L2L L2L Microarray Analysis Tool

Results for P02C.profile.d50

Results summary View all lists in L2L MDB View all genes in P02C.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 0.84 7 8.30 2.75e-05
stemcell_neural_up Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells 2805 6.93 20 2.88 3.79e-05
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 6 7.93 1.32e-04
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.49 5 10.27 1.46e-04
rb_creko_up Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 344 0.85 6 7.06 2.47e-04
tnfalpha_4hrs_up Upregulated 4hrs after TNF-alpha treatment of HeLa cells 62 0.15 3 19.57 5.12e-04
stemcell_embryonic_up Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 4.92 14 2.85 5.84e-04
vhl_normal_up Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) 754 1.86 8 4.29 6.87e-04
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.42 4 9.46 9.25e-04
cmv_hcmv_timecourse_14hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours 95 0.23 3 12.77 1.76e-03
cmv-uv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 207 0.51 4 7.82 1.86e-03
tgfb_hmvec_2hr_dn Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 0.87 5 5.73 2.01e-03
tnfalpha_all_up Upregulated at any timepoint after TNF-alpha treatment of HeLa cells 122 0.30 3 9.95 3.58e-03
5fu_resist_gastric_up Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 42 0.10 2 19.26 4.93e-03
cited1_ko_het_up Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes 43 0.11 2 18.82 5.16e-03
serum_fibroblast_core_up Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) 292 0.72 4 5.54 6.31e-03
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 9 2.76 6.41e-03
5azac-tsa_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 2343 5.79 13 2.24 6.65e-03
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 4 5.41 6.85e-03
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 5 4.26 7.01e-03
cmv_uv-cmv_common_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 54 0.13 2 14.98 8.03e-03

Raw data (tab-delimited .txt)