#list name reference description total probes expected actual enrichment bin prob analysis_name 17aag_ovca_dn 17409432 Down-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) 129 0.318880704009492 0 0 1 C07AA.profile.d50 17aag_ovca_up 17409432 Up-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) 53 0.131013002422505 0 0 1 C07AA.profile.d50 3ab_gamma_dn 12379459 Downregulated synergystically by gamma-irradiation and 3-aminobenzamine (PARP inhibitor) 20 0.049438868838681 0 0 1 C07AA.profile.d50 3ab_gamma_up 12379459 Upregulated synergystically by gamma-irradiation and 3-aminobenzamine (PARP inhibitor) 11 0.0271913778612745 0 0 1 C07AA.profile.d50 4nqo_esr_old_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of fibroblasts from elderly donors with 4-nitroquinoline-1-oxide (4NQO) 21 0.051910812280615 0 0 1 C07AA.profile.d50 4nqo_esr_ws_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of Werner syndrome fibroblasts with 4-nitroquinoline-1-oxide (4NQO) 59 0.145844663074109 0 0 1 C07AA.profile.d50 4nqo-gamma_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with gamma radiation or 4-NQO, but not by UV light 18 0.0444949819548129 0 0 1 C07AA.profile.d50 4nqo-gamma_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with gamma radiation or 4-NQO, but not by UV light 9 0.0222474909774064 1 44.9488888888889 0.0220287769316943 C07AA.profile.d50 4nqo_unique_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with 4-nitroquinoline-1-oxide (4NQO), but not UV or gamma radiation 25 0.0617985860483512 0 0 1 C07AA.profile.d50 4nqo_unique_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with 4-nitroquinoline-1-oxide (4NQO), but not by UV or gamma radiation 38 0.0939338507934939 0 0 1 C07AA.profile.d50 5azac_hepg2_dn 16854234 Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1830 4.52365649873931 6 1.3263606557377 0.301014838652006 C07AA.profile.d50 5azac_hepg2_up 16854234 Up-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1630 4.0292678103525 2 0.496368098159509 0.910811066708742 C07AA.profile.d50 5azac-tsa_hepg2_dn 16854234 Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 2343 5.79176348445148 5 0.8632949210414 0.68642169892698 C07AA.profile.d50 5azac-tsa_hepg2_up 16854234 Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 1966 4.85984080684234 3 0.617304170905392 0.863359698558556 C07AA.profile.d50 5fu_resist_gastric_dn 14734480 Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.0741583032580215 0 0 1 C07AA.profile.d50 5fu_resist_gastric_up 14734480 Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 42 0.10382162456123 1 9.63190476190476 0.0987297816990099 C07AA.profile.d50 5fu_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to 5-fluorouracil (5FU) 7 0.0173036040935383 0 0 1 C07AA.profile.d50 5fu_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to 5-fluorouracil (5FU) 7 0.0173036040935383 0 0 1 C07AA.profile.d50 acnu_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to ACNU 11 0.0271913778612745 0 0 1 C07AA.profile.d50 ad12_12hrs_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 12 hours post-infection 9 0.0222474909774064 0 0 1 C07AA.profile.d50 ad12_12hrs_up 15681441 Up-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 12 hours post-infection 7 0.0173036040935383 0 0 1 C07AA.profile.d50 ad12_24hrs_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 24 hours post-infection 24 0.0593266426064172 1 16.8558333333333 0.0576703226918033 C07AA.profile.d50 ad12_32hrs_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection 27 0.0667424729322193 1 14.982962962963 0.0646412195945478 C07AA.profile.d50 ad12_48hrs_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 48 hours post-infection 21 0.051910812280615 1 19.2638095238095 0.0506474741693736 C07AA.profile.d50 ad12_any_dn 15681441 Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection 42 0.10382162456123 1 9.63190476190476 0.0987297816990099 C07AA.profile.d50 ad12_any_up 15681441 Up-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection 15 0.0370791516290107 0 0 1 C07AA.profile.d50 adip_diff_cluster1 12137940 Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) 96 0.237306570425669 1 4.21395833333333 0.211482247754845 C07AA.profile.d50 adip_diff_cluster2 12137940 Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) 64 0.158204380283779 0 0 1 C07AA.profile.d50 adip_diff_cluster3 12137940 Strongly upregulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 3) 68 0.168092154051515 0 0 1 C07AA.profile.d50 adip_diff_cluster4 12137940 Strongly upregulated at 16 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 4) 56 0.138428832748307 0 0 1 C07AA.profile.d50 adip_diff_cluster5 12137940 Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) 67 0.165620210609581 0 0 1 C07AA.profile.d50 adip_diff_up 12732648 Upregulated in mature adipocytes following diffferentiation from 3T3-L1 fibroblasts 123 0.304049043357888 0 0 1 C07AA.profile.d50 adip_human_dn 15051823 Down-regulated in primary human adipocytes, versus preadipocytes 52 0.128541058980571 0 0 1 C07AA.profile.d50 adip_human_up 15051823 Up-regulated in primary human adipocytes, versus preadipocytes 94 0.232362683541801 0 0 1 C07AA.profile.d50 adipocyte_brca_dn 14508521 Downregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 13 0.0321352647451426 0 0 1 C07AA.profile.d50 adipocyte_brca_up 14508521 Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 14 0.0346072081870767 0 0 1 C07AA.profile.d50 adipocyte_pparg_up 11981038 Adipocyte genes induced by both PPARgamma and rosiglitazone 23 0.0568546991644831 2 35.1773913043478 0.00149343591373489 C07AA.profile.d50 adipogenesis_hmsc_class1_up 12646203 Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.0766302466999555 0 0 1 C07AA.profile.d50 adipogenesis_hmsc_class2_up 12646203 Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) 15 0.0370791516290107 0 0 1 C07AA.profile.d50 adipogenesis_hmsc_class3_up 12646203 Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.269441835170811 0 0 1 C07AA.profile.d50 adipogenesis_hmsc_class4_up 12646203 Up-regulated 14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class IV) 8 0.0197755475354724 0 0 1 C07AA.profile.d50 adipogenesis_hmsc_class5_up 12646203 Up-regulated 9 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class V) 16 0.0395510950709448 0 0 1 C07AA.profile.d50 adipogenesis_hmsc_class7_dn 12646203 Down-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class VII) 9 0.0222474909774064 0 0 1 C07AA.profile.d50 adipogenesis_hmsc_class8_dn 12646203 Down-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class VIII) 59 0.145844663074109 0 0 1 C07AA.profile.d50 adip_vs_fibro_dn 12021175 Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes 64 0.158204380283779 1 6.3209375 0.146491893854714 C07AA.profile.d50 adip_vs_fibro_up 12021175 Upregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes 59 0.145844663074109 0 0 1 C07AA.profile.d50 adip_vs_preadip_dn 12021175 Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 84 0.20764324912246 0 0 1 C07AA.profile.d50 adip_vs_preadip_up 12021175 Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 57 0.140900776190241 0 0 1 C07AA.profile.d50 adr_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to adriamycin 10 0.0247194344193405 0 0 1 C07AA.profile.d50 aged_mouse_cerebellum_dn 10888876 Downregulated in the cerebellum of aged adult mice (30-month) vs. young adult (5-month) 87 0.215059079448262 0 0 1 C07AA.profile.d50 aged_mouse_cerebellum_up 10888876 Upregulated in the cerebellum of aged adult mice (30-month) vs. young adult (5-month) 92 0.227418796657932 1 4.39717391304348 0.203637140954062 C07AA.profile.d50 aged_mouse_cortex_dn 11172053 Down-regulated in the cerebral cortex of aged (22 months) BALB/c mice, compared to young (2 months) controls 98 0.242250457309537 0 0 1 C07AA.profile.d50 aged_mouse_cortex_up 11172053 Up-regulated in the cerebral cortex of aged (22 months) BALB/c mice, compared to young (2 months) controls 71 0.175507984377317 0 0 1 C07AA.profile.d50 aged_mouse_hippocampus_any_dn 15960800 Down-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 60 0.148316606516043 0 0 1 C07AA.profile.d50 aged_mouse_hippocampus_any_up 15960800 Up-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 78 0.192811588470856 1 5.18641025641026 0.175559489333073 C07AA.profile.d50 aged_mouse_hippocampus_multi_dn 15960800 Down-regulated in the hippocampus of 16-month aged mice from at least two of four strains (S8, S10, SR1, B6J), versus 3-month young controls 17 0.0420230385128788 0 0 1 C07AA.profile.d50 aged_mouse_hippocampus_multi_up 15960800 Up-regulated in the hippocampus of 16-month aged mice from at least two of four strains (S8, S10, SR1, B6J), versus 3-month young controls 38 0.0939338507934939 1 10.6457894736842 0.089762880067684 C07AA.profile.d50 aged_mouse_hypoth_dn 11172053 Down-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls 62 0.153260493399911 1 6.52483870967742 0.142256548500238 C07AA.profile.d50 aged_mouse_hypoth_up 11172053 Up-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls 79 0.19528353191279 0 0 1 C07AA.profile.d50 aged_mouse_muscle_dn 10464095 Downregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) 59 0.145844663074109 0 0 1 C07AA.profile.d50 aged_mouse_muscle_up 10464095 Upregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) 51 0.126069115538636 0 0 1 C07AA.profile.d50 aged_mouse_neocortex_dn 10888876 Downregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 102 0.252138231077273 1 3.96607843137255 0.22310523962343 C07AA.profile.d50 aged_mouse_neocortex_up 10888876 Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.274385722054679 1 3.6445045045045 0.240219280999167 C07AA.profile.d50 aged_mouse_retina_any_dn 15960800 Down-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 24 0.0593266426064172 0 0 1 C07AA.profile.d50 aged_mouse_retina_any_up 15960800 Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 36 0.0889899639096258 0 0 1 C07AA.profile.d50 aged_mouse_retina_multi_up 15960800 Up-regulated in the retina of 16-month aged mice from at least two of four strains (S8, S10, SR1, B6J), versus 3-month young controls 11 0.0271913778612745 0 0 1 C07AA.profile.d50 aged_rhesus_dn 11309484 Downregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys 232 0.573490878528699 1 1.74370689655172 0.436845275615967 C07AA.profile.d50 aged_rhesus_up 11309484 Upregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys 390 0.964057942354279 1 1.03728205128205 0.61911258948358 C07AA.profile.d50 ageing_brain_dn 15190254 Age-downregulated in the human frontal cortex 244 0.603154199831908 0 0 1 C07AA.profile.d50 ageing_brain_up 15190254 Age-upregulated in the human frontal cortex 446 1.10248677510259 4 3.62816143497758 0.0257517801423061 C07AA.profile.d50 ageing_kidney_dn 15562319 Down-regulation is associated with increasing age in normal human kidney tissue from 74 patients 238 0.588322539180304 1 1.69974789915966 0.445146347803161 C07AA.profile.d50 ageing_kidney_specific_dn 15562319 Down-regulation is associated with increasing age in normal human kidney tissue from 74 patients, and expression is higher in kidney than in whole blood 248 0.613041973599644 1 1.63120967741935 0.458710448043807 C07AA.profile.d50 ageing_kidney_specific_up 15562319 Up-regulation is associated with increasing age in normal human kidney tissue from 74 patients, and expression is higher in kidney than in whole blood 277 0.684728333415731 4 5.84173285198556 0.00525363444739215 C07AA.profile.d50 ageing_kidney_up 15562319 Up-regulation is associated with increasing age in normal human kidney tissue from 74 patients 611 1.5103574430217 3 1.98628477905074 0.193604680537475 C07AA.profile.d50 ageing_lymph_dn 12618007 Downregulated in human lymphocytes from old individuals, compared to young 30 0.0741583032580215 1 13.4846666666667 0.0715605491904371 C07AA.profile.d50 ageing_lymph_up 12618007 Upregulated in human lymphocytes from old individuals, compared to young 7 0.0173036040935383 0 0 1 C07AA.profile.d50 alk1_hmvec_2hr_dn 16405919 Down-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 189 0.467197310525535 1 2.14042328042328 0.373605996032068 C07AA.profile.d50 alk1_hmvec_2hr_up 16405919 Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.46586246106689 2 1.3643844856661 0.430879762191562 C07AA.profile.d50 alk1_hmvec_4hr_dn 16405919 Down-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 189 0.467197310525535 1 2.14042328042328 0.373605996032068 C07AA.profile.d50 alk1_hmvec_4hr_up 16405919 Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.46586246106689 2 1.3643844856661 0.430879762191562 C07AA.profile.d50 alk5_hmvec_2hr_dn 16405919 Down-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 202 0.499332575270678 0 0 1 C07AA.profile.d50 alk5_hmvec_2hr_up 16405919 Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.857764374351115 1 1.16582132564841 0.576340959590959 C07AA.profile.d50 alk5_hmvec_4hr_dn 16405919 Down-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 202 0.499332575270678 0 0 1 C07AA.profile.d50 alk5_hmvec_4hr_up 16405919 Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.857764374351115 1 1.16582132564841 0.576340959590959 C07AA.profile.d50 alzheimers_disease_dn 14769913 Downregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus 2117 5.23310426657438 7 1.33763816721776 0.272489243518028 C07AA.profile.d50 alzheimers_disease_up 14769913 Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus 3137 7.75448657734711 4 0.515830411220912 0.950223482217444 C07AA.profile.d50 alzheimers_incipient_dn 14769913 Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus 312 0.771246353883423 2 2.59320512820513 0.180810038972731 C07AA.profile.d50 alzheimers_incipient_up 14769913 Upregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus 754 1.86384535521827 0 0 1 C07AA.profile.d50 aom-dss_colon_10wks_dn 17506908 Down-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 6 0.0148316606516043 0 0 1 C07AA.profile.d50 aom-dss_colon_10wks_up 17506908 Up-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 22 0.0543827557225491 0 0 1 C07AA.profile.d50 aom-dss_colon_5wks_dn 17506908 Down-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 57 0.140900776190241 0 0 1 C07AA.profile.d50 aom-dss_colon_5wks_up 17506908 Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 133 0.328768477777228 1 3.04165413533835 0.280483267512633 C07AA.profile.d50 arthritis_mouse_common_dn 16805906 Dn-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 1 0.00247194344193405 0 0 1 C07AA.profile.d50 arthritis_mouse_common_up 16805906 Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 1.13462203984773 1 0.881350762527233 0.678907718524119 C07AA.profile.d50 arthritis_mouse_htlv1_dn 16805906 Down-regulated in joint tissue from severely arthritic 6-9 week-old HTLV-I transgenic mice, versus wild-type littermate controls. 159 0.393039007267514 0 0 1 C07AA.profile.d50 arthritis_mouse_htlv1_up 16805906 Up-regulated in joint tissue from severely arthritic 6-9 week-old HTLV-I transgenic mice, versus wild-type littermate controls. 251 0.620457803925446 1 1.61171314741036 0.462714645037791 C07AA.profile.d50 arthritis_mouse_il1ko_dn 16805906 Down-regulated in joint tissue from severely arthritic 13 week-old IL-1Ra knock-out mice, versus wild-type littermate controls. 105 0.259554061403075 0 0 1 C07AA.profile.d50 arthritis_mouse_il1ko_up 16805906 Up-regulated in joint tissue from severely arthritic 13 week-old IL-1Ra knock-out mice, versus wild-type littermate controls. 271 0.669896672764127 1 1.49276752767528 0.488662794523127 C07AA.profile.d50 as3_fibro_c1 12016162 Upregulated strongly by sodium arsenite in fibroblasts (Cluster 1) 67 0.165620210609581 0 0 1 C07AA.profile.d50 as3_fibro_c2 12016162 Upregulated moderately by sodium arsenite in fibroblasts (Cluster 2) 67 0.165620210609581 0 0 1 C07AA.profile.d50 as3_fibro_c3 12016162 Upregulated late by sodium arsenite in fibroblasts (Cluster 3) 95 0.234834626983735 0 0 1 C07AA.profile.d50 as3_fibro_c4 12016162 Downregulated early by sodium arsenite in fibroblasts (Cluster 4) 35 0.0865180204676917 0 0 1 C07AA.profile.d50 as3_fibro_c5 12016162 Downregulated moderately by sodium arsenite in fibroblasts (Cluster 5) 20 0.049438868838681 0 0 1 C07AA.profile.d50 as3_fibro_dn 12016162 Downregulated by sodium arsenite in fibroblasts (Clusters 4, 5, and 6) 59 0.145844663074109 0 0 1 C07AA.profile.d50 as3_fibro_up 12016162 Upregulated by sodium arsenite in fibroblasts (Clusters 1, 2, and 3) 95 0.234834626983735 0 0 1 C07AA.profile.d50 as3_hek293_dn 12679051 Downregulated in HEK293 cells by treatment with arsenite 12 0.0296633213032086 0 0 1 C07AA.profile.d50 as3_hek293_up 12679051 Upregulated in HEK293 cells by treatment with arsenite 19 0.0469669253967469 0 0 1 C07AA.profile.d50 atria_up 15103417 Upregulated in the atria of healthy hearts, compared to venticles 384 0.949226281702675 0 0 1 C07AA.profile.d50 avoidance_dn 15720406 Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. 40 0.098877737677362 0 0 1 C07AA.profile.d50 avoidance_up 15720406 Up-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. 34 0.0840460770257577 0 0 1 C07AA.profile.d50 baf57_bt549_dn 16135788 Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 554 1.36945666683146 1 0.730216606498195 0.746185621158123 C07AA.profile.d50 baf57_bt549_up 16135788 Up-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 364 0.899787412863994 1 1.11137362637363 0.593796641097246 C07AA.profile.d50 bap_hepg2_dn 17042939 Down-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 56 0.138428832748307 0 0 1 C07AA.profile.d50 bap_hepg2_up 17042939 Up-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 83 0.205171305680526 0 0 1 C07AA.profile.d50 bap_mcf7_dn 17042939 Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 135 0.333712364661097 0 0 1 C07AA.profile.d50 bap_mcf7_up 17042939 Up-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 87 0.215059079448262 0 0 1 C07AA.profile.d50 bay-il2_pbmc_early_up 17471163 Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 12 0.0296633213032086 0 0 1 C07AA.profile.d50 bay-il2_pbmc_late_dn 17471163 Down-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 205 0.50674840559648 1 1.97336585365854 0.397926511001564 C07AA.profile.d50 bay-il2_pbmc_late_up 17471163 Up-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 130 0.321352647451426 0 0 1 C07AA.profile.d50 bay-il2_pbmc_middle_dn 17471163 Down-regulated at 2-6 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 64 0.158204380283779 0 0 1 C07AA.profile.d50 bay-il2_pbmc_middle_up 17471163 Up-regulated at 2-6 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. 