L2L L2L Microarray Analysis Tool

Results for R06A.profile.d50

Results summary View all lists in L2L MDB View all genes in R06A.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 0.84 7 8.30 2.75e-05
elongina_ko_dn Downregulated in MES cells from elongin-A knockout mice 267 0.66 5 7.58 5.88e-04
reovirus_hek293_dn Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 488 1.21 6 4.97 1.51e-03
scchn_hpvpos_up Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 31 0.08 2 26.10 2.71e-03
vhl_normal_up Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) 754 1.86 7 3.76 3.06e-03
breastca_two_classes Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers 247 0.61 4 6.55 3.51e-03
p21_p53_middle_dn Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 37 0.09 2 21.87 3.84e-03
stemcell_embryonic_up Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 4.92 12 2.44 4.74e-03
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.34 3 8.92 4.85e-03
serum_fibroblast_core_up Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) 292 0.72 4 5.54 6.31e-03
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 4 5.41 6.85e-03
rcc_nl_up Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) 899 2.22 7 3.15 7.77e-03
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.42 3 7.10 9.09e-03
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 5 3.96 9.41e-03

Raw data (tab-delimited .txt)