L2L L2L Microarray Analysis Tool

Results for C04AX.profile.ud50

Results summary View all lists in L2L MDB View all genes in C04AX.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 3.13 15 4.79 1.03e-06
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 10 5.83 1.18e-05
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 10 5.83 1.18e-05
reovirus_hek293_up Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 2.43 11 4.53 4.44e-05
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.43 5 11.76 7.37e-05
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.22 4 17.98 7.57e-05
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 11 3.75 2.29e-04
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 11 3.75 2.29e-04
il2_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 4 12.26 3.37e-04
il2_pbmc_30min_up Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 4 12.26 3.37e-04
mkk6ee_up Upregulated by expression of constitutively active MKK6 31 0.15 3 19.57 4.90e-04
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 11 3.30 6.71e-04
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.41 4 9.87 7.69e-04
diab_neph_dn Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 829 4.10 12 2.93 1.08e-03
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 2.03 8 3.95 1.15e-03
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 4.15 12 2.89 1.20e-03
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.23 3 13.19 1.56e-03
brca_er_neg Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors 1519 7.51 17 2.26 1.93e-03
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 6.53 15 2.30 3.01e-03
h2o2_csbdiff_c2 Deficient induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 2) 63 0.31 3 9.63 3.85e-03
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.09 2 21.29 3.95e-03
bay_pbmc_2hr_dn Down-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 398 1.97 7 3.56 4.05e-03
bay_pbmc_4hr_dn Down-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 400 1.98 7 3.54 4.16e-03
uvb_scc_dn Downregulated by UV-B light in squamous cell carinoma cells 219 1.08 5 4.62 4.95e-03
calres_presenillin_ko_hippocampus_up Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. 137 0.68 4 5.91 4.98e-03
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 2.62 8 3.05 5.45e-03
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 1.58 6 3.80 5.50e-03
cmv-uv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 226 1.12 5 4.47 5.64e-03
middleage_up Upregulated in fibroblasts from middle-age individuals, compared to young 25 0.12 2 16.18 6.80e-03
dac_cgi_bladder_up Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island 26 0.13 2 15.56 7.34e-03
tnfa_nfkb_dep_up Up-regulated at any timepoint following TNFa treatment, only with functional NFkB 26 0.13 2 15.56 7.34e-03
ageing_brain_up Age-upregulated in the human frontal cortex 446 2.20 7 3.17 7.38e-03
cmv_hcmv_timecourse_24hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.41 3 7.40 8.00e-03
uvc_high_d2_dn Down-regulated consistently at 6-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d2) 82 0.41 3 7.40 8.00e-03
uvb_nhek2_dn Downregulated by UV-B light in normal human epidermal keratinocytes 160 0.79 4 5.06 8.54e-03
tzd_adip_dn Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 29 0.14 2 13.95 9.08e-03
hdaci_colon_but48hrs_dn Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 165 0.82 4 4.90 9.48e-03

Raw data (tab-delimited .txt)