74 0.18292381470312 1 5.46675675675676 0.167356980462907 C07AA.profile.d50 bay_pbmc_24hr_dn 17471163 Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 268 0.662480842438325 0 0 1 C07AA.profile.d50 bay_pbmc_24hr_up 17471163 Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.499332575270678 1 2.00267326732673 0.393439471046837 C07AA.profile.d50 bay_pbmc_2hr_dn 17471163 Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 398 0.983833489889751 0 0 1 C07AA.profile.d50 bay_pbmc_2hr_up 17471163 Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.49799772581203 4 2.67023102310231 0.0651584727591771 C07AA.profile.d50 bay_pbmc_30min_dn 17471163 Down-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 10 0.0247194344193405 0 0 1 C07AA.profile.d50 bay_pbmc_30min_up 17471163 up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.202699362238592 2 9.86682926829268 0.0178038530970577 C07AA.profile.d50 bay_pbmc_48hr_dn 17471163 Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 318 0.786078014535027 1 1.27213836477987 0.544814926968059 C07AA.profile.d50 bay_pbmc_48hr_up 17471163 Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17417313491867 1 0.851663157894737 0.691374519912312 C07AA.profile.d50 bay_pbmc_4hr_dn 17471163 Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 400 0.988777376773619 1 1.01135 0.628423864621069 C07AA.profile.d50 bay_pbmc_4hr_up 17471163 Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 1.34473723241212 3 2.23091911764706 0.153119692923422 C07AA.profile.d50 bay_pbmc_6hr_dn 17471163 Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 483 1.19394868245415 1 0.837556935817805 0.69742521401068 C07AA.profile.d50 bay_pbmc_6hr_up 17471163 Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17417313491867 4 3.40665263157895 0.0313836255748811 C07AA.profile.d50 bcnu_glioma_mgmt_24hrs_dn 15980968 Down-regulated in an MGMT+ glioma cell line (T98G) at 24 hours following treatment with BCNU 54 0.133484945864439 0 0 1 C07AA.profile.d50 bcnu_glioma_mgmt_24hrs_up 15980968 Up-regulated in an MGMT+ glioma cell line (T98G) at 24 hours following treatment with BCNU 15 0.0370791516290107 0 0 1 C07AA.profile.d50 bcnu_glioma_mgmt_48hrs_dn 15980968 Down-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU 253 0.625401690809314 0 0 1 C07AA.profile.d50 bcnu_glioma_mgmt_48hrs_up 15980968 Up-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU 33 0.0815741335838236 0 0 1 C07AA.profile.d50 bcnu_glioma_nomgmt_24hrs_dn 15980968 Down-regulated in an MGMT-deficient glioma cell line (A172) at 24 hours following treatment with BCNU 22 0.0543827557225491 0 0 1 C07AA.profile.d50 bcnu_glioma_nomgmt_24hrs_up 15980968 Up-regulated in an MGMT-deficient glioma cell line (A172) at 24 hours following treatment with BCNU 25 0.0617985860483512 0 0 1 C07AA.profile.d50 bcnu_glioma_nomgmt_48hrs_dn 15980968 Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU 50 0.123597172096702 0 0 1 C07AA.profile.d50 bcnu_glioma_nomgmt_48hrs_up 15980968 Up-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU 31 0.0766302466999555 0 0 1 C07AA.profile.d50 bcrabl_hl60_affy_dn 15155749 Down-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by Affymetrix arrays 19 0.0469669253967469 0 0 1 C07AA.profile.d50 bcrabl_hl60_affy_up 15155749 Up-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by Affymetrix arrays 36 0.0889899639096258 0 0 1 C07AA.profile.d50 bcrabl_hl60_cdna_dn 15155749 Down-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by spotted cDNA arrays 54 0.133484945864439 0 0 1 C07AA.profile.d50 bcrabl_hl60_cdna_up 15155749 Up-regulated by expression of p210(BCR-ABL) in human leukemia (HL-60) cells; detected by spotted cDNA arrays 39 0.0964057942354279 0 0 1 C07AA.profile.d50 bep_mcf7_dn 17042939 Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with non-carcinogenic benzo(e)pyrene (BeP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 34 0.0840460770257577 0 0 1 C07AA.profile.d50 bep_mcf7_up 17042939 Up-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with non-carcinogenic benzo(e)pyrene (BeP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 6 0.0148316606516043 0 0 1 C07AA.profile.d50 bleo_human_lymph_high_24hrs_dn 15515172 Down-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 4 0.00988777376773619 0 0 1 C07AA.profile.d50 bleo_human_lymph_high_24hrs_up 15515172 Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 197 0.486972858061008 0 0 1 C07AA.profile.d50 bleo_human_lymph_high_4hrs_dn 15515172 Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 15 0.0370791516290107 0 0 1 C07AA.profile.d50 bleo_human_lymph_high_4hrs_up 15515172 Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 32 0.0791021901418896 0 0 1 C07AA.profile.d50 bleo_human_lymph_low_24hrs_up 15515172 Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a low dose of bleomycin 5 0.0123597172096702 0 0 1 C07AA.profile.d50 bleo_mouse_lymph_high_24hrs_dn 15515172 Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin 71 0.175507984377317 0 0 1 C07AA.profile.d50 bleo_mouse_lymph_high_4hrs_up 15515172 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin 17 0.0420230385128788 0 0 1 C07AA.profile.d50 bleo_mouse_lymph_low_24hrs_dn 15515172 Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of bleomycin 56 0.138428832748307 0 0 1 C07AA.profile.d50 bleo_mouse_lymph_low_4hrs_up 15515172 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of bleomycin 7 0.0173036040935383 0 0 1 C07AA.profile.d50 brcax_a_dn 12610208 Down-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 15 0.0370791516290107 0 0 1 C07AA.profile.d50 brcax_a_up 12610208 Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 30 0.0741583032580215 0 0 1 C07AA.profile.d50 brca1_irradiated_up 14871973 Up-regulated in germline-mutant BRCA1 tumor cells compared to non-BRCA1 control tumors, following 15 Gy irradiation. 105 0.259554061403075 0 0 1 C07AA.profile.d50 brca1ko_mef_dn 15520196 Down-regulated in mouse embryonic fibroblasts following targeted deletion of BRCA1 (exon 11) compared to wild-type MEFs 182 0.449893706431997 0 0 1 C07AA.profile.d50 brca1ko_mef_up 15520196 Up-regulated in mouse embryonic fibroblasts following targeted deletion of BRCA1 (exon 11) compared to wild-type MEFs 19 0.0469669253967469 2 42.5831578947368 0.00101605301260307 C07AA.profile.d50 brca1_mes_up 11384963 Genes with reduced expression in mouse embryonic stem cells with a targeted deletion of BRCA1, whose expression was rescued by ectopic expression of a BRCA1 transgene 86 0.212587136006328 0 0 1 C07AA.profile.d50 brca1_overexp_dn 12032322 Downregulated by induction of exogenous BRCA1 in EcR-293 cells 220 0.543827557225491 0 0 1 C07AA.profile.d50 brca1_overexp_prostate_dn 15520196 Down-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 168 0.41528649824492 1 2.40797619047619 0.340188194664701 C07AA.profile.d50 brca1_overexp_prostate_up 15520196 Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 308 0.761358580115687 3 3.94032467532467 0.0418211150460026 C07AA.profile.d50 brca1_overexp_up 12032322 Upregulated by induction of exogenous BRCA1 in EcR-293 cells 328 0.810797448954368 0 0 1 C07AA.profile.d50 brca1_sw480_dn 10644742 Down-regulated by infection of human colon adenocarcinoma cells (SW480) with Ad-BRCA1, versus Ad-LacZ control 33 0.0815741335838236 0 0 1 C07AA.profile.d50 brca1_sw480_up 10644742 Up-regulated by infection of human colon adenocarcinoma cells (SW480) with Ad-BRCA1, versus Ad-LacZ control 50 0.123597172096702 2 16.1816 0.00691829144494662 C07AA.profile.d50 brca2_brca1_dn 12096084 Genes down-regulated in BRCA2-linked breast tumors, relative to BRCA1-linked tumors 83 0.205171305680526 1 4.87397590361446 0.185699087804022 C07AA.profile.d50 brca2_brca1_up 12096084 Genes up-regulated in BRCA2-linked breast tumors, relative to BRCA1-linked tumors 99 0.244722400751471 0 0 1 C07AA.profile.d50 brca2kd_dn 15670748 Down-regulated following transient RNAi knock-down of BRCA2 in both HMEC (human mammary epithelial) and BT549 (human breast carcinoma) cell lines 15 0.0370791516290107 0 0 1 C07AA.profile.d50 brca_brca1_neg 11823860 Genes whose expression is consistently negatively correlated with brca1 germline status in breast cancer - higher expression is associated with BRCA1 tumors 250 0.617985860483512 1 1.61816 0.46138321480792 C07AA.profile.d50 brca_brca1_pos 11823860 Genes whose expression is consistently positively correlated with brca1 germline status in breast cancer - higher expression is associated with sporadic tumors 182 0.449893706431997 0 0 1 C07AA.profile.d50 brca_er_neg 11823860 Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors 1519 3.75488208829782 2 0.532639894667544 0.889019834923031 C07AA.profile.d50 brca_er_pos 11823860 Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-positive tumors 842 2.08137637810847 3 1.4413539192399 0.345364963931258 C07AA.profile.d50 brca_prognosis_neg 11823860 Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis 166 0.410342611361052 0 0 1 C07AA.profile.d50 brca_prognosis_pos 11823860 Genes whose expression is consistently positively correlated with breast cancer outcomes - higher expression is associated with good prognosis 57 0.140900776190241 0 0 1 C07AA.profile.d50 breastca_three_classes 11207349 Gene set that can be used to differentiate BRCA1-linked, BRCA2-linked, and sporadic primary breast cancers 70 0.173036040935383 0 0 1 C07AA.profile.d50 breastca_two_classes 11207349 Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers 247 0.61057003015771 0 0 1 C07AA.profile.d50 brg1_alab_dn 14673169 Down-regulated at 18 and 24 hours following adenovirus-mediated expression of BRG1 in ALAB breast cancer cells with mutant, inactive BRG1 65 0.160676323725713 2 12.4473846153846 0.0114631728548189 C07AA.profile.d50 brg1_alab_up 14673169 Up-regulated at 18 and 24 hours following adenovirus-mediated expression of BRG1 in ALAB breast cancer cells with mutant, inactive BRG1 91 0.224946853215998 0 0 1 C07AA.profile.d50 brg1_h1299_up 15731117 Up-regulated by transient expression of BRG1 in H1299 lung cancer cells with mutant, inactive BRG1 50 0.123597172096702 0 0 1 C07AA.profile.d50 brg1_sw13_up 11509180 Up-regulated by transient expression of BRG1 at 24 hours in human, BRG1-lacking SW-13 cells 51 0.126069115538636 1 7.9321568627451 0.118583662293142 C07AA.profile.d50 but_tsa_up 11423116 Upregulated by the combination of TSA and butyrate in HT-29 cells 36 0.0889899639096258 1 11.2372222222222 0.0852460295192012 C07AA.profile.d50 bws_imprinted 12668598 Imprinted genes on Chr. 11p15 that are dysregulated in Beckwith-Wiedmann syndrome 15 0.0370791516290107 0 0 1 C07AA.profile.d50 calres_mouse_dn 10464095 Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.19528353191279 0 0 1 C07AA.profile.d50 calres_mouse_neocortex_dn 10888876 Downregulated in the neocortex of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 114 0.281801552380482 0 0 1 C07AA.profile.d50 calres_mouse_neocortex_up 10888876 Upregulated in the neocortex of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 99 0.244722400751471 0 0 1 C07AA.profile.d50 calres_mouse_up 10464095 Upregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 51 0.126069115538636 0 0 1 C07AA.profile.d50 calres_presenillin_ko_hippocampus_dn 17499883 Down-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. 15 0.0370791516290107 0 0 1 C07AA.profile.d50 calres_presenillin_ko_hippocampus_up 17499883 Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. 137 0.338656251544965 1 2.95284671532847 0.287571349970517 C07AA.profile.d50 calres_rhesus_dn 11309484 Downregulated in the vastus lateralis muscle of middle-aged rhesus monkeys subjected to caloric restriction since young adulthood vs. age-matched controls 110 0.271913778612745 1 3.67763636363636 0.238336491885323 C07AA.profile.d50 calres_rhesus_up 11309484 Upregulated in the vastus lateralis muscle of middle-aged rhesus monkeys subjected to caloric restriction since young adulthood vs. age-matched controls 122 0.301577099915954 0 0 1 C07AA.profile.d50 camptothecin_probcell_dn 12447701 Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin 52 0.128541058980571 0 0 1 C07AA.profile.d50 camptothecin_probcell_up 12447701 Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin 28 0.0692144163741534 0 0 1 C07AA.profile.d50 cancerdrugs_probcell_dn 12447701 Down-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 26 0.0642705294902853 0 0 1 C07AA.profile.d50 cancerdrugs_probcell_up 12447701 Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 24 0.0593266426064172 0 0 1 C07AA.profile.d50 cancer_neoplastic_meta_up 15184677 Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database 115 0.284273495822416 0 0 1 C07AA.profile.d50 cancer_undifferentiated_meta_up 15184677 Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database 98 0.242250457309537 0 0 1 C07AA.profile.d50 cantharidin_dn 14639605 Downregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin 83 0.205171305680526 0 0 1 C07AA.profile.d50 cantharidin_up 14639605 Upregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin 27 0.0667424729322193 0 0 1 C07AA.profile.d50 caries_pulp_dn 15869869 Down-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 131 0.32382459089336 1 3.08809160305344 0.276912824738315 C07AA.profile.d50 caries_pulp_high_up 15869869 Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 168 0.41528649824492 0 0 1 C07AA.profile.d50 caries_pulp_up 15869869 Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01349681119296 0 0 1 C07AA.profile.d50 cisplatin_probcell_dn 12447701 Down-regulated in pro-B cells (FL5.12) following treatment with cisplatin 9 0.0222474909774064 0 0 1 C07AA.profile.d50 cisplatin_probcell_up 12447701 Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin 23 0.0568546991644831 0 0 1 C07AA.profile.d50 cis_resist_gastric_dn 14734480 Downregulated in gastric cancer cell lines reistant to cisplatin, compared to parent chemosensitive lines 10 0.0247194344193405 0 0 1 C07AA.profile.d50 cis_resist_gastric_up 14734480 Upregulated in gastric cancer cell lines reistant to cisplatin, compared to parent chemosensitive lines 29 0.0716863598160874 0 0 1 C07AA.profile.d50 cis_resist_lung_dn 14737109 Transient down-regulation is associated with transient cisplatin resistance in a human squamous cell lung cancer line (NCI-H2170) 18 0.0444949819548129 0 0 1 C07AA.profile.d50 cis_resist_lung_up 14737109 Transient up-regulation is associated with transient cisplatin resistance in a human squamous cell lung cancer line (NCI-H2170) 21 0.051910812280615 0 0 1 C07AA.profile.d50 cis_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to cisplatin 3 0.00741583032580215 0 0 1 C07AA.profile.d50 cis_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to cisplatin 10 0.0247194344193405 0 0 1 C07AA.profile.d50 cis_xpc_dn 15107491 Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 363 0.89731546942206 0 0 1 C07AA.profile.d50 cis_xpc_up 15107491 Increased expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 242 0.59821031294804 0 0 1 C07AA.profile.d50 cited1_ko_het_dn 16278680 Down-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes 56 0.138428832748307 0 0 1 C07AA.profile.d50 cited1_ko_het_up 16278680 Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes 43 0.106293568003164 0 0 1 C07AA.profile.d50 cited1_ko_wt_dn 16278680 Down-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus wild-type controls 21 0.051910812280615 0 0 1 C07AA.profile.d50 cited1_ko_wt_up 16278680 Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus wild-type controls 32 0.0791021901418896 0 0 1 C07AA.profile.d50 cmv_24hrs_dn 9826724 Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 140 0.346072081870767 0 0 1 C07AA.profile.d50 cmv_24hrs_up 9826724 Upregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 133 0.328768477777228 2 6.08330827067669 0.0433426484393846 C07AA.profile.d50 cmv_40min_dn 9826724 Downregulated at 40 min following infection of primary human foreskin fibroblasts with CMV 11 0.0271913778612745 0 0 1 C07AA.profile.d50 cmv_8hrs_dn 9826724 Downregulated at 8hrs following infection of primary human foreskin fibroblasts with CMV 102 0.252138231077273 0 0 1 C07AA.profile.d50 cmv_8hrs_up 9826724 Upregulated at 8hrs following infection of primary human foreskin fibroblasts with CMV 56 0.138428832748307 0 0 1 C07AA.profile.d50 cmv_all_dn 9826724 Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 213 0.526523953131952 0 0 1 C07AA.profile.d50 cmv_all_up 9826724 Upregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 173 0.42764621545459 2 4.67676300578035 0.0689167080000073 C07AA.profile.d50 cmv-chx_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus in the presence of cyclohexamide (CHX) 26 0.0642705294902853 0 0 1 C07AA.profile.d50 cmv-chx_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus in the presence of cyclohexamide (CHX) 10 0.0247194344193405 0 0 1 C07AA.profile.d50 cmv_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 109 0.269441835170811 0 0 1 C07AA.profile.d50 cmv_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 46 0.113709398328966 1 8.79434782608696 0.107608348847919 C07AA.profile.d50 cmv_hcmv_timecourse_10hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours 30 0.0741583032580215 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_10hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours 23 0.0568546991644831 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_12hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 12 hours 33 0.0815741335838236 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_12hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 12 hours 45 0.111237454887032 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_14hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours 95 0.234834626983735 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_14hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours 84 0.20764324912246 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_16hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 16 hours 38 0.0939338507934939 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_16hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 16 hours 93 0.229890740099867 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_18hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 18 hours 44 0.108765511445098 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_18hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 18 hours 142 0.351015968754635 2 5.69774647887324 0.0487230284725566 C07AA.profile.d50 cmv_hcmv_timecourse_1hr_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 1 hour 73 0.180451871261186 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_1hr_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 