L2L L2L Microarray Analysis Tool

Results for L01D.profile.ud50

Results summary View all lists in L2L MDB View all genes in L01D.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.06 4 67.42 2.86e-07
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.28 5 18.06 9.15e-06
et743_sarcoma_72hrs_up Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines 106 0.52 6 11.45 1.63e-05
hypoxia_review Genes known to be induced by hypoxia 160 0.79 7 8.85 1.74e-05
hypoxia_fibro_up Upregulated by hypoxia in normal fibroblasts from both young and old donors (Table 3) 34 0.17 4 23.80 2.46e-05
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.19 4 21.29 3.86e-05
bleo_human_lymph_high_4hrs_dn Down-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 15 0.07 3 40.45 5.26e-05
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.07 3 40.45 5.26e-05
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.08 3 37.93 6.45e-05
uvb_nhek1_dn Downregulated by UV-B light in normal human epidermal keratinocytes 542 2.68 11 4.11 1.06e-04
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.47 5 10.65 1.18e-04
uvb_scc_dn Downregulated by UV-B light in squamous cell carinoma cells 219 1.08 7 6.47 1.26e-04
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.10 3 28.90 1.50e-04
cmv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 109 0.54 5 9.28 2.25e-04
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 11 3.75 2.29e-04
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 11 3.75 2.29e-04
et743_sarcoma_up Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 111 0.55 5 9.11 2.45e-04
uvc_xpcs_all_up Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 112 0.55 5 9.03 2.55e-04
hif1_targets Hif-1 (hypoxia-inducible factor 1) transcripional targets 67 0.33 4 12.08 3.57e-04
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.15 3 19.57 4.90e-04
hdaci_colon_cur24hrs_up Upregulated by curcumin at 24 hrs in SW260 colon carcinoma cells 73 0.36 4 11.08 4.95e-04
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.67 5 7.49 6.01e-04
cmv-uv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 207 1.02 6 5.86 6.37e-04
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.39 4 10.37 6.37e-04
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.17 3 17.85 6.45e-04
atria_up Upregulated in the atria of healthy hearts, compared to venticles 384 1.90 8 4.21 7.56e-04
ad12_12hrs_dn Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 12 hours post-infection 9 0.04 2 44.95 8.60e-04
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.19 3 15.97 8.96e-04
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.43 4 9.30 9.59e-04
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.44 4 9.09 1.04e-03
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 1.15 6 5.21 1.17e-03
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 6.53 16 2.45 1.18e-03
vegf_hmmec_3hrs_up Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 99 0.49 4 8.17 1.55e-03
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.23 3 12.91 1.67e-03
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 1.69 7 4.15 1.73e-03
hdaci_colon_cur_up Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 174 0.86 5 5.81 1.86e-03
hdaci_colon_cur2hrs_up Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells 49 0.24 3 12.38 1.88e-03
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.24 3 12.38 1.88e-03
uvc_xpcs_8hr_up Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 108 0.53 4 7.49 2.13e-03
elongina_ko_up Upregulated in MES cells from elongin-A knockout mice 263 1.30 6 4.61 2.16e-03
uvc_high_d4_dn Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d4) 110 0.54 4 7.36 2.27e-03
aged_mouse_neocortex_up Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.55 4 7.29 2.35e-03
5azac-tsa_hepg2_up Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 1966 9.72 20 2.06 2.47e-03
cmv_uv-cmv_common_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 54 0.27 3 11.24 2.48e-03
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.27 3 11.24 2.48e-03
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.27 3 11.24 2.48e-03
h2o2_csbrescued_c2_up Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 2) 17 0.08 2 23.80 3.16e-03
tnfalpha_all_up Upregulated at any timepoint after TNF-alpha treatment of HeLa cells 122 0.60 4 6.63 3.30e-03
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.30 3 9.95 3.51e-03
oxstress_rpethree_dn Downregulated by all three of H2O2, HNE and t-BH in retinal pigment epithelium cells (Table 2) 61 0.30 3 9.95 3.51e-03
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 3.00 9 3.00 3.67e-03
tnfalpha_4hrs_up Upregulated 4hrs after TNF-alpha treatment of HeLa cells 62 0.31 3 9.79 3.68e-03
ros_mouse_aorta_dn Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.63 4 6.37 3.81e-03
5azac_hepg2_up Up-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1630 8.06 17 2.11 3.90e-03
platelet_expressed Fifty genes most strongly expressed in human platlets from three healthy donors 66 0.33 3 9.19 4.38e-03
tsa_hepatoma_up Up-regulated in more than one of several human hepatoma cell lines by 24-hour treatment with trichostatin A 67 0.33 3 9.06 4.57e-03
dsrna_up Upregulated by dsRNA (polyI:C) in IFN-null GRE cells 68 0.34 3 8.92 4.77e-03
alzheimers_incipient_dn Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus 312 1.54 6 3.89 4.95e-03
methotrexate_probcell_dn Down-regulated in pro-B cells (FL5.12) following treatment with methotrexate 22 0.11 2 18.39 5.29e-03
uvc_xpcs_4hr_up Up-regulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 23 0.11 2 17.59 5.77e-03
vegf_hmmec_all_up Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells 147 0.73 4 5.50 6.37e-03
idx_tsa_up_cluster5 Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) 149 0.74 4 5.43 6.68e-03
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.39 3 7.68 7.22e-03
hippocampus_development_postnatal Highly expressed in late postnatal mouse hippocampus (clusters 11 and 15) 79 0.39 3 7.68 7.22e-03
cancerdrugs_probcell_dn Down-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 26 0.13 2 15.56 7.34e-03
rb_creko_dn Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 1.24 5 4.05 8.53e-03
old_fibro_up Upregulated in fibroblasts from old individuals, compared to young 84 0.42 3 7.22 8.55e-03
brcax_a_up Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 30 0.15 2 13.48 9.70e-03
vegf_hmmec_6hrs_up Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 88 0.44 3 6.90 9.70e-03

Raw data (tab-delimited .txt)