Results summary | View all lists in L2L MDB | View all genes in S01B.profile.d50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
uvc_low_a2_up | Up-regulated at 6-12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a2) | 17 | 0.04 | 3 | 71.39 | 1.00e-05 |
heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 4.52 | 16 | 3.54 | 2.07e-05 |
bleo_mouse_lymph_high_24hrs_dn | Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin | 71 | 0.18 | 4 | 22.79 | 3.18e-05 |
tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 0.87 | 7 | 8.02 | 3.42e-05 |
tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.07 | 3 | 41.85 | 5.26e-05 |
uvc_low_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) | 33 | 0.08 | 3 | 36.78 | 7.80e-05 |
tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 12 | 3.67 | 1.51e-04 |
alk5_hmvec_2hr_dn | Down-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 202 | 0.50 | 5 | 10.01 | 1.64e-04 |
alk5_hmvec_4hr_dn | Down-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 202 | 0.50 | 5 | 10.01 | 1.64e-04 |
cmv_all_dn | Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV | 213 | 0.53 | 5 | 9.50 | 2.10e-04 |
microrna_vertebrate | Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu | 214 | 0.53 | 5 | 9.45 | 2.15e-04 |
xpb_ttd-cs_up | Up-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
jnk_up | Upregulated by expression of constitutively active JNK in 3T3 cells | 66 | 0.16 | 3 | 18.39 | 6.15e-04 |
adip_vs_preadip_dn | Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
il6_fibro_up | Upregulated following IL-6 treatment in normal skin fibroblasts | 85 | 0.21 | 3 | 14.28 | 1.28e-03 |
bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.49 | 4 | 8.21 | 1.56e-03 |
uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 0.54 | 4 | 7.39 | 2.28e-03 |
hsc_hscandprogenitors_fetal | Up-regulated in mouse hematopoietic stem cells and progenitors from fetal liver (HSC and Progenitors Shared) | 717 | 1.77 | 7 | 3.95 | 2.32e-03 |
hsc_hscandprogenitors_shared | Up-regulated in mouse hematopoietic stem cells and progenitors from both adult bone marrow and fetal liver (Cluster iii, HSC and Progenitors Shared) | 717 | 1.77 | 7 | 3.95 | 2.32e-03 |
hsc_hscandprogenitors_adult | Up-regulated in mouse hematopoietic stem cells and progenitors from adult bone marrow (HSC and Progenitors Shared + Adult) | 724 | 1.79 | 7 | 3.91 | 2.45e-03 |
hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 0.58 | 4 | 6.94 | 2.85e-03 |
cancer_neoplastic_meta_up | Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database | 115 | 0.28 | 3 | 10.55 | 3.03e-03 |
inos_all_dn | Downregulated following iNOS induction in hepatocytes (Tables 3-17) | 117 | 0.29 | 3 | 10.37 | 3.18e-03 |
aom-dss_colon_5wks_up | Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. | 133 | 0.33 | 3 | 9.12 | 4.56e-03 |
bap_mcf7_dn | Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 135 | 0.33 | 3 | 8.99 | 4.75e-03 |
hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.33 | 3 | 8.99 | 4.75e-03 |
5fu_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 42 | 0.10 | 2 | 19.26 | 4.93e-03 |
cited1_ko_het_up | Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
uvc_xpcs_all_dn | Down-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 1048 | 2.59 | 8 | 3.09 | 5.16e-03 |
cmv_24hrs_dn | Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
uvc_ttd-xpcs_common_up | Up-regulated at any timepoint following treatment of both XPB/CS and XPB/TTD fibroblasts with 3 J/m^2 UVC | 44 | 0.11 | 2 | 18.39 | 5.40e-03 |
idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.12 | 2 | 16.86 | 6.39e-03 |
senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 4 | 5.41 | 6.85e-03 |
prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 0.76 | 4 | 5.29 | 7.41e-03 |
cmv_uv-cmv_common_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
adip_diff_cluster4 | Strongly upregulated at 16 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 4) | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
pod1_ko_up | Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 508 | 1.26 | 5 | 3.98 | 9.19e-03 |