite in fibroblasts (Cluster 4) 35 0.173036040935383 0 0 1 C07AB.profile.ud50 as3_fibro_c5 12016162 Downregulated moderately by sodium arsenite in fibroblasts (Cluster 5) 20 0.098877737677362 0 0 1 C07AB.profile.ud50 as3_fibro_dn 12016162 Downregulated by sodium arsenite in fibroblasts (Clusters 4, 5, and 6) 59 0.291689326148218 0 0 1 C07AB.profile.ud50 as3_fibro_up 12016162 Upregulated by sodium arsenite in fibroblasts (Clusters 1, 2, and 3) 95 0.469669253967469 0 0 1 C07AB.profile.ud50 as3_hek293_dn 12679051 Downregulated in HEK293 cells by treatment with arsenite 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 as3_hek293_up 12679051 Upregulated in HEK293 cells by treatment with arsenite 19 0.0939338507934939 0 0 1 C07AB.profile.ud50 atria_up 15103417 Upregulated in the atria of healthy hearts, compared to venticles 384 1.89845256340535 1 0.526744791666667 0.850903414123399 C07AB.profile.ud50 avoidance_dn 15720406 Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. 40 0.197755475354724 0 0 1 C07AB.profile.ud50 avoidance_up 15720406 Up-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. 34 0.168092154051515 0 0 1 C07AB.profile.ud50 baf57_bt549_dn 16135788 Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 554 2.73891333366293 2 0.730216606498195 0.759077062845601 C07AB.profile.ud50 baf57_bt549_up 16135788 Up-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 364 1.79957482572799 2 1.11137362637363 0.537626275020779 C07AB.profile.ud50 bap_hepg2_dn 17042939 Down-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 56 0.276857665496613 0 0 1 C07AB.profile.ud50 bap_hepg2_up 17042939 Up-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 83 0.410342611361052 0 0 1 C07AB.profile.ud50 bap_mcf7_dn 17042939 Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 135 0.667424729322193 1 1.4982962962963 0.487820445728013 C07AB.profile.ud50 bap_mcf7_up 17042939 Up-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 87 0.430118158896524 0 0 1 C07AB.profile.ud50 bay-il2_pbmc_early_up 17471163 Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 bay-il2_pbmc_late_dn 17471163 Down-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 205 1.01349681119296 1 0.986682926829268 0.637963558838198 C07AB.profile.ud50 bay-il2_pbmc_late_up 17471163 Up-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 130 0.642705294902853 1 1.55592307692308 0.474969688503152 C07AB.profile.ud50 bay-il2_pbmc_middle_dn 17471163 Down-regulated at 2-6 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 64 0.316408760567558 0 0 1 C07AB.profile.ud50 bay-il2_pbmc_middle_up 17471163 Up-regulated at 2-6 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 74 0.365847629406239 0 0 1 C07AB.profile.ud50 bay_pbmc_24hr_dn 17471163 Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 268 1.32496168487665 3 2.26421641791045 0.148282601865523 C07AB.profile.ud50 bay_pbmc_24hr_up 17471163 Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.998665150541356 0 0 1 C07AB.profile.ud50 bay_pbmc_2hr_dn 17471163 Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 398 1.9676669797795 2 1.01643216080402 0.585831372228258 C07AB.profile.ud50 bay_pbmc_2hr_up 17471163 Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 2.99599545162407 1 0.333778877887789 0.950383204478821 C07AB.profile.ud50 bay_pbmc_30min_dn 17471163 Down-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 10 0.049438868838681 0 0 1 C07AB.profile.ud50 bay_pbmc_30min_up 17471163 up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.405398724477184 0 0 1 C07AB.profile.ud50 bay_pbmc_48hr_dn 17471163 Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 318 1.57215602907005 1 0.636069182389937 0.793210759540472 C07AB.profile.ud50 bay_pbmc_48hr_up 17471163 Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.34834626983735 0 0 1 C07AB.profile.ud50 bay_pbmc_4hr_dn 17471163 Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 400 1.97755475354724 2 1.01135 0.588547844511327 C07AB.profile.ud50 bay_pbmc_4hr_up 17471163 Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 2.68947446482425 0 0 1 C07AB.profile.ud50 bay_pbmc_6hr_dn 17471163 Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 483 2.38789736490829 1 0.418778467908903 0.908719640917001 C07AB.profile.ud50 bay_pbmc_6hr_up 17471163 Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.34834626983735 1 0.425831578947368 0.905027742181944 C07AB.profile.ud50 bcnu_glioma_mgmt_24hrs_dn 15980968 Down-regulated in an MGMT+ glioma cell line (T98G) at 24 hours following treatment with BCNU 54 0.266969891728877 0 0 1 C07AB.profile.ud50 bcnu_glioma_mgmt_24hrs_up 15980968 Up-regulated in an MGMT+ glioma cell line (T98G) at 24 hours following treatment with BCNU 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 bcnu_glioma_mgmt_48hrs_dn 15980968 Down-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU 253 1.25080338161863 1 0.799486166007905 0.714611972721612 C07AB.profile.ud50 bcnu_glioma_mgmt_48hrs_up 15980968 Up-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU 33 0.163148267167647 0 0 1 C07AB.profile.ud50 bcnu_glioma_nomgmt_24hrs_dn 15980968 Down-regulated in an MGMT-deficient glioma cell line (A172) at 24 hours following treatment with BCNU 22 0.108765511445098 0 0 1 C07AB.profile.ud50 bcnu_glioma_nomgmt_24hrs_up 15980968 Up-regulated in an MGMT-deficient glioma cell line (A172) at 24 hours following treatment with BCNU 25 0.123597172096702 0 0 1 C07AB.profile.ud50 bcnu_glioma_nomgmt_48hrs_dn 15980968 Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU 50 0.247194344193405 0 0 1 C07AB.profile.ud50 bcnu_glioma_nomgmt_48hrs_up 15980968 Up-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU 31 0.153260493399911 0 0 1 C07AB.profile.ud50 bcrabl_hl60_affy_dn 15155749 Down-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by Affymetrix arrays 19 0.0939338507934939 0 0 1 C07AB.profile.ud50 bcrabl_hl60_affy_up 15155749 Up-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by Affymetrix arrays 36 0.177979927819252 0 0 1 C07AB.profile.ud50 bcrabl_hl60_cdna_dn 15155749 Down-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by spotted cDNA arrays 54 0.266969891728877 0 0 1 C07AB.profile.ud50 bcrabl_hl60_cdna_up 15155749 Up-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by spotted cDNA arrays 39 0.192811588470856 0 0 1 C07AB.profile.ud50 bep_mcf7_dn 17042939 Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with non-carcinogenic benzo(e)pyrene (BeP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 34 0.168092154051515 0 0 1 C07AB.profile.ud50 bep_mcf7_up 17042939 Up-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with non-carcinogenic benzo(e)pyrene (BeP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 bleo_human_lymph_high_24hrs_dn 15515172 Down-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 4 0.0197755475354724 1 50.5675 0.0196293781872164 C07AB.profile.ud50 bleo_human_lymph_high_24hrs_up 15515172 Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 197 0.973945716122015 3 3.0802538071066 0.0751156953203669 C07AB.profile.ud50 bleo_human_lymph_high_4hrs_dn 15515172 Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 bleo_human_lymph_high_4hrs_up 15515172 Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 32 0.158204380283779 2 12.641875 0.0109866565496021 C07AB.profile.ud50 bleo_human_lymph_low_24hrs_up 15515172 Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a low dose of bleomycin 5 0.0247194344193405 0 0 1 C07AB.profile.ud50 bleo_mouse_lymph_high_24hrs_dn 15515172 Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin 71 0.351015968754635 0 0 1 C07AB.profile.ud50 bleo_mouse_lymph_high_4hrs_up 15515172 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 bleo_mouse_lymph_low_24hrs_dn 15515172 Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of bleomycin 56 0.276857665496613 0 0 1 C07AB.profile.ud50 bleo_mouse_lymph_low_4hrs_up 15515172 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of bleomycin 7 0.0346072081870767 0 0 1 C07AB.profile.ud50 brcax_a_dn 12610208 Down-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 brcax_a_up 12610208 Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 30 0.148316606516043 0 0 1 C07AB.profile.ud50 brca1_irradiated_up 14871973 Up-regulated in germline-mutant BRCA1 tumor cells compared to non-BRCA1 control tumors, following 15 Gy irradiation. 105 0.51910812280615 1 1.92638095238095 0.40571458228544 C07AB.profile.ud50 brca1ko_mef_dn 15520196 Down-regulated in mouse embryonic fibroblasts following targeted deletion of BRCA1 (exon 11) compared to wild-type MEFs 182 0.899787412863994 2 2.22274725274725 0.227348044354149 C07AB.profile.ud50 brca1ko_mef_up 15520196 Up-regulated in mouse embryonic fibroblasts following targeted deletion of BRCA1 (exon 11) compared to wild-type MEFs 19 0.0939338507934939 0 0 1 C07AB.profile.ud50 brca1_mes_up 11384963 Genes with reduced expression in mouse embryonic stem cells with a targeted deletion of BRCA1, whose expression was rescued by ectopic expression of a BRCA1 transgene 86 0.425174272012656 0 0 1 C07AB.profile.ud50 brca1_overexp_dn 12032322 Downregulated by induction of exogenous BRCA1 in EcR-293 cells 220 1.08765511445098 1 0.919409090909091 0.66390204570354 C07AB.profile.ud50 brca1_overexp_prostate_dn 15520196 Down-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 168 0.83057299648984 0 0 1 C07AB.profile.ud50 brca1_overexp_prostate_up 15520196 Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 308 1.52271716023137 0 0 1 C07AB.profile.ud50 brca1_overexp_up 12032322 Upregulated by induction of exogenous BRCA1 in EcR-293 cells 328 1.62159489790874 2 1.23335365853659 0.482510084643076 C07AB.profile.ud50 brca1_sw480_dn 10644742 Down-regulated by infection of human colon adenocarcinoma cells (SW480) with Ad-BRCA1, versus Ad-LacZ control 33 0.163148267167647 0 0 1 C07AB.profile.ud50 brca1_sw480_up 10644742 Up-regulated by infection of human colon adenocarcinoma cells (SW480) with Ad-BRCA1, versus Ad-LacZ control 50 0.247194344193405 0 0 1 C07AB.profile.ud50 brca2_brca1_dn 12096084 Genes down-regulated in BRCA2-linked breast tumors, relative to BRCA1-linked tumors 83 0.410342611361052 0 0 1 C07AB.profile.ud50 brca2_brca1_up 12096084 Genes up-regulated in BRCA2-linked breast tumors, relative to BRCA1-linked tumors 99 0.489444801502942 0 0 1 C07AB.profile.ud50 brca2kd_dn 15670748 Down-regulated following transient RNAi knock-down of BRCA2 in both HMEC (human mammary epithelial) and BT549 (human breast carcinoma) cell lines 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 brca_brca1_neg 11823860 Genes whose expression is consistently negatively correlated with brca1 germline status in breast cancer - higher expression is associated with BRCA1 tumors 250 1.23597172096702 3 2.42724 0.127984370559103 C07AB.profile.ud50 brca_brca1_pos 11823860 Genes whose expression is consistently positively correlated with brca1 germline status in breast cancer - higher expression is associated with sporadic tumors 182 0.899787412863994 2 2.22274725274725 0.227348044354149 C07AB.profile.ud50 brca_er_neg 11823860 Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors 1519 7.50976417659564 6 0.798959842001317 0.76030768598413 C07AB.profile.ud50 brca_er_pos 11823860 Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-positive tumors 842 4.16275275621694 1 0.240225653206651 0.984595211667449 C07AB.profile.ud50 brca_prognosis_neg 11823860 Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis 166 0.820685222722104 0 0 1 C07AB.profile.ud50 brca_prognosis_pos 11823860 Genes whose expression is consistently positively correlated with breast cancer outcomes - higher expression is associated with good prognosis 57 0.281801552380482 0 0 1 C07AB.profile.ud50 breastca_three_classes 11207349 Gene set that can be used to differentiate BRCA1-linked, BRCA2-linked, and sporadic primary breast cancers 70 0.346072081870767 0 0 1 C07AB.profile.ud50 breastca_two_classes 11207349 Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers 247 1.22114006031542 0 0 1 C07AB.profile.ud50 brg1_alab_dn 14673169 Down-regulated at 18 and 24 hours following adenovirus-mediated expression of BRG1 in ALAB breast cancer cells with mutant, inactive BRG1 65 0.321352647451426 0 0 1 C07AB.profile.ud50 brg1_alab_up 14673169 Up-regulated at 18 and 24 hours following adenovirus-mediated expression of BRG1 in ALAB breast cancer cells with mutant, inactive BRG1 91 0.449893706431997 0 0 1 C07AB.profile.ud50 brg1_h1299_up 15731117 Up-regulated by transient expression of BRG1 in H1299 lung cancer cells with mutant, inactive BRG1 50 0.247194344193405 0 0 1 C07AB.profile.ud50 brg1_sw13_up 11509180 Up-regulated by transient expression of BRG1 at 24 hours in human, BRG1-lacking SW-13 cells 51 0.252138231077273 0 0 1 C07AB.profile.ud50 but_tsa_up 11423116 Upregulated by the combination of TSA and butyrate in HT-29 cells 36 0.177979927819252 0 0 1 C07AB.profile.ud50 bws_imprinted 12668598 Imprinted genes on Chr. 11p15 that are dysregulated in Beckwith-Wiedmann syndrome 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 calres_mouse_dn 10464095 Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.39056706382558 1 2.56037974683544 0.323982095569325 C07AB.profile.ud50 calres_mouse_neocortex_dn 10888876 Downregulated in the neocortex of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 114 0.563603104760963 0 0 1 C07AB.profile.ud50 calres_mouse_neocortex_up 10888876 Upregulated in the neocortex of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 99 0.489444801502942 1 2.04313131313131 0.387777000081364 C07AB.profile.ud50 calres_mouse_up 10464095 Upregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 51 0.252138231077273 1 3.96607843137255 0.223348511843017 C07AB.profile.ud50 calres_presenillin_ko_hippocampus_dn 17499883 Down-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 calres_presenillin_ko_hippocampus_up 17499883 Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. 137 0.677312503089929 0 0 1 C07AB.profile.ud50 calres_rhesus_dn 11309484 Downregulated in the vastus lateralis muscle of middle-aged rhesus monkeys subjected to caloric restriction since young adulthood vs. age-matched controls 110 0.543827557225491 0 0 1 C07AB.profile.ud50 calres_rhesus_up 11309484 Upregulated in the vastus lateralis muscle of middle-aged rhesus monkeys subjected to caloric restriction since young adulthood vs. age-matched controls 122 0.603154199831908 1 1.65795081967213 0.453734465916889 C07AB.profile.ud50 camptothecin_probcell_dn 12447701 Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin 52 0.257082117961141 0 0 1 C07AB.profile.ud50 camptothecin_probcell_up 12447701 Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin 28 0.138428832748307 0 0 1 C07AB.profile.ud50 cancerdrugs_probcell_dn 12447701 Down-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 26 0.128541058980571 0 0 1 C07AB.profile.ud50 cancerdrugs_probcell_up 12447701 Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 24 0.118653285212834 0 0 1 C07AB.profile.ud50 cancer_neoplastic_meta_up 15184677 Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database 115 0.568546991644831 1 1.75886956521739 0.434450275443423 C07AB.profile.ud50 cancer_undifferentiated_meta_up 15184677 Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database 98 0.484500914619074 0 0 1 C07AB.profile.ud50 cantharidin_dn 14639605 Downregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin 83 0.410342611361052 1 2.43698795180723 0.337251906676725 C07AB.profile.ud50 cantharidin_up 14639605 Upregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin 27 0.133484945864439 0 0 1 C07AB.profile.ud50 caries_pulp_dn 15869869 Down-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 131 0.647649181786721 0 0 1 C07AB.profile.ud50 caries_pulp_high_up 15869869 Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 168 0.83057299648984 1 1.2039880952381 0.565097285664894 C07AB.profile.ud50 caries_pulp_up 15869869 Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 2.02699362238592 1 0.493341463414634 0.868929615270897 C07AB.profile.ud50 cisplatin_probcell_dn 12447701 Down-regulated in pro-B cells (FL5.12) following treatment with cisplatin 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 cisplatin_probcell_up 12447701 Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin 23 0.113709398328966 0 0 1 C07AB.profile.ud50 cis_resist_gastric_dn 14734480 Downregulated in gastric cancer cell lines reistant to cisplatin, compared to parent chemosensitive lines 10 0.049438868838681 0 0 1 C07AB.profile.ud50 cis_resist_gastric_up 14734480 Upregulated in gastric cancer cell lines reistant to cisplatin, compared to parent chemosensitive lines 29 