L2L L2L Microarray Analysis Tool

Results for R06A.profile.d50

Results summary View all lists in L2L MDB View all genes in R06A.profile.d50
List Name Description Total
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 0.84 7 8.30 2.75e-05
elongina_ko_dn Downregulated in MES cells from elongin-A knockout mice 267 0.66 5 7.58 5.88e-04
reovirus_hek293_dn Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 488 1.21 6 4.97 1.51e-03
scchn_hpvpos_up Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 31 0.08 2 26.10 2.71e-03
vhl_normal_up Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) 754 1.86 7 3.76 3.06e-03
breastca_two_classes Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers 247 0.61 4 6.55 3.51e-03
p21_p53_middle_dn Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 37 0.09 2 21.87 3.84e-03
stemcell_embryonic_up Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 4.92 12 2.44 4.74e-03
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.34 3 8.92 4.85e-03
serum_fibroblast_core_up Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) 292 0.72 4 5.54 6.31e-03
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 4 5.41 6.85e-03
rcc_nl_up Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) 899 2.22 7 3.15 7.77e-03
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.42 3 7.10 9.09e-03
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 5 3.96 9.41e-03

Raw data (tab-delimited .txt)