1 hour 21 0.051910812280615 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_20hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 20 hours 87 0.215059079448262 2 9.29977011494253 0.0198935742493423 C07AA.profile.d50 cmv_hcmv_timecourse_20hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 20 hours 174 0.430118158896524 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_24hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.202699362238592 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_24hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 123 0.304049043357888 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_2hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 2 hours 7 0.0173036040935383 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_30min_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 30 minutes 17 0.0420230385128788 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_30min_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 30 minutes 12 0.0296633213032086 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_48hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours 235 0.580906708854501 2 3.44289361702128 0.115486208939634 C07AA.profile.d50 cmv_hcmv_timecourse_48hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours 135 0.333712364661097 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_4hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours 69 0.170564097493449 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_4hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours 26 0.0642705294902853 1 15.5592307692308 0.0623233359141062 C07AA.profile.d50 cmv_hcmv_timecourse_6hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 6 hours 95 0.234834626983735 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_6hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 6 hours 16 0.0395510950709448 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_8hrs_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 8 hours 27 0.0667424729322193 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_8hrs_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 8 hours 63 0.155732436841845 0 0 1 C07AA.profile.d50 cmv_hcmv_timecourse_all_dn 11711622 Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 2.07396054778267 3 1.44650774731824 0.343358192751693 C07AA.profile.d50 cmv_hcmv_timecourse_all_up 11711622 Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 895 2.21238938053097 3 1.356 0.38067679142703 C07AA.profile.d50 cmv_ie86_up 11867723 Upregulated by expression of cytomegalovirus IE86 protein in primary human fibroblasts 82 0.202699362238592 0 0 1 C07AA.profile.d50 cmv_uv-cmv_common_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 54 0.133484945864439 0 0 1 C07AA.profile.d50 cmvuv-cmv_common_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 37 0.0914619073515598 1 10.9335135135135 0.0875072495975143 C07AA.profile.d50 cmv-uv_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 207 0.511692292480348 0 0 1 C07AA.profile.d50 cmv-uv_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 226 0.558659217877095 2 3.58 0.108310290575842 C07AA.profile.d50 cocaine_brain_4wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 4 weeks of cocaine treatment 112 0.276857665496613 1 3.61196428571429 0.242097415964809 C07AA.profile.d50 cocaine_brain_5d_up 14566342 Up-regulated in the nucleus accumbens of mice after 5 days of cocaine treatment 113 0.279329608938548 0 0 1 C07AA.profile.d50 cortex_enrichment_early_dn 11070096 Down-regulated in the cortex of mice that are exposed to an enriched environmental habitat for 3 or 6 hours 22 0.0543827557225491 0 0 1 C07AA.profile.d50 cortex_enrichment_early_up 11070096 Up-regulated in the cortex of mice that are exposed to an enriched environmental habitat for 3 or 6 hours 25 0.0617985860483512 0 0 1 C07AA.profile.d50 cortex_enrichment_late_dn 11070096 Down-regulated in the cortex of mice that are exposed to an enriched environmental habitat for 2 or 14 days 10 0.0247194344193405 0 0 1 C07AA.profile.d50 cortex_enrichment_late_up 11070096 Up-regulated in the cortex of mice that are exposed to an enriched environmental habitat for 2 or 14 days 34 0.0840460770257577 0 0 1 C07AA.profile.d50 cox1_ko_cortex_dn 17266762 Down-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. 57 0.140900776190241 0 0 1 C07AA.profile.d50 cox1_ko_cortex_up 17266762 Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. 80 0.197755475354724 0 0 1 C07AA.profile.d50 cox1_ko_hippocampus_dn 17266762 Down-regulated in the hippocampus of COX1-/- mice compared to wild-type controls. 77 0.190339645028922 0 0 1 C07AA.profile.d50 cox1_ko_hippocampus_up 17266762 Up-regulated in the hippocampus of COX1-/- mice compared to wild-type controls. 81 0.200227418796658 1 4.99432098765432 0.181658299484868 C07AA.profile.d50 cox2_ko_cortex_dn 17266762 Down-regulated in the cerebral cortex of COX2-/- mice compared to wild-type controls. 39 0.0964057942354279 0 0 1 C07AA.profile.d50 cox2_ko_cortex_up 17266762 Up-regulated in the cerebral cortex of COX2-/- mice compared to wild-type controls. 129 0.318880704009492 0 0 1 C07AA.profile.d50 cox2_ko_hippocampus_dn 17266762 Down-regulated in the hippocampus of COX2-/- mice compared to wild-type controls. 84 0.20764324912246 3 14.4478571428571 0.00123932136569846 C07AA.profile.d50 cox2_ko_hippocampus_up 17266762 Up-regulated in the hippocampus of COX2-/- mice compared to wild-type controls. 79 0.19528353191279 0 0 1 C07AA.profile.d50 cpm_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to cyclophosphamide 3 0.00741583032580215 0 0 1 C07AA.profile.d50 cpm_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to cyclophosphamide 6 0.0148316606516043 0 0 1 C07AA.profile.d50 cpr_low_liver_dn 16006652 Down-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls 40 0.098877737677362 0 0 1 C07AA.profile.d50 cpr_low_liver_up 16006652 Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls 32 0.0791021901418896 0 0 1 C07AA.profile.d50 cpr_null_liver_dn 16006652 Down-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls 26 0.0642705294902853 0 0 1 C07AA.profile.d50 cpr_null_liver_up 16006652 Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls 64 0.158204380283779 0 0 1 C07AA.profile.d50 cpr_null-low_liver_dn 16006652 Down-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus mice with low expression of CPR 4 0.00988777376773619 0 0 1 C07AA.profile.d50 cpr_null-low_liver_up 16006652 Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus mice with low expression of CPR 34 0.0840460770257577 0 0 1 C07AA.profile.d50 creb_brain_2wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic CREB 39 0.0964057942354279 1 10.3728205128205 0.0920129347469056 C07AA.profile.d50 creb_brain_8wks_dn 14566342 Down-regulated in the nucleus accumbens of mice after 8 weeks of induction of transgenic CREB 85 0.210115192564394 0 0 1 C07AA.profile.d50 creb_brain_8wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 8 weeks of induction of transgenic CREB 114 0.281801552380482 1 3.54859649122807 0.245839769442211 C07AA.profile.d50 csb_reliable_dn 16772382 Down-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 558 1.3793444405992 1 0.724982078853047 0.748685990037674 C07AA.profile.d50 csb_reliable_up 16772382 Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 1.26810698571217 0 0 1 C07AA.profile.d50 csb_robust_dn 16772382 Down-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). 169 0.417758441686854 0 0 1 C07AA.profile.d50 csb_robust_up 16772382 Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). 140 0.346072081870767 0 0 1 C07AA.profile.d50 dac_bladder_up 11861364 Upregulated by DAC treatment in T24 bladder carcinoma cells 60 0.148316606516043 0 0 1 C07AA.profile.d50 dac_cgi_bladder_up 11861364 Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island 26 0.0642705294902853 0 0 1 C07AA.profile.d50 dac_cgi_fibro_dn 11861364 Downregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island 12 0.0296633213032086 0 0 1 C07AA.profile.d50 dac_cgi_fibro_up 11861364 Upregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island 20 0.049438868838681 0 0 1 C07AA.profile.d50 dac_fibro_dn 11861364 Downregulated by DAC treatment in LD419 fibroblast cells 17 0.0420230385128788 0 0 1 C07AA.profile.d50 dac_fibro_up 11861364 Upregulated by DAC treatment in LD419 fibroblast cells 34 0.0840460770257577 0 0 1 C07AA.profile.d50 dac_ifn_bladder_up 11861364 Interferon-regulated genes upregulated by DAC treatment in T24 bladder carcinoma cells 34 0.0840460770257577 0 0 1 C07AA.profile.d50 dac_ifn_fibro_up 11861364 Interferon-regulated genes upregulated by DAC treatment in LD419 fibroblast cells 9 0.0222474909774064 0 0 1 C07AA.profile.d50 dac_panc50_up 12839967 50 "most interesting" genes upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 80 0.197755475354724 0 0 1 C07AA.profile.d50 dac_panc_up 12839967 Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 654 1.61665101102487 2 1.237125382263 0.480676006183967 C07AA.profile.d50 dex_keratinocyte_1hr_dn 17095510 Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.0593266426064172 0 0 1 C07AA.profile.d50 dex_keratinocyte_1hr_up 17095510 Up-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 8 0.0197755475354724 0 0 1 C07AA.profile.d50 dex_keratinocyte_4hr_dn 17095510 Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 69 0.170564097493449 0 0 1 C07AA.profile.d50 dex_keratinocyte_4hr_up 17095510 Up-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 35 0.0865180204676917 0 0 1 C07AA.profile.d50 dfosb_brain_2wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic deltaFosB 51 0.126069115538636 1 7.9321568627451 0.118583662293142 C07AA.profile.d50 dfosb_brain_8wks_up 14566342 Up-regulated in the nucleus accumbens of mice after 8 weeks of induction of transgenic deltaFosB 73 0.180451871261186 0 0 1 C07AA.profile.d50 diab_neph_dn 15042541 Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 829 2.04924111336333 3 1.46395657418577 0.336665403052589 C07AA.profile.d50 diab_neph_up 15042541 Upregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 116 0.28674543926435 0 0 1 C07AA.profile.d50 dixoin_chloracne_pbmnc_dn 17101203 Down-regulated in peripheral blood mononuclear cells of subjects who developed chloracne as a result of dioxin exposure, compared to subjects who did not. 6 0.0148316606516043 0 0 1 C07AA.profile.d50 dixoin_chloracne_pbmnc_up 17101203 Up-regulated in peripheral blood mononuclear cells of subjects who developed chloracne as a result of dioxin exposure, compared to subjects who did not. 34 0.0840460770257577 0 0 1 C07AA.profile.d50 dixoin_pbmnc_dn 17101203 Down-regulated in peripheral blood mononuclear cells of subjects with high exposure to dioxin, compared to low-exposure controls. 117 0.289217382706284 0 0 1 C07AA.profile.d50 dixoin_pbmnc_up 17101203 Up-regulated in peripheral blood mononuclear cells of subjects with high exposure to dioxin, compared to low-exposure controls. 17 0.0420230385128788 0 0 1 C07AA.profile.d50 dnmt1_ko_dn 11137995 Downregulated following conditional knock-out of DNMT1 in MEFs 38 0.0939338507934939 1 10.6457894736842 0.089762880067684 C07AA.profile.d50 dnmt1_ko_up 11137995 Upregulated following conditional knock-out of DNMT1 in MEFs 117 0.289217382706284 0 0 1 C07AA.profile.d50 dox_resist_gastric_dn 14734480 Downregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 43 0.106293568003164 0 0 1 C07AA.profile.d50 dox_resist_gastric_up 14734480 Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.18292381470312 0 0 1 C07AA.profile.d50 dsrna_dn 11487589 Downregulated by dsRNA (polyI:C) in IFN-null GRE cells 24 0.0593266426064172 0 0 1 C07AA.profile.d50 dsrna_up 11487589 Upregulated by dsRNA (polyI:C) in IFN-null GRE cells 68 0.168092154051515 1 5.94911764705882 0.154899948263562 C07AA.profile.d50 e2f1_dna_up 11313881 DNA replication genes upregulated by E2F1 induction 15 0.0370791516290107 0 0 1 C07AA.profile.d50 egf_hdmec_up 14517420 Up-regulated in human dermal (foreskin) microvascular endothelial cells that were stimulated to proliferate with prolonged EGF treatment, versus non-stimulated quiescent controls. 105 0.259554061403075 1 3.8527619047619 0.228852329425735 C07AA.profile.d50 elongina_ko_dn 12604609 Downregulated in MES cells from elongin-A knockout mice 267 0.660008898996391 1 1.51513108614232 0.483575407489977 C07AA.profile.d50 elongina_ko_up 12604609 Upregulated in MES cells from elongin-A knockout mice 263 0.650121125228655 2 3.07634980988593 0.138518283209003 C07AA.profile.d50 emt_dn 14562044 Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22000296633213 0 0 1 C07AA.profile.d50 emt_up 14562044 Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 105 0.259554061403075 1 3.8527619047619 0.228852329425735 C07AA.profile.d50 erm_ko_sertoli_dn 16107850 Down-regulated in Sertoli cells from both 4 and 10 week old ERM knockout mice, compared to 4 week wild-type controls 29 0.0716863598160874 0 0 1 C07AA.profile.d50 erm_ko_testes_dn 16107850 Down-regulated in testes from 4 week old ERM knockout mice, compared to wild-type controls 24 0.0593266426064172 0 0 1 C07AA.profile.d50 esr_fibroblast_dn 15897889 Down-regulated in the environmental stress response in human fibroblasts (regulated similarly by gamma and UV rediation and 4-NQO) 21 0.051910812280615 0 0 1 C07AA.profile.d50 esr_fibroblast_up 15897889 Up-regulated in the environmental stress response in human fibroblasts (regulated similarly by gamma and UV rediation and 4-NQO) 98 0.242250457309537 0 0 1 C07AA.profile.d50 et743_blockstsa 12067978 Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.0370791516290107 0 0 1 C07AA.profile.d50 et743_hela_dn 12198119 Downregulated by Et-743 in HeLa cells 28 0.0692144163741534 0 0 1 C07AA.profile.d50 et743_hela_up 12198119 Upregulated by Et-743 in HeLa cells 99 0.244722400751471 0 0 1 C07AA.profile.d50 et743pt650_breastca_dn 11755394 Downregulated by both Et-743 and Pt-650 in MDA-MB-435 cells (Fig. 6G) 20 0.049438868838681 0 0 1 C07AA.profile.d50 et743pt650_colonca_dn 11755394 Downregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6 A) 76 0.187867701586988 0 0 1 C07AA.profile.d50 et743pt650_colonca_up 11755394 Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) 13 0.0321352647451426 0 0 1 C07AA.profile.d50 et743_resist_dn 15661559 Down-regulated in two Et-743-resistant cell lines (chondrosarcoma and ovarian carcinoma) compared to sensitive parental lines 95 0.234834626983735 0 0 1 C07AA.profile.d50 et743_resist_up 15661559 Up-regulated in two Et-743-resistant cell lines (chondrosarcoma and ovarian carcinoma) compared to sensitive parental lines 31 0.0766302466999555 0 0 1 C07AA.profile.d50 et743_sarcoma_24hrs_dn 15897246 Down-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 163 0.40292678103525 0 0 1 C07AA.profile.d50 et743_sarcoma_24hrs_up 15897246 Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.0395510950709448 0 0 1 C07AA.profile.d50 et743_sarcoma_48hrs_dn 15897246 Down-regulated at48 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 304 0.751470806347951 0 0 1 C07AA.profile.d50 et743_sarcoma_6hrs_up 15897246 Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.138428832748307 0 0 1 C07AA.profile.d50 et743_sarcoma_72hrs_dn 15897246 Down-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines 376 0.929450734167202 0 0 1 C07AA.profile.d50 et743_sarcoma_72hrs_up 15897246 Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines 106 0.262026004845009 0 0 1 C07AA.profile.d50 et743_sarcoma_dn 15897246 Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 459 1.13462203984773 0 0 1 C07AA.profile.d50 et743_sarcoma_resist_dn 15897246 Constiutively down-regulated in three sarcoma cell lines resistant to Et-743 compared to six sensitive lines 8 0.0197755475354724 0 0 1 C07AA.profile.d50 et743_sarcoma_resist_up 15897246 Constiutively up-regulated in three sarcoma cell lines resistant to Et-743 compared to six sensitive lines 22 0.0543827557225491 0 0 1 C07AA.profile.d50 et743_sarcoma_up 15897246 Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 111 0.274385722054679 0 0 1 C07AA.profile.d50 fsh_granulosa_dn 15026540 Down-regulated in human granulosa cells stimulated with follicle stimulation hormone (FSH) 191 0.472141197409403 1 2.11801047120419 0.376698989549114 C07AA.profile.d50 fsh_granulosa_up 15026540 Up-regulated in human granulosa cells stimulated with follicle stimulation hormone (FSH) 163 0.40292678103525 0 0 1 C07AA.profile.d50 fsh_human_granulosa_dn 12832290 Down-regulated by FSH in primary human granulosa cells (rFSH-17) 7 0.0173036040935383 0 0 1 C07AA.profile.d50 fsh_human_granulosa_up 12832290 Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.0766302466999555 0 0 1 C07AA.profile.d50 fsh_ovary_mcv152_dn 15386376 Down-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 111 0.274385722054679 1 3.6445045045045 0.240219280999167 C07AA.profile.d50 fsh_ovary_mcv152_up 15386376 Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 120 0.296633213032086 0 0 1 C07AA.profile.d50 fsh_rat_granulosa_dn 12832290 Down-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 11 0.0271913778612745 0 0 1 C07AA.profile.d50 fsh_rat_granulosa_up 12832290 Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.0370791516290107 0 0 1 C07AA.profile.d50 gamma_esr_old_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of fibroblasts from elderly donors with gamma radiation 49 0.121125228654768 0 0 1 C07AA.profile.d50 gamma_esr_ws_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of Werner syndrome fibroblasts with gamma radiation 52 0.128541058980571 0 0 1 C07AA.profile.d50 gamma_unique_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with gamma radiation, but not by UV lght or 4-NQO 120 0.296633213032086 0 0 1 C07AA.profile.d50 gamma_unique_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with gamma radiation, but not by UV lght or 4-NQO 27 0.0667424729322193 0 0 1 C07AA.profile.d50 gamma-uv_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO 78 0.192811588470856 0 0 1 C07AA.profile.d50 gamma-uv_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO 57 0.140900776190241 0 0 1 C07AA.profile.d50 genotoxins_24hrs_discr 15120960 Group of genes whose regulation pattern significantly discriminates between direct (cisplatin, methyl methanesulfonate, mitomycin C) and indirect (taxol, hydroxyurea, etoposide) genotoxins, 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) 69 0.170564097493449 1 5.86289855072464 0.15698898779423 C07AA.profile.d50 genotoxins_4hrs_discr 15120960 Group of genes whose regulation pattern significantly discriminates between direct (cisplatin, methyl