0.143372719632175 1 6.9748275862069 0.133876959437779 C07AB.profile.ud50 cis_resist_lung_dn 14737109 Transient down-regulation is associated with transient cisplatin resistance in a human squamous cell lung cancer line (NCI-H2170) 18 0.0889899639096258 0 0 1 C07AB.profile.ud50 cis_resist_lung_up 14737109 Transient up-regulation is associated with transient cisplatin resistance in a human squamous cell lung cancer line (NCI-H2170) 21 0.10382162456123 0 0 1 C07AB.profile.ud50 cis_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to cisplatin 3 0.0148316606516043 0 0 1 C07AB.profile.ud50 cis_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to cisplatin 10 0.049438868838681 0 0 1 C07AB.profile.ud50 cis_xpc_dn 15107491 Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 363 1.79463093884412 1 0.557217630853994 0.834549271407385 C07AB.profile.ud50 cis_xpc_up 15107491 Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 242 1.19642062589608 1 0.835826446280992 0.69862136885145 C07AB.profile.ud50 cited1_ko_het_dn 16278680 Down-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes 56 0.276857665496613 0 0 1 C07AB.profile.ud50 cited1_ko_het_up 16278680 Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes 43 0.212587136006328 0 0 1 C07AB.profile.ud50 cited1_ko_wt_dn 16278680 Down-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus wild-type controls 21 0.10382162456123 0 0 1 C07AB.profile.ud50 cited1_ko_wt_up 16278680 Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus wild-type controls 32 0.158204380283779 0 0 1 C07AB.profile.ud50 cmv_24hrs_dn 9826724 Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 140 0.692144163741534 1 1.44478571428571 0.500356664996424 C07AB.profile.ud50 cmv_24hrs_up 9826724 Upregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 133 0.657536955554457 1 1.52082706766917 0.482718324958774 C07AB.profile.ud50 cmv_40min_dn 9826724 Downregulated at 40 min following infection of primary human foreskin fibroblasts with CMV 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 cmv_8hrs_dn 9826724 Downregulated at 8hrs following infection of primary human foreskin fibroblasts with CMV 102 0.504276462154546 0 0 1 C07AB.profile.ud50 cmv_8hrs_up 9826724 Upregulated at 8hrs following infection of primary human foreskin fibroblasts with CMV 56 0.276857665496613 0 0 1 C07AB.profile.ud50 cmv_all_dn 9826724 Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 213 1.0530479062639 1 0.94962441314554 0.652037162118539 C07AB.profile.ud50 cmv_all_up 9826724 Upregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 173 0.855292430909181 1 1.16919075144509 0.575742060025483 C07AB.profile.ud50 cmv-chx_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus in the presence of cyclohexamide (CHX) 26 0.128541058980571 0 0 1 C07AB.profile.ud50 cmv-chx_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus in the presence of cyclohexamide (CHX) 10 0.049438868838681 0 0 1 C07AB.profile.ud50 cmv_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 109 0.538883670341623 0 0 1 C07AB.profile.ud50 cmv_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 46 0.227418796657932 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_10hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours 30 0.148316606516043 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_10hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours 23 0.113709398328966 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_12hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 12 hours 33 0.163148267167647 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_12hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 12 hours 45 0.222474909774064 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_14hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours 95 0.469669253967469 1 2.12915789473684 0.375518822884975 C07AB.profile.ud50 cmv_hcmv_timecourse_14hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours 84 0.41528649824492 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_16hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 16 hours 38 0.187867701586988 1 5.3228947368421 0.171661702549689 C07AB.profile.ud50 cmv_hcmv_timecourse_16hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 16 hours 93 0.459781480199733 1 2.17494623655914 0.369297999821692 C07AB.profile.ud50 cmv_hcmv_timecourse_18hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 18 hours 44 0.217531022890196 1 4.59704545454545 0.195931268223102 C07AB.profile.ud50 cmv_hcmv_timecourse_18hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 18 hours 142 0.70203193750927 1 1.42443661971831 0.505284812966348 C07AB.profile.ud50 cmv_hcmv_timecourse_1hr_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 1 hour 73 0.360903742522371 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_1hr_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 1 hour 21 0.10382162456123 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_20hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 20 hours 87 0.430118158896524 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_20hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 20 hours 174 0.860236317793049 2 2.32494252873563 0.212877455212161 C07AB.profile.ud50 cmv_hcmv_timecourse_24hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.405398724477184 1 2.46670731707317 0.333959075686894 C07AB.profile.ud50 cmv_hcmv_timecourse_24hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 123 0.608098086715776 1 1.64447154471545 0.456435140925951 C07AB.profile.ud50 cmv_hcmv_timecourse_2hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 2 hours 7 0.0346072081870767 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_30min_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 30 minutes 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_30min_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 30 minutes 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_48hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours 235 1.161813417709 2 1.72144680851064 0.323674512340421 C07AB.profile.ud50 cmv_hcmv_timecourse_48hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours 135 0.667424729322193 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_4hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours 69 0.341128194986899 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_4hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours 26 0.128541058980571 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_6hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 6 hours 95 0.469669253967469 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_6hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 6 hours 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_8hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 8 hours 27 0.133484945864439 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_8hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 8 hours 63 0.31146487368369 0 0 1 C07AB.profile.ud50 cmv_hcmv_timecourse_all_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 4.14792109556533 3 0.723253873659118 0.783502510465532 C07AB.profile.ud50 cmv_hcmv_timecourse_all_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 895 4.42477876106195 4 0.904 0.645464899779761 C07AB.profile.ud50 cmv_ie86_up 11867723 Upregulated by expression of cytomegalovirus IE86 protein in primary human fibroblasts 82 0.405398724477184 0 0 1 C07AB.profile.ud50 cmv_uv-cmv_common_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 54 0.266969891728877 0 0 1 C07AB.profile.ud50 cmvuv-cmv_common_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 37 0.18292381470312 0 0 1 C07AB.profile.ud50 cmv-uv_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 207 1.0233845849607 0 0 1 C07AB.profile.ud50 cmv-uv_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 226 1.11731843575419 1 0.895 0.673749412895913 C07AB.profile.ud50 cocaine_brain_4wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 4 weeks of cocaine treatment 112 0.553715330993227 1 1.80598214285714 0.42597860628403 C07AB.profile.ud50 cocaine_brain_5d_up 14566342 Up-regulated in the nucleus accumbens of mice after 5 days of cocaine treatment 113 0.558659217877095 0 0 1 C07AB.profile.ud50 cortex_enrichment_early_dn 11070096 Down-regulated in the cortex of mice that are exposed to an enriched environmental habitat for 3 or 6 hours 22 0.108765511445098 0 0 1 C07AB.profile.ud50 cortex_enrichment_early_up 11070096 Up-regulated in the cortex of mice that are exposed to an enriched environmental habitat for 3 or 6 hours 25 0.123597172096702 0 0 1 C07AB.profile.ud50 cortex_enrichment_late_dn 11070096 Down-regulated in the cortex of mice that are exposed to an enriched environmental habitat for 2 or 14 days 10 0.049438868838681 0 0 1 C07AB.profile.ud50 cortex_enrichment_late_up 11070096 Up-regulated in the cortex of mice that are exposed to an enriched environmental habitat for 2 or 14 days 34 0.168092154051515 0 0 1 C07AB.profile.ud50 cox1_ko_cortex_dn 17266762 Down-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. 57 0.281801552380482 0 0 1 C07AB.profile.ud50 cox1_ko_cortex_up 17266762 Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. 80 0.395510950709448 2 5.05675 0.0599517675423186 C07AB.profile.ud50 cox1_ko_hippocampus_dn 17266762 Down-regulated in the hippocampus of COX1-/- mice compared to wild-type controls. 77 0.380679290057844 1 2.62688311688312 0.31724788495548 C07AB.profile.ud50 cox1_ko_hippocampus_up 17266762 Up-regulated in the hippocampus of COX1-/- mice compared to wild-type controls. 81 0.400454837593316 0 0 1 C07AB.profile.ud50 cox2_ko_cortex_dn 17266762 Down-regulated in the cerebral cortex of COX2-/- mice compared to wild-type controls. 39 0.192811588470856 0 0 1 C07AB.profile.ud50 cox2_ko_cortex_up 17266762 Up-regulated in the cerebral cortex of COX2-/- mice compared to wild-type controls. 129 0.637761408018985 1 1.56798449612403 0.472361101473307 C07AB.profile.ud50 cox2_ko_hippocampus_dn 17266762 Down-regulated in the hippocampus of COX2-/- mice compared to wild-type controls. 84 0.41528649824492 0 0 1 C07AB.profile.ud50 cox2_ko_hippocampus_up 17266762 Up-regulated in the hippocampus of COX2-/- mice compared to wild-type controls. 79 0.39056706382558 2 5.12075949367089 0.058639945969173 C07AB.profile.ud50 cpm_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to cyclophosphamide 3 0.0148316606516043 0 0 1 C07AB.profile.ud50 cpm_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to cyclophosphamide 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 cpr_low_liver_dn 16006652 Down-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls 40 0.197755475354724 0 0 1 C07AB.profile.ud50 cpr_low_liver_up 16006652 Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls 32 0.158204380283779 0 0 1 C07AB.profile.ud50 cpr_null_liver_dn 16006652 Down-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls 26 0.128541058980571 0 0 1 C07AB.profile.ud50 cpr_null_liver_up 16006652 Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls 64 0.316408760567558 0 0 1 C07AB.profile.ud50 cpr_null-low_liver_dn 16006652 Down-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus mice with low expression of CPR 4 0.0197755475354724 0 0 1 C07AB.profile.ud50 cpr_null-low_liver_up 16006652 Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus mice with low expression of CPR 34 0.168092154051515 0 0 1 C07AB.profile.ud50 creb_brain_2wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic CREB 39 0.192811588470856 0 0 1 C07AB.profile.ud50 creb_brain_8wks_dn 14566342 Down-regulated in the nucleus accumbens of mice after 8 weeks of induction of transgenic CREB 85 0.420230385128788 0 0 1 C07AB.profile.ud50 creb_brain_8wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 8 weeks of induction of transgenic CREB 114 0.563603104760963 1 1.77429824561404 0.431640369721972 C07AB.profile.ud50 csb_reliable_dn 16772382 Down-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 558 2.7586888811984 2 0.724982078853047 0.762555319918109 C07AB.profile.ud50 csb_reliable_up 16772382 Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 2.53621397142433 2 0.788576998050682 0.720817708889494 C07AB.profile.ud50 csb_robust_dn 16772382 Down-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). 169 0.835516883373708 1 1.19686390532544 0.567247395490054 C07AB.profile.ud50 csb_robust_up 16772382 Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). 140 0.692144163741534 2 2.88957142857143 0.15281323129791 C07AB.profile.ud50 dac_bladder_up 11861364 Upregulated by DAC treatment in T24 bladder carcinoma cells 60 0.296633213032086 0 0 1 C07AB.profile.ud50 dac_cgi_bladder_up 11861364 Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island 26 0.128541058980571 0 0 1 C07AB.profile.ud50 dac_cgi_fibro_dn 11861364 Downregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 dac_cgi_fibro_up 11861364 Upregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island 20 0.098877737677362 0 0 1 C07AB.profile.ud50 dac_fibro_dn 11861364 Downregulated by DAC treatment in LD419 fibroblast cells 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 dac_fibro_up 11861364 Upregulated by DAC treatment in LD419 fibroblast cells 34 0.168092154051515 0 0 1 C07AB.profile.ud50 dac_ifn_bladder_up 11861364 Interferon-regulated genes upregulated by DAC treatment in T24 bladder carcinoma cells 34 0.168092154051515 0 0 1 C07AB.profile.ud50 dac_ifn_fibro_up 11861364 Interferon-regulated genes upregulated by DAC treatment in LD419 fibroblast cells 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 dac_panc50_up 12839967 50 "most interesting" genes upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 80 0.395510950709448 0 0 1 C07AB.profile.ud50 dac_panc_up 12839967 Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 654 3.23330202204974 1 0.309281345565749 0.960887806353902 C07AB.profile.ud50 dex_keratinocyte_1hr_dn 17095510 Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.118653285212834 0 0 1 C07AB.profile.ud50 dex_keratinocyte_1hr_up 17095510 Up-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 dex_keratinocyte_4hr_dn 17095510 Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 69 0.341128194986899 0 0 1 C07AB.profile.ud50 dex_keratinocyte_4hr_up 17095510 Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 35 0.173036040935383 0 0 1 C07AB.profile.ud50 dfosb_brain_2wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic deltaFosB 51 0.252138231077273 0 0 1 C07AB.profile.ud50 dfosb_brain_8wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 8 weeks of induction of transgenic deltaFosB 73 0.360903742522371 0 0 1 C07AB.profile.ud50 diab_neph_dn 15042541 Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 829 4.09848222672665 4 0.975971049457177 0.586047989908435 C07AB.profile.ud50 diab_neph_up 15042541 Upregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 116 0.573490878528699 0 0 1 C07AB.profile.ud50 dixoin_chloracne_pbmnc_dn 17101203 Down-regulated in peripheral blood mononuclear cells of subjects who developed chloracne as a result of dioxin exposure, compared to subjects who did not. 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 dixoin_chloracne_pbmnc_up 17101203 Up-regulated in peripheral blood mononuclear cells of subjects who developed chloracne as a result of dioxin exposure, compared to subjects who did not. 34 0.168092154051515 0 0 1 C07AB.profile.ud50 dixoin_pbmnc_dn 17101203 Down-regulated in peripheral blood mononuclear cells of subjects with high exposure to dioxin, compared to low-exposure controls. 117 0.578434765412567 1 1.72880341880342 0.440028479997968 C07AB.profile.ud50 dixoin_pbmnc_up 17101203 Up-regulated in peripheral blood mononuclear cells of subjects with high exposure to dioxin, compared to low-exposure controls. 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 dnmt1_ko_dn 11137995 Downregulated following conditional knock-out of DNMT1 in MEFs 38 0.187867701586988 0 0 1 C07AB.profile.ud50 dnmt1_ko_up 11137995 Upregulated following conditional knock-out of DNMT1 in MEFs 117 0.578434765412567 0 0 1 C07AB.profile.ud50 dox_resist_gastric_dn 14734480 Downregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 43 0.212587136006328 0 0 1 C07AB.profile.ud50 dox_resist_gastric_up 14734480 Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.365847629406239 0 0 1 C07AB.profile.ud50 dsrna_dn 11487589 Downregulated by dsRNA (polyI:C) in IFN-null GRE cells 24 0.118653285212834 0 0 1 C07AB.profile.ud50 dsrna_up 11487589 Upregulated by dsRNA (polyI:C) in IFN-null GRE cells 68 0.336184308103031 0 0 1 C07AB.profile.ud50 e2f1_dna_up 11313881 DNA replication genes upregulated by E2F1 induction 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 egf_hdmec_up 14517420 Up-regulated in human dermal (foreskin) microvascular endothelial cells that were stimulated to proliferate with prolonged EGF treatment, versus non-stimulated quiescent controls. 