L2L L2L Microarray Analysis Tool

Results for R03B.profile.u50

Results summary View all lists in L2L MDB View all genes in R03B.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 14 31.46 5.55e-17
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.06 6 101.14 2.96e-11
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.05 4 85.17 1.40e-07
dex_keratinocyte_4hr_dn Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 69 0.17 5 29.31 9.09e-07
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.08 4 52.20 1.11e-06
fsh_human_granulosa_up Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.08 3 39.15 6.45e-05
bay_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 318 0.79 6 7.63 1.62e-04
hdaci_three_up Upregulated in several cell lines by all of TSA, SAHA, and MS-275 8 0.02 2 101.14 1.69e-04
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 3 27.58 1.85e-04
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.11 3 26.97 1.98e-04
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.11 3 26.38 2.12e-04
hdaci_colon_cluster2 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) 9 0.02 2 89.90 2.17e-04
il2_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 503 1.24 7 5.63 3.02e-04
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 5 8.68 3.17e-04
ni2_mouse_up Upregulated by nickel(II) in sensitive A/J mouse lung tissue 65 0.16 3 18.67 5.88e-04
adipogenesis_hmsc_class2_up Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) 15 0.04 2 53.94 6.28e-04
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 2 53.94 6.28e-04
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.04 2 53.94 6.28e-04
tnfalpha_30min_up Upregulated 30min after TNF-alpha treatment of HeLa cells 68 0.17 3 17.85 6.71e-04
uvc_high_d8_dn Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.17 3 17.34 7.31e-04
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
et743pt650_breastca_dn Downregulated by both Et-743 and Pt-650 in MDA-MB-435 cells (Fig. 6G) 20 0.05 2 40.45 1.13e-03
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.21 3 14.11 1.33e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
pdgf_es_up Up-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis 28 0.07 2 28.90 2.21e-03
il2_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 531 1.31 6 4.57 2.30e-03
scw_joint_4hrs_up Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 230 0.57 4 7.04 2.72e-03
fsh_ovary_mcv152_dn Down-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 111 0.27 3 10.93 2.75e-03
cocaine_brain_4wks_up Up-regulated in the nucleus accumbens of mice after 4 weeks of cocaine treatment 112 0.28 3 10.84 2.82e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 3 9.95 3.58e-03
tnfalpha_all_up Upregulated at any timepoint after TNF-alpha treatment of HeLa cells 122 0.30 3 9.95 3.58e-03
senescence_hela_up Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 262 0.65 4 6.18 4.32e-03
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 0.66 4 6.08 4.56e-03
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.57 6 3.83 5.41e-03
scw_joint_24hrs_up Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 143 0.35 3 8.49 5.57e-03
arthritis_mouse_common_up Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 1.13 5 4.41 6.09e-03
alzheimers_disease_up Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus 3137 7.75 16 2.06 6.18e-03
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 1.67 6 3.60 7.26e-03
uvc_high_d9_dn Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.13 2 15.27 7.74e-03
scw_joint_react_up Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.41 3 7.31 8.38e-03
lh_granulosa_up Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) 167 0.41 3 7.27 8.52e-03

Raw data (tab-delimited .txt)