L2L Microarray Analysis Tool
Results for C04AX.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in C04AX.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 10 | 11.66 | 2.45e-08 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 10 | 11.66 | 2.45e-08 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 11 | 7.50 | 4.12e-07 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 11 | 7.50 | 4.12e-07 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 15 | 4.59 | 1.78e-06 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.21 | 5 | 23.52 | 2.72e-06 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 4 | 35.96 | 5.13e-06 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 4 | 24.52 | 2.38e-05 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 4 | 24.52 | 2.38e-05 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 1.21 | 8 | 6.59 | 3.84e-05 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.20 | 4 | 19.73 | 5.60e-05 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 9 | 5.39 | 6.01e-05 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 8 | 6.11 | 6.53e-05 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 1.01 | 7 | 6.91 | 8.70e-05 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 8 | 5.10 | 2.21e-04 |
| calres_presenillin_ko_hippocampus_up | Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. | 137 | 0.34 | 4 | 11.81 | 4.04e-04 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 7 | 5.21 | 4.80e-04 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 8 | 4.31 | 6.70e-04 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.05 | 2 | 42.58 | 1.02e-03 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 4 | 9.14 | 1.05e-03 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 4 | 8.99 | 1.12e-03 |
| middleage_up | Upregulated in fibroblasts from middle-age individuals, compared to young | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 6 | 4.76 | 1.88e-03 |
| dac_cgi_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| tnfa_nfkb_dep_up | Up-regulated at any timepoint following TNFa treatment, only with functional NFkB | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 0.54 | 4 | 7.39 | 2.28e-03 |
| egf_hdmec_up | Up-regulated in human dermal (foreskin) microvascular endothelial cells that were stimulated to proliferate with prolonged EGF treatment, versus non-stimulated quiescent controls. | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
| tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 4 | 7.16 | 2.56e-03 |
| fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| mkk6ee_up | Upregulated by expression of constitutively active MKK6 | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| hdaci_colon_tsa2hrs_dn | Downregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 33 | 0.08 | 2 | 24.52 | 3.07e-03 |
| as3_fibro_c4 | Downregulated early by sodium arsenite in fibroblasts (Cluster 4) | 35 | 0.09 | 2 | 23.12 | 3.44e-03 |
| aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| uvb_nhek3_c3 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
| arthritis_mouse_il1ko_up | Up-regulated in joint tissue from severely arthritic 13 week-old IL-1Ra knock-out mice, versus wild-type littermate controls. | 271 | 0.67 | 4 | 5.97 | 4.87e-03 |
| scw_joint_24hrs_up | Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 143 | 0.35 | 3 | 8.49 | 5.57e-03 |
| o6bg_resist_medulloblastoma_up | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 46 | 0.11 | 2 | 17.59 | 5.88e-03 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 6 | 3.76 | 5.91e-03 |
| hg_progeria_dn | Downregulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals | 48 | 0.12 | 2 | 16.86 | 6.39e-03 |
| tsa_hepatoma_cancer_dn | Cancer-related genes down-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |
| uvb_nhek2_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |
| hdaci_colon_but48hrs_dn | Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 165 | 0.41 | 3 | 7.36 | 8.25e-03 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 4 | 5.07 | 8.55e-03 |
| caries_pulp_high_up | Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 168 | 0.42 | 3 | 7.22 | 8.66e-03 |
| as3_fibro_dn | Downregulated by sodium arsenite in fibroblasts (Clusters 4, 5, and 6) | 59 | 0.15 | 2 | 13.71 | 9.52e-03 |
| hdaci_colon_cur_up | Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 174 | 0.43 | 3 | 6.97 | 9.52e-03 |
| dac_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells | 60 | 0.15 | 2 | 13.48 | 9.83e-03 |