105 0.51910812280615 1 1.92638095238095 0.40571458228544 C07AB.profile.ud50 elongina_ko_dn 12604609 Downregulated in MES cells from elongin-A knockout mice 267 1.32001779799278 0 0 1 C07AB.profile.ud50 elongina_ko_up 12604609 Upregulated in MES cells from elongin-A knockout mice 263 1.30024225045731 2 1.53817490494297 0.373526008461517 C07AB.profile.ud50 emt_dn 14562044 Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.440005932664261 0 0 1 C07AB.profile.ud50 emt_up 14562044 Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 105 0.51910812280615 0 0 1 C07AB.profile.ud50 erm_ko_sertoli_dn 16107850 Down-regulated in Sertoli cells from both 4 and 10 week old ERM knockout mice, compared to 4 week wild-type controls 29 0.143372719632175 0 0 1 C07AB.profile.ud50 erm_ko_testes_dn 16107850 Down-regulated in testes from 4 week old ERM knockout mice, compared to wild-type controls 24 0.118653285212834 0 0 1 C07AB.profile.ud50 esr_fibroblast_dn 15897889 Down-regulated in the environmental stress response in human fibroblasts (regulated similarly by gamma and UV rediation and 4-NQO) 21 0.10382162456123 0 0 1 C07AB.profile.ud50 esr_fibroblast_up 15897889 Up-regulated in the environmental stress response in human fibroblasts (regulated similarly by gamma and UV rediation and 4-NQO) 98 0.484500914619074 0 0 1 C07AB.profile.ud50 et743_blockstsa 12067978 Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 et743_hela_dn 12198119 Downregulated by Et-743 in HeLa cells 28 0.138428832748307 0 0 1 C07AB.profile.ud50 et743_hela_up 12198119 Upregulated by Et-743 in HeLa cells 99 0.489444801502942 1 2.04313131313131 0.387777000081364 C07AB.profile.ud50 et743pt650_breastca_dn 11755394 Downregulated by both Et-743 and Pt-650 in MDA-MB-435 cells (Fig. 6G) 20 0.098877737677362 0 0 1 C07AB.profile.ud50 et743pt650_colonca_dn 11755394 Downregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6 A) 76 0.375735403173975 0 0 1 C07AB.profile.ud50 et743pt650_colonca_up 11755394 Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) 13 0.0642705294902853 1 15.5592307692308 0.0623981885811924 C07AB.profile.ud50 et743_resist_dn 15661559 Down-regulated in two Et-743-resistant cell lines (chondrosarcoma and ovarian carcinoma) compared to sensitive parental lines 95 0.469669253967469 1 2.12915789473684 0.375518822884975 C07AB.profile.ud50 et743_resist_up 15661559 Up-regulated in two Et-743-resistant cell lines (chondrosarcoma and ovarian carcinoma) compared to sensitive parental lines 31 0.153260493399911 0 0 1 C07AB.profile.ud50 et743_sarcoma_24hrs_dn 15897246 Down-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 163 0.8058535620705 1 1.24092024539877 0.554185430336547 C07AB.profile.ud50 et743_sarcoma_24hrs_up 15897246 Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 et743_sarcoma_48hrs_dn 15897246 Down-regulated at48 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 304 1.5029416126959 1 0.665361842105263 0.778352963912054 C07AB.profile.ud50 et743_sarcoma_6hrs_up 15897246 Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.276857665496613 0 0 1 C07AB.profile.ud50 et743_sarcoma_72hrs_dn 15897246 Down-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines 376 1.8589014683344 1 0.537952127659574 0.844873097171002 C07AB.profile.ud50 et743_sarcoma_72hrs_up 15897246 Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines 106 0.524052009690018 0 0 1 C07AB.profile.ud50 et743_sarcoma_dn 15897246 Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 459 2.26924407969546 3 1.32202614379085 0.39596662240268 C07AB.profile.ud50 et743_sarcoma_resist_dn 15897246 Constiutively down-regulated in three sarcoma cell lines resistant to Et-743 compared to six sensitive lines 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 et743_sarcoma_resist_up 15897246 Constiutively up-regulated in three sarcoma cell lines resistant to Et-743 compared to six sensitive lines 22 0.108765511445098 0 0 1 C07AB.profile.ud50 et743_sarcoma_up 15897246 Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 111 0.548771444109359 1 1.82225225225225 0.42312660949506 C07AB.profile.ud50 fsh_granulosa_dn 15026540 Down-regulated in human granulosa cells stimulated with follicle stimulation hormone (FSH) 191 0.944282394818807 3 3.17701570680628 0.0698889287423251 C07AB.profile.ud50 fsh_granulosa_up 15026540 Up-regulated in human granulosa cells stimulated with follicle stimulation hormone (FSH) 163 0.8058535620705 0 0 1 C07AB.profile.ud50 fsh_human_granulosa_dn 12832290 Down-regulated by FSH in primary human granulosa cells (rFSH-17) 7 0.0346072081870767 0 0 1 C07AB.profile.ud50 fsh_human_granulosa_up 12832290 Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.153260493399911 0 0 1 C07AB.profile.ud50 fsh_ovary_mcv152_dn 15386376 Down-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 111 0.548771444109359 0 0 1 C07AB.profile.ud50 fsh_ovary_mcv152_up 15386376 Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 120 0.593266426064172 0 0 1 C07AB.profile.ud50 fsh_rat_granulosa_dn 12832290 Down-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 fsh_rat_granulosa_up 12832290 Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.0741583032580215 1 13.4846666666667 0.0716460662968192 C07AB.profile.ud50 gamma_esr_old_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of fibroblasts from elderly donors with gamma radiation 49 0.242250457309537 0 0 1 C07AB.profile.ud50 gamma_esr_ws_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of Werner syndrome fibroblasts with gamma radiation 52 0.257082117961141 0 0 1 C07AB.profile.ud50 gamma_unique_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with gamma radiation, but not by UV lght or 4-NQO 120 0.593266426064172 1 1.68558333333333 0.44829279472225 C07AB.profile.ud50 gamma_unique_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with gamma radiation, but not by UV lght or 4-NQO 27 0.133484945864439 0 0 1 C07AB.profile.ud50 gamma-uv_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO 78 0.385623176941712 2 5.18641025641026 0.057338294514844 C07AB.profile.ud50 gamma-uv_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO 57 0.281801552380482 1 3.54859649122807 0.246103700580757 C07AB.profile.ud50 genotoxins_24hrs_discr 15120960 Group of genes whose regulation pattern significantly discriminates between direct (cisplatin, methyl methanesulfonate, mitomycin C) and indirect (taxol, hydroxyurea, etoposide) genotoxins, 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) 69 0.341128194986899 0 0 1 C07AB.profile.ud50 genotoxins_4hrs_discr 15120960 Group of genes whose regulation pattern significantly discriminates between direct (cisplatin, methyl methanesulfonate, mitomycin C) and indirect (taxol, hydroxyurea, etoposide) genotoxins, 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) 58 0.28674543926435 0 0 1 C07AB.profile.ud50 genotoxins_all_24hrs_reg 15120960 Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 49 0.242250457309537 0 0 1 C07AB.profile.ud50 genotoxins_all_4hrs_reg 15120960 Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 45 0.222474909774064 0 0 1 C07AB.profile.ud50 gh_autocrine_dn 15845533 Down-regulated following stable autocrine expression of human growth hormone in mammary carcinoma cells (MCF-7) 189 0.93439462105107 0 0 1 C07AB.profile.ud50 gh_autocrine_up 15845533 Up-regulated following stable autocrine expression of human growth hormone in mammary carcinoma cells (MCF-7) 227 1.12226232263806 3 2.6731718061674 0.103660553672918 C07AB.profile.ud50 gh_exogenous_all_up 15845533 Up-regulated consistently at all time points (1-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 66 0.326296534335294 0 0 1 C07AB.profile.ud50 gh_exogenous_any_dn 15845533 Down-regulated at any time point (1-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 142 0.70203193750927 0 0 1 C07AB.profile.ud50 gh_exogenous_any_up 15845533 Up-regulated at any time point (1-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 305 1.50788549957977 4 2.65272131147541 0.0661679001802865 C07AB.profile.ud50 gh_exogenous_early_dn 15845533 Down-regulated at early time points (1-4 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 gh_exogenous_early_up 15845533 Up-regulated at early time points (1-4 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 31 0.153260493399911 0 0 1 C07AB.profile.ud50 gh_exogenous_late_dn 15845533 Down-regulated at late time points (12-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 123 0.608098086715776 0 0 1 C07AB.profile.ud50 gh_exogenous_late_up 15845533 Up-regulated at late time points (12-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 67 0.331240421219163 3 9.05686567164179 0.00457252626848519 C07AB.profile.ud50 gh_exogenous_middle_dn 15845533 Down-regulated at middle time points (6-8 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 5 0.0247194344193405 0 0 1 C07AB.profile.ud50 gh_exogenous_middle_up 15845533 Up-regulated at middle time points (6-8 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 141 0.697088050625402 1 1.4345390070922 0.50282684512696 C07AB.profile.ud50 gh_ghrhr_ko_24hrs_dn 16464905 Down-regulated at least 2-fold 24 hours following injection of human growth hormone (GH) into mice lacking functional GHRHR (lit/lit), and with no detectable endogenous GH 277 1.36945666683146 3 2.19064981949458 0.158796648359445 C07AB.profile.ud50 gh_ghrhr_ko_24hrs_up 16464905 Up-regulated at least 2-fold 24 hours following injection of human growth hormone (GH) into mice lacking functional GHRHR (lit/lit), and with no detectable endogenous GH 187 0.924506847283334 1 1.0816577540107 0.604181591079594 C07AB.profile.ud50 gh_ghrhr_ko_6hrs_dn 16464905 Down-regulated at least 2-fold 6 hours following injection of human growth hormone (GH) into mice lacking functional GHRHR (lit/lit), and with no detectable endogenous GH 58 0.28674543926435 0 0 1 C07AB.profile.ud50 gh_ghrhr_ko_6hrs_up 16464905 Up-regulated at least 2-fold 6 hours following injection of human growth hormone (GH) into mice lacking functional GHRHR (lit/lit), and with no detectable endogenous GH 108 0.533939783457755 0 0 1 C07AB.profile.ud50 gh_hypophysectomy_rat_dn 11416039 Down-regulated in liver, heart or kidney tissue following treatment of hypophysectomized rats with growth hormone 29 0.143372719632175 0 0 1 C07AB.profile.ud50 gh_hypophysectomy_rat_up 11416039 Up-regulated in liver, heart or kidney tissue following treatment of hypophysectomized rats with growth hormone 39 0.192811588470856 0 0 1 C07AB.profile.ud50 gh_igf_chondrocytes_up 11416039 Up-regulated in cultured human chondrocytes by both GH and IGF-1 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 gn_camp_granulosa_dn 15026540 Down-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin 135 0.667424729322193 2 2.99659259259259 0.144280723828487 C07AB.profile.ud50 gn_camp_granulosa_up 15026540 Up-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin 99 0.489444801502942 0 0 1 C07AB.profile.ud50 h2o2_csbcombined 12606941 Upregulated by H2O2 in CSB-rescued fibroblasts, but deficient induction in CSB-null (Table 3) 26 0.128541058980571 0 0 1 C07AB.profile.ud50 h2o2_csbdiff_c1 12606941 Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) 58 0.28674543926435 1 3.48741379310345 0.249830878607253 C07AB.profile.ud50 h2o2_csbdiff_c2 12606941 Deficient induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 2) 63 0.31146487368369 1 3.21063492063492 0.268192182793903 C07AB.profile.ud50 h2o2_csbdiff_c3 12606941 Deficient induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 3) 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 h2o2_csbrescued_c1_up 12606941 Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 1) 84 0.41528649824492 0 0 1 C07AB.profile.ud50 h2o2_csbrescued_c2_up 12606941 Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 2) 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 h2o2_csbrescued_up 12606941 Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1) 101 0.499332575270678 0 0 1 C07AB.profile.ud50 hbx_hcc_dn 11439330 Downregulated by expression of Hepatitis B virus HBx protein in SK-Hep-1 hepatocellular carcinoma cells (Fig. 3B+D) 47 0.232362683541801 0 0 1 C07AB.profile.ud50 hbx_hcc_up 11439330 Upregulated by expression of Hepatitis B virus HBx protein in SK-Hep-1 hepatocellular carcinoma cells (Fig. 3A+C) 20 0.098877737677362 1 10.1135 0.0943686610871122 C07AB.profile.ud50 hbx_hep_dn 11439330 Downregulated both by expression of Hepatitis B virus HBx protein in normal hepatoctyes and by HBV infection in liver samples with chronic active hepatitis 30 0.148316606516043 0 0 1 C07AB.profile.ud50 hbx_hep_up 11439330 Upregulated both by expression of Hepatitis B virus HBx protein in normal hepatoctyes and by HBV infection in liver samples with chronic active hepatitis 33 0.163148267167647 1 6.12939393939394 0.150878416157636 C07AB.profile.ud50 hbx_nl_dn 11439330 Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) 27 0.133484945864439 0 0 1 C07AB.profile.ud50 hbx_nl_up 11439330 Upregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3A+D) 40 0.197755475354724 1 5.05675 0.17983187797885 C07AB.profile.ud50 hdaci_colon_but12hrs_dn 10969808 Downregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 109 0.538883670341623 0 0 1 C07AB.profile.ud50 hdaci_colon_but12hrs_up 10969808 Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.266969891728877 0 0 1 C07AB.profile.ud50 hdaci_colon_but16hrs_dn 10969808 Downregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 167 0.825629109605972 1 1.21119760479042 0.562936493125841 C07AB.profile.ud50 hdaci_colon_but16hrs_up 10969808 Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.232362683541801 0 0 1 C07AB.profile.ud50 hdaci_colon_but24hrs_dn 10969808 Downregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 168 0.83057299648984 0 0 1 C07AB.profile.ud50 hdaci_colon_but24hrs_up 10969808 Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.469669253967469 0 0 1 C07AB.profile.ud50 hdaci_colon_but2hrs_dn 10969808 Downregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 23 0.113709398328966 0 0 1 C07AB.profile.ud50 hdaci_colon_but2hrs_up 10969808 Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.430118158896524 0 0 1 C07AB.profile.ud50 hdaci_colon_but30min_dn 10969808 Downregulated by butyrate at 30 min in SW260 colon carcinoma cells 79 0.39056706382558 0 0 1 C07AB.profile.ud50 hdaci_colon_but48hrs_dn 10969808 Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 165 0.815741335838236 0 0 1 C07AB.profile.ud50 hdaci_colon_but48hrs_up 10969808 Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.667424729322193 0 0 1 C07AB.profile.ud50 hdaci_colon_but_dn 10969808 Downregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 387 1.91328422405695 1 0.52266149870801 0.853103849441959 C07AB.profile.ud50 hdaci_colon_but_up 10969808 Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 1.15192564394127 0 0 1 C07AB.profile.ud50 hdaci_colon_cluster1 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 hdaci_colon_cluster10 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 10, associated with histone hyperAc) 60 0.296633213032086 1 3.37116666666667 0.257230045520317 C07AB.profile.ud50 hdaci_colon_cluster2 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 hdaci_colon_cluster3 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 3) 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 hdaci_colon_cluster4 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 4) 19 0.0939338507934939 0 0 1 C07AB.profile.ud50 hdaci_colon_cluster5 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 5) 32 0.158204380283779 0 0 1 C07AB.profile.ud50 hdaci_colon_cluster6 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 6) 63 0.31146487368369 0 0 1 C07AB.profile.ud50 hdaci_colon_cluster7 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 7) 21 0.10382162456123 0 0 1 C07AB.profile.ud50 hdaci_colon_cluster8 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 8) 18 0.0889899639096258 0 0 1 C07AB.profile.ud50 hdaci_colon_cluster9 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.385623176941712 2 5.18641025641026 0.057338294514844 C07AB.profile.ud50 hdaci_colon_cur12hrs_dn 10969808 Downregulated by curcumin at 12 hrs in SW260 colon carcinoma cells 5 0.0247194344193405 0 0 1 C07AB.profile.ud50 hdaci_colon_cur12hrs_up 10969808 Upregulated by curcumin at 12 hrs in SW260 colon carcinoma cells 22 0.108765511445098 0 0 1 C07AB.profile.ud50 