L2L Microarray Analysis Tool
Results for S01C.profile.ud50
| Results summary | View all lists in GO:BiolProc | View all genes in S01C.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| transcription from RNA polymerase II promoter | The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). | 997 | 4.93 | 18 | 3.65 | 4.12e-06 |
| negative regulation of cellular process | Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. | 1642 | 8.12 | 23 | 2.83 | 1.34e-05 |
| regulation of transcription from RNA polymerase II promoter | Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. | 701 | 3.47 | 14 | 4.04 | 1.55e-05 |
| negative regulation of biological process | Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. | 1697 | 8.39 | 23 | 2.74 | 2.22e-05 |
| cell death | The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. | 1152 | 5.70 | 16 | 2.81 | 2.80e-04 |
| death | A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. | 1152 | 5.70 | 16 | 2.81 | 2.80e-04 |
| B cell proliferation | The rapid expansion of a B cell population by cell division. Follows B cell activation. | 27 | 0.13 | 3 | 22.47 | 3.23e-04 |
| negative regulation of apoptosis | Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis. | 345 | 1.71 | 8 | 4.69 | 3.77e-04 |
| negative regulation of programmed cell death | Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. | 347 | 1.72 | 8 | 4.66 | 3.91e-04 |
| negative regulation of transcription | Any process that stops, prevents or reduces the frequency, rate or extent of transcription. | 439 | 2.17 | 9 | 4.15 | 4.07e-04 |
| negative regulation of cellular metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. | 536 | 2.65 | 10 | 3.77 | 4.15e-04 |
| regulation of transcription | Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. | 2702 | 13.36 | 27 | 2.02 | 6.50e-04 |
| regulation of interleukin-6 biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. | 8 | 0.04 | 2 | 50.57 | 6.71e-04 |
| negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. | 478 | 2.36 | 9 | 3.81 | 7.43e-04 |
| regulation of Rho GTPase activity | Any process that modulates the activity of a GTPase of the Rho family. | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
| negative regulation of small GTPase mediated signal transduction | Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction. | 9 | 0.04 | 2 | 44.95 | 8.60e-04 |
| regulation of cellular metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. | 3041 | 15.03 | 29 | 1.93 | 8.63e-04 |
| regulation of transcription, DNA-dependent | Any process that modulates the frequency, rate or extent of DNA-dependent transcription. | 2510 | 12.41 | 25 | 2.01 | 1.05e-03 |
| positive regulation of B cell proliferation | Any process that activates or increases the rate or extent of B cell proliferation. | 10 | 0.05 | 2 | 40.45 | 1.07e-03 |
| interleukin-6 production | The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 10 | 0.05 | 2 | 40.45 | 1.07e-03 |
| interleukin-6 biosynthetic process | The chemical reactions and pathways resulting in the formation of interleukin-6. | 10 | 0.05 | 2 | 40.45 | 1.07e-03 |
| negative regulation of cell differentiation | Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation. | 90 | 0.44 | 4 | 8.99 | 1.09e-03 |
| regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. | 2802 | 13.85 | 27 | 1.95 | 1.10e-03 |
| negative regulation of metabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. | 615 | 3.04 | 10 | 3.29 | 1.17e-03 |
| apoptosis | A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface. | 1078 | 5.33 | 14 | 2.63 | 1.22e-03 |
| transcription | The synthesis of either RNA on a template of DNA or DNA on a template of RNA. | 2826 | 13.97 | 27 | 1.93 | 1.23e-03 |
| negative regulation of cell-cell adhesion | Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. | 11 | 0.05 | 2 | 36.78 | 1.31e-03 |
| negative regulation of B cell activation | Any process that stops, prevents or reduces the frequency, rate or extent of B cell activation. | 11 | 0.05 | 2 | 36.78 | 1.31e-03 |
| programmed cell death | Cell death resulting from activation of endogenous cellular processes. | 1086 | 5.37 | 14 | 2.61 | 1.31e-03 |
| regulation of cell-matrix adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
| transcription, DNA-dependent | The synthesis of RNA on a template of DNA. | 2588 | 12.79 | 25 | 1.95 | 1.58e-03 |
| RNA biosynthetic process | The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. | 2591 | 12.81 | 25 | 1.95 | 1.60e-03 |
| regulation of metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. | 3184 | 15.74 | 29 | 1.84 | 1.69e-03 |
| regulation of cell-cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| regulation of T-helper cell differentiation | Any process that modulates the frequency, rate or extent of T-helper cell differentiation. | 13 | 0.06 | 2 | 31.12 | 1.84e-03 |
| cell differentiation | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate. | 2359 | 11.66 | 23 | 1.97 | 2.10e-03 |
| cellular developmental process | A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. | 2359 | 11.66 | 23 | 1.97 | 2.11e-03 |
| cytokine production during immune response | The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| regulation of production of molecular mediator of immune response | Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| regulation of cytokine production during immune response | Any process that modulates the frequency, rate, or extent of cytokine production during immune response. | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| negative regulation of developmental process | Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | 110 | 0.54 | 4 | 7.36 | 2.27e-03 |
| RNA metabolic process | The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. | 3263 | 16.13 | 29 | 1.80 | 2.39e-03 |
| erythrocyte differentiation | The process by which a myeloid precursor cell acquires specializes features of an erythrocyte. | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
| regulation of B cell proliferation | Any process that modulates the frequency, rate or extent of B cell proliferation. | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| anti-apoptosis | A process which directly inhibits any of the steps required for cell death by apoptosis. | 278 | 1.37 | 6 | 4.37 | 2.84e-03 |
| cell activation during immune response | A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| lymphocyte activation during immune response | A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| T cell activation during immune response | The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| T cell differentiation during immune response | The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| alpha-beta T cell differentiation during immune response | The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| CD4-positive, alpha-beta T cell differentiation during immune response | The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| leukocyte activation during immune response | A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| T-helper cell differentiation | The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
| developmental process | A biological process whose specific outcome is the progression of an integrated living unit: a cell, tissue, organ, or organism over time from an initial condition to a later condition. | 4255 | 21.04 | 35 | 1.66 | 3.21e-03 |
| negative regulation of transcription from RNA polymerase II promoter | Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. | 201 | 0.99 | 5 | 5.03 | 3.45e-03 |
| regulation of isotype switching | Any process that modulates the frequency, rate or extent of isotype switching. | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
| CD4-positive, alpha beta T cell differentiation | The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. | 19 | 0.09 | 2 | 21.29 | 3.95e-03 |
| cell-matrix adhesion | The binding of a cell to the extracellular matrix via adhesion molecules. | 132 | 0.65 | 4 | 6.13 | 4.37e-03 |
| negative regulation of immune system process | Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| regulation of immune effector process | Any process that modulates the frequency, rate, or extent of an immune effector process. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| T-helper 2 type immune response | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| negative regulation of immune response | Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
| cell-substrate adhesion | The attachment of a cell to the underlying substrate via adhesion molecules. | 135 | 0.67 | 4 | 5.99 | 4.73e-03 |
| regulation of progression through cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. | 875 | 4.33 | 11 | 2.54 | 4.92e-03 |
| regulation of cell cycle | A cell cycle process that modulates the rate, extent or mode of the cell cycle. | 880 | 4.35 | 11 | 2.53 | 5.13e-03 |
| cell development | The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. | 1692 | 8.37 | 17 | 2.03 | 5.57e-03 |
| regulation of adaptive immune response | Any process that modulates the frequency, rate, or extent of an adaptive immune response. | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. | Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| regulation of T cell differentiation | Any process that modulates the frequency, rate or extent of T cell differentiation. | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| regulation of defense response | Any process that modulates the frequency, rate or extent of a defense response. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| positive regulation of locomotion | Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| positive regulation of B cell activation | Any process that activates or increases the frequency, rate or extent of B cell activation. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| positive regulation of cell motility | Any process that activates or increases the frequency, rate or extent of the movement of a cell. | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
| cytokine production | The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. | 153 | 0.76 | 4 | 5.29 | 7.32e-03 |
| negative regulation of progression through cell cycle | Any process that stops, prevents or reduces the frequency, rate or extent of progression through the cell cycle. | 347 | 1.72 | 6 | 3.50 | 8.16e-03 |
| alpha-beta T cell differentiation | The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an alpha-beta T cell. | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
| negative regulation of cell proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. | 353 | 1.75 | 6 | 3.44 | 8.83e-03 |
| somatic recombination of immunoglobulin genes during immune response | The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| somatic diversification of immunoglobulins during immune response | The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| immunoglobulin production during immune response | The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| isotype switching | The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| regulation of lymphocyte differentiation | Any process that modulates the frequency, rate or extent of lymphocyte differentiation. | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |