L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in R01A.profile.ud50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
regulation of interleukin-6 biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	8	0.04	3	75.85	6.64e-06
interleukin-6 production	The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	10	0.05	3	60.68	1.41e-05
interleukin-6 biosynthetic process	The chemical reactions and pathways resulting in the formation of interleukin-6.	10	0.05	3	60.68	1.41e-05
positive regulation of interleukin-6 biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.	7	0.03	2	57.79	5.05e-04
regulation of chemokine biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.	8	0.04	2	50.57	6.71e-04
chemokine production	The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	9	0.04	2	44.95	8.60e-04
chemokine biosynthetic process	The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.04	2	44.95	8.60e-04
chemokine metabolic process	The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.	9	0.04	2	44.95	8.60e-04
acute-phase response	Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.	44	0.22	3	13.79	1.38e-03
thermoregulation	A homeostatic process by which an organism modulates its internal body temperature.	12	0.06	2	33.71	1.56e-03
regulation of isotype switching	Any process that modulates the frequency, rate or extent of isotype switching.	18	0.09	2	22.47	3.55e-03
regulation of translation	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.	211	1.04	5	4.79	4.24e-03
regulation of cellular biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.	225	1.11	5	4.49	5.54e-03
neutrophil chemotaxis	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.	24	0.12	2	16.86	6.28e-03
positive regulation of B cell activation	Any process that activates or increases the frequency, rate or extent of B cell activation.	25	0.12	2	16.18	6.80e-03
cytokine production	The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.	153	0.76	4	5.29	7.32e-03
mesoderm development	The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.	82	0.41	3	7.40	8.00e-03
positive regulation of metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.	567	2.80	8	2.85	8.01e-03
transcription initiation from RNA polymerase II promoter	Processes involved in starting transcription from the RNA polymerase II promoter.	28	0.14	2	14.45	8.48e-03
regulation of cytokine biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.	85	0.42	3	7.14	8.83e-03
regulation of biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.	253	1.25	5	4.00	8.95e-03
somatic recombination of immunoglobulin genes during immune response	The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.	30	0.15	2	13.48	9.70e-03
somatic diversification of immunoglobulins during immune response	The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.	30	0.15	2	13.48	9.70e-03
immunoglobulin production during immune response	The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.	30	0.15	2	13.48	9.70e-03
isotype switching	The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.	30	0.15	2	13.48	9.70e-03

regulation of interleukin-6 biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

8

0.04

3

75.85

6.64e-06

interleukin-6 production

The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

10

0.05

3

60.68

1.41e-05

interleukin-6 biosynthetic process

The chemical reactions and pathways resulting in the formation of interleukin-6.

10

0.05

3

60.68

1.41e-05

positive regulation of interleukin-6 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

7

0.03

2

57.79

5.05e-04

regulation of chemokine biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.

8

0.04

2

50.57

6.71e-04

chemokine production

The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

9

0.04

2

44.95

8.60e-04

chemokine biosynthetic process

The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.04

2

44.95

8.60e-04

chemokine metabolic process

The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.04

2

44.95

8.60e-04

acute-phase response

Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

44

0.22

3

13.79

1.38e-03

thermoregulation

A homeostatic process by which an organism modulates its internal body temperature.

12

0.06

2

33.71

1.56e-03

regulation of isotype switching

Any process that modulates the frequency, rate or extent of isotype switching.

18

0.09

2

22.47

3.55e-03

regulation of translation

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

211

1.04

5

4.79

4.24e-03

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

225

1.11

5

4.49

5.54e-03

neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

24

0.12

2

16.86

6.28e-03

positive regulation of B cell activation

Any process that activates or increases the frequency, rate or extent of B cell activation.

25

0.12

2

16.18

6.80e-03

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

153

0.76

4

5.29

7.32e-03

mesoderm development

The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.

82

0.41

3

7.40

8.00e-03

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

567

2.80

8

2.85

8.01e-03

transcription initiation from RNA polymerase II promoter

Processes involved in starting transcription from the RNA polymerase II promoter.

28

0.14

2

14.45

8.48e-03

regulation of cytokine biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.

85

0.42

3

7.14

8.83e-03

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

253

1.25

5

4.00

8.95e-03

somatic recombination of immunoglobulin genes during immune response

The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response.

30

0.15

2

13.48

9.70e-03

somatic diversification of immunoglobulins during immune response

The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response.

30

0.15

2

13.48

9.70e-03

immunoglobulin production during immune response

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.

30

0.15

2

13.48

9.70e-03

isotype switching

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.

30

0.15

2

13.48

9.70e-03

Results for R01A.profile.ud50