L2L Microarray Analysis Tool
Results for P02C.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in P02C.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 7 | 8.30 | 2.75e-05 |
| stemcell_neural_up | Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells | 2805 | 6.93 | 20 | 2.88 | 3.79e-05 |
| prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 0.76 | 6 | 7.93 | 1.32e-04 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 5 | 10.27 | 1.46e-04 |
| rb_creko_up | Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 344 | 0.85 | 6 | 7.06 | 2.47e-04 |
| tnfalpha_4hrs_up | Upregulated 4hrs after TNF-alpha treatment of HeLa cells | 62 | 0.15 | 3 | 19.57 | 5.12e-04 |
| stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 4.92 | 14 | 2.85 | 5.84e-04 |
| vhl_normal_up | Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) | 754 | 1.86 | 8 | 4.29 | 6.87e-04 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 4 | 9.46 | 9.25e-04 |
| cmv_hcmv_timecourse_14hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 0.51 | 4 | 7.82 | 1.86e-03 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 0.87 | 5 | 5.73 | 2.01e-03 |
| tnfalpha_all_up | Upregulated at any timepoint after TNF-alpha treatment of HeLa cells | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
| 5fu_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 42 | 0.10 | 2 | 19.26 | 4.93e-03 |
| cited1_ko_het_up | Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
| serum_fibroblast_core_up | Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) | 292 | 0.72 | 4 | 5.54 | 6.31e-03 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 9 | 2.76 | 6.41e-03 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 5.79 | 13 | 2.24 | 6.65e-03 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 4 | 5.41 | 6.85e-03 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 5 | 4.26 | 7.01e-03 |
| cmv_uv-cmv_common_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |