Results summary | View all lists in L2L MDB | View all genes in P01B.profile.u50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 11 | 7.50 | 4.12e-07 |
alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 11 | 7.50 | 4.12e-07 |
bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 9 | 7.66 | 3.86e-06 |
p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 4 | 33.02 | 7.24e-06 |
il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 9 | 6.87 | 9.24e-06 |
hdaci_colon_cur12hrs_up | Upregulated by curcumin at 12 hrs in SW260 colon carcinoma cells | 22 | 0.05 | 3 | 55.16 | 2.25e-05 |
csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.35 | 5 | 14.45 | 2.92e-05 |
il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 8 | 6.33 | 5.07e-05 |
bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.20 | 4 | 19.73 | 5.60e-05 |
uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 12 | 3.67 | 1.51e-04 |
uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.27 | 4 | 14.98 | 1.63e-04 |
bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 5 | 10.01 | 1.64e-04 |
uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.28 | 4 | 14.45 | 1.87e-04 |
hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.12 | 3 | 25.82 | 2.26e-04 |
il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 8 | 5.01 | 2.50e-04 |
hdaci_colon_cursul_up | Upregulated by both curcumin and sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 53 | 0.13 | 3 | 22.90 | 3.23e-04 |
hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.33 | 4 | 11.99 | 3.82e-04 |
hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 0.65 | 5 | 7.69 | 5.49e-04 |
et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
hdaci_colon_sul16hrs_up | Upregulated by sulindac at 16 hrs in SW260 colon carcinoma cells | 67 | 0.17 | 3 | 18.11 | 6.43e-04 |
tsa_hepatoma_up | Up-regulated in more than one of several human hepatoma cell lines by 24-hour treatment with trichostatin A | 67 | 0.17 | 3 | 18.11 | 6.43e-04 |
et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
hsc_mature_adult | Up-regulated in mouse mature bood cells from adult bone marrow, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared + Adult) | 427 | 1.06 | 6 | 5.68 | 7.66e-04 |
senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 0.70 | 5 | 7.12 | 7.75e-04 |
bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 7 | 4.67 | 9.00e-04 |
hdaci_colon_cur_up | Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 174 | 0.43 | 4 | 9.30 | 9.86e-04 |
heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 5 | 6.34 | 1.30e-03 |
hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
heatshock_old_up | Upregulated after heat shock in lymphocytes from old individuals, compared to young | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
hdaci_colon_sul24hrs_up | Upregulated by sulindac at 24 hrs in SW260 colon carcinoma cells | 102 | 0.25 | 3 | 11.90 | 2.16e-03 |
uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 5 | 5.38 | 2.64e-03 |
aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.27 | 3 | 10.93 | 2.75e-03 |
hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 0.58 | 4 | 6.94 | 2.85e-03 |
bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
cpr_low_liver_up | Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
hdaci_colon_sul12hrs_up | Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 4 | 6.08 | 4.56e-03 |
gn_camp_granulosa_dn | Down-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin | 135 | 0.33 | 3 | 8.99 | 4.75e-03 |
hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 5 | 4.26 | 7.01e-03 |
oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 5 | 3.97 | 9.34e-03 |
csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 1.27 | 5 | 3.94 | 9.56e-03 |