Results summary | View all lists in L2L MDB | View all genes in R06A.profile.d50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 7 | 8.30 | 2.75e-05 |
elongina_ko_dn | Downregulated in MES cells from elongin-A knockout mice | 267 | 0.66 | 5 | 7.58 | 5.88e-04 |
reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 1.21 | 6 | 4.97 | 1.51e-03 |
scchn_hpvpos_up | Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
vhl_normal_up | Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) | 754 | 1.86 | 7 | 3.76 | 3.06e-03 |
breastca_two_classes | Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers | 247 | 0.61 | 4 | 6.55 | 3.51e-03 |
p21_p53_middle_dn | Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 4.92 | 12 | 2.44 | 4.74e-03 |
idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.34 | 3 | 8.92 | 4.85e-03 |
serum_fibroblast_core_up | Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) | 292 | 0.72 | 4 | 5.54 | 6.31e-03 |
senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 4 | 5.41 | 6.85e-03 |
rcc_nl_up | Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) | 899 | 2.22 | 7 | 3.15 | 7.77e-03 |
senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 3 | 7.10 | 9.09e-03 |
il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 5 | 3.96 | 9.41e-03 |