L2L Microarray Analysis Tool
Results for R06A.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in R06A.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 15 | 17.49 | 2.61e-14 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 15 | 17.49 | 2.61e-14 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 17 | 12.98 | 6.47e-14 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 17 | 11.60 | 3.88e-13 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 17 | 11.60 | 3.88e-13 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 8 | 49.04 | 7.05e-12 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 8 | 49.04 | 7.05e-12 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 21 | 6.43 | 4.85e-11 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 12 | 8.92 | 1.93e-08 |
| dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 0.17 | 6 | 35.69 | 2.19e-08 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 10 | 10.76 | 5.17e-08 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.20 | 6 | 29.60 | 6.80e-08 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 11 | 8.71 | 9.49e-08 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 10 | 8.52 | 4.40e-07 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 11 | 7.34 | 5.09e-07 |
| adipocyte_brca_up | Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 14 | 0.03 | 3 | 86.69 | 5.39e-06 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 6 | 13.71 | 6.23e-06 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 10 | 6.26 | 6.69e-06 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 9 | 7.14 | 6.81e-06 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 4 | 33.02 | 7.24e-06 |
| et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.04 | 3 | 75.85 | 8.26e-06 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.49 | 6 | 12.32 | 1.15e-05 |
| et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.14 | 4 | 28.90 | 1.24e-05 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 7 | 8.88 | 1.80e-05 |
| ros_mouse_aorta_dn | Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 127 | 0.31 | 5 | 15.93 | 1.83e-05 |
| calres_presenillin_ko_hippocampus_up | Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. | 137 | 0.34 | 5 | 14.76 | 2.63e-05 |
| insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.06 | 3 | 48.54 | 3.34e-05 |
| tnfa_nfkb_dep_up | Up-regulated at any timepoint following TNFa treatment, only with functional NFkB | 26 | 0.06 | 3 | 46.68 | 3.76e-05 |
| uvb_nhek1_c3 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 26 | 0.06 | 3 | 46.68 | 3.76e-05 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 5 | 12.64 | 5.51e-05 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 9 | 5.39 | 6.01e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 5 | 11.24 | 9.60e-05 |
| aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.09 | 3 | 33.71 | 1.01e-04 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 4 | 16.35 | 1.17e-04 |
| nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 3 | 31.94 | 1.19e-04 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 5 | 10.01 | 1.64e-04 |
| adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.27 | 4 | 14.85 | 1.69e-04 |
| et743_sarcoma_up | Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 111 | 0.27 | 4 | 14.58 | 1.81e-04 |
| reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 1.21 | 7 | 5.77 | 2.61e-04 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 5 | 8.95 | 2.76e-04 |
| hsc_hsc_adult | Up-regulated in mouse hematopoietic stem cells from adult bone marrow (HSC Shared + Adult) | 363 | 0.90 | 6 | 6.69 | 3.28e-04 |
| oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
| as3_hek293_dn | Downregulated in HEK293 cells by treatment with arsenite | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
| hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| rb_creko_dn | Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 250 | 0.62 | 5 | 8.09 | 4.37e-04 |
| cpr_null_liver_up | Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls | 64 | 0.16 | 3 | 18.96 | 5.62e-04 |
| et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
| hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 7 | 4.47 | 1.16e-03 |
| alzheimers_incipient_dn | Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus | 312 | 0.77 | 5 | 6.48 | 1.18e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
| hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
| hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.22 | 3 | 13.95 | 1.37e-03 |
| emt_dn | Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 89 | 0.22 | 3 | 13.64 | 1.46e-03 |
| uv-cmv_unique_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 194 | 0.48 | 4 | 8.34 | 1.47e-03 |
| uvb_nhek1_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 336 | 0.83 | 5 | 6.02 | 1.63e-03 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
| dac_cgi_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| gn_camp_granulosa_up | Up-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin | 99 | 0.24 | 3 | 12.26 | 1.98e-03 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 0.54 | 4 | 7.39 | 2.28e-03 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| et743_sarcoma_72hrs_up | Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines | 106 | 0.26 | 3 | 11.45 | 2.41e-03 |
| brcax_a_up | Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.27 | 3 | 11.24 | 2.54e-03 |
| uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
| hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 0.58 | 4 | 6.94 | 2.85e-03 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| cpr_low_liver_up | Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 7 | 3.77 | 2.99e-03 |
| uvc_low_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) | 33 | 0.08 | 2 | 24.52 | 3.07e-03 |
| dac_ifn_bladder_up | Interferon-regulated genes upregulated by DAC treatment in T24 bladder carcinoma cells | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| tgfb_mammary_up | Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). | 118 | 0.29 | 3 | 10.28 | 3.26e-03 |
| hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
| vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 0.65 | 4 | 6.15 | 4.38e-03 |
| hsc_hsc_shared | Up-regulated in mouse hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster ii, HSC Shared) | 270 | 0.67 | 4 | 5.99 | 4.80e-03 |
| microrna_human | Predicted human MicroRNA targets | 2276 | 5.63 | 13 | 2.31 | 5.28e-03 |
| senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 0.70 | 4 | 5.70 | 5.73e-03 |
| idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.11 | 2 | 17.59 | 5.88e-03 |
| hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1331 | 3.29 | 9 | 2.74 | 6.71e-03 |
| bcnu_glioma_nomgmt_48hrs_dn | Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| hsc_hsc_fetal | Up-regulated in mouse hematopoietic stem cells from fetal liver (HSC Shared + Fetal) | 303 | 0.75 | 4 | 5.34 | 7.17e-03 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.39 | 3 | 7.63 | 7.45e-03 |
| fsh_granulosa_up | Up-regulated in human granulosa cells stimulated with follicle stimulation hormone (FSH) | 163 | 0.40 | 3 | 7.45 | 7.98e-03 |
| hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| lh_granulosa_up | Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) | 167 | 0.41 | 3 | 7.27 | 8.52e-03 |
| adip_vs_preadip_up | Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |
| dac_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells | 60 | 0.15 | 2 | 13.48 | 9.83e-03 |