L2L L2L Microarray Analysis Tool

Results for A07EA.profile.u50

Results summary View all lists in L2L MDB View all genes in A07EA.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 10 22.47 4.44e-11
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.06 5 84.28 3.77e-09
idx_tsa_up_cluster4 Progressively up-regulated from 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 65 0.16 4 24.89 2.24e-05
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 3 27.58 1.85e-04
hdaci_colon_cluster2 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) 9 0.02 2 89.90 2.17e-04
dex_keratinocyte_4hr_dn Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 69 0.17 3 17.59 7.01e-04
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22 3 13.64 1.46e-03
idx_tsa_up_cluster2 Strongly up-regulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 2) 105 0.26 3 11.56 2.35e-03
pubertal_mammary_6-7wks_dn Down-regulated > 1.5-fold in the developing mouse mammary gland between 6 and 7 weeks of age. 106 0.26 3 11.45 2.41e-03
5fu_resist_gastric_dn Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.07 2 26.97 2.54e-03
heartfailure_ventricles_dn Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls 120 0.30 3 10.11 3.42e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 3 9.95 3.58e-03
senescence_hela_up Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 262 0.65 4 6.18 4.32e-03
myod_nih3t3_up Up-regulated at 24 hours in NIH 3T3 murine fibroblasts following transduction with MyoD and incubation in differentiation medium 134 0.33 3 9.06 4.65e-03
arthritis_mouse_il1ko_up Up-regulated in joint tissue from severely arthritic 13 week-old IL-1Ra knock-out mice, versus wild-type littermate controls. 271 0.67 4 5.97 4.87e-03
arthritis_mouse_common_up Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 1.13 5 4.41 6.09e-03
alzheimers_disease_up Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus 3137 7.75 16 2.06 6.18e-03
pubertal_mammary_3-4wks_dn Down-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. 55 0.14 2 14.71 8.32e-03
scw_joint_react_up Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.41 3 7.31 8.38e-03

Raw data (tab-delimited .txt)