Results summary | View all lists in L2L MDB | View all genes in N05A.profile.ud50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
cpr_low_liver_up | Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls | 32 | 0.16 | 11 | 69.53 | 5.06e-18 |
il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 3.19 | 26 | 8.14 | 1.01e-15 |
serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 1.58 | 19 | 12.05 | 6.68e-15 |
il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 2.53 | 22 | 8.71 | 3.99e-14 |
fsh_ovary_mcv152_up | Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated | 120 | 0.59 | 11 | 18.54 | 3.05e-11 |
cpr_null_liver_up | Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls | 64 | 0.32 | 9 | 28.44 | 3.80e-11 |
adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.54 | 10 | 18.56 | 2.38e-10 |
bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 1.00 | 12 | 12.02 | 6.19e-10 |
stemcell_neural_up | Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells | 2805 | 13.87 | 41 | 2.96 | 2.46e-09 |
il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 2.62 | 17 | 6.49 | 2.57e-09 |
idx_tsa_dn_cluster4 | Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) | 46 | 0.23 | 7 | 30.78 | 3.26e-09 |
senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 1.69 | 13 | 7.71 | 2.52e-08 |
bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 15 | 6.39 | 2.65e-08 |
bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 2.35 | 15 | 6.39 | 2.65e-08 |
stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 9.83 | 31 | 3.15 | 4.98e-08 |
senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.85 | 9 | 10.65 | 2.39e-07 |
idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.67 | 8 | 11.90 | 4.79e-07 |
hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 1.86 | 12 | 6.46 | 5.68e-07 |
uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 3.13 | 15 | 4.79 | 1.03e-06 |
il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 6 | 18.39 | 1.03e-06 |
il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.33 | 6 | 18.39 | 1.03e-06 |
rb_ko_up | Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. | 155 | 0.77 | 8 | 10.44 | 1.29e-06 |
irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.79 | 8 | 10.18 | 1.56e-06 |
alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 11 | 6.41 | 1.77e-06 |
alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 1.72 | 11 | 6.41 | 1.77e-06 |
5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 11.58 | 30 | 2.59 | 4.25e-06 |
reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 2.41 | 12 | 4.97 | 8.16e-06 |
5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 9.05 | 25 | 2.76 | 8.82e-06 |
alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 13 | 4.43 | 1.18e-05 |
alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 13 | 4.43 | 1.18e-05 |
bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 3.00 | 13 | 4.34 | 1.47e-05 |
scw_joint_react_dn | Down-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 231 | 1.14 | 8 | 7.01 | 2.39e-05 |
as3_hek293_dn | Downregulated in HEK293 cells by treatment with arsenite | 12 | 0.06 | 3 | 50.57 | 2.57e-05 |
cox1_ko_hippocampus_dn | Down-regulated in the hippocampus of COX1-/- mice compared to wild-type controls. | 77 | 0.38 | 5 | 13.13 | 4.34e-05 |
tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 19 | 2.91 | 5.08e-05 |
hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) | 15 | 0.07 | 3 | 40.45 | 5.26e-05 |
bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.41 | 5 | 12.33 | 5.87e-05 |
cantharidin_dn | Downregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin | 83 | 0.41 | 5 | 12.18 | 6.22e-05 |
p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.24 | 4 | 16.51 | 1.06e-04 |
senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 1.48 | 8 | 5.41 | 1.44e-04 |
heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 6 | 6.86 | 2.79e-04 |
heatshock_old_up | Upregulated after heat shock in lymphocytes from old individuals, compared to young | 27 | 0.13 | 3 | 22.47 | 3.23e-04 |
insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.14 | 3 | 20.92 | 4.01e-04 |
uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.35 | 4 | 11.56 | 4.22e-04 |
5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.15 | 3 | 20.23 | 4.44e-04 |
bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 2.69 | 10 | 3.72 | 4.65e-04 |
scchn_hpvpos_up | Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
uvc_high_d1_dn | Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 6 | 6.16 | 4.91e-04 |
