L2L L2L Microarray Analysis Tool

Results for C05AD.profile.u50

Results summary View all lists in L2L MDB View all genes in C05AD.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
adipogenesis_hmsc_class3_up Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.27 7 25.98 1.35e-08
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 0.79 9 11.41 1.46e-07
hdaci_colon_tsa48hrs_dn Downregulated by TSA at 48 hrs in SW260 colon carcinoma cells 11 0.03 3 110.33 2.46e-06
as3_hek293_dn Downregulated in HEK293 cells by treatment with arsenite 12 0.03 3 101.14 3.27e-06
hypoxia_fibro_young_up Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) 15 0.04 3 80.91 6.72e-06
cisplatin_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin 23 0.06 3 52.77 2.58e-05
cancerdrugs_probcell_up Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 24 0.06 3 50.57 2.94e-05
methotrexate_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate 24 0.06 3 50.57 2.94e-05
camptothecin_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin 28 0.07 3 43.34 4.72e-05
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 5 10.01 1.64e-04
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 3 24.77 2.56e-04
heatshock_hela_2hr_dn Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 223 0.55 5 9.07 2.59e-04
bcnu_glioma_nomgmt_48hrs_dn Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU 50 0.12 3 24.27 2.71e-04
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 7 5.54 3.31e-04
heatshock_hela_30min_dn Down-regulated at 30 minutes following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 67 0.17 3 18.11 6.43e-04
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 7 4.38 1.30e-03
aom-dss_colon_10wks_up Up-regulated in mouse colonic mucosa after 10 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 22 0.05 2 36.78 1.37e-03
werneronly_fibro_dn Downregulated in fibroblasts from Werner (but not old) individuals, compared to young 90 0.22 3 13.48 1.51e-03
hdaci_colon_tsa_dn Downregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 109 0.27 3 11.13 2.61e-03
aged_rhesus_dn Downregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys 232 0.57 4 6.97 2.81e-03
cpr_low_liver_up Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls 32 0.08 2 25.28 2.88e-03
aged_rhesus_up Upregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys 390 0.96 5 5.19 3.09e-03
fsh_ovary_mcv152_up Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 120 0.30 3 10.11 3.42e-03
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.11 2 17.98 5.64e-03
idx_tsa_up_cluster5 Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) 149 0.37 3 8.15 6.24e-03
rb_ko_up Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. 155 0.38 3 7.83 6.95e-03
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 5 4.26 7.01e-03
hypoxia_review Genes known to be induced by hypoxia 160 0.40 3 7.59 7.58e-03

Raw data (tab-delimited .txt)