L2L L2L Microarray Analysis Tool

Results for P01B.profile.u50

Results summary View all lists in L2L MDB View all genes in P01B.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 11 7.50 4.12e-07
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 11 7.50 4.12e-07
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 9 7.66 3.86e-06
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 4 33.02 7.24e-06
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 9 6.87 9.24e-06
hdaci_colon_cur12hrs_up Upregulated by curcumin at 12 hrs in SW260 colon carcinoma cells 22 0.05 3 55.16 2.25e-05
csb_robust_up Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). 140 0.35 5 14.45 2.92e-05
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 8 6.33 5.07e-05
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.20 4 19.73 5.60e-05
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 3 35.69 8.53e-05
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 12 3.67 1.51e-04
uvc_xpcs_8hr_up Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 108 0.27 4 14.98 1.63e-04
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 5 10.01 1.64e-04
uvc_xpcs_all_up Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 112 0.28 4 14.45 1.87e-04
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 3 25.82 2.26e-04
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 8 5.01 2.50e-04
hdaci_colon_cursul_up Upregulated by both curcumin and sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 53 0.13 3 22.90 3.23e-04
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 3 22.47 3.41e-04
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 4 11.99 3.82e-04
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.03 2 67.42 3.97e-04
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.15 3 19.90 4.88e-04
elongina_ko_up Upregulated in MES cells from elongin-A knockout mice 263 0.65 5 7.69 5.49e-04
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 2 53.94 6.28e-04
hdaci_colon_sul16hrs_up Upregulated by sulindac at 16 hrs in SW260 colon carcinoma cells 67 0.17 3 18.11 6.43e-04
tsa_hepatoma_up Up-regulated in more than one of several human hepatoma cell lines by 24-hour treatment with trichostatin A 67 0.17 3 18.11 6.43e-04
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.04 2 50.57 7.17e-04
hsc_mature_adult Up-regulated in mouse mature bood cells from adult bone marrow, compared to hematopoietic progenitors (Cluster vii, Mature Blood Cells Shared + Adult) 427 1.06 6 5.68 7.66e-04
senescence_hff_up Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 0.70 5 7.12 7.75e-04
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 7 4.67 9.00e-04
hdaci_colon_cur_up Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 174 0.43 4 9.30 9.86e-04
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.19 3 15.56 1.00e-03
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
old_fibro_up Upregulated in fibroblasts from old individuals, compared to young 84 0.21 3 14.45 1.24e-03
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.05 2 38.53 1.24e-03
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 0.79 5 6.34 1.30e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 3 12.77 1.76e-03
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 5 5.83 1.87e-03
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 5 5.83 1.87e-03
heatshock_old_up Upregulated after heat shock in lymphocytes from old individuals, compared to young 27 0.07 2 29.97 2.06e-03
hdaci_colon_sul24hrs_up Upregulated by sulindac at 24 hrs in SW260 colon carcinoma cells 102 0.25 3 11.90 2.16e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.07 2 28.90 2.21e-03
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.93 5 5.38 2.64e-03
aged_mouse_neocortex_up Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.27 3 10.93 2.75e-03
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 4 6.94 2.85e-03
bleo_human_lymph_high_4hrs_up Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 32 0.08 2 25.28 2.88e-03
cpr_low_liver_up Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls 32 0.08 2 25.28 2.88e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 3 9.95 3.58e-03
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 2 21.29 4.05e-03
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.09 2 21.29 4.05e-03
hdaci_colon_sul12hrs_up Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells 40 0.10 2 20.23 4.48e-03
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 0.66 4 6.08 4.56e-03
gn_camp_granulosa_dn Down-regulated in human granulosa cells by the gonadotropins LH and FSH, as well as by cAMP-stimulator forskolin 135 0.33 3 8.99 4.75e-03
hdaci_colon_sul48hrs_up Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells 140 0.35 3 8.67 5.25e-03
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 5 4.26 7.01e-03
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.13 2 14.98 8.03e-03
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.14 2 14.45 8.61e-03
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 5 3.97 9.34e-03
csb_reliable_up Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 1.27 5 3.94 9.56e-03

Raw data (tab-delimited .txt)