hdaci_colon_cur16hrs_dn 10969808 Downregulated by curcumin at 16 hrs in SW260 colon carcinoma cells 22 0.108765511445098 0 0 1 C07AB.profile.ud50 hdaci_colon_cur16hrs_up 10969808 Upregulated by curcumin at 16 hrs in SW260 colon carcinoma cells 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 hdaci_colon_cur24hrs_dn 10969808 Downregulated by curcumin at 24 hrs in SW260 colon carcinoma cells 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 hdaci_colon_cur24hrs_up 10969808 Upregulated by curcumin at 24 hrs in SW260 colon carcinoma cells 73 0.360903742522371 1 2.77082191780822 0.303577545212384 C07AB.profile.ud50 hdaci_colon_cur2hrs_up 10969808 Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells 49 0.242250457309537 0 0 1 C07AB.profile.ud50 hdaci_colon_cur30min_dn 10969808 Downregulated by curcumin at 30 min in SW260 colon carcinoma cells 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 hdaci_colon_cur30min_up 10969808 Upregulated by curcumin at 30 min in SW260 colon carcinoma cells 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 hdaci_colon_cur48hrs_up 10969808 Upregulated by curcumin at 48 hrs in SW260 colon carcinoma cells 109 0.538883670341623 1 1.8556880733945 0.417380035500907 C07AB.profile.ud50 hdaci_colon_cur_dn 10969808 Downregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 51 0.252138231077273 0 0 1 C07AB.profile.ud50 hdaci_colon_cursul_dn 10969808 Downregulated by both curcumin and sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 20 0.098877737677362 0 0 1 C07AB.profile.ud50 hdaci_colon_cursul_up 10969808 Upregulated by both curcumin and sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 53 0.262026004845009 0 0 1 C07AB.profile.ud50 hdaci_colon_cur_up 10969808 Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 174 0.860236317793049 1 1.16247126436782 0.5778395432903 C07AB.profile.ud50 hdaci_colon_sul12hrs_dn 10969808 Downregulated by sulindac at 12 hrs in SW260 colon carcinoma cells 49 0.242250457309537 0 0 1 C07AB.profile.ud50 hdaci_colon_sul12hrs_up 10969808 Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells 40 0.197755475354724 0 0 1 C07AB.profile.ud50 hdaci_colon_sul16hrs_dn 10969808 Downregulated by sulindac at 16 hrs in SW260 colon carcinoma cells 111 0.548771444109359 0 0 1 C07AB.profile.ud50 hdaci_colon_sul16hrs_up 10969808 Upregulated by sulindac at 16 hrs in SW260 colon carcinoma cells 67 0.331240421219163 0 0 1 C07AB.profile.ud50 hdaci_colon_sul24hrs_dn 10969808 Downregulated by sulindac at 24 hrs in SW260 colon carcinoma cells 191 0.944282394818807 2 2.11801047120419 0.243703089811773 C07AB.profile.ud50 hdaci_colon_sul24hrs_up 10969808 Upregulated by sulindac at 24 hrs in SW260 colon carcinoma cells 102 0.504276462154546 0 0 1 C07AB.profile.ud50 hdaci_colon_sul2hrs_dn 10969808 Downregulated by sulindac at 2 hrs in SW260 colon carcinoma cells 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 hdaci_colon_sul2hrs_up 10969808 Upregulated by sulindac at 2 hrs in SW260 colon carcinoma cells 10 0.049438868838681 0 0 1 C07AB.profile.ud50 hdaci_colon_sul30min_dn 10969808 Downregulated by sulindac at 30 min in SW260 colon carcinoma cells 79 0.39056706382558 1 2.56037974683544 0.323982095569325 C07AB.profile.ud50 hdaci_colon_sul48hrs_dn 10969808 Downregulated by sulindac at 48 hrs in SW260 colon carcinoma cells 95 0.469669253967469 0 0 1 C07AB.profile.ud50 hdaci_colon_sul48hrs_up 10969808 Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells 140 0.692144163741534 0 0 1 C07AB.profile.ud50 hdaci_colon_sul_dn 10969808 Downregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 340 1.68092154051515 3 1.78473529411765 0.237540286952648 C07AB.profile.ud50 hdaci_colon_sul_up 10969808 Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 192 0.949226281702675 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa12hrs_dn 10969808 Downregulated by TSA at 12 hrs in SW260 colon carcinoma cells 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa12hrs_up 10969808 Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.10382162456123 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa24hrs_dn 10969808 Downregulated by TSA at 24 hrs in SW260 colon carcinoma cells 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa24hrs_up 10969808 Upregulated by TSA at 24 hrs in SW260 colon carcinoma cells 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa2hrs_dn 10969808 Downregulated by TSA at 2 hrs in SW260 colon carcinoma cells 33 0.163148267167647 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa2hrs_up 10969808 Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.301577099915954 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa30min_dn 10969808 Downregulated by TSA at 30 min in SW260 colon carcinoma cells 34 0.168092154051515 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa48hrs_dn 10969808 Downregulated by TSA at 48 hrs in SW260 colon carcinoma cells 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa48hrs_up 10969808 Upregulated by TSA at 48 hrs in SW260 colon carcinoma cells 43 0.212587136006328 0 0 1 C07AB.profile.ud50 hdaci_colon_tsabut_dn 10969808 Downregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 46 0.227418796657932 0 0 1 C07AB.profile.ud50 hdaci_colon_tsabut_up 10969808 Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.39056706382558 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa_dn 10969808 Downregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 109 0.538883670341623 0 0 1 C07AB.profile.ud50 hdaci_colon_tsa_up 10969808 Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.603154199831908 0 0 1 C07AB.profile.ud50 hdaci_three_dn 12589032 Downregulated in several cell lines by all of TSA, SAHA, and MS-275 10 0.049438868838681 0 0 1 C07AB.profile.ud50 hdaci_three_up 12589032 Upregulated in several cell lines by all of TSA, SAHA, and MS-275 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 heartfailure_atria_dn 15103417 Downregulated in the atria of failing hearts (DCM and ICM) compared to healthy controls 213 1.0530479062639 0 0 1 C07AB.profile.ud50 heartfailure_atria_up 15103417 Upregulated in atria of failing hearts (DCM and ICM) compared to healthy controls 58 0.28674543926435 0 0 1 C07AB.profile.ud50 heartfailure_ventricles_dn 15103417 Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls 120 0.593266426064172 0 0 1 C07AB.profile.ud50 heartfailure_ventricles_up 15103417 Upregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 heat_glioblastoma_dn 16802863 Down-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 32 0.158204380283779 1 6.3209375 0.146659597735406 C07AB.profile.ud50 heat_glioblastoma_up 16802863 Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.385623176941712 0 0 1 C07AB.profile.ud50 heatshock_hela_2hr_dn 17216044 Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 223 1.10248677510259 0 0 1 C07AB.profile.ud50 heatshock_hela_2hr_up 17216044 Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.875067978444653 0 0 1 C07AB.profile.ud50 heatshock_hela_30min_dn 17216044 Down-regulated at 30 minutes following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 67 0.331240421219163 0 0 1 C07AB.profile.ud50 heatshock_hela_30min_up 17216044 Up-regulated at 30 minutes following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, p < 0.05). 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 heatshock_hela_4hr_dn 17216044 Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 9.04236911059475 9 0.995314379442318 0.550255302898184 C07AB.profile.ud50 heatshock_hela_4hr_up 17216044 Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.33712364661097 1 0.299659259259259 0.964753890246465 C07AB.profile.ud50 heatshock_old_dn 12618007 Downregulated after heat shock in lymphocytes from old individuals, compared to young 13 0.0642705294902853 0 0 1 C07AB.profile.ud50 heatshock_old_up 12618007 Upregulated after heat shock in lymphocytes from old individuals, compared to young 27 0.133484945864439 0 0 1 C07AB.profile.ud50 heatshock_young_dn 12618007 Downregulated after heat shock in lymphocytes from young individuals, compared to old 10 0.049438868838681 0 0 1 C07AB.profile.ud50 heatshock_young_up 12618007 Upregulated after heat shock in lymphocytes from young individuals, compared to old 18 0.0889899639096258 0 0 1 C07AB.profile.ud50 hematop_stem_all_up 15231652 Up-regulated in populations of human hematopoietic stem cells (CD34+/CD38-/Lin-) from bone marrow, umbilical cord blood, and peripheral blood stem-progenitor cells, compared to the stem cell-depleted population (CD34+/[CD38/Lin++]) 52 0.257082117961141 0 0 1 C07AB.profile.ud50 hg_progeria_dn 10741968 Downregulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals 48 0.237306570425669 0 0 1 C07AB.profile.ud50 hg_progeria_up 10741968 regulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 hif1_targets 11516994 Hif-1 (hypoxia-inducible factor 1) transcripional targets 67 0.331240421219163 0 0 1 C07AB.profile.ud50 hippocampus_development_neonatal 11438693 Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) 51 0.252138231077273 1 3.96607843137255 0.223348511843017 C07AB.profile.ud50 hippocampus_development_postnatal 11438693 Highly expressed in late postnatal mouse hippocampus (clusters 11 and 15) 79 0.39056706382558 1 2.56037974683544 0.323982095569325 C07AB.profile.ud50 hippocampus_development_prenatal 11438693 Highly expressed in prenatal mouse hippocampus (cluster 1) 58 0.28674543926435 0 0 1 C07AB.profile.ud50 hpv31_dn 10756030 Downregulated in normal human keratinocytes carrying episomal HPV31 DNA 82 0.405398724477184 0 0 1 C07AB.profile.ud50 hpv31_up 10756030 Upregulated in normal human keratinocytes carrying episomal HPV31 DNA 69 0.341128194986899 0 0 1 C07AB.profile.ud50 hpve7_hpve6_hfk_dn 14517073 Down-regulated in human foreskin keratinocytes expressing both HPV E6 and E7 proteins compared to E7 expression only 39 0.192811588470856 0 0 1 C07AB.profile.ud50 hpve7_hpve6_hfk_up 14517073 Up-regulated in human foreskin keratinocytes expressing both HPV E6 and E7 proteins compared to E7 expression only 18 0.0889899639096258 0 0 1 C07AB.profile.ud50 hpv_high-risk_up 17309674 Up-regulated in both HPV16- and HPV18-positive cervical tumors compared to normal cervial tissue. 21 0.10382162456123 0 0 1 C07AB.profile.ud50 hpv_hnscc_up 16467079 Up-regulated in HPV-positive head and neck squamous cell carcinomas (HNSCC) compared to HPV-negative HNSCC. 68 0.336184308103031 0 0 1 C07AB.profile.ud50 hsc_earlyprogenitors_adult 12228721 Up-regulated in mouse hematopoietic early progenitors from adult bone marrow (Early Progenitors Shared + Adult) 526 2.60048450091462 3 1.15363117870722 0.482065540953446 C07AB.profile.ud50 hsc_earlyprogenitors_fetal 12228721 Up-regulated in mouse hematopoietic early progenitors from fetal liver (Early Progenitors Shared) 520 2.57082117961141 3 1.16694230769231 0.474578246963352 C07AB.profile.ud50 hsc_earlyprogenitors_shared 12228721 Up-regulated in mouse hematopoietic early progenitors from both adult bone marrow and fetal liver (Cluster iv, Early Progenitors Shared) 520 2.57082117961141 3 1.16694230769231 0.474578246963352 C07AB.profile.ud50 hsc_hsc_adult 12228721 Up-regulated in mouse hematopoietic stem cells from adult bone marrow (HSC Shared + Adult) 363 1.79463093884412 0 0 1 C07AB.profile.ud50 hsc_hscandprogenitors_adult 12228721 Up-regulated in mouse hematopoietic stem cells and progenitors from adult bone marrow (HSC and Progenitors Shared + Adult) 724 3.5793741039205 1 0.279378453038674 0.972353368510011 C07AB.profile.ud50 hsc_hscandprogenitors_fetal 12228721 Up-regulated in mouse hematopoietic stem cells and progenitors from fetal liver (HSC and Progenitors Shared) 717 3.54476689573343 1 0.2821059972106 0.971377390941707 C07AB.profile.ud50 hsc_hscandprogenitors_shared 12228721 Up-regulated in mouse hematopoietic stem cells and progenitors from both adult bone marrow and fetal liver (Cluster iii, HSC and Progenitors Shared) 717 3.54476689573343 1 0.2821059972106 0.971377390941707 C07AB.profile.ud50 hsc_hsc_fetal 12228721 Up-regulated in mouse hematopoietic stem cells from fetal liver (HSC Shared + Fetal) 303 1.49799772581203 0 0 1 C07AB.profile.ud50 hsc_hsc_shared 12228721 Up-regulated in mouse hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster ii, HSC Shared) 270 1.33484945864439 0 0 1 C07AB.profile.ud50 hsc_intermediateprogenitors_adult 12228721 Up-regulated in mouse hematopoietic intermediate progenitors from adult bone marrow (Intermediate Progenitors Shared + Adult) 161 0.795965788302764 0 0 1 C07AB.profile.ud50 hsc_intermediateprogenitors_fetal 12228721 Up-regulated in mouse hematopoietic intermediate progenitors from fetal liver (Intermediate Progenitors Shared + Fetal) 167 0.825629109605972 1 1.21119760479042 0.562936493125841 C07AB.profile.ud50 hsc_intermediateprogenitors_shared 12228721 Up-regulated in mouse hematopoietic intermediate progenitors from both adult bone marrow and fetal liver (Cluster v, Intermediate Progenitors Shared) 151 0.746526919464083 0 0 1 C07AB.profile.ud50 hsc_lateprogenitors_adult 12228721 Up-regulated in mouse hematopoietic late progenitors from adult bone marrow (Late Progenitors Shared + Adult) 558 2.7586888811984 2 0.724982078853047 0.762555319918109 C07AB.profile.ud50 hsc_lateprogenitors_fetal 12228721 Up-regulated in mouse hematopoietic late progenitors from fetal liver (Late Progenitors Shared + Fetal) 558 2.7586888811984 2 0.724982078853047 0.762555319918109 C07AB.profile.ud50 hsc_lateprogenitors_shared 12228721 Up-regulated in mouse hematopoietic late progenitors from both adult bone marrow and fetal liver (Cluster vi, Late Progenitors Shared) 549 2.71419389924359 2 0.736867030965392 0.754667188835372 C07AB.profile.ud50 hsc_lthsc_adult 12228721 Up-regulated in mouse long-term functional hematopoietic stem cells from adult bone marrow (LT-HSC Shared + Adult) 385 1.90339645028922 4 2.10150649350649 0.125412663322744 C07AB.profile.ud50 hsc_lthsc_fetal 12228721 Up-regulated in mouse long-term functional hematopoietic stem cells from fetal liver (LT-HSC Shared) 272 1.34473723241212 2 1.48727941176471 0.389241458510717 C07AB.profile.ud50 hsc_lthsc_shared 12228721 Up-regulated in mouse long-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster i, LT-HSC Shared) 272 1.34473723241212 2 1.48727941176471 0.389241458510717 C07AB.profile.ud50 hsc_mature_adult 12228721 Up-regulated in mouse mature bood cells from adult bone marrow, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared + Adult) 427 2.11103969941168 3 1.42110070257611 0.353422562031055 C07AB.profile.ud50 hsc_mature_fetal 12228721 Up-regulated in mouse mature bood cells from fetal liver, compared to hematopoietic progenitors (Mature Blood Cells Shared + Fetal) 376 1.8589014683344 3 1.61385638297872 0.28510309895353 C07AB.profile.ud50 hsc_mature_shared 12228721 Up-regulated in mouse mature bood cells from both adult bone marrow and fetal liver, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared) 309 1.52766104711524 3 1.96378640776699 0.197830538115153 C07AB.profile.ud50 hsc_sthsc_adult 12228721 Up-regulated in mouse short-term functional hematopoietic stem cells from adult bone marrow (ST-HSC Shared + Adult) 51 0.252138231077273 0 0 1 C07AB.profile.ud50 hsc_sthsc_fetal 12228721 Up-regulated in mouse short-term functional hematopoietic stem cells from fetal liver (ST-HSC Shared) 44 0.217531022890196 0 0 1 C07AB.profile.ud50 hsc_sthsc_shared 12228721 Up-regulated in mouse short-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (ST-HSC Shared) 44 0.217531022890196 0 0 1 C07AB.profile.ud50 htert_dn 12702554 Downregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 112 0.553715330993227 0 0 1 C07AB.profile.ud50 htert_up 12702554 Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 97 0.479557027735205 0 0 1 C07AB.profile.ud50 human_tissue_cerebellum 11904358 Genes expressed specifically in human cerebellum tissue 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 human_tissue_heart 11904358 Genes expressed specifically in human heart tissue 19 0.0939338507934939 0 0 1 C07AB.profile.ud50 human_tissue_kidney 11904358 Genes expressed specifically in human kidney tissue 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 human_tissue_liver 11904358 Genes expressed specifically in human liver tissue 55 0.271913778612745 0 0 1 C07AB.profile.ud50 human_tissue_lung 11904358 Genes expressed specifically in human lung tissue 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 human_tissue_pancreas 11904358 Genes expressed specifically in human pancreas tissue 71 0.351015968754635 0 0 1 C07AB.profile.ud50 human_tissue_pituitary 11904358 Genes expressed specifically in human pituitary gland tissue 