L2L Microarray Analysis Tool
Results for A07EA.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in A07EA.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 10 | 22.47 | 4.44e-11 |
| dex_keratinocyte_1hr_dn | Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 24 | 0.06 | 5 | 84.28 | 3.77e-09 |
| idx_tsa_up_cluster4 | Progressively up-regulated from 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 65 | 0.16 | 4 | 24.89 | 2.24e-05 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 3 | 27.58 | 1.85e-04 |
| hdaci_colon_cluster2 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) | 9 | 0.02 | 2 | 89.90 | 2.17e-04 |
| dex_keratinocyte_4hr_dn | Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone | 69 | 0.17 | 3 | 17.59 | 7.01e-04 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.22 | 3 | 13.95 | 1.37e-03 |
| emt_dn | Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 89 | 0.22 | 3 | 13.64 | 1.46e-03 |
| idx_tsa_up_cluster2 | Strongly up-regulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 2) | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
| pubertal_mammary_6-7wks_dn | Down-regulated > 1.5-fold in the developing mouse mammary gland between 6 and 7 weeks of age. | 106 | 0.26 | 3 | 11.45 | 2.41e-03 |
| 5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| heartfailure_ventricles_dn | Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls | 120 | 0.30 | 3 | 10.11 | 3.42e-03 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 0.65 | 4 | 6.18 | 4.32e-03 |
| myod_nih3t3_up | Up-regulated at 24 hours in NIH 3T3 murine fibroblasts following transduction with MyoD and incubation in differentiation medium | 134 | 0.33 | 3 | 9.06 | 4.65e-03 |
| arthritis_mouse_il1ko_up | Up-regulated in joint tissue from severely arthritic 13 week-old IL-1Ra knock-out mice, versus wild-type littermate controls. | 271 | 0.67 | 4 | 5.97 | 4.87e-03 |
| arthritis_mouse_common_up | Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. | 459 | 1.13 | 5 | 4.41 | 6.09e-03 |
| alzheimers_disease_up | Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus | 3137 | 7.75 | 16 | 2.06 | 6.18e-03 |
| pubertal_mammary_3-4wks_dn | Down-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. | 55 | 0.14 | 2 | 14.71 | 8.32e-03 |
| scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.41 | 3 | 7.31 | 8.38e-03 |