L2L L2L Microarray Analysis Tool

Results for S01C.profile.ud50

Results summary View all lists in L2L MDB View all genes in S01C.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.89 15 16.86 3.39e-14
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.12 6 50.57 1.82e-09
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 1.15 11 9.55 3.42e-08
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 4.15 17 4.10 1.67e-06
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.09 4 42.58 2.18e-06
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 2.52 13 5.16 2.36e-06
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.22 5 22.99 2.73e-06
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.67 7 10.49 5.75e-06
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 3.00 13 4.34 1.47e-05
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.15 4 26.10 1.69e-05
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.35 11 4.68 3.30e-05
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.07 3 40.45 5.26e-05
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.23 4 17.59 8.26e-05
cmv_all_dn Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 213 1.05 7 6.65 1.06e-04
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 2.69 11 4.09 1.10e-04
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.47 5 10.65 1.18e-04
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 2.62 10 3.82 3.81e-04
dex_keratinocyte_4hr_dn Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 69 0.34 4 11.73 4.00e-04
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 3.19 11 3.44 4.69e-04
hdaci_colon_cluster9 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.39 4 10.37 6.37e-04
calres_mouse_dn Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.39 4 10.24 6.68e-04
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.39 4 10.24 6.68e-04
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 11 3.30 6.71e-04
cmv_24hrs_dn Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 140 0.69 5 7.22 7.09e-04
hdaci_colon_cluster2 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) 9 0.04 2 44.95 8.60e-04
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.43 4 9.30 9.59e-04
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.44 4 9.09 1.04e-03
htert_up Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 97 0.48 4 8.34 1.44e-03
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 3.13 10 3.19 1.47e-03
scw_joint_react_up Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.82 5 6.09 1.51e-03
ribavirin_rsv_dn Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin 101 0.50 4 8.01 1.67e-03
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.24 3 12.64 1.77e-03
idx_tsa_up_cluster2 Strongly up-regulated at 8 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 2) 105 0.52 4 7.71 1.92e-03
arthritis_mouse_common_up Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 2.27 8 3.53 2.31e-03
cocaine_brain_4wks_up Up-regulated in the nucleus accumbens of mice after 4 weeks of cocaine treatment 112 0.55 4 7.22 2.43e-03
sarcomas_synovial_up Top 20 positive significant genes associated with synovial sarcomas, versus other soft-tissue tumors. 16 0.08 2 25.28 2.80e-03
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.35 8 3.41 2.85e-03
microrna_human Predicted human MicroRNA targets 2276 11.25 22 1.96 2.86e-03
bleo_human_lymph_high_24hrs_up Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 197 0.97 5 5.13 3.17e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.60 4 6.63 3.30e-03
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 1.00 5 5.01 3.53e-03
adip_diff_cluster2 Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) 64 0.32 3 9.48 4.02e-03
adip_vs_fibro_dn Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes 64 0.32 3 9.48 4.02e-03
ni2_mouse_up Upregulated by nickel(II) in sensitive A/J mouse lung tissue 65 0.32 3 9.34 4.20e-03
il2_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 3 9.19 4.38e-03
il2_pbmc_30min_up Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 3 9.19 4.38e-03
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 2.03 7 3.45 4.74e-03
stemcell_hematopoietic_up Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells 2092 10.34 20 1.93 4.84e-03
uvc_high_d8_dn Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.35 3 8.67 5.17e-03
scw_joint_24hrs_up Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 143 0.71 4 5.66 5.79e-03
scw_joint_4hrs_up Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 230 1.14 5 4.40 6.07e-03
cmv_hcmv_timecourse_48hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 48 hours 235 1.16 5 4.30 6.63e-03
ifnalpha_resist_dn Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line 25 0.12 2 16.18 6.80e-03
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.39 3 7.78 6.98e-03
hypoxia_reg_up Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.40 3 7.59 7.48e-03
microrna_mammal Predicted MicroRNA targets conserved across human, mouse and rat 1331 6.58 14 2.13 7.69e-03
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.41 3 7.40 8.00e-03
cmv_hcmv_timecourse_24hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.41 3 7.40 8.00e-03
pdgf_es_up Up-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis 28 0.14 2 14.45 8.48e-03
alzheimers_disease_up Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus 3137 15.51 26 1.68 9.03e-03
tzd_adip_dn Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 29 0.14 2 13.95 9.08e-03
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.43 3 7.06 9.11e-03
brcax_a_up Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 30 0.15 2 13.48 9.70e-03

Raw data (tab-delimited .txt)