L2L L2L Microarray Analysis Tool

Results for L01D.profile.u50

Results summary View all lists in L2L MDB View all genes in L01D.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.03 4 134.85 1.82e-08
et743_sarcoma_72hrs_up Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines 106 0.26 6 22.90 3.15e-07
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.14 5 36.12 3.17e-07
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 4 42.58 2.58e-06
hypoxia_review Genes known to be induced by hypoxia 160 0.40 6 15.17 3.49e-06
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 5 21.29 4.44e-06
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 3 80.91 6.72e-06
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.04 3 75.85 8.26e-06
et743_sarcoma_up Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 111 0.27 5 18.22 9.51e-06
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.05 3 57.79 1.94e-05
5azac_hepg2_up Up-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1630 4.03 15 3.72 2.09e-05
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 5 14.98 2.45e-05
hif1_targets Hif-1 (hypoxia-inducible factor 1) transcripional targets 67 0.17 4 24.15 2.53e-05
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22 4 18.18 7.71e-05
hypoxia_fibro_up Upregulated by hypoxia in normal fibroblasts from both young and old donors (Table 3) 34 0.08 3 35.69 8.53e-05
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 3 35.69 8.53e-05
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.09 3 31.94 1.19e-04
5azac-tsa_hepg2_up Up-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). 1966 4.86 15 3.09 1.64e-04
aged_mouse_neocortex_up Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.27 4 14.58 1.81e-04
uvc_xpcs_all_up Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 112 0.28 4 14.45 1.87e-04
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 3 25.82 2.26e-04
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 3 24.77 2.56e-04
ros_mouse_aorta_dn Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.31 4 12.74 3.03e-04
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 5 8.68 3.17e-04
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 3 22.47 3.41e-04
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.13 3 22.47 3.41e-04
rb_creko_dn Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 0.62 5 8.09 4.37e-04
atria_up Upregulated in the atria of healthy hearts, compared to venticles 384 0.95 6 6.32 4.41e-04
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.15 3 19.90 4.88e-04
oxstress_rpethree_dn Downregulated by all three of H2O2, HNE and t-BH in retinal pigment epithelium cells (Table 2) 61 0.15 3 19.90 4.88e-04
idx_tsa_up_cluster5 Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) 149 0.37 4 10.86 5.54e-04
platelet_expressed Fifty genes most strongly expressed in human platlets from three healthy donors 66 0.16 3 18.39 6.15e-04
dsrna_up Upregulated by dsRNA (polyI:C) in IFN-null GRE cells 68 0.17 3 17.85 6.71e-04
hdaci_colon_cur24hrs_up Upregulated by curcumin at 24 hrs in SW260 colon carcinoma cells 73 0.18 3 16.62 8.25e-04
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.19 3 15.56 1.00e-03
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
hippocampus_development_postnatal Highly expressed in late postnatal mouse hippocampus (clusters 11 and 15) 79 0.20 3 15.36 1.04e-03
alzheimers_incipient_dn Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus 312 0.77 5 6.48 1.18e-03
old_fibro_up Upregulated in fibroblasts from old individuals, compared to young 84 0.21 3 14.45 1.24e-03
methotrexate_probcell_dn Down-regulated in pro-B cells (FL5.12) following treatment with methotrexate 22 0.05 2 36.78 1.37e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
vegf_hmmec_6hrs_up Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 88 0.22 3 13.79 1.42e-03
cancerdrugs_probcell_dn Down-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrextate and/or paclitaxel) in pro-B cells (FL5.12) 26 0.06 2 31.12 1.91e-03
vegf_hmmec_3hrs_up Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 99 0.24 3 12.26 1.98e-03
uvc_ttd_4hr_up Up-regulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 105 0.26 3 11.56 2.35e-03
uvc_xpcs_8hr_up Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 108 0.27 3 11.24 2.54e-03
ventricle_up Upregulated in the ventricles of healthy hearts, compared to atria 373 0.92 5 5.42 2.55e-03
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.93 5 5.38 2.64e-03
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.08 2 26.10 2.71e-03
htert_dn Downregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 112 0.28 3 10.84 2.82e-03
tgfb_mammary_up Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). 118 0.29 3 10.28 3.26e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 3 9.95 3.58e-03
uvb_nhek2_up Upregulated by UV-B light in normal human epidermal keratinocytes 125 0.31 3 9.71 3.83e-03
elongina_ko_up Upregulated in MES cells from elongin-A knockout mice 263 0.65 4 6.15 4.38e-03
elongina_ko_dn Downregulated in MES cells from elongin-A knockout mice 267 0.66 4 6.06 4.62e-03
pubertal_mammary Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. 1260 3.11 9 2.89 4.77e-03
uvc_ttd_all_up Up-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 140 0.35 3 8.67 5.25e-03
senescence_hff_up Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 0.70 4 5.70 5.73e-03
vegf_hmmec_all_up Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells 147 0.36 3 8.26 6.01e-03
hdaci_colon_cur2hrs_up Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells 49 0.12 2 16.51 6.65e-03
camptothecin_probcell_dn Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin 52 0.13 2 15.56 7.46e-03
igf_vs_pdgf_dn Down-regulated in mouse C2AS12 myoblasts by treatment with IGF1, compared to treatment with PDGF 53 0.13 2 15.27 7.74e-03
tsadac_panc50_up 50 "most interesting" genes upregulated by the combination of TSA and DAC in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 56 0.14 2 14.45 8.61e-03
tpa_resist_early_up Upregulated by TPA at two consecutive timepoints between 15min-3hrs in resistant HL-525 cells 57 0.14 2 14.19 8.91e-03
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 5 3.97 9.34e-03
hdaci_colon_cur_up Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 174 0.43 3 6.97 9.52e-03

Raw data (tab-delimited .txt)