L2L L2L Microarray Analysis Tool

Results for N05A.profile.ud50

Results summary View all lists in L2L MDB View all genes in N05A.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
cpr_low_liver_up Up-regulated in mouse liver tissue from mice with reduced liver expression of NADPH-cytochrome P450 reductase (CPR), versus normal controls 32 0.16 11 69.53 5.06e-18
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 3.19 26 8.14 1.01e-15
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 1.58 19 12.05 6.68e-15
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 2.53 22 8.71 3.99e-14
fsh_ovary_mcv152_up Up-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 120 0.59 11 18.54 3.05e-11
cpr_null_liver_up Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus lox-only controls 64 0.32 9 28.44 3.80e-11
adipogenesis_hmsc_class3_up Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.54 10 18.56 2.38e-10
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 1.00 12 12.02 6.19e-10
stemcell_neural_up Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells 2805 13.87 41 2.96 2.46e-09
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 2.62 17 6.49 2.57e-09
idx_tsa_dn_cluster4 Strongly down-regulated at 8-48 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 4) 46 0.23 7 30.78 3.26e-09
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 1.69 13 7.71 2.52e-08
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.35 15 6.39 2.65e-08
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.35 15 6.39 2.65e-08
stemcell_embryonic_up Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 9.83 31 3.15 4.98e-08
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.85 9 10.65 2.39e-07
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.67 8 11.90 4.79e-07
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 1.86 12 6.46 5.68e-07
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 3.13 15 4.79 1.03e-06
il2_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 6 18.39 1.03e-06
il2_pbmc_30min_up Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 66 0.33 6 18.39 1.03e-06
rb_ko_up Up-regulated in MEFs derived from Rb knock-out mice, versus wild-type controls. 155 0.77 8 10.44 1.29e-06
irs1_ko_adip_up Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.79 8 10.18 1.56e-06
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 11 6.41 1.77e-06
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 11 6.41 1.77e-06
5azac-tsa_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 2343 11.58 30 2.59 4.25e-06
reovirus_hek293_dn Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 488 2.41 12 4.97 8.16e-06
5azac_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1830 9.05 25 2.76 8.82e-06
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 13 4.43 1.18e-05
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 13 4.43 1.18e-05
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 3.00 13 4.34 1.47e-05
scw_joint_react_dn Down-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 231 1.14 8 7.01 2.39e-05
as3_hek293_dn Downregulated in HEK293 cells by treatment with arsenite 12 0.06 3 50.57 2.57e-05
cox1_ko_hippocampus_dn Down-regulated in the hippocampus of COX1-/- mice compared to wild-type controls. 77 0.38 5 13.13 4.34e-05
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 6.53 19 2.91 5.08e-05
hypoxia_fibro_young_up Upregulated by hypoxia in normal fibroblasts from young, but not old, donors (Table 1) 15 0.07 3 40.45 5.26e-05
bay_pbmc_30min_up up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 82 0.41 5 12.33 5.87e-05
cantharidin_dn Downregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin 83 0.41 5 12.18 6.22e-05
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.24 4 16.51 1.06e-04
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 1.48 8 5.41 1.44e-04
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.88 6 6.86 2.79e-04
heatshock_old_up Upregulated after heat shock in lymphocytes from old individuals, compared to young 27 0.13 3 22.47 3.23e-04
insulin_adip_sens_dn Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.14 3 20.92 4.01e-04
uvc_high_d8_dn Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.35 4 11.56 4.22e-04
5fu_resist_gastric_dn Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.15 3 20.23 4.44e-04
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 2.69 10 3.72 4.65e-04
scchn_hpvpos_up Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 31 0.15 3 19.57 4.90e-04
uvc_high_d1_dn Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) 31 0.15 3 19.57 4.90e-04
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.97 6 6.16 4.91e-04
calres_presenillin_ko_hippocampus_up Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. 137 0.68 5 7.38 6.43e-04
