Results summary | View all lists in L2L MDB | View all genes in C05AD.profile.u50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.27 | 7 | 25.98 | 1.35e-08 |
serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 9 | 11.41 | 1.46e-07 |
hdaci_colon_tsa48hrs_dn | Downregulated by TSA at 48 hrs in SW260 colon carcinoma cells | 11 | 0.03 | 3 | 110.33 | 2.46e-06 |
as3_hek293_dn | Downregulated in HEK293 cells by treatment with arsenite | 12 | 0.03 | 3 | 101.14 | 3.27e-06 |
hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.04 | 3 | 80.91 | 6.72e-06 |
cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.06 | 3 | 52.77 | 2.58e-05 |
cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.06 | 3 | 50.57 | 2.94e-05 |
camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.07 | 3 | 43.34 | 4.72e-05 |
bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 5 | 10.01 | 1.64e-04 |
p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 3 | 24.77 | 2.56e-04 |
heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 0.55 | 5 | 9.07 | 2.59e-04 |
bcnu_glioma_nomgmt_48hrs_dn | Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU | 50 | 0.12 | 3 | 24.27 | 2.71e-04 |
il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 7 | 5.54 | 3.31e-04 |
heatshock_hela_30min_dn | Down-regulated at 30 minutes following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 67 | 0.17 | 3 | 18.11 | 6.43e-04 |
il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 7 | 4.38 | 1.30e-03 |
aom-dss_colon_10wks_up | Up-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. | 22 | 0.05 | 2 | 36.78 | 1.37e-03 |
werneronly_fibro_dn | Downregulated in fibroblasts from Werner (but not old) individuals, compared to young | 90 | 0.22 | 3 | 13.48 | 1.51e-03 |
hdaci_colon_tsa_dn | Downregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 109 | 0.27 | 3 | 11.13 | 2.61e-03 |
aged_rhesus_dn | Downregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys | 232 | 0.57 | 4 | 6.97 | 2.81e-03 |
cpr_low_liver_up | Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
aged_rhesus_up | Upregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys | 390 | 0.96 | 5 | 5.19 | 3.09e-03 |
fsh_ovary_mcv152_up | Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated | 120 | 0.30 | 3 | 10.11 | 3.42e-03 |
oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
idx_tsa_up_cluster5 | Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) | 149 | 0.37 | 3 | 8.15 | 6.24e-03 |
rb_ko_up | Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. | 155 | 0.38 | 3 | 7.83 | 6.95e-03 |
bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 5 | 4.26 | 7.01e-03 |
hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |