L2L L2L Microarray Analysis Tool

Results for S01B.profile.d50

Results summary View all lists in L2L MDB View all genes in S01B.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
uvc_low_a2_up Up-regulated at 6-12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a2) 17 0.04 3 71.39 1.00e-05
heatshock_hela_4hr_dn Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 4.52 16 3.54 2.07e-05
bleo_mouse_lymph_high_24hrs_dn Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin 71 0.18 4 22.79 3.18e-05
tgfb_hmvec_2hr_dn Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 0.87 7 8.02 3.42e-05
tzd_adip_dn Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 29 0.07 3 41.85 5.26e-05
uvc_low_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) 33 0.08 3 36.78 7.80e-05
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 12 3.67 1.51e-04
alk5_hmvec_2hr_dn Down-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 202 0.50 5 10.01 1.64e-04
alk5_hmvec_4hr_dn Down-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 202 0.50 5 10.01 1.64e-04
cmv_all_dn Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 213 0.53 5 9.50 2.10e-04
microrna_vertebrate Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu 214 0.53 5 9.45 2.15e-04
xpb_ttd-cs_up Up-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) 57 0.14 3 21.29 4.00e-04
jnk_up Upregulated by expression of constitutively active JNK in 3T3 cells 66 0.16 3 18.39 6.15e-04
adip_vs_preadip_dn Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 84 0.21 3 14.45 1.24e-03
il6_fibro_up Upregulated following IL-6 treatment in normal skin fibroblasts 85 0.21 3 14.28 1.28e-03
bleo_human_lymph_high_24hrs_up Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 197 0.49 4 8.21 1.56e-03
uvb_scc_dn Downregulated by UV-B light in squamous cell carinoma cells 219 0.54 4 7.39 2.28e-03
hsc_hscandprogenitors_fetal Up-regulated in mouse hematopoietic stem cells and progenitors from fetal liver (HSC and Progenitors Shared) 717 1.77 7 3.95 2.32e-03
hsc_hscandprogenitors_shared Up-regulated in mouse hematopoietic stem cells and progenitors from both adult bone marrow and fetal liver (Cluster iii, HSC and Progenitors Shared) 717 1.77 7 3.95 2.32e-03
hsc_hscandprogenitors_adult Up-regulated in mouse hematopoietic stem cells and progenitors from adult bone marrow (HSC and Progenitors Shared + Adult) 724 1.79 7 3.91 2.45e-03
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 4 6.94 2.85e-03
cancer_neoplastic_meta_up Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database 115 0.28 3 10.55 3.03e-03
inos_all_dn Downregulated following iNOS induction in hepatocytes (Tables 3-17) 117 0.29 3 10.37 3.18e-03
aom-dss_colon_5wks_up Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 133 0.33 3 9.12 4.56e-03
bap_mcf7_dn Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 135 0.33 3 8.99 4.75e-03
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 3 8.99 4.75e-03
5fu_resist_gastric_up Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 42 0.10 2 19.26 4.93e-03
cited1_ko_het_up Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes 43 0.11 2 18.82 5.16e-03
uvc_xpcs_all_dn Down-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 1048 2.59 8 3.09 5.16e-03
cmv_24hrs_dn Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 140 0.35 3 8.67 5.25e-03
uvc_ttd-xpcs_common_up Up-regulated at any timepoint following treatment of both XPB/CS and XPB/TTD fibroblasts with 3 J/m^2 UVC 44 0.11 2 18.39 5.40e-03
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 2 16.86 6.39e-03
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 4 5.41 6.85e-03
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 4 5.29 7.41e-03
cmv_uv-cmv_common_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 54 0.13 2 14.98 8.03e-03
adip_diff_cluster4 Strongly upregulated at 16 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 4) 56 0.14 2 14.45 8.61e-03
pod1_ko_up Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 508 1.26 5 3.98 9.19e-03

Raw data (tab-delimited .txt)