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.17 3 17.85 6.45e-04
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.39 4 10.24 6.68e-04
aged_mouse_retina_any_up Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 36 0.18 3 16.86 7.64e-04
heatshock_hela_2hr_dn Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 223 1.10 6 5.44 9.36e-04
idx_tsa_up_cluster5 Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) 149 0.74 5 6.79 9.37e-04
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 2.52 9 3.57 1.16e-03
hdaci_colon_tsa48hrs_dn Downregulated by TSA at 48 hrs in SW260 colon carcinoma cells 11 0.05 2 36.78 1.31e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.47 4 8.52 1.33e-03
htert_up Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 97 0.48 4 8.34 1.44e-03
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.22 3 13.48 1.47e-03
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.23 3 12.91 1.67e-03
tgfb-wnt3a_mammary_dn Down-regulated in common by both TGF-beta and Wnt3A in normal mouse mammary gland cells (top 124 genes). 106 0.52 4 7.63 1.99e-03
bcnu_glioma_nomgmt_48hrs_dn Down-regulated in an MGMT-deficient glioma cell line (A172) at 48 hours following treatment with BCNU 50 0.25 3 12.14 1.99e-03
hippocampus_development_neonatal Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) 51 0.25 3 11.90 2.11e-03
senescence_hela_up Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 262 1.30 6 4.63 2.12e-03
uvc_high_d9_dn Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.26 3 11.45 2.35e-03
ad12_any_up Up-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at any timepoint to 48 hrs hours post-infection 15 0.07 2 26.97 2.46e-03
uvc_high_b2_up Up-regulated at 18-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b2) 15 0.07 2 26.97 2.46e-03
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.27 3 11.24 2.48e-03
vegf_huvec_2hrs_up Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells 54 0.27 3 11.24 2.48e-03
bap_hepg2_dn Down-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 56 0.28 3 10.84 2.75e-03
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.08 2 25.28 2.80e-03
adip_vs_preadip_up Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 57 0.28 3 10.65 2.90e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.60 4 6.63 3.30e-03
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.30 3 9.95 3.51e-03
serum_fibroblast_core_up Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) 292 1.44 6 4.16 3.60e-03
tpa_resist_middle_dn Downregulated by TPA at two consecutive timepoints between 2-24hrs in resistant HL-525 cells 209 1.03 5 4.84 4.07e-03
tsa_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). 1237 6.12 14 2.29 4.17e-03
wnt3a_mammary_up Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). 133 0.66 4 6.08 4.49e-03
brca1_overexp_prostate_up Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 308 1.52 6 3.94 4.66e-03
hdaci_colon_cur12hrs_up Upregulated by curcumin at 12 hrs in SW260 colon carcinoma cells 22 0.11 2 18.39 5.29e-03
heatshock_hela_4hr_dn Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 9.04 18 1.99 5.45e-03
cisplatin_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with cisplatin 23 0.11 2 17.59 5.77e-03
dox_resist_gastric_up Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.37 3 8.20 6.03e-03
cancerdrugs_probcell_up Up-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 24 0.12 2 16.86 6.28e-03
methotrexate_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with methotrexate 24 0.12 2 16.86 6.28e-03
p21_p53_any_dn Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 77 0.38 3 7.88 6.73e-03
insulin_adip_insens_dn Down-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 25 0.12 2 16.18 6.80e-03
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.39 3 7.78 6.98e-03
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 9 2.70 7.25e-03
cmv_hcmv_timecourse_4hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 4 hours 26 0.13 2 15.56 7.34e-03
ageing_brain_up Age-upregulated in the human frontal cortex 446 2.20 7 3.17 7.38e-03
uvc_high_d2_dn Down-regulated consistently at 6-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d2) 82 0.41 3 7.40 8.00e-03
camptothecin_probcell_up Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin 28 0.14 2 14.45 8.48e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.14 2 14.45 8.48e-03
rb_creko_dn Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 1.24 5 4.05 8.53e-03
ageing_lymph_dn Downregulated in human lymphocytes from old individuals, compared to young 30 0.15 2 13.48 9.70e-03
brcax_a_up Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 30 0.15 2 13.48 9.70e-03

Raw data (tab-delimited .txt)