methanesulfonate, mitomycin C) and indirect (taxol, hydroxyurea, etoposide) genotoxins, 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) 58 0.143372719632175 1 6.9748275862069 0.133722702603265 C07AA.profile.d50 genotoxins_all_24hrs_reg 15120960 Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 49 0.121125228654768 0 0 1 C07AA.profile.d50 genotoxins_all_4hrs_reg 15120960 Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 45 0.111237454887032 0 0 1 C07AA.profile.d50 gh_autocrine_dn 15845533 Down-regulated following stable autocrine expression of human growth hormone in mammary carcinoma cells (MCF-7) 189 0.467197310525535 0 0 1 C07AA.profile.d50 gh_autocrine_up 15845533 Up-regulated following stable autocrine expression of human growth hormone in mammary carcinoma cells (MCF-7) 227 0.561131161319029 0 0 1 C07AA.profile.d50 gh_exogenous_all_up 15845533 Up-regulated consistently at all time points (1-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 66 0.163148267167647 0 0 1 C07AA.profile.d50 gh_exogenous_any_dn 15845533 Down-regulated at any time point (1-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 142 0.351015968754635 0 0 1 C07AA.profile.d50 gh_exogenous_any_up 15845533 Up-regulated at any time point (1-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 305 0.753942749789885 1 1.3263606557377 0.529931166251457 C07AA.profile.d50 gh_exogenous_early_dn 15845533 Down-regulated at early time points (1-4 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 14 0.0346072081870767 0 0 1 C07AA.profile.d50 gh_exogenous_early_up 15845533 Up-regulated at early time points (1-4 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 31 0.0766302466999555 0 0 1 C07AA.profile.d50 gh_exogenous_late_dn 15845533 Down-regulated at late time points (12-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 123 0.304049043357888 0 0 1 C07AA.profile.d50 gh_exogenous_late_up 15845533 Up-regulated at late time points (12-24 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 67 0.165620210609581 1 6.03791044776119 0.152805731948608 C07AA.profile.d50 gh_exogenous_middle_dn 15845533 Down-regulated at middle time points (6-8 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 5 0.0123597172096702 0 0 1 C07AA.profile.d50 gh_exogenous_middle_up 15845533 Up-regulated at middle time points (6-8 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 141 0.348544025312701 0 0 1 C07AA.profile.d50 gh_ghrhr_ko_24hrs_dn 16464905 Down-regulated at least 2-fold 24 hours following injection of human growth hormone (GH) into mice lacking functional GHRHR (lit/lit), and with no detectable endogenous GH 277 0.684728333415731 1 1.46043321299639 0.49620006069683 C07AA.profile.d50 gh_ghrhr_ko_24hrs_up 16464905 Up-regulated at least 2-fold 24 hours following injection of human growth hormone (GH) into mice lacking functional GHRHR (lit/lit), and with no detectable endogenous GH 187 0.462253423641667 0 0 1 C07AA.profile.d50 gh_ghrhr_ko_6hrs_dn 16464905 Down-regulated at least 2-fold 6 hours following injection of human growth hormone (GH) into mice lacking functional GHRHR (lit/lit), and with no detectable endogenous GH 58 0.143372719632175 0 0 1 C07AA.profile.d50 gh_ghrhr_ko_6hrs_up 16464905 Up-regulated at least 2-fold 6 hours following injection of human growth hormone (GH) into mice lacking functional GHRHR (lit/lit), and with no detectable endogenous GH 108 0.266969891728877 0 0 1 C07AA.profile.d50 gh_hypophysectomy_rat_dn 11416039 Down-regulated in liver, heart or kidney tissue following treatment of hypophysectomized rats with growth hormone 29 0.0716863598160874 0 0 1 C07AA.profile.d50 gh_hypophysectomy_rat_up 11416039 Up-regulated in liver, heart or kidney tissue following treatment of hypophysectomized rats with growth hormone 39 0.0964057942354279 0 0 1 C07AA.profile.d50 gh_igf_chondrocytes_up 11416039 Up-regulated in cultured human chondrocytes by both GH and IGF-1 17 0.0420230385128788 0 0 1 C07AA.profile.d50 gn_camp_granulosa_dn 15026540 Down-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin 135 0.333712364661097 1 2.99659259259259 0.284036080238956 C07AA.profile.d50 gn_camp_granulosa_up 15026540 Up-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin 99 0.244722400751471 0 0 1 C07AA.profile.d50 h2o2_csbcombined 12606941 Upregulated by H2O2 in CSB-rescued fibroblasts, but deficient induction in CSB-null (Table 3) 26 0.0642705294902853 0 0 1 C07AA.profile.d50 h2o2_csbdiff_c1 12606941 Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) 58 0.143372719632175 0 0 1 C07AA.profile.d50 h2o2_csbdiff_c2 12606941 Deficient induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 2) 63 0.155732436841845 0 0 1 C07AA.profile.d50 h2o2_csbdiff_c3 12606941 Deficient induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 3) 9 0.0222474909774064 0 0 1 C07AA.profile.d50 h2o2_csbrescued_c1_up 12606941 Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 1) 84 0.20764324912246 0 0 1 C07AA.profile.d50 h2o2_csbrescued_c2_up 12606941 Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 2) 17 0.0420230385128788 0 0 1 C07AA.profile.d50 h2o2_csbrescued_up 12606941 Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1) 101 0.249666287635339 0 0 1 C07AA.profile.d50 hbx_hcc_dn 11439330 Downregulated by expression of Hepatitis B virus HBx protein in SK-Hep-1 hepatocellular carcinoma cells (Fig. 3B+D) 47 0.1161813417709 0 0 1 C07AA.profile.d50 hbx_hcc_up 11439330 Upregulated by expression of Hepatitis B virus HBx protein in SK-Hep-1 hepatocellular carcinoma cells (Fig. 3A+C) 20 0.049438868838681 0 0 1 C07AA.profile.d50 hbx_hep_dn 11439330 Downregulated both by expression of Hepatitis B virus HBx protein in normal hepatoctyes and by HBV infection in liver samples with chronic active hepatitis 30 0.0741583032580215 0 0 1 C07AA.profile.d50 hbx_hep_up 11439330 Upregulated both by expression of Hepatitis B virus HBx protein in normal hepatoctyes and by HBV infection in liver samples with chronic active hepatitis 33 0.0815741335838236 0 0 1 C07AA.profile.d50 hbx_nl_dn 11439330 Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) 27 0.0667424729322193 0 0 1 C07AA.profile.d50 hbx_nl_up 11439330 Upregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3A+D) 40 0.098877737677362 0 0 1 C07AA.profile.d50 hdaci_colon_but12hrs_dn 10969808 Downregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 109 0.269441835170811 1 3.71137614678899 0.236449037089975 C07AA.profile.d50 hdaci_colon_but12hrs_up 10969808 Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.133484945864439 0 0 1 C07AA.profile.d50 hdaci_colon_but16hrs_dn 10969808 Downregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 167 0.412814554802986 2 4.84479041916168 0.0648215936108923 C07AA.profile.d50 hdaci_colon_but16hrs_up 10969808 Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.1161813417709 0 0 1 C07AA.profile.d50 hdaci_colon_but24hrs_dn 10969808 Downregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 168 0.41528649824492 1 2.40797619047619 0.340188194664701 C07AA.profile.d50 hdaci_colon_but24hrs_up 10969808 Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.234834626983735 0 0 1 C07AA.profile.d50 hdaci_colon_but2hrs_dn 10969808 Downregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 23 0.0568546991644831 1 17.5886956521739 0.0553351646472273 C07AA.profile.d50 hdaci_colon_but2hrs_up 10969808 Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.215059079448262 0 0 1 C07AA.profile.d50 hdaci_colon_but30min_dn 10969808 Downregulated by butyrate at 30 min in SW260 colon carcinoma cells 79 0.19528353191279 1 5.12075949367089 0.177597459646681 C07AA.profile.d50 hdaci_colon_but48hrs_dn 10969808 Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 165 0.407870667919118 4 9.8070303030303 0.000810025776413973 C07AA.profile.d50 hdaci_colon_but48hrs_up 10969808 Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.333712364661097 0 0 1 C07AA.profile.d50 hdaci_colon_but_dn 10969808 Downregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 387 0.956642112028477 4 4.18129198966408 0.0163025317164975 C07AA.profile.d50 hdaci_colon_but_up 10969808 Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.575962821970633 0 0 1 C07AA.profile.d50 hdaci_colon_cluster1 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.0296633213032086 0 0 1 C07AA.profile.d50 hdaci_colon_cluster10 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 10, associated with histone hyperAc) 60 0.148316606516043 0 0 1 C07AA.profile.d50 hdaci_colon_cluster2 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) 9 0.0222474909774064 0 0 1 C07AA.profile.d50 hdaci_colon_cluster3 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 3) 9 0.0222474909774064 0 0 1 C07AA.profile.d50 hdaci_colon_cluster4 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 4) 19 0.0469669253967469 1 21.2915789473684 0.0459365220634866 C07AA.profile.d50 hdaci_colon_cluster5 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 5) 32 0.0791021901418896 1 12.641875 0.0761449755804292 C07AA.profile.d50 hdaci_colon_cluster6 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 6) 63 0.155732436841845 0 0 1 C07AA.profile.d50 hdaci_colon_cluster7 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 7) 21 0.051910812280615 0 0 1 C07AA.profile.d50 hdaci_colon_cluster8 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 8) 18 0.0444949819548129 0 0 1 C07AA.profile.d50 hdaci_colon_cluster9 10969808 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.192811588470856 0 0 1 C07AA.profile.d50 hdaci_colon_cur12hrs_dn 10969808 Downregulated by curcumin at 12 hrs in SW260 colon carcinoma cells 5 0.0123597172096702 0 0 1 C07AA.profile.d50 hdaci_colon_cur12hrs_up 10969808 Upregulated by curcumin at 12 hrs in SW260 colon carcinoma cells 22 0.0543827557225491 0 0 1 C07AA.profile.d50 hdaci_colon_cur16hrs_dn 10969808 Downregulated by curcumin at 16 hrs in SW260 colon carcinoma cells 22 0.0543827557225491 0 0 1 C07AA.profile.d50 hdaci_colon_cur16hrs_up 10969808 Upregulated by curcumin at 16 hrs in SW260 colon carcinoma cells 6 0.0148316606516043 0 0 1 C07AA.profile.d50 hdaci_colon_cur24hrs_dn 10969808 Downregulated by curcumin at 24 hrs in SW260 colon carcinoma cells 9 0.0222474909774064 0 0 1 C07AA.profile.d50 hdaci_colon_cur24hrs_up 10969808 Upregulated by curcumin at 24 hrs in SW260 colon carcinoma cells 73 0.180451871261186 0 0 1 C07AA.profile.d50 hdaci_colon_cur2hrs_up 10969808 Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells 49 0.121125228654768 1 8.25591836734694 0.114209828507162 C07AA.profile.d50 hdaci_colon_cur30min_dn 10969808 Downregulated by curcumin at 30 min in SW260 colon carcinoma cells 17 0.0420230385128788 0 0 1 C07AA.profile.d50 hdaci_colon_cur30min_up 10969808 Upregulated by curcumin at 30 min in SW260 colon carcinoma cells 9 0.0222474909774064 0 0 1 C07AA.profile.d50 hdaci_colon_cur48hrs_up 10969808 Upregulated by curcumin at 48 hrs in SW260 colon carcinoma cells 109 0.269441835170811 0 0 1 C07AA.profile.d50 hdaci_colon_cur_dn 10969808 Downregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 51 0.126069115538636 0 0 1 C07AA.profile.d50 hdaci_colon_cursul_dn 10969808 Downregulated by both curcumin and sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 20 0.049438868838681 0 0 1 C07AA.profile.d50 hdaci_colon_cursul_up 10969808 Upregulated by both curcumin and sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 53 0.131013002422505 0 0 1 C07AA.profile.d50 hdaci_colon_cur_up 10969808 Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 174 0.430118158896524 1 2.32494252873563 0.349914021669067 C07AA.profile.d50 hdaci_colon_sul12hrs_dn 10969808 Downregulated by sulindac at 12 hrs in SW260 colon carcinoma cells 49 0.121125228654768 1 8.25591836734694 0.114209828507162 C07AA.profile.d50 hdaci_colon_sul12hrs_up 10969808 Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells 40 0.098877737677362 0 0 1 C07AA.profile.d50 hdaci_colon_sul16hrs_dn 10969808 Downregulated by sulindac at 16 hrs in SW260 colon carcinoma cells 111 0.274385722054679 1 3.6445045045045 0.240219280999167 C07AA.profile.d50 hdaci_colon_sul16hrs_up 10969808 Upregulated by sulindac at 16 hrs in SW260 colon carcinoma cells 67 0.165620210609581 0 0 1 C07AA.profile.d50 hdaci_colon_sul24hrs_dn 10969808 Downregulated by sulindac at 24 hrs in SW260 colon carcinoma cells 191 0.472141197409403 2 4.23602094240838 0.0816836428768688 C07AA.profile.d50 hdaci_colon_sul24hrs_up 10969808 Upregulated by sulindac at 24 hrs in SW260 colon carcinoma cells 102 0.252138231077273 1 3.96607843137255 0.22310523962343 C07AA.profile.d50 hdaci_colon_sul2hrs_dn 10969808 Downregulated by sulindac at 2 hrs in SW260 colon carcinoma cells 14 0.0346072081870767 0 0 1 C07AA.profile.d50 hdaci_colon_sul2hrs_up 10969808 Upregulated by sulindac at 2 hrs in SW260 colon carcinoma cells 10 0.0247194344193405 0 0 1 C07AA.profile.d50 hdaci_colon_sul30min_dn 10969808 Downregulated by sulindac at 30 min in SW260 colon carcinoma cells 79 0.19528353191279 0 0 1 C07AA.profile.d50 hdaci_colon_sul48hrs_dn 10969808 Downregulated by sulindac at 48 hrs in SW260 colon carcinoma cells 95 0.234834626983735 3 12.7749473684211 0.00176432360732473 C07AA.profile.d50 hdaci_colon_sul48hrs_up 10969808 Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells 140 0.346072081870767 1 2.88957142857143 0.292841550824324 C07AA.profile.d50 hdaci_colon_sul_dn 10969808 Downregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 340 0.840460770257577 4 4.75929411764706 0.0106048130362264 C07AA.profile.d50 hdaci_colon_sul_up 10969808 Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 192 0.474613140851337 1 2.10697916666667 0.378239754394249 C07AA.profile.d50 hdaci_colon_tsa12hrs_dn 10969808 Downregulated by TSA at 12 hrs in SW260 colon carcinoma cells 12 0.0296633213032086 0 0 1 C07AA.profile.d50 hdaci_colon_tsa12hrs_up 10969808 Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.051910812280615 0 0 1 C07AA.profile.d50 hdaci_colon_tsa24hrs_dn 10969808 Downregulated by TSA at 24 hrs in SW260 colon carcinoma cells 12 0.0296633213032086 0 0 1 C07AA.profile.d50 hdaci_colon_tsa24hrs_up 10969808 Upregulated by TSA at 24 hrs in SW260 colon carcinoma cells 8 0.0197755475354724 0 0 1 C07AA.profile.d50 hdaci_colon_tsa2hrs_dn 10969808 Downregulated by TSA at 2 hrs in SW260 colon carcinoma cells 33 0.0815741335838236 0 0 1 C07AA.profile.d50 hdaci_colon_tsa2hrs_up 10969808 Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.150788549957977 0 0 1 C07AA.profile.d50 hdaci_colon_tsa30min_dn 10969808 Downregulated by TSA at 30 min in SW260 colon carcinoma cells 34 0.0840460770257577 0 0 1 C07AA.profile.d50 hdaci_colon_tsa48hrs_dn 10969808 Downregulated by TSA at 48 hrs in SW260 colon carcinoma cells 11 0.0271913778612745 0 0 1 C07AA.profile.d50 hdaci_colon_tsa48hrs_up 10969808 Upregulated by TSA at 48 hrs in SW260 colon carcinoma cells 43 0.106293568003164 0 0 1 C07AA.profile.d50 hdaci_colon_tsabut_dn 10969808 Downregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 46 0.113709398328966 0 0 1 C07AA.profile.d50 hdaci_colon_tsabut_up 10969808 Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.19528353191279 0 0 1 C07AA.profile.d50 hdaci_colon_tsa_dn 10969808 Downregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 109 0.269441835170811 0 0 1 C07AA.profile.d50 hdaci_colon_tsa_up 10969808 Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.301577099915954 0 0 1 C07AA.profile.d50 hdaci_three_dn 12589032 Downregulated in several cell lines by all of TSA, SAHA, and MS-275 10 0.0247194344193405 0 0 1 C07AA.profile.d50 hdaci_three_up 12589032 Upregulated in several cell lines by all of TSA, SAHA, and MS-275 8 0.0197755475354724 0 0 1 C07AA.profile.d50 heartfailure_atria_dn 15103417 Downregulated in the atria of failing hearts (DCM and ICM) compared to healthy controls 213 0.526523953131952 1 1.89924882629108 0.40973034037311 C07AA.profile.d50 heartfailure_atria_up 15103417 Upregulated in atria of failing hearts (DCM and ICM) compared to healthy controls 58 0.143372719632175 0 0 1 C07AA.profile.d50 heartfailure_ventricles_dn 15103417 Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls 120 0.296633213032086 0 0 1 C07AA.profile.d50 heartfailure_ventricles_up 15103417 Upregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls 14 0.0346072081870767 0 0 1 C07AA.profile.d50 heat_glioblastoma_dn 16802863 Down-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 32 0.0791021901418896 0 0 1 C07AA.profile.d50 heat_glioblastoma_up 16802863 Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.192811588470856 1 5.18641025641026 0.175559489333073 C07AA.profile.d50 heatshock_hela_2hr_dn 17216044 Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 223 0.551243387551293 1 1.81408071748879 0.424160229769154 C07AA.profile.d50 heatshock_hela_2hr_up 17216044 Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.437533989222327 1 2.28553672316384 0.354723041741331 C07AA.profile.d50 heatshock_hela_30min_dn 17216044 Down-regulated at 30 minutes following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 67 0.165620210609581 0 0 1 C07AA.profile.d50 heatshock_hela_30min_up 17216044 Up-regulated at 30 minutes following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, p < 0.05). 14 0.0346072081870767 0 0 1 C07AA.profile.d50 heatshock_hela_4hr_dn 17216044 Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 4.52118455529738 5 1.10590486604702 0.472034734875374 C07AA.profile.d50 heatshock_hela_4hr_up 17216044 Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 1.66856182330548 1 0.599318518518518 0.811871026749173 C07AA.profile.d50 heatshock_old_dn 12618007 Downregulated after heat shock in lymphocytes from old individuals, compared to young 13 0.0321352647451426 0 0 1 C07AA.profile.d50 heatshock_old_up 12618007 Upregulated after heat shock in lymphocytes from old individuals, compared to young 27 0.0667424729322193 0 0 1 C07AA.profile.d50 heatshock_young_dn 12618007 Downregulated after heat shock in lymphocytes from young individuals, compared to old 10 0.0247194344193405 0 0 1 C07AA.profile.d50 heatshock_young_up 12618007 Upregulated after heat shock in lymphocytes from young individuals, compared to old 18 0.0444949819548129 0 0 1 C07AA.profile.d50 hematop_stem_all_up 15231652 Up-regulated in populations of human hematopoietic stem cells (CD34+/CD38-/Lin-) from bone marrow, umbilical cord blood, and peripheral blood stem-progenitor cells, compared to the stem cell-depleted population (CD34+/[CD38/Lin++]) 52 0.128541058980571 0 0 1 C07AA.profile.d50 hg_progeria_dn 10741968 Downregulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals 48 0.118653285212834 0 0 1 C07AA.profile.d50 hg_progeria_up 10741968 regulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals 12 0.0296633213032086 0 0 1 C07AA.profile.d50 hif1_targets 11516994 Hif-1 (hypoxia-inducible factor 1) transcripional targets 67 0.165620210609581 2 12.0758208955224 0.0121455347948132 C07AA.profile.d50 hippocampus_development_neonatal 11438693 Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) 51 0.126069115538636 0 0 1 C07AA.profile.d50 hippocampus_development_postnatal 11438693 Highly expressed in late postnatal mouse hippocampus (clusters 11 and 15) 79 0.19528353191279 0 0 1 C07AA.profile.d50 hippocampus_development_prenatal 11438693 Highly expressed in prenatal mouse hippocampus (cluster 1) 58 0.143372719632175 0 0 1 C07AA.profile.d50 hpv31_dn 10756030 Downregulated in normal human keratinocytes carrying episomal HPV31 DNA 82 0.202699362238592 0 0 1 C07AA.profile.d50 hpv31_up 10756030 Upregulated in normal human keratinocytes carrying episomal HPV31 DNA 69 0.170564097493449 0 0 1 C07AA.profile.d50 hpve7_hpve6_hfk_dn 14517073 Down-regulated in human foreskin keratinocytes expressing both HPV E6 and E7 proteins compared to E7 expression only 39 0.0964057942354279 0 0 1 C07AA.profile.d50 hpve7_hpve6_hfk_up 14517073 Up-regulated in human foreskin keratinocytes expressing both HPV E6 and E7 proteins compared to E7 expression only 18 0.0444949819548129 0 0 1 C07AA.profile.d50 hpv_high-risk_up 17309674 Up-regulated in both HPV16- and HPV18-positive cervical tumors compared to normal cervial tissue. 21 0.051910812280615 0 0 1 C07AA.profile.d50 hpv_hnscc_up 16467079 Up-regulated in HPV-positive head and neck squamous cell carcinomas (HNSCC) compared to HPV-negative HNSCC. 68 0.168092154051515 0 0 1 C07AA.profile.d50 hsc_earlyprogenitors_adult 12228721 Up-regulated in mouse hematopoietic early progenitors from adult bone marrow (Early Progenitors Shared + Adult) 526 1.30024225045731 1 0.769087452471483 0.727972459618089 C07AA.profile.d50 hsc_earlyprogenitors_fetal 12228721 Up-regulated in mouse hematopoietic early progenitors from fetal liver (Early Progenitors Shared) 520 1.28541058980571 1 0.777961538461538 0.723902701330162 C07AA.profile.d50 hsc_earlyprogenitors_shared 12228721 Up-regulated in mouse hematopoietic early progenitors from both adult bone marrow and fetal liver (Cluster iv, Early Progenitors Shared) 520 1.28541058980571 1 0.777961538461538 0.723902701330162 C07AA.profile.d50 hsc_hsc_adult 12228721 Up-regulated in mouse hematopoietic stem cells from adult bone marrow (HSC Shared + Adult) 363 0.89731546942206 0 0 1 C07AA.profile.d50 hsc_hscandprogenitors_adult 12228721 Up-regulated in mouse hematopoietic stem cells and progenitors from adult bone marrow (HSC and Progenitors Shared + Adult) 724 1.78968705196025 1 0.558756906077348 0.833357204521378 C07AA.profile.d50 hsc_hscandprogenitors_fetal 12228721 Up-regulated in mouse hematopoietic stem cells and progenitors from fetal liver (HSC and Progenitors Shared) 717 1.77238344786671 1 0.564211994421199 0.830444959209486 C07AA.profile.d50 hsc_hscandprogenitors_shared 12228721 Up-regulated in mouse hematopoietic stem cells and progenitors from both adult bone marrow and fetal liver (Cluster iii, HSC and Progenitors Shared) 717 1.77238344786671 1 0.564211994421199 0.830444959209486 C07AA.profile.d50 hsc_hsc_fetal 12228721 Up-regulated in mouse hematopoietic stem cells from fetal liver (HSC Shared + Fetal) 303 0.748998862906017 0 0 1 C07AA.profile.d50 hsc_hsc_shared 12228721 Up-regulated in mouse hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster ii, HSC Shared) 270 0.667424729322193 0 0 1 C07AA.profile.d50 hsc_intermediateprogenitors_adult 12228721 Up-regulated in mouse hematopoietic intermediate progenitors from adult bone marrow (Intermediate Progenitors Shared + Adult) 161 0.397982894151382 0 0 1 C07AA.profile.d50 hsc_intermediateprogenitors_fetal 12228721 Up-regulated in mouse hematopoietic intermediate progenitors from fetal liver (Intermediate Progenitors Shared + Fetal) 167 0.412814554802986 0 0 1 C07AA.profile.d50 hsc_intermediateprogenitors_shared 12228721 Up-regulated in mouse hematopoietic intermediate progenitors from both adult bone marrow and fetal liver (Cluster v, Intermediate Progenitors Shared) 151 0.373263459732041 0 0 1 C07AA.profile.d50 hsc_lateprogenitors_adult 12228721 Up-regulated in mouse hematopoietic late progenitors from adult bone marrow (Late Progenitors Shared + Adult) 558 1.3793444405992 0 0 1 C07AA.profile.d50 hsc_lateprogenitors_fetal 12228721 Up-regulated in mouse hematopoietic late progenitors from fetal liver (Late Progenitors Shared + Fetal) 558 1.3793444405992 0 0 1 C07AA.profile.d50 hsc_lateprogenitors_shared 12228721 Up-regulated in mouse hematopoietic late progenitors from both adult bone marrow and fetal liver (Cluster vi, Late Progenitors Shared) 549 1.35709694962179 0 0 1 C07AA.profile.d50 hsc_lthsc_adult 12228721 Up-regulated in mouse long-term functional hematopoietic stem cells from adult bone marrow (LT-HSC Shared + Adult) 385 0.951698225144609 0 0 1 C07AA.profile.d50 hsc_lthsc_fetal 12228721 Up-regulated in mouse long-term functional hematopoietic stem cells from fetal liver (LT-HSC Shared) 272 0.672368616206061 0 0 1 C07AA.profile.d50 hsc_lthsc_shared 12228721 Up-regulated in mouse long-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster i, LT-HSC Shared) 272 0.672368616206061 0 0 1 C07AA.profile.d50 hsc_mature_adult 12228721 Up-regulated in mouse mature bood cells from adult bone marrow, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared + Adult) 427 1.05551984970584 0 0 1 C07AA.profile.d50 hsc_mature_fetal 12228721 Up-regulated in mouse mature bood cells from fetal liver, compared to hematopoietic progenitors (Mature Blood Cells Shared + Fetal) 376 0.929450734167202 0 0 1 C07AA.profile.d50 hsc_mature_shared 12228721 Up-regulated in mouse mature bood cells from both adult bone marrow and fetal liver, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared) 309 0.763830523557621 0 0 1 C07AA.profile.d50 hsc_sthsc_adult 12228721 Up-regulated in mouse short-term functional hematopoietic stem cells from adult bone marrow (ST-HSC Shared + Adult) 51 0.126069115538636 0 0 1 C07AA.profile.d50 hsc_sthsc_fetal 12228721 Up-regulated in mouse short-term functional hematopoietic stem cells from fetal liver (ST-HSC Shared) 44 0.108765511445098 0 0 1 C07AA.profile.d50 hsc_sthsc_shared 12228721 Up-regulated in mouse short-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (ST-HSC Shared) 44 0.108765511445098 0 0 1 C07AA.profile.d50 htert_dn 12702554 Downregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 112 0.276857665496613 0 0 1 C07AA.profile.d50 htert_up 12702554 Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 97 0.239778513867603 0 0 1 C07AA.profile.d50 human_tissue_cerebellum 11904358 Genes expressed specifically in human cerebellum tissue 8 0.0197755475354724 0 0 1 C07AA.profile.d50 human_tissue_heart 11904358 Genes expressed specifically in human heart tissue 19 0.0469669253967469 0 0 1 C07AA.profile.d50 human_tissue_kidney 11904358 Genes expressed specifically in human kidney tissue 14 0.0346072081870767 0 0 1 C07AA.profile.d50 human_tissue_liver 11904358 Genes expressed specifically in human liver tissue 55 0.135956889306373 0 0 1 C07AA.profile.d50 human_tissue_lung 11904358 Genes expressed specifically in human lung tissue 11 0.0271913778612745 0 0 1 C07AA.profile.d50 human_tissue_pancreas 11904358 Genes expressed specifically in human pancreas tissue 71 0.175507984377317 0 0 1 C07AA.profile.d50 human_tissue_pituitary 11904358 Genes expressed specifically in human pituitary gland tissue 11 0.0271913778612745 0 0 1 C07AA.profile.d50 human_tissue_placenta 11904358 Genes expressed specifically in human placental tissue 40 0.098877737677362 0 0 1 C07AA.profile.d50 human_tissue_prostate 11904358 Genes expressed specifically in human prostate tissue 5 0.0123597172096702 1 80.908 0.0122987630274822 C07AA.profile.d50 human_tissue_salivary 11904358 Genes expressed specifically in human salivary gland tissue 18 0.0444949819548129 0 0 1 C07AA.profile.d50 human_tissue_spleen 11904358 Genes expressed specifically in human spleen tissue 12 0.0296633213032086 0 0 1 C07AA.profile.d50 human_tissue_testis 11904358 Genes expressed specifically in human testis tissue 122 0.301577099915954 0 0 1 C07AA.profile.d50 human_tissue_thymus 11904358 Genes expressed specifically in human thymus tissue 21 0.051910812280615 0 0 1 C07AA.profile.d50 human_tissue_trachea 11904358 Genes expressed specifically in human tracheal tissue 9 0.0222474909774064 0 0 1 C07AA.profile.d50 hyperme_colonca_sw48 16007088 Gene identified by chromatin IP and CpG island microarray as being hypermethylated in SW48 colon cancer cells, versus normal colon murcosa or WI38 fibroblasts 20 0.049438868838681 0 0 1 C07AA.profile.d50 hyperthyroid_rat_neuron_up 15234464 Up-regulated in cerebral tissue from hyperthyroid rats, compared to euthyroid controls 15 0.0370791516290107 0 0 1 C07AA.profile.d50 hypophysectomy_rat_dn 11416039 Down-regulated in liver, heart or kidney tissue from hypophysectomized rats (lacking growth hormone), compared to normal controls 95 0.234834626983735 0 0 1 C07AA.profile.d50 hypophysectomy_rat_up 11416039 Up-regulated in liver, heart or kidney tissue from hypophysectomized rats (lacking growth hormone), compared to normal controls 59 0.145844663074109 1 6.85661016949152 0.135864091087461 C07AA.profile.d50 hypoxia_fibro_up 14499499 Upregulated by hypoxia in normal fibroblasts from both young and old donors (Table 3) 34 0.0840460770257577 0 0 1 C07AA.profile.d50 hypoxia_fibro_young_up 14499499 Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) 15 0.0370791516290107 0 0 1 C07AA.profile.d50 hypoxia_normal_up 12692265 Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.929450734167202 0 0 1 C07AA.profile.d50 hypoxia_rcc_novhl_up 12692265 Upregulated by hypoxia in VHL-null renal carcinoma cells (Fig. 4h+i) 88 0.217531022890196 0 0 1 C07AA.profile.d50 hypoxia_rcc_up 12692265 Upregulated by hypoxia in VHL-rescued renal carcinoma cells (Fig. 3f+g) 170 0.420230385128788 1 2.37964705882353 0.343446197811993 C07AA.profile.d50 hypoxia_reg_up 12885785 Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.197755475354724 0 0 1 C07AA.profile.d50 hypoxia_review 11902584 Genes known to be induced by hypoxia 160 0.395510950709448 2 5.05675 0.0601527318933485 C07AA.profile.d50 icf_dn 11741835 Downregulated in B-cells from ICF syndrome (DNMT3B) compared to normals 23 0.0568546991644831 0 0 1 C07AA.profile.d50 icf_up 11741835 Upregulated in B-cells from ICF syndrome (DNMT3B) compared to normals 17 0.0420230385128788 0 0 1 C07AA.profile.d50 idx_tsa_dn_cluster1 15033539 Down-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 84 0.20764324912246 0 0 1 C07AA.profile.d50 idx_tsa_dn_cluster2 15033539 Progressively down-regulated from 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 2) 114 0.281801552380482 0 0 1 C07AA.profile.d50 idx_tsa_dn_cluster3 15033539 Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 108 0.266969891728877 0 0 1 C07AA.profile.d50 idx_tsa_dn_cluster4 15033539 Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 46 0.113709398328966 0 0 1 C07AA.profile.d50 idx_tsa_dn_cluster5 15033539 Strongly down-regulated at 2-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) 96 0.237306570425669 0 0 1 C07AA.profile.d50 idx_tsa_dn_cluster6 15033539 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.118653285212834 0 0 1 C07AA.profile.d50 idx_tsa_up_cluster1 15033539 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.108765511445098 0 0 1 C07AA.profile.d50 idx_tsa_up_cluster2 15033539 Strongly up-regulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 2) 105 0.259554061403075 0 0 1 C07AA.profile.d50 idx_tsa_up_cluster3 15033539 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.336184308103031 0 0 1 C07AA.profile.d50 idx_tsa_up_cluster4 15033539 Progressively up-regulated from 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 65 0.160676323725713 0 0 1 C07AA.profile.d50 idx_tsa_up_cluster5 15033539 Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) 149 0.368319572848173 0 0 1 C07AA.profile.d50 idx_tsa_up_cluster6 15033539 Strongly up-regulated at 96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 249 0.615513917041578 0 0 1 C07AA.profile.d50 ifna_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following treatment with interferon-alpha 103 0.254610174519207 0 0 1 C07AA.profile.d50 ifn_all_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferons alpha, beta and gamma 41 0.101349681119296 0 0 1 C07AA.profile.d50 ifnalpha_hcc_dn 11910354 Downregulated by interferon alpha treatment in Hep3B hepatocellular carcinoma cells 22 0.0543827557225491 0 0 1 C07AA.profile.d50 ifnalpha_hcc_up 11910354 Upregulated by interferon alpha treatment in Hep3B hepatocellular carcinoma cells 50 0.123597172096702 0 0 1 C07AA.profile.d50 ifnalpha_nl_dn 11910354 Downregulated by interferon alpha treatment in normal primary hepatocytes 17 0.0420230385128788 0 0 1 C07AA.profile.d50 ifnalpha_nl_hcc_dn 11910354 Downregulated by interferon alpha treatment in both primary normal hepatocytes and Hep3B hepatocellular carcinoma cells 14 0.0346072081870767 0 0 1 C07AA.profile.d50 ifnalpha_nl_hcc_up 11910354 Upregulated by interferon alpha treatment in both normal primary hepatocytes and Hep3B hepatocellular carcinoma cells 30 0.0741583032580215 0 0 1 C07AA.profile.d50 ifnalpha_nl_up 11910354 Upregulated by interferon alpha treatment in normal primary hepatocytes 53 0.131013002422505 0 0 1 C07AA.profile.d50 ifnalpha_resist_dn 12414529 Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line 25 0.0617985860483512 0 0 1 C07AA.profile.d50 ifn_alpha_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon alpha 80 0.197755475354724 1 5.05675 0.179630392212937 C07AA.profile.d50 ifn_any_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with any of interferons alpha, beta and gamma 172 0.425174272012656 1 2.35197674418605 0.3466881136683 C07AA.profile.d50 ifna_uv-cmv_common_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following either infection with UV-inactivated CMV or interferon-alpha 47 0.1161813417709 0 0 1 C07AA.profile.d50 ifn_beta_glioma_dn 16140920 Down-regulated in human glioma cells (T98) at 48 hours following treatment with interferon-beta 92 0.227418796657932 3 13.1915217391304 0.00160955505021683 C07AA.profile.d50 ifn_beta_glioma_up 16140920 Up-regulated in human glioma cells (T98) at 48 hours following treatment with interferon-beta 124 0.306520986799822 0 0 1 C07AA.profile.d50 ifn_beta_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon beta 143 0.353487912196569 0 0 1 C07AA.profile.d50 ifn_gamma_up 9861020 Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon gamma 80 0.197755475354724 0 0 1 C07AA.profile.d50 igf1_nih3t3_up 11606465 Up-regulated by treatment with IGF1 of NIH3T3 cells overexpressing IGF1R (Tables 1+3) 61 0.150788549957977 0 0 1 C07AA.profile.d50 igfr_ir_dn 12213819 Down-regulated in common following stimulation of chimeric TrkC/IR or TrkC/IGFR in NIH3T3 cells 17 0.0420230385128788 0 0 1 C07AA.profile.d50 igfr_ir_up 12213819 Up-regulated in common following stimulation of chimeric TrkC/IR or TrkC/IGFR in NIH3T3 cells 36 0.0889899639096258 0 0 1 C07AA.profile.d50 igfr_vs_ir_up 12213819 Up-regulated following stimulation of chimeric TrkC/IGFR in NIH3T3 cells, compared to stimulation of TrkC/IR 13 0.0321352647451426 0 0 1 C07AA.profile.d50 igf_vs_pdgf_dn 15475267 Down-regulated in mouse C2AS12 myoblasts by treatment with IGF1, compared to treatment with PDGF 53 0.131013002422505 0 0 1 C07AA.profile.d50 igf_vs_pdgf_up 15475267 Up-regulated in mouse C2AS12 myoblasts by treatment with IGF1, compared to treatment with PDGF 87 0.215059079448262 0 0 1 C07AA.profile.d50 il1_cornea_dn 12091409 Downregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 3) 163 0.40292678103525 0 0 1 C07AA.profile.d50 il1_cornea_up 12091409 Upregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 2) 136 0.336184308103031 1 2.97455882352941 0.28580590255507 C07AA.profile.d50 il2_pbmc_24hr_dn 17471163 Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.5968754634894 0 0 1 C07AA.profile.d50 il2_pbmc_24hr_up 17471163 Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 503 1.24338755129283 1 0.804254473161034 0.71203803698237 C07AA.profile.d50 il2_pbmc_2hr_dn 17471163 Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 27 0.0667424729322193 0 0 1 C07AA.profile.d50 il2_pbmc_2hr_up 17471163 Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.163148267167647 1 6.12939393939394 0.15070632602094 C07AA.profile.d50 il2_pbmc_30min_dn 17471163 Down-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 27 0.0667424729322193 0 0 1 C07AA.profile.d50 il2_pbmc_30min_up 17471163 Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.163148267167647 1 6.12939393939394 0.15070632602094 C07AA.profile.d50 il2_pbmc_48hr_dn 17471163 Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 531 1.31260196766698 1 0.761845574387947 0.731318061874195 C07AA.profile.d50 il2_pbmc_48hr_up 17471163 Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.2631630988283 1 0.791663405088063 0.717683616698245 C07AA.profile.d50 il2_pbmc_4hr_dn 17471163 Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 555 1.3719286102734 1 0.728900900900901 0.746813035947369 C07AA.profile.d50 il2_pbmc_4hr_up 17471163 Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26069115538636 2 1.58643137254902 0.35930410633112 C07AA.profile.d50 il2_pbmc_6hr_dn 17471163 Down-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31013002422505 2 1.52656603773585 0.376897212095414 C07AA.profile.d50 il2_pbmc_6hr_up 17471163 Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31013002422505 1 0.763283018867924 0.73065224946867 C07AA.profile.d50 il6_fibro_dn 15095275 Downregulated following IL-6 treatment in normal skin fibroblasts 10 0.0247194344193405 0 0 1 C07AA.profile.d50 il6_fibro_up 15095275 Upregulated following IL-6 treatment in normal skin fibroblasts 85 0.210115192564394 0 0 1 C07AA.profile.d50 il6_scar_fibro_dn 15095275 Downregulated following IL-6 treatment in hypertrophic scar fibroblasts 22 0.0543827557225491 0 0 1 C07AA.profile.d50 il6_scar_fibro_up 15095275 Upregulated following IL-6 treatment in hypertrophic scar fibroblasts 44 0.108765511445098 1 9.19409090909091 0.103180052494472 C07AA.profile.d50 innerear_up 11888886 Genes prefentially expressed in human inner ear tissue (cochlea and vestibule), at least 10-fold higher from a mixture of 29 other tissues 53 0.131013002422505 1 7.63283018867924 0.122935899065965 C07AA.profile.d50 inos_10_dn 12381414 Ten most-downregulated genes following iNOS induction in hepatocytes 12 0.0296633213032086 0 0 1 C07AA.profile.d50 inos_10_up 12381414 Ten most-upregulated genes following iNOS induction in hepatocytes 10 0.0247194344193405 0 0 1 C07AA.profile.d50 inos_all_dn 12381414 Downregulated following iNOS induction in hepatocytes (Tables 3-17) 117 0.289217382706284 1 3.45760683760684 0.251418680243775 C07AA.profile.d50 inos_all_up 12381414 Upregulated following iNOS induction in hepatocytes (Tables 3-17) 87 0.215059079448262 0 0 1 C07AA.profile.d50 insulin_adip_insens_dn 14530283 Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 25 0.0617985860483512 0 0 1 C07AA.profile.d50 insulin_adip_insens_up 14530283 Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 37 0.0914619073515598 0 0 1 C07AA.profile.d50 insulin_adip_sens_dn 14530283 Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.0716863598160874 0 0 1 C07AA.profile.d50 insulin_adip_sens_up 14530283 Up-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 21 0.051910812280615 0 0 1 C07AA.profile.d50 insulin_nih3t3_up 11606465 Up-regulated by treatment with insulin of NIH3T3 cells overexpressing insulin receptor 30 0.0741583032580215 1 13.4846666666667 0.0715605491904371 C07AA.profile.d50 irs1_ko_adip_dn 15895078 Down-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 201 0.496860631828744 1 2.0126368159204 0.391936372149694 C07AA.profile.d50 irs1_ko_adip_up 15895078 Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.393039007267514 1 2.54427672955975 0.325325950527263 C07AA.profile.d50 irs_ko_adip_dn 15895078 Progressively down-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) 64 0.158204380283779 0 0 1 C07AA.profile.d50 irs_ko_adip_up 15895078 Progressively up-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) 36 0.0889899639096258 1 11.2372222222222 0.0852460295192012 C07AA.profile.d50 jnk_dn 12354774 Downregulated by expression of constitutively active JNK in 3T3 cells 57 0.140900776190241 0 0 1 C07AA.profile.d50 jnk_up 12354774 Upregulated by expression of constitutively active JNK in 3T3 cells 66 0.163148267167647 0 0 1 C07AA.profile.d50 lal_ko_1mo_up 16127159 Up-regulated at 1 month of age in lungs from lysosomal acid lipase (LAL) knockout mice, which display pulmonary pathology, versus wild-type controls 6 0.0148316606516043 0 0 1 C07AA.profile.d50 lal_ko_3mo_up 16127159 Up-regulated at 3 months of age in lungs from lysosomal acid lipase (LAL) knockout mice, which display pulmonary pathology, versus wild-type controls 69 0.170564097493449 1 5.86289855072464 0.15698898779423 C07AA.profile.d50 lal_ko_6mo_up 16127159 Up-regulated at 6 months of age in lungs from lysosomal acid lipase (LAL) knockout mice, which display pulmonary pathology, versus wild-type controls 106 0.262026004845009 1 3.81641509433962 0.230758562852774 C07AA.profile.d50 lh_granulosa_dn 15026540 Down-regulated in human granulosa cells stimulated with luteinizing hormone (LH) 191 0.472141197409403 1 2.11801047120419 0.376698989549114 C07AA.profile.d50 lh_granulosa_up 15026540 Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) 167 0.412814554802986 0 0 1 C07AA.profile.d50 lvad_heartfailure_dn 12824457 Downregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 78 0.192811588470856 0 0 1 C07AA.profile.d50 lvad_heartfailure_up 12824457 Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.444949819548129 2 4.49488888888889 0.0737983348269049 C07AA.profile.d50 mammary_dev_up 16278680 Up-regulated in the intact developing mouse mammary gland; higher expression in 5/6 week pubertal glands than in 3 week, mid-pregnant, lactating, involuting or resuckled glands 84 0.20764324912246 1 4.81595238095238 0.187711993603686 C07AA.profile.d50 maternalcare_tsa-met_all 14635221 Top 100 genes significantly altered in hippocampi from adult offspring of mice with high versus low maternal care, following treatment with either trichostatin, methionine or vehicle control and exposure to open-field stress. 151 0.373263459732041 1 2.67907284768212 0.31183425697415 C07AA.profile.d50 mbd_targets_all 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by any of several methyl-CpG binding proteins (MeCP2, MBD1, MBD2, MBD3) in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 24 0.0593266426064172 0 0 1 C07AA.profile.d50 mbd_targets_mbd1 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by the methyl-CpG binding protein MBD1 in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 10 0.0247194344193405 0 0 1 C07AA.profile.d50 mbd_targets_mbd2 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by the methyl-CpG binding protein MBD2 in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 14 0.0346072081870767 0 0 1 C07AA.profile.d50 mbd_targets_mbd3 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by the methyl-CpG binding protein MBD3 in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 8 0.0197755475354724 0 0 1 C07AA.profile.d50 mbd_targets_mecp2 14633992 Genes identified by ChIP-CpG microarray analysis as being bound by the methyl-CpG binding protein MeCP2 in either of two breast cancer cell lines (MCF7 or MDA-MB-231) 10 0.0247194344193405 0 0 1 C07AA.profile.d50 metastasis_adenocarc_dn 12469122 Down-regulated in adenocarcinoma metastases, compared to similar primary tumors; predictive of metastatic potential 97 0.239778513867603 2 8.34103092783505 0.0243618042497929 C07AA.profile.d50 metastasis_adenocarc_up 12469122 Up-regulated in adenocarcinoma metastases, compared to similar primary tumors; predictive of metastatic potential 81 0.200227418796658 0 0 1 C07AA.profile.d50 methotrexate_probcell_dn 12447701 Down-regulated in pro-B cells (FL5.12) following treatment with methotrexate 22 0.0543827557225491 0 0 1 C07AA.profile.d50 methotrexate_probcell_up 12447701 Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate 24 0.0593266426064172 0 0 1 C07AA.profile.d50 microrna_human 15502875 Predicted human MicroRNA targets 2276 5.62614327384189 4 0.710966608084359 0.812537426835673 C07AA.profile.d50 microrna_mammal 15502875 Predicted MicroRNA targets conserved across human, mouse and rat 1331 3.29015672121422 2 0.607873779113449 0.840547317733355 C07AA.profile.d50 microrna_vertebrate 15502875 Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu 214 0.528995896573886 0 0 1 C07AA.profile.d50 middleage_dn 10741968 Downregulated in fibroblasts from middle-age individuals, compared to young 23 0.0568546991644831 0 0 1 C07AA.profile.d50 middleage_up 10741968 Upregulated in fibroblasts from middle-age individuals, compared to young 25 0.0617985860483512 0 0 1 C07AA.profile.d50 mkk6ee_up 12208764 Upregulated by expression of constitutively active MKK6 31 0.0766302466999555 0 0 1 C07AA.profile.d50 mmc_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to mitomycin C 14 0.0346072081870767 0 0 1 C07AA.profile.d50 mms_human_lymph_high_24hrs_dn 15515172 Down-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS) 30 0.0741583032580215 0 0 1 C07AA.profile.d50 mms_human_lymph_high_24hrs_up 15515172 Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS) 32 0.0791021901418896 0 0 1 C07AA.profile.d50 mms_human_lymph_high_4hrs_dn 15515172 Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS) 11 0.0271913778612745 0 0 1 C07AA.profile.d50 mms_human_lymph_low_4hrs_dn 15515172 Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a low dose of methyl methanesulfonate (MMS) 38 0.0939338507934939 0 0 1 C07AA.profile.d50 mms_mouse_lymph_high_24hrs_up 15515172 Up-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of methyl methanesulfonate (MMS) 63 0.155732436841845 1 6.42126984126984 0.144376841800035 C07AA.profile.d50 mms_mouse_lymph_high_4hrs_up 15515172 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of methyl methanesulfonate (MMS) 64 0.158204380283779 0 0 1 C07AA.profile.d50 mms_mouse_lymph_low_4hrs_up 15515172 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a low dose of methyl methanesulfonate (MMS) 17 0.0420230385128788 0 0 1 C07AA.profile.d50 mouse_tissue_adrenal 11904358 Genes expressed specifically in mouse adrenal gland tissue 17 0.0420230385128788 0 0 1 C07AA.profile.d50 mouse_tissue_bradipose 11904358 Genes expressed specifically in mouse brown adipose tissue 4 0.00988777376773619 0 0 1 C07AA.profile.d50 mouse_tissue_cerebellum 11904358 Genes expressed specifically in mouse cerebellum tissue 13 0.0321352647451426 0 0 1 C07AA.profile.d50 mouse_tissue_eye 11904358 Genes expressed specifically in mouse eye tissue 8 0.0197755475354724 0 0 1 C07AA.profile.d50 mouse_tissue_kidney 11904358 Genes expressed specifically in mouse kidney tissue 20 0.049438868838681 0 0 1 C07AA.profile.d50 mouse_tissue_mammary 11904358 Genes expressed specifically in mouse mammary gland tissue 6 0.0148316606516043 0 0 1 C07AA.profile.d50 mouse_tissue_placenta 11904358 Genes expressed specifically in mouse placenta tissue 12 0.0296633213032086 0 0 1 C07AA.profile.d50 mouse_tissue_salivary 11904358 Genes expressed specifically in mouse salivary gland tissue 8 0.0197755475354724 0 0 1 C07AA.profile.d50 mouse_tissue_smintestine 11904358 Genes expressed specifically in mouse small intestine tissue 3 0.00741583032580215 0 0 1 C07AA.profile.d50 mouse_tissue_stomach 11904358 Genes expressed specifically in mouse stomach tissue 2 0.0049438868838681 0 0 1 C07AA.profile.d50 mouse_tissue_prostate 11904358 Genes expressed specifically in mouse testis tissue 47 0.1161813417709 0 0 1 C07AA.profile.d50 mouse_tissue_thymus 11904358 Genes expressed specifically in mouse thymus tissue 7 0.0173036040935383 0 0 1 C07AA.profile.d50 mtx_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to methotrexate 10 0.0247194344193405 0 0 1 C07AA.profile.d50 myc_targets 14519204 Myc-responsive genes reported in multiple systems 77 0.190339645028922 1 5.25376623376623 0.173516468788228 C07AA.profile.d50 myod_brg1_up 15870273 Genes up-regulated following transduction of MyoD in NIH 3T3 cells that fail to acheive full induction with expression of a dominant-negative BRG1 allele; induction thought to require functional BRG1 40 0.098877737677362 0 0 1 C07AA.profile.d50 myod_nih3t3_dn 15870273 Down-regulated at 24 hours in NIH 3T3 murine fibroblasts following transduction with MyoD and incubation in differentiation medium 91 0.224946853215998 1 4.4454945054945 0.201663698769778 C07AA.profile.d50 myod_nih3t3_up 15870273 Up-regulated at 24 hours in NIH 3T3 murine fibroblasts following transduction with MyoD and incubation in differentiation medium 134 0.331240421219163 1 3.0189552238806 0.282261872180867 C07AA.profile.d50 nab_lung_dn 15318170 Down-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 96 0.237306570425669 2 8.42791666666667 0.0238981068629042 C07AA.profile.d50 nab_lung_up 15318170 Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.0939338507934939 0 0 1 C07AA.profile.d50 nf90_dn 12036489 Downregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells 66 0.163148267167647 0 0 1 C07AA.profile.d50 nf90_up 12036489 Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells 56 0.138428832748307 0 0 1 C07AA.profile.d50 ni2_lung_dn 12915101 Downregulated by nickel(II) in human peripheral lung epithelial cells 40 0.098877737677362 0 0 1 C07AA.profile.d50 ni2_lung_up 12915101 Upregulated by nickel(II) in human peripheral lung epithelial cells 5 0.0123597172096702 0 0 1 C07AA.profile.d50 ni2_mouse_dn 12540486 Downregulated by nickel(II) in sensitive A/J mouse lung tissue 89 0.22000296633213 1 4.54539325842697 0.19770213130442 C07AA.profile.d50 ni2_mouse_up 12540486 Upregulated by nickel(II) in sensitive A/J mouse lung tissue 65 0.160676323725713 1 6.22369230769231 0.148601717620338 C07AA.profile.d50 nova2_ko_splicing 16041372 Genes that are alternatively spliced in the neocortex of mice deficient in the neuron-specific splicing factor Nova2, compared to wild-type controls 85 0.210115192564394 0 0 1 C07AA.profile.d50 o6bg_resist_medulloblastoma_dn 12479369 Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 109 0.269441835170811 0 0 1 C07AA.profile.d50 o6bg_resist_medulloblastoma_up 12479369 Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.113709398328966 0 0 1 C07AA.profile.d50 oldage_dn 10741968 Downregulated in fibroblasts from old individuals, compared to young 76 0.187867701586988 0 0 1 C07AA.profile.d50 oldage_up 10741968 Upregulated in fibroblasts from old individuals, compared to young 9 0.0222474909774064 0 0 1 C07AA.profile.d50 old_fibro_dn 14527998 Downregulated in fibroblasts from old individuals, compared to young 211 0.521580066248084 1 1.91725118483412 0.406801257634717 C07AA.profile.d50 old_fibro_up 14527998 Upregulated in fibroblasts from old individuals, compared to young 84 0.20764324912246 0 0 1 C07AA.profile.d50 oldonly_fibro_dn 14527998 Downregulated in fibroblasts from old (but not Werner) individuals, compared to young 61 0.150788549957977 1 6.63180327868852 0.140131000967157 C07AA.profile.d50 oldonly_fibro_up 14527998 Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.133484945864439 0 0 1 C07AA.profile.d50 oldwerner_fibro_dn 14527998 Commonly downregulated in fibroblasts from Werner Syndrome and old individuals, compared to young 150 0.370791516290107 0 0 1 C07AA.profile.d50 oldwerner_fibro_up 14527998 Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young 30 0.0741583032580215 0 0 1 C07AA.profile.d50 oxstress_breastca_dn 12414654 Downregulated by H2O2, Menadione and t-BH in breast cancer cells 16 0.0395510950709448 0 0 1 C07AA.profile.d50 oxstress_breastca_up 12414654 Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.111237454887032 0 0 1 C07AA.profile.d50 oxstress_rpe_h2o2hne_dn 12419474 Downregulated by H2O2 and HNE in retinal pigment epithelium cells (Tables 4) 73 0.180451871261186 0 0 1 C07AA.profile.d50 oxstress_rpe_h2o2tbh_dn 12419474 Downregulated by H2O2 and t-BH in retinal pigment epithelium cells (Tables 5) 67 0.165620210609581 0 0 1 C07AA.profile.d50 oxstress_rpe_hnetbh_dn 12419474 Downregulated by HNE and t-BH in retinal pigment epithelium cells (Tables 3) 137 0.338656251544965 0 0 1 C07AA.profile.d50 oxstress_rpethree_dn 12419474 Downregulated by all three of H2O2, HNE and t-BH in retinal pigment epithelium cells (Table 2) 61 0.150788549957977 0 0 1 C07AA.profile.d50 oxstress_rpetwo_dn 12419474 Downregulated by two of H2O2, HNE and t-BH in retinal pigment epithelium cells (Tables 3-5) 275 0.679784446531863 0 0 1 C07AA.profile.d50 p21_any_dn 12138103 Down-regulated at any timepoint (4-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 50 0.123597172096702 0 0 1 C07AA.profile.d50 p21_any_up 12138103 Up-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells 15 0.0370791516290107 0 0 1 C07AA.profile.d50 p21_early_dn 12138103 Down-regulated at early timepoints (4-8 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 16 0.0395510950709448 0 0 1 C07AA.profile.d50 p21_early_up 12138103 Up-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells 12 0.0296633213032086 0 0 1 C07AA.profile.d50 p21_late_dn 12138103 Down-regulated at late timepoints (20-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 8 0.0197755475354724 0 0 1 C07AA.profile.d50 p21_middle_dn 12138103 Down-regulated at intermediate timepoints (12-16 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 26 0.0642705294902853 0 0 1 C07AA.profile.d50 p21_p53_any_dn 12138103 Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 77 0.190339645028922 1 5.25376623376623 0.173516468788228 C07AA.profile.d50 p21_p53_early_dn 12138103 Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 23 0.0568546991644831 0 0 1 C07AA.profile.d50 p21_p53_late_dn 12138103 Down-regulated at late timepoints (20-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 17 0.0420230385128788 1 23.7964705882353 0.0412021928988779 C07AA.profile.d50 p21_p53_middle_dn 12138103 Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 37 0.0914619073515598 0 0 1 C07AA.profile.d50 p53_brca1_up 12802282 Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.121125228654768 0 0 1 C07AA.profile.d50 p53genes_all 12446780 p53 transcriptional targets 33 0.0815741335838236 0 0 1 C07AA.profile.d50 p53genes_apoptosis 12446780 p53 transcriptional targets involved in apoptosis 14 0.0346072081870767 0 0 1 C07AA.profile.d50 p53genes_arrest 12446780 p53 transcriptional targets involved in cell cycle arrest 10 0.0247194344193405 0 0 1 C07AA.profile.d50 paclitaxel_probcell_up 12447701 Up-regulated in pro-B cells (FL5.12) following treatment with paclitaxel 5 0.0123597172096702 0 0 1 C07AA.profile.d50 parp_ko_dn 11016956 Downregulated in MEF cells from PARP knockout mice 23 0.0568546991644831 0 0 1 C07AA.profile.d50 parp_ko_up 11016956 Upregulated in MEF cells from PARP knockout mice 61 0.150788549957977 1 6.63180327868852 0.140131000967157 C07AA.profile.d50 pdgf_es_dn 14981515 Down-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis 6 0.0148316606516043 0 0 1 C07AA.profile.d50 pdgf_es_up 14981515 Up-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis 28 0.0692144163741534 0 0 1 C07AA.profile.d50 pgj2_up 12032289 Upregulated by treatment with the prostaglandin 15d-PGJ2 12 0.0296633213032086 0 0 1 C07AA.profile.d50 pituitary_fetal_dn 15894316 Down-regulated in human fetal pituitary tissue, compared to adult pituitary tissue 15 0.0370791516290107 0 0 1 C07AA.profile.d50 pituitary_fetal_up 15894316 Up-regulated in human fetal pituitary tissue, compared to adult pituitary tissue 21 0.051910812280615 0 0 1 C07AA.profile.d50 platelet_expressed 12433680 Fifty genes most strongly expressed in human platlets from three healthy donors 66 0.163148267167647 2 12.2587878787879 0.0118021715811884 C07AA.profile.d50 pod1_ko_dn 16207825 Down-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 1135 2.80565580659515 2 0.712845814977974 0.77026198045398 C07AA.profile.d50 pod1_ko_most_dn 16207825 Most strongly down-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 43 0.106293568003164 0 0 1 C07AA.profile.d50 pod1_ko_most_up 16207825 Most strongly up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 61 0.150788549957977 0 0 1 C07AA.profile.d50 pod1_ko_up 16207825 Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 508 1.2557472685025 1 0.796338582677165 0.715579612926452 C07AA.profile.d50 preadip_vs_fibro_dn 12021175 Downregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 17 0.0420230385128788 0 0 1 C07AA.profile.d50 preadip_vs_fibro_up 12021175 Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 29 0.0716863598160874 0 0 1 C07AA.profile.d50 prmt5_kd_dn 15485929 Down-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 45 0.111237454887032 0 0 1 C07AA.profile.d50 prmt5_kd_up 15485929 Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.756414693231819 1 1.32202614379085 0.531093149822299 C07AA.profile.d50 pt650_colonca_dn 11755394 Downregulated by Pt-650, but not Et-743, in HCT116 cells (Fig. 6C) 24 0.0593266426064172 0 0 1 C07AA.profile.d50 pubertal_mammary 17486082 Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. 1260 3.1146487368369 9 2.88957142857143 0.0047657043215493 C07AA.profile.d50 pubertal_mammary_3-4wks_dn 17486082 Down-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. 55 0.135956889306373 1 7.35527272727273 0.127266645466854 C07AA.profile.d50 pubertal_mammary_3-4wks_up 17486082 Up-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. 301 0.744054976022149 4 5.37594684385382 0.00700559976251018 C07AA.profile.d50 pubertal_mammary_4-5wks_dn 17486082 Down-regulated > 1.5-fold in the developing mouse mammary gland between 4 and 5 weeks of age. 283 0.699559994067336 2 2.85893992932862 0.155522497639961 C07AA.profile.d50 pubertal_mammary_4-5wks_up 17486082 Up-regulated > 1.5-fold in the developing mouse mammary gland between 4 and 5 weeks of age. 368 0.90967518663173 4 4.39717391304348 0.0138115489272962 C07AA.profile.d50 pubertal_mammary_5-6wks_dn 17486082 Down-regulated > 1.5-fold in the developing mouse mammary gland between 5 and 6 weeks of age. 256 0.632817521135116 0 0 1 C07AA.profile.d50 pubertal_mammary_5-6wks_up 17486082 Up-regulated > 1.5-fold in the developing mouse mammary gland between 5 and 6 weeks of age. 143 0.353487912196569 1 2.82895104895105 0.298072765293967 C07AA.profile.d50 pubertal_mammary_6-7wks_dn 17486082 Down-regulated > 1.5-fold in the developing mouse mammary gland between 6 and 7 weeks of age. 106 0.262026004845009 2 7.63283018867924 0.0286978195866661 C07AA.profile.d50 pubertal_mammary_6-7wks_up 17486082 Up-regulated > 1.5-fold in the developing mouse mammary gland between 6 and 7 weeks of age. 363 0.89731546942206 0 0 1 C07AA.profile.d50 ra_saha_up 11696577 Upregulated by the combination of retinoic acid and the HDACi SAHA in NB4 (APL) cells 12 0.0296633213032086 0 0 1 C07AA.profile.d50 ras-grf1_ko_dn 17321057 Down-regulated in LCM-dissected hippocampus samples of Ras-GRF1 knockout mice compared to wild-type controls. 41 0.101349681119296 0 0 1 C07AA.profile.d50 ras-grf1_ko_up 17321057 Up-regulated in LCM-dissected hippocampus samples of Ras-GRF1 knockout mice compared to wild-type controls. 10 0.0247194344193405 0 0 1 C07AA.profile.d50 rb_creko_dn 17452985 Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 0.617985860483512 1 1.61816 0.46138321480792 C07AA.profile.d50 rb_creko_up 17452985 Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 344 0.850348544025313 0 0 1 C07AA.profile.d50 rb_ko_dn 17452985 Down-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. 149 0.368319572848173 0 0 1 C07AA.profile.d50 rb_ko_up 17452985 Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. 155 0.383151233499778 1 2.60993548387097 0.318613495469961 C07AA.profile.d50 rcc_nl_up 12692265 Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) 899 2.22227715429871 4 1.79995550611791 0.184854696360023 C07AA.profile.d50 refractory_gastric_dn 15033468 Downregulated in samples of gastric cancer refractory to 5-FU/cisplatin treatment, compared to chemosensitive controls 16 0.0395510950709448 0 0 1 C07AA.profile.d50 refractory_gastric_up 15033468 Upregulated in samples of gastric cancer refractory to 5-FU/cisplatin treatment, compared to chemosensitive controls 204 0.504276462154546 0 0 1 C07AA.profile.d50 reovirus_hek293_dn 12885910 Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 488 1.20630839966382 2 1.65795081967213 0.339743666477326 C07AA.profile.d50 reovirus_hek293_up 12885910 Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 1.21372422998962 1 0.823910386965377 0.703357282456164 C07AA.profile.d50 resistance_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to at least six of seven anticancer drugs tested 45 0.111237454887032 0 0 1 C07AA.profile.d50 rett_dn 12418965 Downregulated by expression of mutant MeCP2 (Rett syndrome) vs. wt MeCP2 in fibroblasts 31 0.0766302466999555 0 0 1 C07AA.profile.d50 rett_up 12418965 Upregulated by expression of mutant MeCP2 (Rett syndrome) vs. wt MeCP2 in fibroblasts 71 0.175507984377317 2 11.3954929577465 0.0135621608940957 C07AA.profile.d50 ribavirin_rsv_dn 12719586 Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin 101 0.249666287635339 1 4.00534653465346 0.221180040732672 C07AA.profile.d50 ribavirin_rsv_up 12719586 Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is enhanced by the anti-viral drug ribavirin 37 0.0914619073515598 0 0 1 C07AA.profile.d50 ros_mouse_aorta_dn 15054141 Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.313936817125624 0 0 1 C07AA.profile.d50 ros_mouse_aorta_up 15054141 Up-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 30 0.0741583032580215 0 0 1 C07AA.profile.d50 sarcomas_gistromal_dn 11965276 Top 20 negative significant genes associated with GI stromal tumors, versus other soft-tissue tumors. 17 0.0420230385128788 0 0 1 C07AA.profile.d50 sarcomas_gistromal_up 11965276 Top 20 positive significant genes associated with GI stromal tumors, versus other soft-tissue tumors. 15 0.0370791516290107 0 0 1 C07AA.profile.d50 sarcomas_histiocytoma_dn 11965276 Top 20 negative significant genes associated with malignant fibrous histiocytomas, versus other soft-tissue tumors. 10 0.0247194344193405 0 0 1 C07AA.profile.d50 sarcomas_histiocytoma_up 11965276 Top 20 positive significant genes associated with malignant fibrous histiocytomas, versus other soft-tissue tumors. 16 0.0395510950709448 0 0 1 C07AA.profile.d50 sarcomas_leiomyosarcoma_calp_dn 11965276 Top 20 negative significant genes associated with calponin positive leiomyosarcoma tumors, versus other soft-tissue tumors. 18 0.0444949819548129 0 0 1 C07AA.profile.d50 sarcomas_leiomyosarcoma_calp_up 11965276 Top 20 positive significant genes associated with calponin positive leiomyosarcoma tumors, versus other soft-tissue tumors. 14 0.0346072081870767 0 0 1 C07AA.profile.d50 sarcomas_leiomyosarcoma_dn 11965276 Top 20 negative significant genes associated with calponin negative leiomyosarcoma tumors, versus other soft-tissue tumors. 13 0.0321352647451426 0 0 1 C07AA.profile.d50 sarcomas_leiomyosarcoma_up 11965276 Top 20 positive significant genes associated with calponin negative leiomyosarcoma tumors, versus other soft-tissue tumors. 12 0.0296633213032086 0 0 1 C07AA.profile.d50 sarcomas_liposarcoma_dn 11965276 Top 20 negative significant genes associated with liposarcomas, versus other soft-tissue tumors. 12 0.0296633213032086 0 0 1 C07AA.profile.d50 sarcomas_liposarcoma_up 11965276 Top 20 positive significant genes associated with liposarcomas, versus other soft-tissue tumors. 14 0.0346072081870767 0 0 1 C07AA.profile.d50 sarcomas_schwannoma_dn 11965276 Top 20 negative significant genes associated with schwannomas, versus other soft-tissue tumors. 15 0.0370791516290107 0 0 1 C07AA.profile.d50 sarcomas_schwannoma_up 11965276 Top 20 positive significant genes associated with schwannomas, versus other soft-tissue tumors. 18 0.0444949819548129 0 0 1 C07AA.profile.d50 sarcomas_synovial_dn 11965276 Top 20 negative significant genes associated with synovial sarcomas, versus other soft-tissue tumors. 29 0.0716863598160874 0 0 1 C07AA.profile.d50 sarcomas_synovial_up 11965276 Top 20 positive significant genes associated with synovial sarcomas, versus other soft-tissue tumors. 16 0.0395510950709448 0 0 1 C07AA.profile.d50 scar_fibro_dn 15095275 Downregulated in hypertrophic scar fibroblasts, compared to normal skin fibroblasts 17 0.0420230385128788 0 0 1 C07AA.profile.d50 scar_fibro_up 15095275 Upregulated in hypertrophic scar fibroblasts, compared to normal skin fibroblasts 12 0.0296633213032086 0 0 1 C07AA.profile.d50 scchn_hpvneg_dn 17079134 Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 47 0.1161813417709 1 8.60723404255319 0.109814290537621 C07AA.profile.d50 scchn_hpvneg_up 17079134 Up-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 30 0.0741583032580215 0 0 1 C07AA.profile.d50 scchn_hpvpos_dn 17079134 Down-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 25 0.0617985860483512 0 0 1 C07AA.profile.d50 scchn_hpvpos_up 17079134 Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 31 0.0766302466999555 0 0 1 C07AA.profile.d50 scw_joint_24hrs_dn 15642130 Down-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 24 0.0593266426064172 0 0 1 C07AA.profile.d50 scw_joint_24hrs_up 15642130 Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 143 0.353487912196569 0 0 1 C07AA.profile.d50 scw_joint_4hrs_up 15642130 Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 230 0.568546991644831 0 0 1 C07AA.profile.d50 scw_joint_react_dn 15642130 Down-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 231 0.571018935086765 1 1.75125541125541 0.435449739301391 C07AA.profile.d50 scw_joint_react_up 15642130 Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.410342611361052 0 0 1 C07AA.profile.d50 senescence_hela_dn 17182682 Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 0.842932713699511 1 1.18633431085044 0.570002667929242 C07AA.profile.d50 senescence_hela_up 17182682 Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 262 0.647649181786721 1 1.54404580152672 0.477144936972078 C07AA.profile.d50 senescence_hff_dn 17182682 Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.739111089138281 1 1.35297658862876 0.522898545475786 C07AA.profile.d50 senescence_hff_up 17182682 Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 0.70203193750927 2 2.84887323943662 0.156382990366592 C07AA.profile.d50 senescence_rep-ind_dn 17182682 Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.422702328570722 1 2.36573099415205 0.345069161677589 C07AA.profile.d50 senescence_rep-ind_up 17182682 Up-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 31 0.0766302466999555 1 13.0496774193548 0.0738555990020986 C07AA.profile.d50 serum_fibroblast_cellcycle 14737219 Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.486972858061008 1 2.05350253807107 0.385886636314863 C07AA.profile.d50 serum_fibroblast_core_dn 14737219 Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 0.788549957976962 2 2.53630094043887 0.187003948513134 C07AA.profile.d50 serum_fibroblast_core_up 14737219 Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) 292 0.721807485044742 1 1.38541095890411 0.514560732429357 C07AA.profile.d50 shh_up 12444557 Upregulated by sonic hedgehog (shh) expression in murine neuronal precursor cells 16 0.0395510950709448 1 25.28375 0.0388262256909156 C07AA.profile.d50 shortattacklatency_up 14635221 Up-regulated in hippocampi from a mouse line selected for long attack latency (LAL) against an intruder, versus a line selected for short attack latency (SAL). 156 0.385623176941712 0 0 1 C07AA.profile.d50 space_up 12039873 Upregulated in space-flown fibroblasts 16 0.0395510950709448 0 0 1 C07AA.profile.d50 stemcell_common_dn 12228720 Depleted in mouse embryonic, neural and hematopoietic stem cells, compared to differentiated brain and bone marrow cells 104 0.257082117961141 0 0 1 C07AA.profile.d50 stemcell_common_up 12228720 Enriched in mouse embryonic, neural and hematopoietic stem cells, compared to differentiated brain and bone marrow cells 265 0.655065012112523 4 6.1062641509434 0.00449956569868173 C07AA.profile.d50 stemcell_embryonic_up 12228720 Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 4.91669550600682 6 1.22033182503771 0.369407355314611 C07AA.profile.d50 stemcell_hematopoietic_up 12228720 Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells 2092 5.17130568052603 6 1.16024856596558 0.414106045087414 C07AA.profile.d50 stemcell_neural_up 12228720 Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells 2805 6.93380135462501 10 1.44221033868093 0.162600722694117 C07AA.profile.d50 stress_arsenic_specific_dn 15824734 Genes down-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 48 0.118653285212834 0 0 1 C07AA.profile.d50 stress_arsenic_specific_up 15824734 Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 0.657536955554457 0 0 1 C07AA.profile.d50 stress_genotoxic_specific_dn 15824734 Genes down-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress 74 0.18292381470312 0 0 1 C07AA.profile.d50 stress_genotoxic_specific_up 15824734 Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress 67 0.165620210609581 0 0 1 C07AA.profile.d50 stress_ionizing_specific_dn 15824734 Genes down-regulated 4 hours following ionizing radiation treatment that discriminate IR from other stress agents 6 0.0148316606516043 0 0 1 C07AA.profile.d50 stress_ionizing_specific_up 15824734 Genes up-regulated 4 hours following ionizing radiation treatment that discriminate IR from other stress agents 29 0.0716863598160874 0 0 1 C07AA.profile.d50 stress_p53_specific_up 15824734 Genes discriminating p53 status 4 hours after DNA-damaging treatments (more strongly up-regulated in p53+/+ TK6 cells than p53-/- NH32 cells) 16 0.0395510950709448 0 0 1 C07AA.profile.d50 stress_tpa_specific_dn 15824734 Genes down-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents 5 0.0123597172096702 0 0 1 C07AA.profile.d50 stress_tpa_specific_up 15824734 Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents 78 0.192811588470856 0 0 1 C07AA.profile.d50 tafi_kd_dn 17179179 Down-regulated by stable siRNA knock-down of histone chaperone TAF-I in HeLa cells. 62 0.153260493399911 0 0 1 C07AA.profile.d50 tafi_kd_up 17179179 Up-regulated by stable siRNA knock-down of histone chaperone TAF-I in HeLa cells. 20 0.049438868838681 0 0 1 C07AA.profile.d50 tcell_anergic_up 15834410 Genes up-regulated in anergic mouse T helper cells (A.E7), versus non-anergic stimulated controls 132 0.326296534335294 0 0 1 C07AA.profile.d50 tff2_ko_dn 16121031 Down-regulated in pyloric atrium tissue from Trefoil Factor 2 (Tff2) knockout mice, compared to wild-type controls 11 0.0271913778612745 0 0 1 C07AA.profile.d50 tff2_ko_up 16121031 Up-regulated in pyloric atrium tissue from Trefoil Factor 2 (Tff2) knockout mice, compared to wild-type controls 36 0.0889899639096258 0 0 1 C07AA.profile.d50 tgfbeta_all_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, at any timepoint 200 0.49438868838681 1 2.0227 0.390429548469636 C07AA.profile.d50 tgfbeta_c1_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 1 42 0.10382162456123 0 0 1 C07AA.profile.d50 tgfbeta_c2_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 2 46 0.113709398328966 0 0 1 C07AA.profile.d50 tgfbeta_c3_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 3 38 0.0939338507934939 0 0 1 C07AA.profile.d50 tgfbeta_c4_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 4 26 0.0642705294902853 0 0 1 C07AA.profile.d50 tgfbeta_c5_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 5 41 0.101349681119296 1 9.86682926829268 0.0964963718305929 C07AA.profile.d50 tgfbeta_c6_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts, cluster 6 7 0.0173036040935383 0 0 1 C07AA.profile.d50 tgfbeta_early_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts at 30 min (clusters 1-3) 126 0.31146487368369 0 0 1 C07AA.profile.d50 tgfbeta_late_up 11279127 Upregulated by TGF-beta treatment of skin fibroblasts only at 1-4 hrs (clusters 4-6) 74 0.18292381470312 1 5.46675675675676 0.167356980462907 C07AA.profile.d50 tgfb_hmvec_2hr_dn 16405919 Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 0.872596035002719 0 0 1 C07AA.profile.d50 tgfb_hmvec_2hr_up 16405919 Up-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1997 4.9364710535423 7 1.41801702553831 0.228397303401675 C07AA.profile.d50 tgfb_hmvec_4hr_dn 16405919 Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.26543728679488 4 1.22495079485238 0.412087627939351 C07AA.profile.d50 tgfb_hmvec_4hr_up 16405919 Up-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1997 4.9364710535423 7 1.41801702553831 0.228397303401675 C07AA.profile.d50 tgfb_mammary_dn 17210685 Down-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). 106 0.262026004845009 1 3.81641509433962 0.230758562852774 C07AA.profile.d50 tgfb_mammary_up 17210685 Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). 118 0.291689326148218 0 0 1 C07AA.profile.d50 tgfb-wnt3a_mammary_dn 17210685 Down-regulated in common by both TGF-beta and Wnt3A in normal mouse mammary gland cells (top 124 genes). 106 0.262026004845009 0 0 1 C07AA.profile.d50 tgfb-wnt3a_mammary_up 17210685 Up-regulated in common by both TGF-beta and Wnt3A in normal mouse mammary gland cells (top 124 genes). 136 0.336184308103031 0 0 1 C07AA.profile.d50 tgz_adip_up 12732648 Upregulated in mature, differentiated adipocytes following treatment with troglitazone 43 0.106293568003164 0 0 1 C07AA.profile.d50 tis7_overexp_dn 12198164 Downregulated by overexpression of TIS7 in murine mammary epithelial cells 27 0.0667424729322193 0 0 1 C07AA.profile.d50 tnfalpha_30min_up 12673210 Upregulated 30min after TNF-alpha treatment of HeLa cells 68 0.168092154051515 0 0 1 C07AA.profile.d50 tnfalpha_4hrs_up 12673210 Upregulated 4hrs after TNF-alpha treatment of HeLa cells 62 0.153260493399911 0 0 1 C07AA.profile.d50 tnfalpha_adip_dn 12732648 Downregulated in mature, differentiated adipocytes following treatment with TNFalpha 101 0.249666287635339 0 0 1 C07AA.profile.d50 tnfalpha_adip_up 12732648 Upregulated in mature, differentiated adipocytes following treatment with TNFalpha 22 0.0543827557225491 0 0 1 C07AA.profile.d50 tnfalpha_all_up 12673210 Upregulated at any timepoint after TNF-alpha treatment of HeLa cells 122 0.301577099915954 0 0 1 C07AA.profile.d50 tnfalpha_tgz_adip_dn 12732648 Downregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha 39 0.0964057942354279 0 0 1 C07AA.profile.d50 tnfalpha_tgz_adip_up 12732648 Upregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha 28 0.0692144163741534 0 0 1 C07AA.profile.d50 tnfa_nfkb_dep_up 15722553 Up-regulated at any timepoint following TNFa treatment, only with functional NFkB 26 0.0642705294902853 0 0 1 C07AA.profile.d50 tnfa_nfkb_ind_dn 15722553 Down-regulated at any timepoint following TNFa treatment, independent of NFkB function 12 0.0296633213032086 1 33.7116666666667 0.0292633326652399 C07AA.profile.d50 tnfa_nfkb_ind_up 15722553 Up-regulated at any timepoint following TNFa treatment, independent of NFkB function 14 0.0346072081870767 0 0 1 C07AA.profile.d50 tpa_resist_early_dn 12384596 Downregulated by TPA at two consecutive timepoints between 15min-3hrs in resistant HL-525 cells 140 0.346072081870767 0 0 1 C07AA.profile.d50 tpa_resist_early_up 12384596 Upregulated by TPA at two consecutive timepoints between 15min-3hrs in resistant HL-525 cells 57 0.140900776190241 0 0 1 C07AA.profile.d50 tpa_resist_late_dn 12384596 Downregulated by TPA at two consecutive timepoints between 12-48 hrs in resistant HL-525 cells 112 0.276857665496613 0 0 1 C07AA.profile.d50 tpa_resist_late_up 12384596 Upregulated by TPA at two consecutive timepoints between 12-48 hrs in resistant HL-525 cells 79 0.19528353191279 0 0 1 C07AA.profile.d50 tpa_resist_middle_dn 12384596 Downregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells 209 0.516636179364216 0 0 1 C07AA.profile.d50 tpa_resist_middle_up 12384596 Upregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells 100 0.247194344193405 0 0 1 C07AA.profile.d50 tpa_sens_early_dn 12384596 Downregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells 564 1.3941761012508 2 1.4345390070922 0.406323639731222 C07AA.profile.d50 tpa_sens_early_up 12384596 Upregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells 97 0.239778513867603 0 0 1 C07AA.profile.d50 tpa_sens_late_dn 12384596 Downregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells 451 1.11484649231226 1 0.896984478935698 0.672486723575035 C07AA.profile.d50 tpa_sens_late_up 12384596 Upregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells 95 0.234834626983735 1 4.25831578947368 0.209528246287221 C07AA.profile.d50 tpa_sens_middle_dn 12384596 Downregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells 561 1.386760270925 0 0 1 C07AA.profile.d50 tpa_sens_middle_up 12384596 Upregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells 114 0.281801552380482 1 3.54859649122807 0.245839769442211 C07AA.profile.d50 tpa_skin_dn 12640676 Downregulated in murine dorsal skin cells 6 hours after treatment with the phorbol ester carcinogen TPA 25 0.0617985860483512 0 0 1 C07AA.profile.d50 tpa_skin_up 12640676 Upregulated in murine dorsal skin cells 6 hours after treatment with the phorbol ester carcinogen TPA 31 0.0766302466999555 0 0 1 C07AA.profile.d50 tsa_cd4_dn 14606959 Down-regulated in mouse CD4+ T-cells following 4 hour treatment with 100 nM trichostatin A 33 0.0815741335838236 0 0 1 C07AA.profile.d50 tsa_cd4_up 14606959 Up-regulated in mouse CD4+ T-cells following 4 hour treatment with 100 nM trichostatin A 43 0.106293568003164 0 0 1 C07AA.profile.d50 tsadac_hypermeth_hyperac_ovca_up 12727835 Genes with basally hypermethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells, with hyperacetylated promoters upon activation 16 0.0395510950709448 0 0 1 C07AA.profile.d50 tsadac_hypermeth_ovca_up 12727835 Genes with basally hypermethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells 18 0.0444949819548129 0 0 1 C07AA.profile.d50 tsadac_hypometh_hyperac_ovca_up 12727835 Genes with basally hypomethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells, with hyperacetylated promoters upon activation 17 0.0420230385128788 0 0 1 C07AA.profile.d50 tsadac_hypometh_ovca_up 12727835 Genes with basally hypomethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells 70 0.173036040935383 0 0 1 C07AA.profile.d50 tsadac_panc50_up 12839967 50 "most interesting" genes upregulated by the combination of TSA and DAC in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 56 0.138428832748307 1 7.22392857142857 0.12942399295915 C07AA.profile.d50 tsadac_rkoexp_up 11992124 Genes with some basal expression and partially-methylated promoters, upregulated by the combination of TSA and DAC in RKO cells 14 0.0346072081870767 0 0 1 C07AA.profile.d50 tsadac_rkosilent_up 11992124 Genes basally silent, with hypermethylated promoters, upregulated by the combination of TSA and DAC in RKO cells 30 0.0741583032580215 0 0 1 C07AA.profile.d50 tsa_hepatoma_cancer_dn 15452378 Cancer-related genes down-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A 51 0.126069115538636 0 0 1 C07AA.profile.d50 tsa_hepatoma_cancer_up 15452378 Cancer-related genes up-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A 69 0.170564097493449 0 0 1 C07AA.profile.d50 tsa_hepatoma_cancer_up_ac 15452378 Cancer-related genes up-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A, which are associated by ChIP with acetylated histone H3 or H4 9 0.0222474909774064 0 0 1 C07AA.profile.d50 tsa_hepatoma_up 15336447 Up-regulated in more than one of several human hepatoma cell lines by 24-hour treatment with trichostatin A 67 0.165620210609581 0 0 1 C07AA.profile.d50 tsa_hepg2_dn 16854234 Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). 1237 3.05779403767242 3 0.981099434114794 0.589920304181542 C07AA.profile.d50 tsa_hepg2_up 16854234 Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). 936 2.31373906165027 1 0.432200854700855 0.901392060584399 C07AA.profile.d50 tsa_panc50_up 12839967 50 "most interesting" genes upregulated by TSA treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 77 0.190339645028922 0 0 1 C07AA.profile.d50 tsa_rko_up 11992124 Upregulated by TSA alone, with non-hypermethylated promoters, in RKO cells 28 0.0692144163741534 0 0 1 C07AA.profile.d50 tzd_adip_dn 12021175 Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 29 0.0716863598160874 0 0 1 C07AA.profile.d50 tzd_adip_up 12021175 Upregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 11 0.0271913778612745 0 0 1 C07AA.profile.d50 uv-4nqo_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with UV light or 4-NQO, but not by gamma radiation 48 0.118653285212834 0 0 1 C07AA.profile.d50 uv-4nqo_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with UV light or 4-NQO, but not by gamma radiation 61 0.150788549957977 1 6.63180327868852 0.140131000967157 C07AA.profile.d50 uvb_nhek1_c1 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 1 112 0.276857665496613 0 0 1 C07AA.profile.d50 uvb_nhek1_c2 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.0692144163741534 0 0 1 C07AA.profile.d50 uvb_nhek1_c3 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 3 26 0.0642705294902853 0 0 1 C07AA.profile.d50 uvb_nhek1_c4 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 4 20 0.049438868838681 0 0 1 C07AA.profile.d50 uvb_nhek1_c5 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 5 17 0.0420230385128788 0 0 1 C07AA.profile.d50 uvb_nhek1_c6 12771951 Downregulated by UV-B light in normal human epidermal keratinocytes, cluster 6 268 0.662480842438325 1 1.5094776119403 0.484851979874686 C07AA.profile.d50 uvb_nhek1_dn 12771951 Downregulated by UV-B light in normal human epidermal keratinocytes 542 1.33979334552825 1 0.746383763837638 0.738534262295102 C07AA.profile.d50 uvb_nhek1_up 12771951 Upregulated by UV-B light in normal human epidermal keratinocytes 336 0.83057299648984 0 0 1 C07AA.profile.d50 uvb_nhek2_dn 11982916 Downregulated by UV-B light in normal human epidermal keratinocytes 160 0.395510950709448 0 0 1 C07AA.profile.d50 uvb_nhek2_up 11982916 Upregulated by UV-B light in normal human epidermal keratinocytes 125 0.308992930241756 1 3.23632 0.266094839102435 C07AA.profile.d50 uvb_nhek3_all 11867738 Regulated by UV-B light in normal human epidermal keratinocytes 751 1.85642952489247 4 2.15467376830892 0.117707182148658 C07AA.profile.d50 uvb_nhek3_c0 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 167 0.412814554802986 1 2.42239520958084 0.338553135425629 C07AA.profile.d50 uvb_nhek3_c1 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 1 104 0.257082117961141 0 0 1 C07AA.profile.d50 uvb_nhek3_c2 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 2 89 0.22000296633213 0 0 1 C07AA.profile.d50 uvb_nhek3_c3 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 3 37 0.0914619073515598 0 0 1 C07AA.profile.d50 uvb_nhek3_c4 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 4 20 0.049438868838681 0 0 1 C07AA.profile.d50 uvb_nhek3_c5 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 5 85 0.210115192564394 0 0 1 C07AA.profile.d50 uvb_nhek3_c6 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 6 47 0.1161813417709 0 0 1 C07AA.profile.d50 uvb_nhek3_c7 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.212587136006328 2 9.40790697674418 0.0194677693331366 C07AA.profile.d50 uvb_nhek3_c8 11867738 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 8 132 0.326296534335294 1 3.06469696969697 0.27870025533915 C07AA.profile.d50 uvb_nhek4_1hr_dn 11532376 Downregulated at 1 hour by UV-B light in normal human epidermal keratinocytes 13 0.0321352647451426 0 0 1 C07AA.profile.d50 uvb_nhek4_1hr_up 11532376 Upregulated at 1 hour by UV-B light in normal human epidermal keratinocytes 18 0.0444949819548129 0 0 1 C07AA.profile.d50 uvb_nhek4_24hrs_dn 11532376 Downregulated at 24 hours by UV-B light in normal human epidermal keratinocytes 23 0.0568546991644831 0 0 1 C07AA.profile.d50 uvb_nhek4_24hrs_up 11532376 Upregulated at 24 hours by UV-B light in normal human epidermal keratinocytes 14 0.0346072081870767 0 0 1 C07AA.profile.d50 uvb_nhek4_6hrs_dn 11532376 Downregulated at 6 hours by UV-B light in normal human epidermal keratinocytes 31 0.0766302466999555 0 0 1 C07AA.profile.d50 uvb_nhek4_6hrs_up 11532376 Upregulated at 6 hours by UV-B light in normal human epidermal keratinocytes 49 0.121125228654768 0 0 1 C07AA.profile.d50 uvb_scc_dn 12771951 Downregulated by UV-B light in squamous cell carinoma cells 219 0.541355613783557 1 1.84721461187215 0.41843109496561 C07AA.profile.d50 uvb_scc_up 12771951 Upregulated by UV-B light in squamous cell carcinoma cells 198 0.489444801502942 1 2.04313131313131 0.387404689816829 C07AA.profile.d50 uvc_high_all_dn 12907719 Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.56721214218619 1 0.63807570977918 0.791778397578772 C07AA.profile.d50 uvc_high_all_up 12907719 Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.0840460770257577 0 0 1 C07AA.profile.d50 uvc_high_b2_up 12907719 Up-regulated at 18-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b2) 15 0.0370791516290107 0 0 1 C07AA.profile.d50 uvc_high_b4_up 12907719 Progressively up-regulated from 12-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b4) 6 0.0148316606516043 0 0 1 C07AA.profile.d50 uvc_high_d1_dn 12907719 Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) 31 0.0766302466999555 0 0 1 C07AA.profile.d50 uvc_high_d2_dn 12907719 Down-regulated consistently at 6-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d2) 82 0.202699362238592 0 0 1 C07AA.profile.d50 uvc_high_d3_dn 12907719 Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d3) 90 0.222474909774064 0 0 1 C07AA.profile.d50 uvc_high_d4_dn 12907719 Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d4) 110 0.271913778612745 1 3.67763636363636 0.238336491885323 C07AA.profile.d50 uvc_high_d5_dn 12907719 Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d5) 74 0.18292381470312 0 0 1 C07AA.profile.d50 uvc_high_d6_dn 12907719 Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d6) 65 0.160676323725713 0 0 1 C07AA.profile.d50 uvc_high_d7_dn 12907719 Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d7) 63 0.155732436841845 0 0 1 C07AA.profile.d50 uvc_high_d8_dn 12907719 Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.173036040935383 0 0 1 C07AA.profile.d50 uvc_high_d9_dn 12907719 Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.131013002422505 0 0 1 C07AA.profile.d50 uvc_low_a1_up 12907719 Up-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a1) 6 0.0148316606516043 0 0 1 C07AA.profile.d50 uvc_low_a2_up 12907719 Up-regulated at 6-12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a2) 17 0.0420230385128788 0 0 1 C07AA.profile.d50 uvc_low_a3_up 12907719 Up-regulated at 12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a3) 6 0.0148316606516043 0 0 1 C07AA.profile.d50 uvc_low_all_dn 12907719 Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters c1-c5) 115 0.284273495822416 0 0 1 C07AA.profile.d50 uvc_low_all_up 12907719 Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) 33 0.0815741335838236 0 0 1 C07AA.profile.d50 uvc_low_c1_dn 12907719 Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster c1) 21 0.051910812280615 0 0 1 C07AA.profile.d50 uvc_low_c2_dn 12907719 Down-regulated at 6-12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster c2) 34 0.0840460770257577 0 0 1 C07AA.profile.d50 uvc_low_c3_dn 12907719 Down-regulated at 12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster c3) 33 0.0815741335838236 0 0 1 C07AA.profile.d50 uv-cmv_unique_hcmv_6hrs_dn 11711622 Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 164 0.405398724477184 0 0 1 C07AA.profile.d50 uv-cmv_unique_hcmv_6hrs_up 11711622 Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 194 0.479557027735205 1 2.08525773195876 0.381309867448706 C07AA.profile.d50 uvc_ttd_4hr_dn 15608684 Down-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 641 1.58451574627973 1 0.631107644305772 0.795354772440049 C07AA.profile.d50 uvc_ttd_4hr_up 15608684 Up-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 105 0.259554061403075 0 0 1 C07AA.profile.d50 uvc_ttd_8hr_dn 15608684 Down-regulated at 8 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 382 0.944282394818807 2 2.11801047120419 0.243729123012247 C07AA.profile.d50 uvc_ttd_8hr_up 15608684 Up-regulated at 8 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 47 0.1161813417709 0 0 1 C07AA.profile.d50 uvc_ttd_all_dn 15608684 Down-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 780 1.92811588470856 2 1.03728205128205 0.574509775300889 C07AA.profile.d50 uvc_ttd_all_up 15608684 Up-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 140 0.346072081870767 0 0 1 C07AA.profile.d50 uvc_ttd-xpcs_common_dn 15608684 Down-regulated at any timepoint following treatment of both XPB/CS and XPB/TTD fibroblasts with 3 J/m^2 UVC 344 0.850348544025313 1 1.17598837209302 0.573183579177716 C07AA.profile.d50 uvc_ttd-xpcs_common_up 15608684 Up-regulated at any timepoint following treatment of both XPB/CS and XPB/TTD fibroblasts with 3 J/m^2 UVC 44 0.108765511445098 0 0 1 C07AA.profile.d50 uvc_xpcs_4hr_dn 15608684 Down-regulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 519 1.28293864636377 1 0.779460500963391 0.723218513148892 C07AA.profile.d50 uvc_xpcs_4hr_up 15608684 Up-regulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 23 0.0568546991644831 0 0 1 C07AA.profile.d50 uvc_xpcs_8hr_dn 15608684 Down-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 911 2.25194047560192 3 1.33218441273326 0.391261468714594 C07AA.profile.d50 uvc_xpcs_8hr_up 15608684 Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 108 0.266969891728877 0 0 1 C07AA.profile.d50 uvc_xpcs_all_dn 15608684 Down-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 1048 2.59059672714688 3 1.15803435114504 0.47939109604773 C07AA.profile.d50 uvc_xpcs_all_up 15608684 Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 112 0.276857665496613 0 0 1 C07AA.profile.d50 uv_esr_old_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of fibroblasts from elderly donors with UV light 36 0.0889899639096258 0 0 1 C07AA.profile.d50 uv_esr_ws_unreg 15897889 Genes involved in the environmental stress response that were not regulated following treatment of Werner syndrome fibroblasts with UV light 23 0.0568546991644831 0 0 1 C07AA.profile.d50 uv_unique_fibro_dn 15897889 Down-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO 66 0.163148267167647 0 0 1 C07AA.profile.d50 uv_unique_fibro_up 15897889 Up-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO 30 0.0741583032580215 1 13.4846666666667 0.0715605491904371 C07AA.profile.d50 vcr_res_xenografts_dn 11809704 Down-regulation is correlated with resistance of human cancer xenografts to vincristine 9 0.0222474909774064 0 0 1 C07AA.profile.d50 vcr_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to vincristine 12 0.0296633213032086 0 0 1 C07AA.profile.d50 vegf_huvec_2hrs_up 12197474 Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells 54 0.133484945864439 1 7.49148148148148 0.125103951918425 C07AA.profile.d50 vegf_huvec_30min_up 12197474 Up-regulated 30 minutes after VEGF treatment in human umbilical vein endothelial cells 41 0.101349681119296 1 9.86682926829268 0.0964963718305929 C07AA.profile.d50 vegf_huvec_up 12197474 20 genes with the largest fold-change up-regulation at any time point (30min to 24 hours) after VEGF treatment in human umbilical vein endothelial cells 24 0.0593266426064172 0 0 1 C07AA.profile.d50 vegf_hmmec_12hrs_up 12200464 Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.0939338507934939 1 10.6457894736842 0.089762880067684 C07AA.profile.d50 vegf_hmmec_3hrs_up 12200464 Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 99 0.244722400751471 2 8.17252525252525 0.0253001940585488 C07AA.profile.d50 vegf_hmmec_6hrs_up 12200464 Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 88 0.217531022890196 1 4.59704545454545 0.195713981756183 C07AA.profile.d50 vegf_hmmec_all_up 12200464 Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells 147 0.363375685964305 3 8.25591836734694 0.00601173568285891 C07AA.profile.d50 ventricle_up 15103417 Upregulated in the ventricles of healthy hearts, compared to atria 373 0.9220349038414 1 1.08455764075067 0.60274480427942 C07AA.profile.d50 vhl_normal_up 12692265 Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) 754 1.86384535521827 0 0 1 C07AA.profile.d50 vhl_rcc_up 12692265 Upregulated in VHL-null renal carcinoma cells vs. VHL-rescued (Fig. 1a+b) 153 0.378207346615909 0 0 1 C07AA.profile.d50 vlb_res_xenografts_up 11809704 Up-regulation is correlated with resistance of human cancer xenografts to vinblastine 28 0.0692144163741534 0 0 1 C07AA.profile.d50 werner_fibro_dn 14527998 Downregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals 238 0.588322539180304 0 0 1 C07AA.profile.d50 werner_fibro_up 14527998 Upregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals 81 0.200227418796658 0 0 1 C07AA.profile.d50 werneronly_fibro_dn 14527998 Downregulated in fibroblasts from Werner (but not old) individuals, compared to young 90 0.222474909774064 0 0 1 C07AA.profile.d50 werneronly_fibro_up 14527998 Upregulated in fibroblasts from Werner (but not old) individuals, compared to young 51 0.126069115538636 0 0 1 C07AA.profile.d50 wnt3a_mammary_dn 17210685 Down-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). 100 0.247194344193405 0 0 1 C07AA.profile.d50 wnt3a_mammary_up 17210685 Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). 133 0.328768477777228 0 0 1 C07AA.profile.d50 xpb_ttd-cs_dn 15608684 Down-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) 41 0.101349681119296 0 0 1 C07AA.profile.d50 xpb_ttd-cs_up 15608684 Up-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) 57 0.140900776190241 1 7.09719298245614 0.131576007610459 C07AA.profile.d50 zmpste24_ko_dn 16079796 Fifty genes most strongly down-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 42 0.10382162456123 0 0 1 C07AA.profile.d50 zmpste24_ko_up 16079796 Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 57 0.140900776190241 0 0 1 C07AA.profile.d50