L2L Microarray Analysis Tool

Results summary	View all lists in L2L MDB	View all genes in L04A.profile.d50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
serum_fibroblast_cellcycle	Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines	197	0.49	6	12.32	1.15e-05
middleage_dn	Downregulated in fibroblasts from middle-age individuals, compared to young	23	0.06	3	52.77	2.58e-05
5azac-tsa_hepg2_dn	Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA).	2343	5.79	17	2.94	1.13e-04
uvc_high_all_dn	Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9)	634	1.57	8	5.10	2.21e-04
uvb_scc_dn	Downregulated by UV-B light in squamous cell carinoma cells	219	0.54	5	9.24	2.39e-04
5azac_hepg2_dn	Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC).	1830	4.52	14	3.09	2.59e-04
mms_human_lymph_high_4hrs_dn	Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS)	11	0.03	2	73.55	3.31e-04
gamma-uv_fibro_up	Up-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO	57	0.14	3	21.29	4.00e-04
oxstress_breastca_dn	Downregulated by H2O2, Menadione and t-BH in breast cancer cells	16	0.04	2	50.57	7.17e-04
heatshock_hela_4hr_dn	Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05).	1829	4.52	13	2.88	8.24e-04
stemcell_neural_up	Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells	2805	6.93	17	2.45	8.51e-04
stress_genotoxic_specific_dn	Genes down-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress	74	0.18	3	16.40	8.59e-04
oldage_dn	Downregulated in fibroblasts from old individuals, compared to young	76	0.19	3	15.97	9.28e-04
myc_targets	Myc-responsive genes reported in multiple systems	77	0.19	3	15.76	9.64e-04
stress_tpa_specific_up	Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents	78	0.19	3	15.56	1.00e-03
werner_fibro_up	Upregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals	81	0.20	3	14.98	1.12e-03
cmv_hcmv_timecourse_14hrs_up	Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours	84	0.21	3	14.45	1.24e-03
stemcell_embryonic_up	Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells	1989	4.92	13	2.64	1.72e-03
senescence_hela_dn	Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb.	341	0.84	5	5.93	1.73e-03
cancer_undifferentiated_meta_up	Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database	98	0.24	3	12.38	1.93e-03
heatshock_hela_2hr_dn	Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05).	223	0.55	4	7.26	2.44e-03
oldwerner_fibro_up	Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young	30	0.07	2	26.97	2.54e-03
tpa_skin_up	Upregulated in murine dorsal skin cells 6 hours after treatment with the phorbol ester carcinogen TPA	31	0.08	2	26.10	2.71e-03
uvc_ttd_all_dn	Down-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC	780	1.93	7	3.63	3.68e-03
uvc_ttd_4hr_dn	Down-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC	641	1.58	6	3.79	5.70e-03
senescence_hff_dn	Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8).	299	0.74	4	5.41	6.85e-03
senescence_rep-ind_dn	Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence.	171	0.42	3	7.10	9.09e-03
aged_mouse_hippocampus_any_dn	Down-regulated in the hippocampus of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls	60	0.15	2	13.48	9.83e-03

serum_fibroblast_cellcycle

Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines

197

0.49

6

12.32

1.15e-05

middleage_dn

Downregulated in fibroblasts from middle-age individuals, compared to young

23

0.06

3

52.77

2.58e-05

5azac-tsa_hepg2_dn

Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA).

2343

5.79

17

2.94

1.13e-04

uvc_high_all_dn

Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9)

634

1.57

8

5.10

2.21e-04

uvb_scc_dn

Downregulated by UV-B light in squamous cell carinoma cells

219

0.54

5

9.24

2.39e-04

5azac_hepg2_dn

Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC).

1830

4.52

14

3.09

2.59e-04

mms_human_lymph_high_4hrs_dn

Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS)

11

0.03

2

73.55

3.31e-04

gamma-uv_fibro_up

Up-regulated at any timepoint by treatment of human fibroblasts with UV light or gamma radiation, but not by 4-NQO

57

0.14

3

21.29

4.00e-04

oxstress_breastca_dn

Downregulated by H2O2, Menadione and t-BH in breast cancer cells

16

0.04

2

50.57

7.17e-04

heatshock_hela_4hr_dn

Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05).

1829

4.52

13

2.88

8.24e-04

stemcell_neural_up

Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells

2805

6.93

17

2.45

8.51e-04

stress_genotoxic_specific_dn

Genes down-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress

74

0.18

3

16.40

8.59e-04

oldage_dn

Downregulated in fibroblasts from old individuals, compared to young

76

0.19

3

15.97

9.28e-04

myc_targets

Myc-responsive genes reported in multiple systems

77

0.19

3

15.76

9.64e-04

stress_tpa_specific_up

Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents

78

0.19

3

15.56

1.00e-03

werner_fibro_up

Upregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals

81

0.20

3

14.98

1.12e-03

cmv_hcmv_timecourse_14hrs_up

Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours

84

0.21

3

14.45

1.24e-03

stemcell_embryonic_up

Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells

1989

4.92

13

2.64

1.72e-03

senescence_hela_dn

Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb.

341

0.84

5

5.93

1.73e-03

cancer_undifferentiated_meta_up

Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database

98

0.24

3

12.38

1.93e-03

heatshock_hela_2hr_dn

Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05).

223

0.55

4

7.26

2.44e-03