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 human_tissue_placenta 11904358 Genes expressed specifically in human placental tissue 40 0.197755475354724 1 5.05675 0.17983187797885 C07AB.profile.ud50 human_tissue_prostate 11904358 Genes expressed specifically in human prostate tissue 5 0.0247194344193405 0 0 1 C07AB.profile.ud50 human_tissue_salivary 11904358 Genes expressed specifically in human salivary gland tissue 18 0.0889899639096258 0 0 1 C07AB.profile.ud50 human_tissue_spleen 11904358 Genes expressed specifically in human spleen tissue 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 human_tissue_testis 11904358 Genes expressed specifically in human testis tissue 122 0.603154199831908 0 0 1 C07AB.profile.ud50 human_tissue_thymus 11904358 Genes expressed specifically in human thymus tissue 21 0.10382162456123 0 0 1 C07AB.profile.ud50 human_tissue_trachea 11904358 Genes expressed specifically in human tracheal tissue 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 hyperme_colonca_sw48 16007088 Gene identified by chromatin IP and CpG island microarray as being hypermethylated in SW48 colon cancer cells, versus normal colon murcosa or WI38 fibroblasts 20 0.098877737677362 0 0 1 C07AB.profile.ud50 hyperthyroid_rat_neuron_up 15234464 Up-regulated in cerebral tissue from hyperthyroid rats, compared to euthyroid controls 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 hypophysectomy_rat_dn 11416039 Down-regulated in liver, heart or kidney tissue from hypophysectomized rats (lacking growth hormone), compared to normal controls 95 0.469669253967469 0 0 1 C07AB.profile.ud50 hypophysectomy_rat_up 11416039 Up-regulated in liver, heart or kidney tissue from hypophysectomized rats (lacking growth hormone), compared to normal controls 59 0.291689326148218 0 0 1 C07AB.profile.ud50 hypoxia_fibro_up 14499499 Upregulated by hypoxia in normal fibroblasts from both young and old donors (Table 3) 34 0.168092154051515 0 0 1 C07AB.profile.ud50 hypoxia_fibro_young_up 14499499 Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 hypoxia_normal_up 12692265 Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 1.8589014683344 2 1.07590425531915 0.555074739424182 C07AB.profile.ud50 hypoxia_rcc_novhl_up 12692265 Upregulated by hypoxia in VHL-null renal carcinoma cells (Fig. 4h+i) 88 0.435062045780393 0 0 1 C07AB.profile.ud50 hypoxia_rcc_up 12692265 Upregulated by hypoxia in VHL-rescued renal carcinoma cells (Fig. 3f+g) 170 0.840460770257577 0 0 1 C07AB.profile.ud50 hypoxia_reg_up 12885785 Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.395510950709448 0 0 1 C07AB.profile.ud50 hypoxia_review 11902584 Genes known to be induced by hypoxia 160 0.791021901418896 0 0 1 C07AB.profile.ud50 icf_dn 11741835 Downregulated in B-cells from ICF syndrome (DNMT3B) compared to normals 23 0.113709398328966 0 0 1 C07AB.profile.ud50 icf_up 11741835 Upregulated in B-cells from ICF syndrome (DNMT3B) compared to normals 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 idx_tsa_dn_cluster1 15033539 Down-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 84 0.41528649824492 0 0 1 C07AB.profile.ud50 idx_tsa_dn_cluster2 15033539 Progressively down-regulated from 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 2) 114 0.563603104760963 0 0 1 C07AB.profile.ud50 idx_tsa_dn_cluster3 15033539 Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 108 0.533939783457755 0 0 1 C07AB.profile.ud50 idx_tsa_dn_cluster4 15033539 Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 46 0.227418796657932 0 0 1 C07AB.profile.ud50 idx_tsa_dn_cluster5 15033539 Strongly down-regulated at 2-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) 96 0.474613140851337 0 0 1 C07AB.profile.ud50 idx_tsa_dn_cluster6 15033539 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.237306570425669 1 4.21395833333333 0.211714637447666 C07AB.profile.ud50 idx_tsa_up_cluster1 15033539 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.217531022890196 0 0 1 C07AB.profile.ud50 idx_tsa_up_cluster2 15033539 Strongly up-regulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 2) 105 0.51910812280615 0 0 1 C07AB.profile.ud50 idx_tsa_up_cluster3 15033539 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.672368616206061 0 0 1 C07AB.profile.ud50 idx_tsa_up_cluster4 15033539 Progressively up-regulated from 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 65 0.321352647451426 0 0 1 C07AB.profile.ud50 idx_tsa_up_cluster5 15033539 Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) 149 0.736639145696346 1 1.35751677852349 0.52215367786475 C07AB.profile.ud50 idx_tsa_up_cluster6 15033539 Strongly up-regulated at 96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 249 1.23102783408316 2 1.62465863453815 0.348762460699245 C07AB.profile.ud50 ifna_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following treatment with interferon-alpha 103 0.509220349038414 0 0 1 C07AB.profile.ud50 ifn_all_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferons alpha, beta and gamma 41 0.202699362238592 0 0 1 C07AB.profile.ud50 ifnalpha_hcc_dn 11910354 Downregulated by interferon alpha treatment in Hep3B hepatocellular carcinoma cells 22 0.108765511445098 0 0 1 C07AB.profile.ud50 ifnalpha_hcc_up 11910354 Upregulated by interferon alpha treatment in Hep3B hepatocellular carcinoma cells 50 0.247194344193405 0 0 1 C07AB.profile.ud50 ifnalpha_nl_dn 11910354 Downregulated by interferon alpha treatment in normal primary hepatocytes 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 ifnalpha_nl_hcc_dn 11910354 Downregulated by interferon alpha treatment in both primary normal hepatocytes and Hep3B hepatocellular carcinoma cells 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 ifnalpha_nl_hcc_up 11910354 Upregulated by interferon alpha treatment in both normal primary hepatocytes and Hep3B hepatocellular carcinoma cells 30 0.148316606516043 0 0 1 C07AB.profile.ud50 ifnalpha_nl_up 11910354 Upregulated by interferon alpha treatment in normal primary hepatocytes 53 0.262026004845009 0 0 1 C07AB.profile.ud50 ifnalpha_resist_dn 12414529 Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line 25 0.123597172096702 0 0 1 C07AB.profile.ud50 ifn_alpha_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon alpha 80 0.395510950709448 1 2.528375 0.3273242516203 C07AB.profile.ud50 ifn_any_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with any of interferons alpha, beta and gamma 172 0.850348544025313 1 1.17598837209302 0.573634155519225 C07AB.profile.ud50 ifna_uv-cmv_common_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following either infection with UV-inactivated CMV or interferon-alpha 47 0.232362683541801 0 0 1 C07AB.profile.ud50 ifn_beta_glioma_dn 16140920 Down-regulated in human glioma cells (T98) at 48 hours following treatment with interferon-beta 92 0.454837593315865 0 0 1 C07AB.profile.ud50 ifn_beta_glioma_up 16140920 Up-regulated in human glioma cells (T98) at 48 hours following treatment with interferon-beta 124 0.613041973599644 1 1.63120967741935 0.459122464103259 C07AB.profile.ud50 ifn_beta_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon beta 143 0.706975824393138 0 0 1 C07AB.profile.ud50 ifn_gamma_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon gamma 80 0.395510950709448 1 2.528375 0.3273242516203 C07AB.profile.ud50 igf1_nih3t3_up 11606465 Up-regulated by treatment with IGF1 of NIH3T3 cells overexpressing IGF1R (Tables 1+3) 61 0.301577099915954 0 0 1 C07AB.profile.ud50 igfr_ir_dn 12213819 Down-regulated in common following stimulation of chimeric TrkC/IR or TrkC/IGFR in NIH3T3 cells 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 igfr_ir_up 12213819 Up-regulated in common following stimulation of chimeric TrkC/IR or TrkC/IGFR in NIH3T3 cells 36 0.177979927819252 0 0 1 C07AB.profile.ud50 igfr_vs_ir_up 12213819 Up-regulated following stimulation of chimeric TrkC/IGFR in NIH3T3 cells, compared to stimulation of TrkC/IR 13 0.0642705294902853 0 0 1 C07AB.profile.ud50 igf_vs_pdgf_dn 15475267 Down-regulated in mouse C2AS12 myoblasts by treatment with IGF1, compared to treatment with PDGF 53 0.262026004845009 0 0 1 C07AB.profile.ud50 igf_vs_pdgf_up 15475267 Up-regulated in mouse C2AS12 myoblasts by treatment with IGF1, compared to treatment with PDGF 87 0.430118158896524 0 0 1 C07AB.profile.ud50 il1_cornea_dn 12091409 Downregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 3) 163 0.8058535620705 2 2.48184049079755 0.193139199625849 C07AB.profile.ud50 il1_cornea_up 12091409 Upregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 2) 136 0.672368616206061 0 0 1 C07AB.profile.ud50 il2_pbmc_24hr_dn 17471163 Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 3.19375092697879 1 0.313111455108359 0.959305885996687 C07AB.profile.ud50 il2_pbmc_24hr_up 17471163 Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 503 2.48677510258565 2 0.804254473161034 0.710739638298156 C07AB.profile.ud50 il2_pbmc_2hr_dn 17471163 Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 27 0.133484945864439 0 0 1 C07AB.profile.ud50 il2_pbmc_2hr_up 17471163 Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.326296534335294 0 0 1 C07AB.profile.ud50 il2_pbmc_30min_dn 17471163 Down-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 27 0.133484945864439 0 0 1 C07AB.profile.ud50 il2_pbmc_30min_up 17471163 Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.326296534335294 0 0 1 C07AB.profile.ud50 il2_pbmc_48hr_dn 17471163 Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 531 2.62520393533396 4 1.52369114877589 0.26928882349666 C07AB.profile.ud50 il2_pbmc_48hr_up 17471163 Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 2.5263261976566 0 0 1 C07AB.profile.ud50 il2_pbmc_4hr_dn 17471163 Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 555 2.74385722054679 2 0.728900900900901 0.75995074648848 C07AB.profile.ud50 il2_pbmc_4hr_up 17471163 Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 2.52138231077273 0 0 1 C07AB.profile.ud50 il2_pbmc_6hr_dn 17471163 Down-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 2.62026004845009 1 0.381641509433962 0.927687524346427 C07AB.profile.ud50 il2_pbmc_6hr_up 17471163 Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 2.62026004845009 0 0 1 C07AB.profile.ud50 il6_fibro_dn 15095275 Downregulated following IL-6 treatment in normal skin fibroblasts 10 0.049438868838681 0 0 1 C07AB.profile.ud50 il6_fibro_up 15095275 Upregulated following IL-6 treatment in normal skin fibroblasts 85 0.420230385128788 0 0 1 C07AB.profile.ud50 il6_scar_fibro_dn 15095275 Downregulated following IL-6 treatment in hypertrophic scar fibroblasts 22 0.108765511445098 0 0 1 C07AB.profile.ud50 il6_scar_fibro_up 15095275 Upregulated following IL-6 treatment in hypertrophic scar fibroblasts 44 0.217531022890196 0 0 1 C07AB.profile.ud50 innerear_up 11888886 Genes prefentially expressed in human inner ear tissue (cochlea and vestibule), at least 10-fold higher from a mixture of 29 other tissues 53 0.262026004845009 0 0 1 C07AB.profile.ud50 inos_10_dn 12381414 Ten most-downregulated genes following iNOS induction in hepatocytes 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 inos_10_up 12381414 Ten most-upregulated genes following iNOS induction in hepatocytes 10 0.049438868838681 0 0 1 C07AB.profile.ud50 inos_all_dn 12381414 Downregulated following iNOS induction in hepatocytes (Tables 3-17) 117 0.578434765412567 2 3.45760683760684 0.114512169369275 C07AB.profile.ud50 inos_all_up 12381414 Upregulated following iNOS induction in hepatocytes (Tables 3-17) 87 0.430118158896524 0 0 1 C07AB.profile.ud50 insulin_adip_insens_dn 14530283 Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 25 0.123597172096702 0 0 1 C07AB.profile.ud50 insulin_adip_insens_up 14530283 Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 37 0.18292381470312 0 0 1 C07AB.profile.ud50 insulin_adip_sens_dn 14530283 Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.143372719632175 0 0 1 C07AB.profile.ud50 insulin_adip_sens_up 14530283 Up-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 21 0.10382162456123 0 0 1 C07AB.profile.ud50 insulin_nih3t3_up 11606465 Up-regulated by treatment with insulin of NIH3T3 cells overexpressing insulin receptor 30 0.148316606516043 0 0 1 C07AB.profile.ud50 irs1_ko_adip_dn 15895078 Down-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 201 0.993721263657488 0 0 1 C07AB.profile.ud50 irs1_ko_adip_up 15895078 Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.786078014535027 0 0 1 C07AB.profile.ud50 irs_ko_adip_dn 15895078 Progressively down-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) 64 0.316408760567558 0 0 1 C07AB.profile.ud50 irs_ko_adip_up 15895078 Progressively up-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) 36 0.177979927819252 0 0 1 C07AB.profile.ud50 jnk_dn 12354774 Downregulated by expression of constitutively active JNK in 3T3 cells 57 0.281801552380482 1 3.54859649122807 0.246103700580757 C07AB.profile.ud50 jnk_up 12354774 Upregulated by expression of constitutively active JNK in 3T3 cells 66 0.326296534335294 0 0 1 C07AB.profile.ud50 lal_ko_1mo_up 16127159 Up-regulated at 1 month of age in lungs from lysosomal acid lipase (LAL) knockout mice, which display pulmonary pathology, versus wild-type controls 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 lal_ko_3mo_up 16127159 Up-regulated at 3 months of age in lungs from lysosomal acid lipase (LAL) knockout mice, which display pulmonary pathology, versus wild-type controls 69 0.341128194986899 0 0 1 C07AB.profile.ud50 lal_ko_6mo_up 16127159 Up-regulated at 6 months of age in lungs from lysosomal acid lipase (LAL) knockout mice, which display pulmonary pathology, versus wild-type controls 106 0.524052009690018 0 0 1 C07AB.profile.ud50 lh_granulosa_dn 15026540 Down-regulated in human granulosa cells stimulated with luteinizing hormone (LH) 191 0.944282394818807 3 3.17701570680628 0.0698889287423251 C07AB.profile.ud50 lh_granulosa_up 15026540 Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) 167 0.825629109605972 0 0 1 C07AB.profile.ud50 lvad_heartfailure_dn 12824457 Downregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 78 0.385623176941712 0 0 1 C07AB.profile.ud50 lvad_heartfailure_up 12824457 Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.889899639096258 0 0 1 C07AB.profile.ud50 mammary_dev_up 16278680 Up-regulated in the intact developing mouse mammary gland; higher expression in 5/6 week pubertal glands than in 3 week, mid-pregnant, lactating, involuting or resuckled glands 84 0.41528649824492 0 0 1 C07AB.profile.ud50 maternalcare_tsa-met_all 14635221 Top 100 genes significantly altered in hippocampi from adult offspring of mice with high versus low maternal care, following treatment with either trichostatin, methionine or vehicle control and exposure to open-field stress. 