L2L L2L Microarray Analysis Tool

Results for R06A.profile.u50

Results summary View all lists in L2L MDB View all genes in R06A.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 15 17.49 2.61e-14
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 15 17.49 2.61e-14
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 17 12.98 6.47e-14
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 17 11.60 3.88e-13
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 17 11.60 3.88e-13
il2_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.16 8 49.04 7.05e-12
il2_pbmc_30min_up Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.16 8 49.04 7.05e-12
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 21 6.43 4.85e-11
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 1.34 12 8.92 1.93e-08
dsrna_up Upregulated by dsRNA (polyI:C) in IFN-null GRE cells 68 0.17 6 35.69 2.19e-08
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.93 10 10.76 5.17e-08
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.20 6 29.60 6.80e-08
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 11 8.71 9.49e-08
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 10 8.52 4.40e-07
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 11 7.34 5.09e-07
adipocyte_brca_up Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 14 0.03 3 86.69 5.39e-06
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.44 6 13.71 6.23e-06
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 10 6.26 6.69e-06
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 9 7.14 6.81e-06
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 4 33.02 7.24e-06
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.04 3 75.85 8.26e-06
bleo_human_lymph_high_24hrs_up Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 197 0.49 6 12.32 1.15e-05
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.14 4 28.90 1.24e-05
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 0.79 7 8.88 1.80e-05
ros_mouse_aorta_dn Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.31 5 15.93 1.83e-05
calres_presenillin_ko_hippocampus_up Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. 137 0.34 5 14.76 2.63e-05
insulin_adip_insens_dn Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 25 0.06 3 48.54 3.34e-05
tnfa_nfkb_dep_up Up-regulated at any timepoint following TNFa treatment, only with functional NFkB 26 0.06 3 46.68 3.76e-05
uvb_nhek1_c3 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 3 26 0.06 3 46.68 3.76e-05
hypoxia_review Genes known to be induced by hypoxia 160 0.40 5 12.64 5.51e-05
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 1.67 9 5.39 6.01e-05
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 3 35.69 8.53e-05
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 5 11.24 9.60e-05
aged_mouse_retina_any_up Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 36 0.09 3 33.71 1.01e-04
et743_hela_up Upregulated by Et-743 in HeLa cells 99 0.24 4 16.35 1.17e-04
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 3 31.94 1.19e-04
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 5 10.01 1.64e-04
adipogenesis_hmsc_class3_up Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.27 4 14.85 1.69e-04
et743_sarcoma_up Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 111 0.27 4 14.58 1.81e-04
reovirus_hek293_up Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 1.21 7 5.77 2.61e-04
cmv-uv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 226 0.56 5 8.95 2.76e-04
hsc_hsc_adult Up-regulated in mouse hematopoietic stem cells from adult bone marrow (HSC Shared + Adult) 363 0.90 6 6.69 3.28e-04
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.13 3 22.47 3.41e-04
as3_hek293_dn Downregulated in HEK293 cells by treatment with arsenite 12 0.03 2 67.42 3.97e-04
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.03 2 67.42 3.97e-04
zmpste24_ko_up Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 57 0.14 3 21.29 4.00e-04
rb_creko_dn Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 0.62 5 8.09 4.37e-04
cpr_null_liver_up Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls 64 0.16 3 18.96 5.62e-04
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 2 53.94 6.28e-04
hypoxia_fibro_young_up Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) 15 0.04 2 53.94 6.28e-04
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.19 3 15.56 1.00e-03
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
hypoxia_reg_up Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.20 3 15.17 1.08e-03
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.57 7 4.47 1.16e-03
alzheimers_incipient_dn Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus 312 0.77 5 6.48 1.18e-03
old_fibro_up Upregulated in fibroblasts from old individuals, compared to young 84 0.21 3 14.45 1.24e-03
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.05 2 38.53 1.24e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22 3 13.64 1.46e-03
uv-cmv_unique_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 194 0.48 4 8.34 1.47e-03
uvb_nhek1_up Upregulated by UV-B light in normal human epidermal keratinocytes 336 0.83 5 6.02 1.63e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 3 12.77 1.76e-03
dac_cgi_bladder_up Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island 26 0.06 2 31.12 1.91e-03
gn_camp_granulosa_up Up-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin 99 0.24 3 12.26 1.98e-03
uvb_scc_dn Downregulated by UV-B light in squamous cell carinoma cells 219 0.54 4 7.39 2.28e-03
insulin_adip_sens_dn Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.07 2 27.90 2.37e-03
tzd_adip_dn Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 29 0.07 2 27.90 2.37e-03
et743_sarcoma_72hrs_up Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines 106 0.26 3 11.45 2.41e-03
brcax_a_up Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 30 0.07 2 26.97 2.54e-03
uvc_xpcs_8hr_up Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 108 0.27 3 11.24 2.54e-03
uvc_xpcs_all_up Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 112 0.28 3 10.84 2.82e-03
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 4 6.94 2.85e-03
bleo_human_lymph_high_4hrs_up Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 32 0.08 2 25.28 2.88e-03
cpr_low_liver_up Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls 32 0.08 2 25.28 2.88e-03
uvb_nhek3_all Regulated by UV-B light in normal human epidermal keratinocytes 751 1.86 7 3.77 2.99e-03
uvc_low_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) 33 0.08 2 24.52 3.07e-03
dac_ifn_bladder_up Interferon-regulated genes upregulated by DAC treatment in T24 bladder carcinoma cells 34 0.08 2 23.80 3.25e-03
tgfb_mammary_up Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). 118 0.29 3 10.28 3.26e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 3 9.95 3.58e-03
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.09 2 21.29 4.05e-03
elongina_ko_up Upregulated in MES cells from elongin-A knockout mice 263 0.65 4 6.15 4.38e-03
hsc_hsc_shared Up-regulated in mouse hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster ii, HSC Shared) 270 0.67 4 5.99 4.80e-03
microrna_human Predicted human MicroRNA targets 2276 5.63 13 2.31 5.28e-03
senescence_hff_up Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 0.70 4 5.70 5.73e-03
idx_tsa_dn_cluster4 Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 46 0.11 2 17.59 5.88e-03
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 2 17.21 6.14e-03
microrna_mammal Predicted MicroRNA targets conserved across human, mouse and rat 1331 3.29 9 2.74 6.71e-03
bcnu_glioma_nomgmt_48hrs_dn Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU 50 0.12 2 16.18 6.92e-03
hsc_hsc_fetal Up-regulated in mouse hematopoietic stem cells from fetal liver (HSC Shared + Fetal) 303 0.75 4 5.34 7.17e-03
irs1_ko_adip_up Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.39 3 7.63 7.45e-03
fsh_granulosa_up Up-regulated in human granulosa cells stimulated with follicle stimulation hormone (FSH) 163 0.40 3 7.45 7.98e-03
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 2 14.98 8.03e-03
lh_granulosa_up Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) 167 0.41 3 7.27 8.52e-03
adip_vs_preadip_up Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 57 0.14 2 14.19 8.91e-03
dac_bladder_up Upregulated by DAC treatment in T24 bladder carcinoma cells 60 0.15 2 13.48 9.83e-03

Raw data (tab-delimited .txt)