calres_presenillin_ko_hippocampus_up | Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. | 137 | 0.68 | 5 | 7.38 | 6.43e-04 |
uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.17 | 3 | 17.85 | 6.45e-04 |
hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.39 | 4 | 10.24 | 6.68e-04 |
aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.18 | 3 | 16.86 | 7.64e-04 |
heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 1.10 | 6 | 5.44 | 9.36e-04 |
idx_tsa_up_cluster5 | Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) | 149 | 0.74 | 5 | 6.79 | 9.37e-04 |
il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 2.52 | 9 | 3.57 | 1.16e-03 |
hdaci_colon_tsa48hrs_dn | Downregulated by TSA at 48 hrs in SW260 colon carcinoma cells | 11 | 0.05 | 2 | 36.78 | 1.31e-03 |
hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.47 | 4 | 8.52 | 1.33e-03 |
htert_up | Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls | 97 | 0.48 | 4 | 8.34 | 1.44e-03 |
oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.22 | 3 | 13.48 | 1.47e-03 |
hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.23 | 3 | 12.91 | 1.67e-03 |
tgfb-wnt3a_mammary_dn | Down-regulated in common by both TGF-beta and Wnt3A in normal mouse mammary gland cells (top 124 genes). | 106 | 0.52 | 4 | 7.63 | 1.99e-03 |
bcnu_glioma_nomgmt_48hrs_dn | Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU | 50 | 0.25 | 3 | 12.14 | 1.99e-03 |
hippocampus_development_neonatal | Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) | 51 | 0.25 | 3 | 11.90 | 2.11e-03 |
senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 1.30 | 6 | 4.63 | 2.12e-03 |
uvc_high_d9_dn | Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) | 53 | 0.26 | 3 | 11.45 | 2.35e-03 |
ad12_any_up | Up-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
uvc_high_b2_up | Up-regulated at 18-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b2) | 15 | 0.07 | 2 | 26.97 | 2.46e-03 |
hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
vegf_huvec_2hrs_up | Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells | 54 | 0.27 | 3 | 11.24 | 2.48e-03 |
bap_hepg2_dn | Down-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 56 | 0.28 | 3 | 10.84 | 2.75e-03 |
et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
adip_vs_preadip_up | Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 57 | 0.28 | 3 | 10.65 | 2.90e-03 |
hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.60 | 4 | 6.63 | 3.30e-03 |
hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.30 | 3 | 9.95 | 3.51e-03 |
serum_fibroblast_core_up | Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) | 292 | 1.44 | 6 | 4.16 | 3.60e-03 |
tpa_resist_middle_dn | Downregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells | 209 | 1.03 | 5 | 4.84 | 4.07e-03 |
tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). | 1237 | 6.12 | 14 | 2.29 | 4.17e-03 |
wnt3a_mammary_up | Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). | 133 | 0.66 | 4 | 6.08 | 4.49e-03 |
brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 1.52 | 6 | 3.94 | 4.66e-03 |
hdaci_colon_cur12hrs_up | Upregulated by curcumin at 12 hrs in SW260 colon carcinoma cells | 22 | 0.11 | 2 | 18.39 | 5.29e-03 |
heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 9.04 | 18 | 1.99 | 5.45e-03 |
cisplatin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.37 | 3 | 8.20 | 6.03e-03 |
cancerdrugs_probcell_up | Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
methotrexate_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.38 | 3 | 7.88 | 6.73e-03 |
insulin_adip_insens_dn | Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 25 | 0.12 | 2 | 16.18 | 6.80e-03 |
heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 3 | 7.78 | 6.98e-03 |
heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 9 | 2.70 | 7.25e-03 |
cmv_hcmv_timecourse_4hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 2.20 | 7 | 3.17 | 7.38e-03 |
uvc_high_d2_dn | Down-regulated consistently at 6-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d2) | 82 | 0.41 | 3 | 7.40 | 8.00e-03 |
camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
rb_creko_dn | Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 250 | 1.24 | 5 | 4.05 | 8.53e-03 |
ageing_lymph_dn | Downregulated in human lymphocytes from old individuals, compared to young | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
brcax_a_up | Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |