L2L L2L Microarray Analysis Tool

Results for R06A.profile.ud50

Results summary View all lists in L2L MDB View all genes in R06A.profile.ud50
List Name Description Total
probes		 Expected
matches		 Actual
matches		 Fold
Enrichment		 Binomial
p-value
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 2.62 19 7.25 4.79e-11
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 15 8.74 3.97e-10
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 15 8.74 3.97e-10
il2_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 8 24.52 1.59e-09
il2_pbmc_30min_up Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 8 24.52 1.59e-09
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 18 6.14 2.09e-09
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 18 6.14 2.09e-09
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 2.53 16 6.33 1.04e-08
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 6.53 24 3.67 1.03e-07
dsrna_up Upregulated by dsRNA (polyI:C) in IFN-null GRE cells 68 0.34 6 17.85 1.23e-06
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.41 6 14.80 3.71e-06
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 1.86 11 5.92 3.81e-06
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 2.69 12 4.46 2.37e-05
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 3.19 13 4.07 2.85e-05
adipocyte_brca_up Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 14 0.07 3 43.34 4.22e-05
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.08 3 37.93 6.45e-05
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.24 4 16.51 1.06e-04
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.35 10 4.26 1.61e-04
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.28 4 14.45 1.79e-04
insulin_adip_insens_dn Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 25 0.12 3 24.27 2.56e-04
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 3.00 11 3.67 2.75e-04
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.88 6 6.86 2.79e-04
tnfa_nfkb_dep_up Up-regulated at any timepoint following TNFa treatment, only with functional NFkB 26 0.13 3 23.34 2.89e-04
uvb_nhek1_c3 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 3 26 0.13 3 23.34 2.89e-04
ros_mouse_aorta_dn Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.63 5 7.96 4.55e-04
bleo_human_lymph_high_24hrs_up Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 197 0.97 6 6.16 4.91e-04
calres_presenillin_ko_hippocampus_up Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. 137 0.68 5 7.38 6.43e-04
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.17 3 17.85 6.45e-04
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 11 3.30 6.71e-04
aged_mouse_retina_any_up Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 36 0.18 3 16.86 7.64e-04
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.19 3 15.97 8.96e-04
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 2.52 9 3.57 1.16e-03
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 1.58 7 4.44 1.18e-03
hypoxia_review Genes known to be induced by hypoxia 160 0.79 5 6.32 1.29e-03
et743_hela_up Upregulated by Et-743 in HeLa cells 99 0.49 4 8.17 1.55e-03
as3_hek293_dn Downregulated in HEK293 cells by treatment with arsenite 12 0.06 2 33.71 1.56e-03
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.06 2 33.71 1.56e-03
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 1.69 7 4.15 1.73e-03
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.89 5 5.62 2.15e-03
adipogenesis_hmsc_class3_up Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.54 4 7.42 2.20e-03
elongina_ko_dn Downregulated in MES cells from elongin-A knockout mice 267 1.32 6 4.55 2.32e-03
et743_sarcoma_up Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 111 0.55 4 7.29 2.35e-03
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.07 2 26.97 2.46e-03
hypoxia_fibro_young_up Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) 15 0.07 2 26.97 2.46e-03
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.27 3 11.24 2.48e-03
zmpste24_ko_up Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 57 0.28 3 10.65 2.90e-03
reovirus_hek293_up Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 2.43 8 3.30 3.47e-03
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 1.00 5 5.01 3.53e-03
cpr_null_liver_up Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls 64 0.32 3 9.48 4.02e-03
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.10 2 19.26 4.82e-03
alzheimers_incipient_dn Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus 312 1.54 6 3.89 4.95e-03
vhl_normal_up Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) 754 3.73 10 2.68 4.98e-03
cmv-uv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 226 1.12 5 4.47 5.64e-03
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.39 3 7.78 6.98e-03
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.39 3 7.68 7.22e-03
dac_cgi_bladder_up Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island 26 0.13 2 15.56 7.34e-03
hypoxia_reg_up Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.40 3 7.59 7.48e-03
irs1_ko_adip_up Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.79 4 5.09 8.35e-03
rb_creko_dn Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 1.24 5 4.05 8.53e-03
old_fibro_up Upregulated in fibroblasts from old individuals, compared to young 84 0.42 3 7.22 8.55e-03
tgfb_hmvec_2hr_dn Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 1.75 6 3.44 8.83e-03
insulin_adip_sens_dn Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.14 2 13.95 9.08e-03
tzd_adip_dn Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 29 0.14 2 13.95 9.08e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.43 3 6.97 9.41e-03
brcax_a_up Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 30 0.15 2 13.48 9.70e-03

Raw data (tab-delimited .txt)