151 0.746526919464083 0 0 1 C07AB.profile.ud50 mbd_targets_all 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by any of several methyl-CpG binding proteins (MeCP2, MBD1, MBD2, MBD3) in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 24 0.118653285212834 0 0 1 C07AB.profile.ud50 mbd_targets_mbd1 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by the methyl-CpG binding protein MBD1 in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 10 0.049438868838681 0 0 1 C07AB.profile.ud50 mbd_targets_mbd2 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by the methyl-CpG binding protein MBD2 in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 mbd_targets_mbd3 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by the methyl-CpG binding protein MBD3 in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 mbd_targets_mecp2 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by the methyl-CpG binding protein MeCP2 in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 10 0.049438868838681 0 0 1 C07AB.profile.ud50 metastasis_adenocarc_dn 12469122 Down-regulated in adenocarcinoma metastases, compared to similar primary tumors; predictive of metastatic potential 97 0.479557027735205 0 0 1 C07AB.profile.ud50 metastasis_adenocarc_up 12469122 Up-regulated in adenocarcinoma metastases, compared to similar primary tumors; predictive of metastatic potential 81 0.400454837593316 1 2.49716049382716 0.330649884429811 C07AB.profile.ud50 methotrexate_probcell_dn 12447701 Down-regulated in pro-B cells (FL5.12) following treatment with methotrexate 22 0.108765511445098 0 0 1 C07AB.profile.ud50 methotrexate_probcell_up 12447701 Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate 24 0.118653285212834 0 0 1 C07AB.profile.ud50 microrna_human 15502875 Predicted human MicroRNA targets 2276 11.2522865476838 10 0.888708260105448 0.6868071875212 C07AB.profile.ud50 microrna_mammal 15502875 Predicted MicroRNA targets conserved across human, mouse and rat 1331 6.58031344242844 7 1.06377911344853 0.486308412786929 C07AB.profile.ud50 microrna_vertebrate 15502875 Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu 214 1.05799179314777 1 0.94518691588785 0.653757451028814 C07AB.profile.ud50 middleage_dn 10741968 Downregulated in fibroblasts from middle-age individuals, compared to young 23 0.113709398328966 0 0 1 C07AB.profile.ud50 middleage_up 10741968 Upregulated in fibroblasts from middle-age individuals, compared to young 25 0.123597172096702 0 0 1 C07AB.profile.ud50 mkk6ee_up 12208764 Upregulated by expression of constitutively active MKK6 31 0.153260493399911 1 6.52483870967742 0.142419818323349 C07AB.profile.ud50 mmc_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to mitomycin C 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 mms_human_lymph_high_24hrs_dn 15515172 Down-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS) 30 0.148316606516043 0 0 1 C07AB.profile.ud50 mms_human_lymph_high_24hrs_up 15515172 Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS) 32 0.158204380283779 1 6.3209375 0.146659597735406 C07AB.profile.ud50 mms_human_lymph_high_4hrs_dn 15515172 Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS) 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 mms_human_lymph_low_4hrs_dn 15515172 Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a low dose of methyl methanesulfonate (MMS) 38 0.187867701586988 0 0 1 C07AB.profile.ud50 mms_mouse_lymph_high_24hrs_up 15515172 Up-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of methyl methanesulfonate (MMS) 63 0.31146487368369 0 0 1 C07AB.profile.ud50 mms_mouse_lymph_high_4hrs_up 15515172 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of methyl methanesulfonate (MMS) 64 0.316408760567558 0 0 1 C07AB.profile.ud50 mms_mouse_lymph_low_4hrs_up 15515172 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of methyl methanesulfonate (MMS) 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 mouse_tissue_adrenal 11904358 Genes expressed specifically in mouse adrenal gland tissue 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 mouse_tissue_bradipose 11904358 Genes expressed specifically in mouse brown adipose tissue 4 0.0197755475354724 0 0 1 C07AB.profile.ud50 mouse_tissue_cerebellum 11904358 Genes expressed specifically in mouse cerebellum tissue 13 0.0642705294902853 0 0 1 C07AB.profile.ud50 mouse_tissue_eye 11904358 Genes expressed specifically in mouse eye tissue 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 mouse_tissue_kidney 11904358 Genes expressed specifically in mouse kidney tissue 20 0.098877737677362 0 0 1 C07AB.profile.ud50 mouse_tissue_mammary 11904358 Genes expressed specifically in mouse mammary gland tissue 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 mouse_tissue_placenta 11904358 Genes expressed specifically in mouse placenta tissue 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 mouse_tissue_salivary 11904358 Genes expressed specifically in mouse salivary gland tissue 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 mouse_tissue_smintestine 11904358 Genes expressed specifically in mouse small intestine tissue 3 0.0148316606516043 0 0 1 C07AB.profile.ud50 mouse_tissue_stomach 11904358 Genes expressed specifically in mouse stomach tissue 2 0.00988777376773619 0 0 1 C07AB.profile.ud50 mouse_tissue_prostate 11904358 Genes expressed specifically in mouse testis tissue 47 0.232362683541801 0 0 1 C07AB.profile.ud50 mouse_tissue_thymus 11904358 Genes expressed specifically in mouse thymus tissue 7 0.0346072081870767 0 0 1 C07AB.profile.ud50 mtx_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to methotrexate 10 0.049438868838681 0 0 1 C07AB.profile.ud50 myc_targets 14519204 Myc-responsive genes reported in multiple systems 77 0.380679290057844 0 0 1 C07AB.profile.ud50 myod_brg1_up 15870273 Genes up-regulated following transduction of MyoD in NIH 3T3 cells that fail to acheive full induction with expression of a dominant-negative BRG1 allele; induction thought to require functional BRG1 40 0.197755475354724 0 0 1 C07AB.profile.ud50 myod_nih3t3_dn 15870273 Down-regulated at 24 hours in NIH 3T3 murine fibroblasts following transduction with MyoD and incubation in differentiation medium 91 0.449893706431997 0 0 1 C07AB.profile.ud50 myod_nih3t3_up 15870273 Up-regulated at 24 hours in NIH 3T3 murine fibroblasts following transduction with MyoD and incubation in differentiation medium 134 0.662480842438325 0 0 1 C07AB.profile.ud50 nab_lung_dn 15318170 Down-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 96 0.474613140851337 0 0 1 C07AB.profile.ud50 nab_lung_up 15318170 Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.187867701586988 0 0 1 C07AB.profile.ud50 nf90_dn 12036489 Downregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells 66 0.326296534335294 0 0 1 C07AB.profile.ud50 nf90_up 12036489 Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells 56 0.276857665496613 0 0 1 C07AB.profile.ud50 ni2_lung_dn 12915101 Downregulated by nickel(II) in human peripheral lung epithelial cells 40 0.197755475354724 0 0 1 C07AB.profile.ud50 ni2_lung_up 12915101 Upregulated by nickel(II) in human peripheral lung epithelial cells 5 0.0247194344193405 0 0 1 C07AB.profile.ud50 ni2_mouse_dn 12540486 Downregulated by nickel(II) in sensitive A/J mouse lung tissue 89 0.440005932664261 0 0 1 C07AB.profile.ud50 ni2_mouse_up 12540486 Upregulated by nickel(II) in sensitive A/J mouse lung tissue 65 0.321352647451426 0 0 1 C07AB.profile.ud50 nova2_ko_splicing 16041372 Genes that are alternatively spliced in the neocortex of mice deficient in the neuron-specific splicing factor Nova2, compared to wild-type controls 85 0.420230385128788 0 0 1 C07AB.profile.ud50 o6bg_resist_medulloblastoma_dn 12479369 Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 109 0.538883670341623 0 0 1 C07AB.profile.ud50 o6bg_resist_medulloblastoma_up 12479369 Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.227418796657932 1 4.39717391304348 0.203862064874593 C07AB.profile.ud50 oldage_dn 10741968 Downregulated in fibroblasts from old individuals, compared to young 76 0.375735403173975 0 0 1 C07AB.profile.ud50 oldage_up 10741968 Upregulated in fibroblasts from old individuals, compared to young 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 old_fibro_dn 14527998 Downregulated in fibroblasts from old individuals, compared to young 211 1.04316013249617 0 0 1 C07AB.profile.ud50 old_fibro_up 14527998 Upregulated in fibroblasts from old individuals, compared to young 84 0.41528649824492 0 0 1 C07AB.profile.ud50 oldonly_fibro_dn 14527998 Downregulated in fibroblasts from old (but not Werner) individuals, compared to young 61 0.301577099915954 0 0 1 C07AB.profile.ud50 oldonly_fibro_up 14527998 Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.266969891728877 0 0 1 C07AB.profile.ud50 oldwerner_fibro_dn 14527998 Commonly downregulated in fibroblasts from Werner Syndrome and old individuals, compared to young 150 0.741583032580215 0 0 1 C07AB.profile.ud50 oldwerner_fibro_up 14527998 Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young 30 0.148316606516043 0 0 1 C07AB.profile.ud50 oxstress_breastca_dn 12414654 Downregulated by H2O2, Menadione and t-BH in breast cancer cells 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 oxstress_breastca_up 12414654 Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.222474909774064 1 4.49488888888889 0.199906493079863 C07AB.profile.ud50 oxstress_rpe_h2o2hne_dn 12419474 Downregulated by H2O2 and HNE in retinal pigment epithelium cells (Tables 4) 73 0.360903742522371 1 2.77082191780822 0.303577545212384 C07AB.profile.ud50 oxstress_rpe_h2o2tbh_dn 12419474 Downregulated by H2O2 and t-BH in retinal pigment epithelium cells (Tables 5) 67 0.331240421219163 0 0 1 C07AB.profile.ud50 oxstress_rpe_hnetbh_dn 12419474 Downregulated by HNE and t-BH in retinal pigment epithelium cells (Tables 3) 137 0.677312503089929 0 0 1 C07AB.profile.ud50 oxstress_rpethree_dn 12419474 Downregulated by all three of H2O2, HNE and t-BH in retinal pigment epithelium cells (Table 2) 61 0.301577099915954 0 0 1 C07AB.profile.ud50 oxstress_rpetwo_dn 12419474 Downregulated by two of H2O2, HNE and t-BH in retinal pigment epithelium cells (Tables 3-5) 275 1.35956889306373 1 0.735527272727273 0.744092899382899 C07AB.profile.ud50 p21_any_dn 12138103 Down-regulated at any timepoint (4-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 50 0.247194344193405 0 0 1 C07AB.profile.ud50 p21_any_up 12138103 Up-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 p21_early_dn 12138103 Down-regulated at early timepoints (4-8 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 p21_early_up 12138103 Up-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 p21_late_dn 12138103 Down-regulated at late timepoints (20-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 8 0.0395510950709448 0 0 1 C07AB.profile.ud50 p21_middle_dn 12138103 Down-regulated at intermediate timepoints (12-16 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 26 0.128541058980571 0 0 1 C07AB.profile.ud50 p21_p53_any_dn 12138103 Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 77 0.380679290057844 0 0 1 C07AB.profile.ud50 p21_p53_early_dn 12138103 Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 23 0.113709398328966 0 0 1 C07AB.profile.ud50 p21_p53_late_dn 12138103 Down-regulated at late timepoints (20-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 p21_p53_middle_dn 12138103 Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 37 0.18292381470312 0 0 1 C07AB.profile.ud50 p53_brca1_up 12802282 Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.242250457309537 1 4.12795918367347 0.215611831112334 C07AB.profile.ud50 p53genes_all 12446780 p53 transcriptional targets 33 0.163148267167647 0 0 1 C07AB.profile.ud50 p53genes_apoptosis 12446780 p53 transcriptional targets involved in apoptosis 14 0.0692144163741534 1 14.4478571428571 0.0670335858789568 C07AB.profile.ud50 p53genes_arrest 12446780 p53 transcriptional targets involved in cell cycle arrest 10 0.049438868838681 0 0 1 C07AB.profile.ud50 paclitaxel_probcell_up 12447701 Up-regulated in pro-B cells (FL5.12) following treatment with paclitaxel 5 0.0247194344193405 0 0 1 C07AB.profile.ud50 parp_ko_dn 11016956 Downregulated in MEF cells from PARP knockout mice 23 0.113709398328966 0 0 1 C07AB.profile.ud50 parp_ko_up 11016956 Upregulated in MEF cells from PARP knockout mice 61 0.301577099915954 0 0 1 C07AB.profile.ud50 pdgf_es_dn 14981515 Down-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 pdgf_es_up 14981515 Up-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis 28 0.138428832748307 0 0 1 C07AB.profile.ud50 pgj2_up 12032289 Upregulated by treatment with the prostaglandin 15d-PGJ2 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 pituitary_fetal_dn 15894316 Down-regulated in human fetal pituitary tissue, compared to adult pituitary tissue 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 pituitary_fetal_up 15894316 Up-regulated in human fetal pituitary tissue, compared to adult pituitary tissue 21 0.10382162456123 0 0 1 C07AB.profile.ud50 platelet_expressed 12433680 Fifty genes most strongly expressed in human platlets from three healthy donors 66 0.326296534335294 0 0 1 C07AB.profile.ud50 pod1_ko_dn 16207825 Down-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 1135 5.61131161319029 1 0.178211453744493 0.99639426031272 C07AB.profile.ud50 pod1_ko_most_dn 16207825 Most strongly down-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 43 0.212587136006328 0 0 1 C07AB.profile.ud50 pod1_ko_most_up 16207825 Most strongly up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 61 0.301577099915954 0 0 1 C07AB.profile.ud50 pod1_ko_up 16207825 Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 508 2.51149453700499 0 0 1 C07AB.profile.ud50 preadip_vs_fibro_dn 12021175 Downregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 preadip_vs_fibro_up 12021175 Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 29 0.143372719632175 0 0 1 C07AB.profile.ud50 prmt5_kd_dn 15485929 Down-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 45 0.222474909774064 0 0 1 C07AB.profile.ud50 prmt5_kd_up 15485929 Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 1.51282938646364 0 0 1 C07AB.profile.ud50 pt650_colonca_dn 11755394 Downregulated by Pt-650, but not Et-743, in HCT116 cells (Fig. 6C) 24 0.118653285212834 0 0 1 C07AB.profile.ud50 pubertal_mammary 17486082 Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. 1260 6.2292974736738 3 0.481595238095238 0.947913626825192 C07AB.profile.ud50 pubertal_mammary_3-4wks_dn 17486082 Down-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. 55 0.271913778612745 0 0 1 C07AB.profile.ud50 pubertal_mammary_3-4wks_up 17486082 Up-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. 301 1.4881099520443 0 0 1 C07AB.profile.ud50 pubertal_mammary_4-5wks_dn 17486082 Down-regulated > 1.5-fold in the developing mouse mammary gland between 4 and 5 weeks of age. 283 1.39911998813467 0 0 1 C07AB.profile.ud50 pubertal_mammary_4-5wks_up 17486082 Up-regulated > 1.5-fold in the developing mouse mammary gland between 4 and 5 weeks of age. 368 1.81935037326346 0 0 1 C07AB.profile.ud50 pubertal_mammary_5-6wks_dn 17486082 Down-regulated > 1.5-fold in the developing mouse mammary gland between 5 and 6 weeks of age. 256 1.26563504227023 1 0.7901171875 0.718823859204628 C07AB.profile.ud50 pubertal_mammary_5-6wks_up 17486082 Up-regulated > 1.5-fold in the developing mouse mammary gland between 5 and 6 weeks of age. 143 0.706975824393138 0 0 1 C07AB.profile.ud50 pubertal_mammary_6-7wks_dn 17486082 Down-regulated > 1.5-fold in the developing mouse mammary gland between 6 and 7 weeks of age. 106 0.524052009690018 0 0 1 C07AB.profile.ud50 pubertal_mammary_6-7wks_up 17486082 Up-regulated > 1.5-fold in the developing mouse mammary gland between 6 and 7 weeks of age. 363 1.79463093884412 2 1.11443526170799 0.536151027858328 C07AB.profile.ud50 ra_saha_up 11696577 Upregulated by the combination of retinoic acid and the HDACi SAHA in NB4 (APL) cells 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 ras-grf1_ko_dn 17321057 Down-regulated in LCM-dissected hippocampus samples of Ras-GRF1 knockout mice compared to wild-type controls. 41 0.202699362238592 0 0 1 C07AB.profile.ud50 ras-grf1_ko_up 17321057 Up-regulated in LCM-dissected hippocampus samples of Ras-GRF1 knockout mice compared to wild-type controls. 10 0.049438868838681 0 0 1 C07AB.profile.ud50 rb_creko_dn 17452985 Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 1.23597172096702 0 0 1 C07AB.profile.ud50 rb_creko_up 17452985 Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 344 1.70069708805063 1 0.587994186046512 0.818212166660196 C07AB.profile.ud50 rb_ko_dn 17452985 Down-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. 149 0.736639145696346 2 2.71503355704698 0.168404475310214 C07AB.profile.ud50 rb_ko_up 17452985 Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. 155 0.766302466999555 1 1.30496774193548 0.536154144500854 C07AB.profile.ud50 rcc_nl_up 12692265 Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) 899 4.44455430859742 3 0.674983314794216 0.820790767316741 C07AB.profile.ud50 refractory_gastric_dn 15033468 Downregulated in samples of gastric cancer refractory to 5-FU/cisplatin treatment, compared to chemosensitive controls 16 0.0791021901418896 1 12.641875 0.0762357431332417 C07AB.profile.ud50 refractory_gastric_up 15033468 Upregulated in samples of gastric cancer refractory to 5-FU/cisplatin treatment, compared to chemosensitive controls 204 1.00855292430909 1 0.991519607843137 0.636164798758892 C07AB.profile.ud50 reovirus_hek293_dn 12885910 Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 488 2.41261679932763 1 0.414487704918033 0.910953839035257 C07AB.profile.ud50 reovirus_hek293_up 12885910 Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 2.42744845997924 2 0.823910386965377 0.698245064674902 C07AB.profile.ud50 resistance_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to at least six of seven anticancer drugs tested 45 0.222474909774064 0 0 1 C07AB.profile.ud50 rett_dn 12418965 Downregulated by expression of mutant MeCP2 (Rett syndrome) vs. wt MeCP2 in fibroblasts 31 0.153260493399911 0 0 1 C07AB.profile.ud50 rett_up 12418965 Upregulated by expression of mutant MeCP2 (Rett syndrome) vs. wt MeCP2 in fibroblasts 71 0.351015968754635 0 0 1 C07AB.profile.ud50 ribavirin_rsv_dn 12719586 Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin 101 0.499332575270678 0 0 1 C07AB.profile.ud50 ribavirin_rsv_up 12719586 Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is enhanced by the anti-viral drug ribavirin 37 0.18292381470312 0 0 1 C07AB.profile.ud50 ros_mouse_aorta_dn 15054141 Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.627873634251248 0 0 1 C07AB.profile.ud50 ros_mouse_aorta_up 15054141 Up-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 30 0.148316606516043 0 0 1 C07AB.profile.ud50 sarcomas_gistromal_dn 11965276 Top 20 negative significant genes associated with GI stromal tumors, versus other soft-tissue tumors. 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 sarcomas_gistromal_up 11965276 Top 20 positive significant genes associated with GI stromal tumors, versus other soft-tissue tumors. 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 sarcomas_histiocytoma_dn 11965276 Top 20 negative significant genes associated with malignant fibrous histiocytomas, versus other soft-tissue tumors. 10 0.049438868838681 0 0 1 C07AB.profile.ud50 sarcomas_histiocytoma_up 11965276 Top 20 positive significant genes associated with malignant fibrous histiocytomas, versus other soft-tissue tumors. 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 sarcomas_leiomyosarcoma_calp_dn 11965276 Top 20 negative significant genes associated with calponin positive leiomyosarcoma tumors, versus other soft-tissue tumors. 18 0.0889899639096258 0 0 1 C07AB.profile.ud50 sarcomas_leiomyosarcoma_calp_up 11965276 Top 20 positive significant genes associated with calponin positive leiomyosarcoma tumors, versus other soft-tissue tumors. 14 0.0692144163741534 1 14.4478571428571 0.0670335858789568 C07AB.profile.ud50 sarcomas_leiomyosarcoma_dn 11965276 Top 20 negative significant genes associated with calponin negative leiomyosarcoma tumors, versus other soft-tissue tumors. 13 0.0642705294902853 0 0 1 C07AB.profile.ud50 sarcomas_leiomyosarcoma_up 11965276 Top 20 positive significant genes associated with calponin negative leiomyosarcoma tumors, versus other soft-tissue tumors. 12 0.0593266426064172 1 16.8558333333333 0.0577397605421464 C07AB.profile.ud50 sarcomas_liposarcoma_dn 11965276 Top 20 negative significant genes associated with liposarcomas, versus other soft-tissue tumors. 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 sarcomas_liposarcoma_up 11965276 Top 20 positive significant genes associated with liposarcomas, versus other soft-tissue tumors. 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 sarcomas_schwannoma_dn 11965276 Top 20 negative significant genes associated with schwannomas, versus other soft-tissue tumors. 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 sarcomas_schwannoma_up 11965276 Top 20 positive significant genes associated with schwannomas, versus other soft-tissue tumors. 18 0.0889899639096258 0 0 1 C07AB.profile.ud50 sarcomas_synovial_dn 11965276 Top 20 negative significant genes associated with synovial sarcomas, versus other soft-tissue tumors. 29 0.143372719632175 0 0 1 C07AB.profile.ud50 sarcomas_synovial_up 11965276 Top 20 positive significant genes associated with synovial sarcomas, versus other soft-tissue tumors. 16 0.0791021901418896 1 12.641875 0.0762357431332417 C07AB.profile.ud50 scar_fibro_dn 15095275 Downregulated in hypertrophic scar fibroblasts, compared to normal skin fibroblasts 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 scar_fibro_up 15095275 Upregulated in hypertrophic scar fibroblasts, compared to normal skin fibroblasts 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 scchn_hpvneg_dn 17079134 Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 47 0.232362683541801 0 0 1 C07AB.profile.ud50 scchn_hpvneg_up 17079134 Up-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 30 0.148316606516043 0 0 1 C07AB.profile.ud50 scchn_hpvpos_dn 17079134 Down-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 25 0.123597172096702 0 0 1 C07AB.profile.ud50 scchn_hpvpos_up 17079134 Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 31 0.153260493399911 0 0 1 C07AB.profile.ud50 scw_joint_24hrs_dn 15642130 Down-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 24 0.118653285212834 0 0 1 C07AB.profile.ud50 scw_joint_24hrs_up 15642130 Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 143 0.706975824393138 1 1.41447552447552 0.507730628890774 C07AB.profile.ud50 scw_joint_4hrs_up 15642130 Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 230 1.13709398328966 1 0.879434782608696 0.680153509053981 C07AB.profile.ud50 scw_joint_react_dn 15642130 Down-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 231 1.14203787017353 3 2.62688311688312 0.107749126846321 C07AB.profile.ud50 scw_joint_react_up 15642130 Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.820685222722104 1 1.21849397590361 0.560764964796363 C07AB.profile.ud50 senescence_hela_dn 17182682 Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 1.68586542739902 0 0 1 C07AB.profile.ud50 senescence_hela_up 17182682 Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 262 1.29529836357344 3 2.31606870229008 0.141403892130622 C07AB.profile.ud50 senescence_hff_dn 17182682 Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 1.47822217827656 0 0 1 C07AB.profile.ud50 senescence_hff_up 17182682 Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 1.40406387501854 0 0 1 C07AB.profile.ud50 senescence_rep-ind_dn 17182682 Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.845404657141445 0 0 1 C07AB.profile.ud50 senescence_rep-ind_up 17182682 Up-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 31 0.153260493399911 0 0 1 C07AB.profile.ud50 serum_fibroblast_cellcycle 14737219 Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.973945716122015 1 1.02675126903553 0.623320738711315 C07AB.profile.ud50 serum_fibroblast_core_dn 14737219 Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 1.57709991595392 1 0.634075235109718 0.794233102154105 C07AB.profile.ud50 serum_fibroblast_core_up 14737219 Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) 292 1.44361497008948 1 0.692705479452055 0.764770891515624 C07AB.profile.ud50 shh_up 12444557 Upregulated by sonic hedgehog (shh) expression in murine neuronal precursor cells 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 shortattacklatency_up 14635221 Up-regulated in hippocampi from a mouse line selected for long attack latency (LAL) against an intruder, versus a line selected for short attack latency (SAL). 156 0.771246353883423 1 1.29660256410256 0.538447345941993 C07AB.profile.ud50 space_up 12039873 Upregulated in space-flown fibroblasts 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 stemcell_common_dn 12228720 Depleted in mouse embryonic, neural and hematopoietic stem cells, compared to differentiated brain and bone marrow cells 104 0.514164235922282 0 0 1 C07AB.profile.ud50 stemcell_common_up 12228720 Enriched in mouse embryonic, neural and hematopoietic stem cells, compared to differentiated brain and bone marrow cells 265 1.31013002422505 1 0.763283018867924 0.731090209078262 C07AB.profile.ud50 stemcell_embryonic_up 12228720 Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 9.83339101201365 8 0.813554550025138 0.76505920874242 C07AB.profile.ud50 stemcell_hematopoietic_up 12228720 Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells 2092 10.3426113610521 6 0.580124282982792 0.945235499262166 C07AB.profile.ud50 stemcell_neural_up 12228720 Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells 2805 13.86760270925 12 0.865326203208556 0.729249674903841 C07AB.profile.ud50 stress_arsenic_specific_dn 15824734 Genes down-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 48 0.237306570425669 1 4.21395833333333 0.211714637447666 C07AB.profile.ud50 stress_arsenic_specific_up 15824734 Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 1.31507391110891 0 0 1 C07AB.profile.ud50 stress_genotoxic_specific_dn 15824734 Genes down-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress 74 0.365847629406239 1 2.73337837837838 0.30702057905224 C07AB.profile.ud50 stress_genotoxic_specific_up 15824734 Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress 67 0.331240421219163 1 3.0189552238806 0.282557115198203 C07AB.profile.ud50 stress_ionizing_specific_dn 15824734 Genes down-regulated 4 hours following ionizing radiation treatment that discriminate IR from other stress agents 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 stress_ionizing_specific_up 15824734 Genes up-regulated 4 hours following ionizing radiation treatment that discriminate IR from other stress agents 29 0.143372719632175 0 0 1 C07AB.profile.ud50 stress_p53_specific_up 15824734 Genes discriminating p53 status 4 hours after DNA-damaging treatments (more strongly up-regulated in p53+/+ TK6 cells than p53-/- NH32 cells) 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 stress_tpa_specific_dn 15824734 Genes down-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents 5 0.0247194344193405 0 0 1 C07AB.profile.ud50 stress_tpa_specific_up 15824734 Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents 78 0.385623176941712 1 2.59320512820513 0.320623334181982 C07AB.profile.ud50 tafi_kd_dn 17179179 Down-regulated by stable siRNA knock-down of histone chaperone TAF-I in HeLa cells. 62 0.306520986799822 0 0 1 C07AB.profile.ud50 tafi_kd_up 17179179 Up-regulated by stable siRNA knock-down of histone chaperone TAF-I in HeLa cells. 20 0.098877737677362 0 0 1 C07AB.profile.ud50 tcell_anergic_up 15834410 Genes up-regulated in anergic mouse T helper cells (A.E7), versus non-anergic stimulated controls 132 0.652593068670589 1 1.53234848484848 0.480148236644364 C07AB.profile.ud50 tff2_ko_dn 16121031 Down-regulated in pyloric atrium tissue from Trefoil Factor 2 (Tff2) knockout mice, compared to wild-type controls 11 0.0543827557225491 0 0 1 C07AB.profile.ud50 tff2_ko_up 16121031 Up-regulated in pyloric atrium tissue from Trefoil Factor 2 (Tff2) knockout mice, compared to wild-type controls 36 0.177979927819252 1 5.61861111111111 0.163410139213889 C07AB.profile.ud50 tgfbeta_all_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, at any timepoint 200 0.988777376773619 0 0 1 C07AB.profile.ud50 tgfbeta_c1_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 1 42 0.20764324912246 0 0 1 C07AB.profile.ud50 tgfbeta_c2_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 2 46 0.227418796657932 0 0 1 C07AB.profile.ud50 tgfbeta_c3_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 3 38 0.187867701586988 0 0 1 C07AB.profile.ud50 tgfbeta_c4_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 4 26 0.128541058980571 0 0 1 C07AB.profile.ud50 tgfbeta_c5_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 5 41 0.202699362238592 0 0 1 C07AB.profile.ud50 tgfbeta_c6_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 6 7 0.0346072081870767 0 0 1 C07AB.profile.ud50 tgfbeta_early_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts at 30 min (clusters 1-3) 126 0.62292974736738 0 0 1 C07AB.profile.ud50 tgfbeta_late_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts only at 1-4 hrs (clusters 4-6) 74 0.365847629406239 0 0 1 C07AB.profile.ud50 tgfb_hmvec_2hr_dn 16405919 Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 1.74519207000544 1 0.57300283286119 0.826142687223598 C07AB.profile.ud50 tgfb_hmvec_2hr_up 16405919 Up-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1997 9.87294210708459 9 0.91158237356034 0.653229458161916 C07AB.profile.ud50 tgfb_hmvec_4hr_dn 16405919 Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 6.53087457358976 1 0.153118849356548 0.998565690791516 C07AB.profile.ud50 tgfb_hmvec_4hr_up 16405919 Up-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1997 9.87294210708459 9 0.91158237356034 0.653229458161916 C07AB.profile.ud50 tgfb_mammary_dn 17210685 Down-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). 106 0.524052009690018 0 0 1 C07AB.profile.ud50 tgfb_mammary_up 17210685 Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). 118 0.583378652296435 0 0 1 C07AB.profile.ud50 tgfb-wnt3a_mammary_dn 17210685 Down-regulated in common by both TGF-beta and Wnt3A in normal mouse mammary gland cells (top 124 genes). 106 0.524052009690018 0 0 1 C07AB.profile.ud50 tgfb-wnt3a_mammary_up 17210685 Up-regulated in common by both TGF-beta and Wnt3A in normal mouse mammary gland cells (top 124 genes). 136 0.672368616206061 1 1.48727941176471 0.490352603508563 C07AB.profile.ud50 tgz_adip_up 12732648 Upregulated in mature, differentiated adipocytes following treatment with troglitazone 43 0.212587136006328 0 0 1 C07AB.profile.ud50 tis7_overexp_dn 12198164 Downregulated by overexpression of TIS7 in murine mammary epithelial cells 27 0.133484945864439 0 0 1 C07AB.profile.ud50 tnfalpha_30min_up 12673210 Upregulated 30min after TNF-alpha treatment of HeLa cells 68 0.336184308103031 0 0 1 C07AB.profile.ud50 tnfalpha_4hrs_up 12673210 Upregulated 4hrs after TNF-alpha treatment of HeLa cells 62 0.306520986799822 0 0 1 C07AB.profile.ud50 tnfalpha_adip_dn 12732648 Downregulated in mature, differentiated adipocytes following treatment with TNFalpha 101 0.499332575270678 0 0 1 C07AB.profile.ud50 tnfalpha_adip_up 12732648 Upregulated in mature, differentiated adipocytes following treatment with TNFalpha 22 0.108765511445098 0 0 1 C07AB.profile.ud50 tnfalpha_all_up 12673210 Upregulated at any timepoint after TNF-alpha treatment of HeLa cells 122 0.603154199831908 0 0 1 C07AB.profile.ud50 tnfalpha_tgz_adip_dn 12732648 Downregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha 39 0.192811588470856 0 0 1 C07AB.profile.ud50 tnfalpha_tgz_adip_up 12732648 Upregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha 28 0.138428832748307 0 0 1 C07AB.profile.ud50 tnfa_nfkb_dep_up 15722553 Up-regulated at any timepoint following TNFa treatment, only with functional NFkB 26 0.128541058980571 0 0 1 C07AB.profile.ud50 tnfa_nfkb_ind_dn 15722553 Down-regulated at any timepoint following TNFa treatment, independent of NFkB function 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 tnfa_nfkb_ind_up 15722553 Up-regulated at any timepoint following TNFa treatment, independent of NFkB function 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 tpa_resist_early_dn 12384596 Downregulated by TPA at two consecutive timepoints between 15min-3hrs in resistant HL-525 cells 140 0.692144163741534 1 1.44478571428571 0.500356664996424 C07AB.profile.ud50 tpa_resist_early_up 12384596 Upregulated by TPA at two consecutive timepoints between 15min-3hrs in resistant HL-525 cells 57 0.281801552380482 0 0 1 C07AB.profile.ud50 tpa_resist_late_dn 12384596 Downregulated by TPA at two consecutive timepoints between 12-48 hrs in resistant HL-525 cells 112 0.553715330993227 0 0 1 C07AB.profile.ud50 tpa_resist_late_up 12384596 Upregulated by TPA at two consecutive timepoints between 12-48 hrs in resistant HL-525 cells 79 0.39056706382558 1 2.56037974683544 0.323982095569325 C07AB.profile.ud50 tpa_resist_middle_dn 12384596 Downregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells 209 1.03327235872843 2 1.9355980861244 0.27650873773422 C07AB.profile.ud50 tpa_resist_middle_up 12384596 Upregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells 100 0.49438868838681 0 0 1 C07AB.profile.ud50 tpa_sens_early_dn 12384596 Downregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells 564 2.78835220250161 2 0.717269503546099 0.767690845333403 C07AB.profile.ud50 tpa_sens_early_up 12384596 Upregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells 97 0.479557027735205 0 0 1 C07AB.profile.ud50 tpa_sens_late_dn 12384596 Downregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells 451 2.22969298462451 2 0.896984478935698 0.65334027400134 C07AB.profile.ud50 tpa_sens_late_up 12384596 Upregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells 95 0.469669253967469 2 4.25831578947368 0.0807619697726046 C07AB.profile.ud50 tpa_sens_middle_dn 12384596 Downregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells 561 2.77352054185 4 1.44221033868093 0.302051890407543 C07AB.profile.ud50 tpa_sens_middle_up 12384596 Upregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells 114 0.563603104760963 2 3.54859649122807 0.109719577494146 C07AB.profile.ud50 tpa_skin_dn 12640676 Downregulated in murine dorsal skin cells 6 hours after treatment with the phorbol ester carcinogen TPA 25 0.123597172096702 1 8.0908 0.116535092656397 C07AB.profile.ud50 tpa_skin_up 12640676 Upregulated in murine dorsal skin cells 6 hours after treatment with the phorbol ester carcinogen TPA 31 0.153260493399911 0 0 1 C07AB.profile.ud50 tsa_cd4_dn 14606959 Down-regulated in mouse CD4+ T-cells following 4 hour treatment with 100 nM trichostatin A 33 0.163148267167647 0 0 1 C07AB.profile.ud50 tsa_cd4_up 14606959 Up-regulated in mouse CD4+ T-cells following 4 hour treatment with 100 nM trichostatin A 43 0.212587136006328 0 0 1 C07AB.profile.ud50 tsadac_hypermeth_hyperac_ovca_up 12727835 Genes with basally hypermethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells, with hyperacetylated promoters upon activation 16 0.0791021901418896 0 0 1 C07AB.profile.ud50 tsadac_hypermeth_ovca_up 12727835 Genes with basally hypermethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells 18 0.0889899639096258 0 0 1 C07AB.profile.ud50 tsadac_hypometh_hyperac_ovca_up 12727835 Genes with basally hypomethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells, with hyperacetylated promoters upon activation 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 tsadac_hypometh_ovca_up 12727835 Genes with basally hypomethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells 70 0.346072081870767 1 2.88957142857143 0.293145464042583 C07AB.profile.ud50 tsadac_panc50_up 12839967 50 "most interesting" genes upregulated by the combination of TSA and DAC in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 56 0.276857665496613 0 0 1 C07AB.profile.ud50 tsadac_rkoexp_up 11992124 Genes with some basal expression and partially-methylated promoters, upregulated by the combination of TSA and DAC in RKO cells 14 0.0692144163741534 1 14.4478571428571 0.0670335858789568 C07AB.profile.ud50 tsadac_rkosilent_up 11992124 Genes basally silent, with hypermethylated promoters, upregulated by the combination of TSA and DAC in RKO cells 30 0.148316606516043 0 0 1 C07AB.profile.ud50 tsa_hepatoma_cancer_dn 15452378 Cancer-related genes down-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A 51 0.252138231077273 1 3.96607843137255 0.223348511843017 C07AB.profile.ud50 tsa_hepatoma_cancer_up 15452378 Cancer-related genes up-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A 69 0.341128194986899 0 0 1 C07AB.profile.ud50 tsa_hepatoma_cancer_up_ac 15452378 Cancer-related genes up-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A, which are associated by ChIP with acetylated histone H3 or H4 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 tsa_hepatoma_up 15336447 Up-regulated in more than one of several human hepatoma cell lines by 24-hour treatment with trichostatin A 67 0.331240421219163 0 0 1 C07AB.profile.ud50 tsa_hepg2_dn 16854234 Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). 1237 6.11558807534484 6 0.981099434114794 0.573138488215954 C07AB.profile.ud50 tsa_hepg2_up 16854234 Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). 936 4.62747812330054 8 1.72880341880342 0.0969378750083678 C07AB.profile.ud50 tsa_panc50_up 12839967 50 "most interesting" genes upregulated by TSA treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 77 0.380679290057844 0 0 1 C07AB.profile.ud50 tsa_rko_up 11992124 Upregulated by TSA alone, with non-hypermethylated promoters, in RKO cells 28 0.138428832748307 1 7.22392857142857 0.129573670122122 C07AB.profile.ud50 tzd_adip_dn 12021175 Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 29 0.143372719632175 0 0 1 C07AB.profile.ud50 tzd_adip_up 12021175 Upregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 11 0.0543827557225491 1 18.3881818181818 0.0530581873347243 C07AB.profile.ud50 uv-4nqo_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with UV light or 4-NQO, but not by gamma radiation 48 0.237306570425669 0 0 1 C07AB.profile.ud50 uv-4nqo_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with UV light or 4-NQO, but not by gamma radiation 61 0.301577099915954 0 0 1 C07AB.profile.ud50 uvb_nhek1_c1 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 1 112 0.553715330993227 0 0 1 C07AB.profile.ud50 uvb_nhek1_c2 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.138428832748307 0 0 1 C07AB.profile.ud50 uvb_nhek1_c3 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 3 26 0.128541058980571 1 7.77961538461538 0.120902843224171 C07AB.profile.ud50 uvb_nhek1_c4 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 4 20 0.098877737677362 0 0 1 C07AB.profile.ud50 uvb_nhek1_c5 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 5 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 uvb_nhek1_c6 12771951 Downregulated by UV-B light in normal human epidermal keratinocytes, cluster 6 268 1.32496168487665 3 2.26421641791045 0.148282601865523 C07AB.profile.ud50 uvb_nhek1_dn 12771951 Downregulated by UV-B light in normal human epidermal keratinocytes 542 2.67958669105651 4 1.49276752767528 0.28123721580178 C07AB.profile.ud50 uvb_nhek1_up 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes 336 1.66114599297968 2 1.2039880952381 0.495108823506698 C07AB.profile.ud50 uvb_nhek2_dn 11982916 Downregulated by UV-B light in normal human epidermal keratinocytes 160 0.791021901418896 1 1.2641875 0.547507337541811 C07AB.profile.ud50 uvb_nhek2_up 11982916 Upregulated by UV-B light in normal human epidermal keratinocytes 125 0.617985860483512 1 1.61816 0.461796501458758 C07AB.profile.ud50 uvb_nhek3_all 11867738 Regulated by UV-B light in normal human epidermal keratinocytes 751 3.71285904978494 3 0.808002663115846 0.717450578316925 C07AB.profile.ud50 uvb_nhek3_c0 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 167 0.825629109605972 2 2.42239520958084 0.200291262102919 C07AB.profile.ud50 uvb_nhek3_c1 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 1 104 0.514164235922282 0 0 1 C07AB.profile.ud50 uvb_nhek3_c2 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 2 89 0.440005932664261 0 0 1 C07AB.profile.ud50 uvb_nhek3_c3 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 3 37 0.18292381470312 0 0 1 C07AB.profile.ud50 uvb_nhek3_c4 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 4 20 0.098877737677362 1 10.1135 0.0943686610871122 C07AB.profile.ud50 uvb_nhek3_c5 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 5 85 0.420230385128788 0 0 1 C07AB.profile.ud50 uvb_nhek3_c6 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 6 47 0.232362683541801 0 0 1 C07AB.profile.ud50 uvb_nhek3_c7 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.425174272012656 0 0 1 C07AB.profile.ud50 uvb_nhek3_c8 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 8 132 0.652593068670589 0 0 1 C07AB.profile.ud50 uvb_nhek4_1hr_dn 11532376 Downregulated at 1 hour by UV-B light in normal human epidermal keratinocytes 13 0.0642705294902853 0 0 1 C07AB.profile.ud50 uvb_nhek4_1hr_up 11532376 Upregulated at 1 hour by UV-B light in normal human epidermal keratinocytes 18 0.0889899639096258 0 0 1 C07AB.profile.ud50 uvb_nhek4_24hrs_dn 11532376 Downregulated at 24 hours by UV-B light in normal human epidermal keratinocytes 23 0.113709398328966 0 0 1 C07AB.profile.ud50 uvb_nhek4_24hrs_up 11532376 Upregulated at 24 hours by UV-B light in normal human epidermal keratinocytes 14 0.0692144163741534 0 0 1 C07AB.profile.ud50 uvb_nhek4_6hrs_dn 11532376 Downregulated at 6 hours by UV-B light in normal human epidermal keratinocytes 31 0.153260493399911 0 0 1 C07AB.profile.ud50 uvb_nhek4_6hrs_up 11532376 Upregulated at 6 hours by UV-B light in normal human epidermal keratinocytes 49 0.242250457309537 0 0 1 C07AB.profile.ud50 uvb_scc_dn 12771951 Downregulated by UV-B light in squamous cell carinoma cells 219 1.08271122756711 2 1.84721461187215 0.294710139417381 C07AB.profile.ud50 uvb_scc_up 12771951 Upregulated by UV-B light in squamous cell carcinoma cells 198 0.978889603005883 2 2.04313131313131 0.256455585827199 C07AB.profile.ud50 uvc_high_all_dn 12907719 Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 3.13442428437237 6 1.91422712933754 0.097564845562593 C07AB.profile.ud50 uvc_high_all_up 12907719 Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.168092154051515 1 5.94911764705882 0.155076377218804 C07AB.profile.ud50 uvc_high_b2_up 12907719 Up-regulated at 18-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b2) 15 0.0741583032580215 0 0 1 C07AB.profile.ud50 uvc_high_b4_up 12907719 Progressively up-regulated from 12-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b4) 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 uvc_high_d1_dn 12907719 Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) 31 0.153260493399911 1 6.52483870967742 0.142419818323349 C07AB.profile.ud50 uvc_high_d2_dn 12907719 Down-regulated consistently at 6-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d2) 82 0.405398724477184 4 9.86682926829268 0.000768615899413914 C07AB.profile.ud50 uvc_high_d3_dn 12907719 Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d3) 90 0.444949819548129 1 2.24744444444444 0.359850380184236 C07AB.profile.ud50 uvc_high_d4_dn 12907719 Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d4) 110 0.543827557225491 0 0 1 C07AB.profile.ud50 uvc_high_d5_dn 12907719 Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d5) 74 0.365847629406239 0 0 1 C07AB.profile.ud50 uvc_high_d6_dn 12907719 Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d6) 65 0.321352647451426 0 0 1 C07AB.profile.ud50 uvc_high_d7_dn 12907719 Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d7) 63 0.31146487368369 0 0 1 C07AB.profile.ud50 uvc_high_d8_dn 12907719 Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.346072081870767 0 0 1 C07AB.profile.ud50 uvc_high_d9_dn 12907719 Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.262026004845009 0 0 1 C07AB.profile.ud50 uvc_low_a1_up 12907719 Up-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a1) 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 uvc_low_a2_up 12907719 Up-regulated at 6-12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a2) 17 0.0840460770257577 0 0 1 C07AB.profile.ud50 uvc_low_a3_up 12907719 Up-regulated at 12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a3) 6 0.0296633213032086 0 0 1 C07AB.profile.ud50 uvc_low_all_dn 12907719 Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters c1-c5) 115 0.568546991644831 0 0 1 C07AB.profile.ud50 uvc_low_all_up 12907719 Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) 33 0.163148267167647 0 0 1 C07AB.profile.ud50 uvc_low_c1_dn 12907719 Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster c1) 21 0.10382162456123 0 0 1 C07AB.profile.ud50 uvc_low_c2_dn 12907719 Down-regulated at 6-12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster c2) 34 0.168092154051515 0 0 1 C07AB.profile.ud50 uvc_low_c3_dn 12907719 Down-regulated at 12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster c3) 33 0.163148267167647 0 0 1 C07AB.profile.ud50 uv-cmv_unique_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 164 0.810797448954368 0 0 1 C07AB.profile.ud50 uv-cmv_unique_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 194 0.959114055470411 1 1.04262886597938 0.617678260353918 C07AB.profile.ud50 uvc_ttd_4hr_dn 15608684 Down-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 641 3.16903149255945 5 1.57776911076443 0.213529179296046 C07AB.profile.ud50 uvc_ttd_4hr_up 15608684 Up-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 105 0.51910812280615 1 1.92638095238095 0.40571458228544 C07AB.profile.ud50 uvc_ttd_8hr_dn 15608684 Down-regulated at 8 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 382 1.88856478963761 2 1.05900523560209 0.563621698723689 C07AB.profile.ud50 uvc_ttd_8hr_up 15608684 Up-regulated at 8 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 47 0.232362683541801 0 0 1 C07AB.profile.ud50 uvc_ttd_all_dn 15608684 Down-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 780 3.85623176941712 6 1.55592307692308 0.192395811690564 C07AB.profile.ud50 uvc_ttd_all_up 15608684 Up-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 140 0.692144163741534 1 1.44478571428571 0.500356664996424 C07AB.profile.ud50 uvc_ttd-xpcs_common_dn 15608684 Down-regulated at any timepoint following treatment of both XPB/CS and XPB/TTD fibroblasts with 3 J/m^2 UVC 344 1.70069708805063 2 1.17598837209302 0.507510051745443 C07AB.profile.ud50 uvc_ttd-xpcs_common_up 15608684 Up-regulated at any timepoint following treatment of both XPB/CS and XPB/TTD fibroblasts with 3 J/m^2 UVC 44 0.217531022890196 0 0 1 C07AB.profile.ud50 uvc_xpcs_4hr_dn 15608684 Down-regulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 519 2.56587729272754 4 1.55892100192678 0.256360724662946 C07AB.profile.ud50 uvc_xpcs_4hr_up 15608684 Up-regulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 23 0.113709398328966 0 0 1 C07AB.profile.ud50 uvc_xpcs_8hr_dn 15608684 Down-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 911 4.50388095120384 6 1.33218441273326 0.297521925986939 C07AB.profile.ud50 uvc_xpcs_8hr_up 15608684 Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 108 0.533939783457755 0 0 1 C07AB.profile.ud50 uvc_xpcs_all_dn 15608684 Down-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 1048 5.18119345429377 7 1.35104007633588 0.264454820232954 C07AB.profile.ud50 uvc_xpcs_all_up 15608684 Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 112 0.553715330993227 0 0 1 C07AB.profile.ud50 uv_esr_old_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of fibroblasts from elderly donors with UV light 36 0.177979927819252 0 0 1 C07AB.profile.ud50 uv_esr_ws_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of Werner syndrome fibroblasts with UV light 23 0.113709398328966 0 0 1 C07AB.profile.ud50 uv_unique_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO 66 0.326296534335294 1 3.06469696969697 0.278992535853036 C07AB.profile.ud50 uv_unique_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO 30 0.148316606516043 0 0 1 C07AB.profile.ud50 vcr_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to vincristine 9 0.0444949819548129 0 0 1 C07AB.profile.ud50 vcr_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to vincristine 12 0.0593266426064172 0 0 1 C07AB.profile.ud50 vegf_huvec_2hrs_up 12197474 Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells 54 0.266969891728877 0 0 1 C07AB.profile.ud50 vegf_huvec_30min_up 12197474 Up-regulated 30 minutes after VEGF treatment in human umbilical vein endothelial cells 41 0.202699362238592 1 4.93341463414634 0.183886696399877 C07AB.profile.ud50 vegf_huvec_up 12197474 20 genes with the largest fold-change up-regulation at any time point (30min to 24 hours) after VEGF treatment in human umbilical vein endothelial cells 24 0.118653285212834 0 0 1 C07AB.profile.ud50 vegf_hmmec_12hrs_up 12200464 Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.187867701586988 0 0 1 C07AB.profile.ud50 vegf_hmmec_3hrs_up 12200464 Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 99 0.489444801502942 0 0 1 C07AB.profile.ud50 vegf_hmmec_6hrs_up 12200464 Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 88 0.435062045780393 0 0 1 C07AB.profile.ud50 vegf_hmmec_all_up 12200464 Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells 147 0.72675137192861 0 0 1 C07AB.profile.ud50 ventricle_up 15103417 Upregulated in the ventricles of healthy hearts, compared to atria 373 1.8440698076828 1 0.542278820375335 0.84254936905051 C07AB.profile.ud50 vhl_normal_up 12692265 Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) 754 3.72769071043655 4 1.07305039787798 0.51198549857427 C07AB.profile.ud50 vhl_rcc_up 12692265 Upregulated in VHL-null renal carcinoma cells vs. VHL-rescued (Fig. 1a+b) 153 0.756414693231819 0 0 1 C07AB.profile.ud50 vlb_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to vinblastine 28 0.138428832748307 0 0 1 C07AB.profile.ud50 werner_fibro_dn 14527998 Downregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals 238 1.17664507836061 0 0 1 C07AB.profile.ud50 werner_fibro_up 14527998 Upregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals 81 0.400454837593316 0 0 1 C07AB.profile.ud50 werneronly_fibro_dn 14527998 Downregulated in fibroblasts from Werner (but not old) individuals, compared to young 90 0.444949819548129 0 0 1 C07AB.profile.ud50 werneronly_fibro_up 14527998 Upregulated in fibroblasts from Werner (but not old) individuals, compared to young 51 0.252138231077273 0 0 1 C07AB.profile.ud50 wnt3a_mammary_dn 17210685 Down-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). 100 0.49438868838681 0 0 1 C07AB.profile.ud50 wnt3a_mammary_up 17210685 Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). 133 0.657536955554457 0 0 1 C07AB.profile.ud50 xpb_ttd-cs_dn 15608684 Down-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) 41 0.202699362238592 0 0 1 C07AB.profile.ud50 xpb_ttd-cs_up 15608684 Up-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) 57 0.281801552380482 0 0 1 C07AB.profile.ud50 zmpste24_ko_dn 16079796 Fifty genes most strongly down-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 42 0.20764324912246 0 0 1 C07AB.profile.ud50 zmpste24_ko_up 16079796 Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 57 0.281801552380482 0 0 1 C07AB.profile.ud50